<![CDATA[BOL: Mauve: a system for constructing multiple genome alignments in the presence of large-scale evolutionary events such as rearrangement and inversion]]> https://bioinformaticsonline.com/bookmarks/view/30375/mauve-a-system-for-constructing-multiple-genome-alignments-in-the-presence-of-large-scale-evolutionary-events-such-as-rearrangement-and-inversion? https://bioinformaticsonline.com/bookmarks/view/30375/mauve-a-system-for-constructing-multiple-genome-alignments-in-the-presence-of-large-scale-evolutionary-events-such-as-rearrangement-and-inversion Sat, 24 Dec 2016 09:20:53 -0600 https://bioinformaticsonline.com/bookmarks/view/30375/mauve-a-system-for-constructing-multiple-genome-alignments-in-the-presence-of-large-scale-evolutionary-events-such-as-rearrangement-and-inversion <![CDATA[Mauve: a system for constructing multiple genome alignments in the presence of large-scale evolutionary events such as rearrangement and inversion]]> Mauve is a system for constructing multiple genome alignments in the presence of large-scale evolutionary events such as rearrangement and inversion. Multiple genome alignments provide a basis for research into comparative genomics and the study of genome-wide evolutionary dynamics.

Mauve has been developed with the idea that a multiple genome aligner should require only modest computational resources. It employs algorithmic techniques that scale well in the lengths of sequences being aligned. For example, a pair of Y. pestis genomes can be aligned in under a minute, while a group of 9 divergent Enterobacterial genomes can be aligned in a few hours. However, the current algorithm’s compute time (progressiveMauve) scales cubically in the number of genomes to align, making it unsuitable for datasets containing more than 50-100 bacterial genomes.

Address of the bookmark: http://darlinglab.org/mauve/mauve.html

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