...h defects in humans such as Down's syndrome.Our laboratory is also interested in understanding the effect of genetic background on mutation rate variation using S. cerevisiae as a mode...
A major focus of our lab is understanding the effects of genetic variation on molecular phenotypes and human disease. We develop methods for integrating diverse functional genomic data...
...lation history and natural selection. As a result, studies of natural variation can provide important insight...o subtle to be detected in lab settings, while analyses of population variation allow for inferences about ev...
The laboratory is focused on the discovery and analysis of structural variation (SVs) from genomic sequence data. As part of the 1000 Genomes Project and other endeavors, we have helpe...
TheLab seek to understand the genetic factors contributing to genomic variation and phenotypic diversity. To this end, we employ molecular and bioinformatic tools to study evolutionar...
...tion and other evolutionary forces lead to particular patterns of evolutionary dynamics, and they leave characteristic signatures on the genetic variation within populations. We use a...
...angements in evolution and cancer.
As a computational genomicists our work involves examining billions of DNA base pairs and interpreting how variation impacts basic biology and dis...
...n of repetitive sequences, and reconstructing ancestral genomes. We are testing causal links between whole-genome duplication events, karyotypic variation and species radiations.
Mo...