<![CDATA[BOL: MAGIC: A tool for predicting transcription factors and cofactors driving gene sets using ENCODE data]]> https://bioinformaticsonline.com/bookmarks/view/42362/magic-a-tool-for-predicting-transcription-factors-and-cofactors-driving-gene-sets-using-encode-data? https://bioinformaticsonline.com/bookmarks/view/42362/magic-a-tool-for-predicting-transcription-factors-and-cofactors-driving-gene-sets-using-encode-data Thu, 26 Nov 2020 11:05:04 -0600 https://bioinformaticsonline.com/bookmarks/view/42362/magic-a-tool-for-predicting-transcription-factors-and-cofactors-driving-gene-sets-using-encode-data <![CDATA[MAGIC: A tool for predicting transcription factors and cofactors driving gene sets using ENCODE data]]> The algorithm presented herein, Mining Algorithm for GenetIc Controllers (MAGIC), uses ENCODE ChIP-seq data to look for statistical enrichment of TFs and cofactors in gene bodies and flanking regions in gene lists without an a priori binary classification of genes as targets or non-targets. When compared to other TF mining resources, MAGIC displayed favourable performance in predicting TFs and cofactors that drive gene changes in 4 settings:

1) A cell line expressing or lacking single TF,

2) Breast tumors divided along PAM50 designations

3) Whole brain samples from WT mice or mice lacking a single TF in a particular neuronal subtype

4) Single cell RNAseq analysis of neurons divided by Immediate Early Gene expression levels.

In summary, MAGIC is a standalone application that produces meaningful predictions of TFs and cofactors in transcriptomic experiments.

More at https://uwmadison.app.box.com/s/8j90e5h2rjrsz3bacaxnq8kor2o64vyg

Address of the bookmark: https://github.com/asroopra/MAGIC

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