<![CDATA[BOL: MSAProbs - Parallel and accurate multiple sequence alignment]]> https://bioinformaticsonline.com/bookmarks/view/39689/msaprobs-parallel-and-accurate-multiple-sequence-alignment? https://bioinformaticsonline.com/bookmarks/view/39689/msaprobs-parallel-and-accurate-multiple-sequence-alignment Tue, 09 Jul 2019 23:58:44 -0500 https://bioinformaticsonline.com/bookmarks/view/39689/msaprobs-parallel-and-accurate-multiple-sequence-alignment <![CDATA[MSAProbs - Parallel and accurate multiple sequence alignment]]> MSAProbs is a well-established state-of-the-art multiple sequence alignment algorithm for protein sequences. The design of MSAProbs is based on a combination of pair hidden Markov models and partition functions to calculate posterior probabilities. Assessed using the popular benchmarks: BAliBASE, PREFAB, SABmark and OXBENCH, MSAProbs achieves statistically significant accuracy improvements over the existing top performing aligners, including ClustalW, MAFFT, MUSCLE, ProbCons and Probalign. In addition, MSAProbs is optimized for shared-memory CPUs by employing a multi-threaded design, and further parallelized for distributed-memory systems using MPI to overcome high memory overhead barrier and achieve good parallel and data-size scalability.

Address of the bookmark: http://msaprobs.sourceforge.net/homepage.htm#latest

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