<![CDATA[BOL: MACSE: Multiple Alignment of Coding SEquences Accounting for Frameshifts and Stop Codons]]> https://bioinformaticsonline.com/bookmarks/view/39017/macse-multiple-alignment-of-coding-sequences-accounting-for-frameshifts-and-stop-codons? https://bioinformaticsonline.com/bookmarks/view/39017/macse-multiple-alignment-of-coding-sequences-accounting-for-frameshifts-and-stop-codons Mon, 18 Feb 2019 04:21:50 -0600 https://bioinformaticsonline.com/bookmarks/view/39017/macse-multiple-alignment-of-coding-sequences-accounting-for-frameshifts-and-stop-codons <![CDATA[MACSE: Multiple Alignment of Coding SEquences Accounting for Frameshifts and Stop Codons]]> MACSE aligns coding NT sequences with respect to their AA translation while allowing NT sequences to contain multiple frameshifts and/or stop codons. MACSE is hence the first automatic solution to align protein-coding gene datasets containing non-functional sequences (pseudogenes) without disrupting the underlying codon structure. It has also proved useful in detecting undocumented frameshifts in public database sequences and in aligning next-generation sequencing reads/contigs against a reference coding sequence.

For further details about the underlying algorithm see the original publication:
MACSE: Multiple Alignment of Coding SEquences accounting for frameshifts and stop codons.
Vincent Ranwez, Sébastien Harispe, Frédéric Delsuc, Emmanuel JP Douzery
PLoS One 2011, 6(9): e22594.

Address of the bookmark: https://bioweb.supagro.inra.fr/macse/index.php?menu=releases

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