Results for "Stability"

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  • Nieduszynski Group

    Complete, accurate replication of the genome is essential for life. All chromosomes in eukaryotic cells must be duplicated and then segregated to daughter cells to ensure genetic integrity and produce the large number of cells that make up a multicellular organism. We are using genetic, genomic a...

    Tags: Bioinformatics, Computational Biology, Genome, Stability, Replication, Chromosome, Cancer, Oxford

    3461 days ago

  • STRUM: structure-based prediction of protein stability changes upon single-point mutation

    STRUM is a method for predicting the fold stability change (ΔΔG) of protein molecules upon single-point nsSNP mutations. STRUM adopts a gradient boosting regression approch to train the Gibbs free-energy changes on a variety of features at different levels of sequence and structure pr...

    Tags: STRUM, structure-based, prediction, protein, stability, changes, single-point, mutation

    2016 days ago