This group seeks to elucidate the principles of protein structure evolution, higher order protein structure and protein folding, and the principles underlying protein complex formation and organization. We have a longstanding interest in understanding gene expression regulation, and in our wetlab at the Sanger Institute use mouse T helper cells as a model of cell differentiation.

This lab focuses on two main areas: (1) transcription factors and the regulation of gene expression, and (2) physical protein-protein interactions and protein complexes

This group also aim to elucidate transcriptional regulatory networks orchestrating T helper cell differentiation and plasticity. Using the T helper cell system, we want to answer questions such as: What is the hierarchy and kinetics of molecular events that contribute to changes in gene expression? Are the kinetics of these interactions graded or switch-like?

PI Sarah Teichmann