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MIRA paper


Motivation: This article presents a method for as­ sembling shotgun sequences which primarily uses high confidence regions whilst taking advantage of additional available information such as low con­ fidence regions, quality values or repetitive region tags. Conflict situations are resolved with routines for analysing trace signals.
Results: Initial tests with different human and mouse genome projects showed promising results but also demonstrated the need to recognise and handle correctly very long, untagged and non­ standard repeats. 
Availability: Current versions of the MIRA assem­ bler are available on request at the canonical project homepage as binary for SGI, Intel Linux and SUN Solaris: http://www.dkfz­heidelberg.de/mbp­ased/ 
Contact: b.chevreux@dkfz­heidelberg.de