<![CDATA[BOL: STRUM: structure-based prediction of protein stability changes upon single-point mutation]]> https://bioinformaticsonline.com/bookmarks/view/37669/strum-structure-based-prediction-of-protein-stability-changes-upon-single-point-mutation? https://bioinformaticsonline.com/bookmarks/view/37669/strum-structure-based-prediction-of-protein-stability-changes-upon-single-point-mutation Mon, 10 Sep 2018 13:21:49 -0500 https://bioinformaticsonline.com/bookmarks/view/37669/strum-structure-based-prediction-of-protein-stability-changes-upon-single-point-mutation <![CDATA[STRUM: structure-based prediction of protein stability changes upon single-point mutation]]> STRUM is a method for predicting the fold stability change (ΔΔG) of protein molecules upon single-point nsSNP mutations. STRUM adopts a gradient boosting regression approch to train the Gibbs free-energy changes on a variety of features at different levels of sequence and structure properties. The unique characteristics of STRUM is the combination of sequence profiles with low-resolution structure models from protein structure prediction, which helps enhance the robustness and accuracy of the method and make it applicable to various protein seqences, including those without experimental structures 

Address of the bookmark: https://zhanglab.ccmb.med.umich.edu/STRUM/

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