<![CDATA[BOL: GraphPath: A graph attention model for molecular stratification with interpretability based on the pathway-pathway interaction network]]> https://bioinformaticsonline.com/bookmarks/view/44497/graphpath-a-graph-attention-model-for-molecular-stratification-with-interpretability-based-on-the-pathway-pathway-interaction-network? https://bioinformaticsonline.com/bookmarks/view/44497/graphpath-a-graph-attention-model-for-molecular-stratification-with-interpretability-based-on-the-pathway-pathway-interaction-network Wed, 27 Mar 2024 20:51:21 -0500 https://bioinformaticsonline.com/bookmarks/view/44497/graphpath-a-graph-attention-model-for-molecular-stratification-with-interpretability-based-on-the-pathway-pathway-interaction-network <![CDATA[GraphPath: A graph attention model for molecular stratification with interpretability based on the pathway-pathway interaction network]]> Achieving accurate and interpretable clinical predictions requires paramount attention to thoroughly characterizing patients at both the molecular and biological pathway levels. In this paper, we present GraphPath, a biological knowledge-driven graph neural network with multi-head self-attention mechanism that implements the pathway-pathway interaction network. We train GraphPath to classify the cancer status of patients with prostate cancer based on their multi-omics profiling.

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Address of the bookmark: https://github.com/amazingma/GraphPath

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