<![CDATA[BOL: RosettaAntibodyDesign (RAbD): A general framework for computational antibody design]]> https://bioinformaticsonline.com/bookmarks/view/42201/rosettaantibodydesign-rabd-a-general-framework-for-computational-antibody-design? https://bioinformaticsonline.com/bookmarks/view/42201/rosettaantibodydesign-rabd-a-general-framework-for-computational-antibody-design Sun, 20 Sep 2020 06:03:42 -0500 https://bioinformaticsonline.com/bookmarks/view/42201/rosettaantibodydesign-rabd-a-general-framework-for-computational-antibody-design <![CDATA[RosettaAntibodyDesign (RAbD): A general framework for computational antibody design]]> RosettaAntibodyDesign (RAbD) is a generalized framework for the design of antibodies, in which a user can easily tailor the run to their project needs. The algorithm is meant to sample the diverse sequence, structure, and binding space of an antibody-antigen complex. It can be used for a multitude of project types, from denovo design to redesigns that improve binding affinity, optimize stability, or manipulate function.

The framework is based on rigorous bioinformatic analysis and rooted very much on our recent clustering of antibody CDR regions. It uses the North/Dunbrack CDR definition as outlined in the North/Dunbrack clustering paper.

More at

https://www.rosettacommons.org/docs/latest/application_documentation/antibody/RosettaAntibodyDesign

https://bio-jade.readthedocs.io/en/latest/installation.html

Address of the bookmark: https://www.rosettacommons.org/docs/latest/application_documentation/antibody/RosettaAntibodyDesign

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