<![CDATA[BOL: Multi-CAR: a tool of contig scaffolding using multiple references]]> https://bioinformaticsonline.com/bookmarks/view/35885/multi-car-a-tool-of-contig-scaffolding-using-multiple-references? https://bioinformaticsonline.com/bookmarks/view/35885/multi-car-a-tool-of-contig-scaffolding-using-multiple-references Tue, 06 Mar 2018 16:39:41 -0600 https://bioinformaticsonline.com/bookmarks/view/35885/multi-car-a-tool-of-contig-scaffolding-using-multiple-references <![CDATA[Multi-CAR: a tool of contig scaffolding using multiple references]]> we design a simple heuristic method to further revise our single reference-based scaffolding tool CAR into a new one called Multi-CAR such that it can utilize multiple complete genomes of related organisms as references to more accurately order and orient the contigs of a draft genome. In practical usage, our Multi-CAR does not require prior knowledge concerning phylogenetic relationships among the draft and reference genomes and libraries of paired-end reads. To validate Multi-CAR, we have tested it on a real dataset composed of several prokaryotic genomes and also compared its accuracy performance with other multiple reference-based scaffolding tools Ragout and MeDuSa. 

Address of the bookmark: http://genome.cs.nthu.edu.tw/Multi-CAR/

]]> Rahul Nayak