Results for "Breakpoints"
Tags
Dynamic chromosome breakpoints !!!
Cell division involves the distribution of identical genetic material, DNA, to two daughters’ cells. During this process, duplicated deoxyribonucleic acid (DNA) goes through a condensation and decondensation process. This is followed by nuclear envelope dissolution, mitotic spindle assembly...Tags: Bioinformatics, Genome, Chromosome, Breaks, Breakpoints, EBRs, Recombination, Cross-over, Abnormalities, DNA
3537 days ago
- The accurate description and annotation of structural variants can be complex. This is due to the different resolution that variants are reported from traditional cytogenetic coordinates down to the actual base pair positions. Furthermore, multiple rearrangements in a single area ...
Tags: Bioinformatics, COSMIC, Chromosome, Cancer, Rearrangement, Breakpoints
2757 days ago
- Development of cancer is driven by somatic alterations, including numerical and structural chromosomal aberrations. Currently, several computational methods are available and are widely applied to detect numerical copy number aberrations (CNAs) of chromosomal segments in tumor genomes. However, t...
Tags: Bioinformatics, GeneBreak, Chromosome, Genome, NGS, Breakpoints, Genes
2138 days ago
- SRBreak is a read-depth and split-read package written in R for identifying copy-number variants in next-generation sequencing datasets. Note: SBReak was designed to work for multiple samples. It can work for >= 2 samples, but we suggest that users should use >= 5 samples as in the work ...
Tags: SRBreak, Read-Depth, Split-Read, Framework, Breakpoints, Copy-Number, Variable, Regions
2167 days ago
- DNA is quite fragile and easily damaged, both by the normal processes of life at work within our cells and by external agents such as the chemicals in tobacco smoke or ultraviolet (UV) rays from the sun. However, our cells have evolved clever ‘repair kits’ that spot DNA damage and patch it up, he...
Tags: DSB, Repair, Breaks, Metabolism, Laboratory, Double, Strand, Breakpoints
1956 days ago
