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  • Proteny: discovering and visualizing statistically significant syntenic clusters at the proteome...

Proteny: discovering and visualizing statistically significant syntenic clusters at the proteome level

https://github.com/thiesgehrmann/proteny

A tool to analyze synteny at the protein level. We develop an algorithm to detect statistically significant clusters of exons between two proteomes. The tool provides algorithms to quickly detect and visualize results in order to support conclusions from genomic data.

The method discovers clusters of hits from a bi-directional BLASTp of translated exon sequences in two organisms. A dendrogram for hits is built based on genomic distances between hits, and cut based on significance of a cluster score based on a permutation test at each node in the tree. The result is a set of large clusters describing high exonic conservation.