<![CDATA[BOL: BRAKER: pipeline for fully automated prediction of protein coding genes with GeneMark-ES/ET and AUGUSTUS in novel eukaryotic genomes]]> https://bioinformaticsonline.com/bookmarks/view/28997/braker-pipeline-for-fully-automated-prediction-of-protein-coding-genes-with-genemark-eset-and-augustus-in-novel-eukaryotic-genomes? https://bioinformaticsonline.com/bookmarks/view/28997/braker-pipeline-for-fully-automated-prediction-of-protein-coding-genes-with-genemark-eset-and-augustus-in-novel-eukaryotic-genomes Thu, 01 Sep 2016 08:02:59 -0500 https://bioinformaticsonline.com/bookmarks/view/28997/braker-pipeline-for-fully-automated-prediction-of-protein-coding-genes-with-genemark-eset-and-augustus-in-novel-eukaryotic-genomes <![CDATA[BRAKER: pipeline for fully automated prediction of protein coding genes with GeneMark-ES/ET and AUGUSTUS in novel eukaryotic genomes]]> Gene finding in eukaryotic genomes is notoriously difficult to automate. The task is to design a work flow with a minimal set of tools that would reach state-of-the-art performance across a wide range of species. GeneMark-ET is a gene prediction tool that incorporates RNA-Seq data into unsupervised training and subsequently generates ab initio gene predictions. AUGUSTUS is a gene finder that usually requires supervised training and uses information from RNA-Seq reads in the prediction step. Complementary strengths of GeneMark-ET and AUGUSTUS provided motivation for designing a new combined tool for automatic gene prediction.

http://www.ncbi.nlm.nih.gov/pubmed/26559507

Address of the bookmark: http://bioinf.uni-greifswald.de/bioinf/braker/

]]> Jit