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  • PEAR: a fast and accurate Illumina Paired-End reAd mergeR

PEAR: a fast and accurate Illumina Paired-End reAd mergeR

http://www.exelixis-lab.org/web/software/pear

PEAR is an ultrafast, memory-efficient and highly accurate pair-end read merger. It is fully parallelized and can run with as low as just a few kilobytes of memory.

PEAR evaluates all possible paired-end read overlaps and without requiring the target fragment size as input. In addition, it implements a statistical test for minimizing false-positive results. Together with a highly optimized implementation, it can merge millions of paired end reads within a couple of minutes on a standard desktop computer.

More at http://www.exelixis-lab.org/web/software/pear

Paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933873/