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	<title><![CDATA[BOL: All site fun]]></title>
	<link>https://bioinformaticsonline.com/fun/all?offset=0</link>
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	<description><![CDATA[]]></description>
	
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	<guid isPermaLink="true">https://bioinformaticsonline.com/fun/view/45093/computational-but-a-biologist</guid>
	<pubDate>Thu, 09 Apr 2026 00:44:46 -0500</pubDate>
	<link>https://bioinformaticsonline.com/fun/view/45093/computational-but-a-biologist</link>
	<title><![CDATA[Computational, but a Biologist !]]></title>
	<description><![CDATA[<p>There was a time when doing biology<br />meant working only with your hands&mdash;<br />and that alone was seen<br />as &ldquo;real science.&rdquo;</p><p>People using computers were often seen<br />as helpers, not leaders&mdash;<br />useful, but not essential.</p><p>Sometimes, the criticism was direct.<br />Sometimes subtle.<br />But the message was the same&mdash;<br />this work doesn&rsquo;t really count.</p><p>Then biology changed.<br />The questions became bigger,<br />and experiments alone<br />were no longer enough.</p><p>Organizing knowledge by hand worked once.<br />Now it needs computers&mdash;<br />to handle scale, speed, and complexity.</p><p>Some patterns are simply invisible<br />if you look at one sample.<br />You need many&mdash;<br />and the right tools to understand them.</p><p>So we started building maps&mdash;<br />of genomes, cells, and systems.<br />Not perfect,<br />but extremely useful.</p><p>Ideas also had to become clearer.<br />It&rsquo;s no longer enough to say something sounds right&mdash;<br />you have to measure it.</p><p>The divide between &ldquo;types&rdquo; of biologists<br />never really made sense.<br />We are solving the same problems&mdash;<br />just in different ways.</p><p>Progress didn&rsquo;t wait for agreement.<br />It moved forward with data,<br />with code,<br />and with careful analysis.</p><p>What matters now is simple:<br />&bull; Biology depends on computation<br />&bull; Coding is an important skill<br />&bull; Statistics helps us think clearly<br />&bull; And the people building these tools<br />are shaping the future of science</p>]]></description>
	<dc:creator>LEGE</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/fun/view/44845/a-bioinformatician%E2%80%99s-lament</guid>
	<pubDate>Thu, 29 May 2025 01:33:31 -0500</pubDate>
	<link>https://bioinformaticsonline.com/fun/view/44845/a-bioinformatician%E2%80%99s-lament</link>
	<title><![CDATA[A Bioinformatician’s Lament]]></title>
	<description><![CDATA[<div><div dir="auto"><p><em>"I have a presentation tomorrow,"</em>&nbsp;they say,</p><p>With hopeful eyes, like it&rsquo;s all child's play.<br />As if results bloom overnight, full-grown&mdash;<br />Not wrangled from chaos, and error-prone.</p><p><strong>Oh brave soul, sit, let&rsquo;s walk through the tale,</strong><br />Of pipelines broken and servers that fail.<br />The journey starts: &ldquo;The data? It&rsquo;s there&mdash;<br />Just fetch it from S3, easy, I swear.&rdquo;</p><p>Now I summon&nbsp;<code>awscli</code>&nbsp;with dread,<br />Reset my keys, credentials fed.<br />Configure regions, IAM roles too&mdash;<br />All this, and still no peek at the view.</p><p>Next up, the tool: &ldquo;It&rsquo;s open source!&rdquo;<br />On GitHub, rotting, no sign of remorse.<br />Python 2.7, some GCC trick&mdash;<br />The install alone might make you sick.</p><p>Finally, progress! The pipeline runs&hellip;<br />Till RAM collapses and error stuns.<br />Oh, and the metadata? A crime,<br />Merged cells, font soup, out of time.</p><p>Sample IDs&mdash;what a cryptic game:<br /><code>Sample_1</code>,&nbsp;<code>S1</code>,&nbsp;<code>sample-1</code>... the same?<br />Controls mislabeled, cases flipped,<br />No wonder my sanity's starting to slip.</p><p>Then QC plots, PCA joy&mdash;<br />Wait, that&rsquo;s a tumor labeled as a boy?<br />Clusters cross, and axes lie,<br />And I still don&rsquo;t know&nbsp;<em>which</em>&nbsp;sample&rsquo;s "guy."</p><p>But the clock ticks on, and it&rsquo;s half-past doom,<br />They want the final UMAP soon.<br />With pastel colors, labeled clear&mdash;<br />"Can we move that legend to&nbsp;<em>right here</em>?"</p><p>Tweak by tweak, I adjust each frame,<br />Resize Panel B, annotate a name.<br />Export the plot&mdash;it starts to gleam&hellip;<br />Then my laptop crashes. I scream.</p><p>This is the grind, the long-haul game,<br />Where science hides behind code and flame.<br />No &ldquo;Export to Nature&rdquo; button to press,<br />Just toil and logic and hope for success.</p><p>So next time you whisper that fated line&mdash;<br />&ldquo;I have a talk, can you make it shine?&rdquo;<br />Know: bioinformatics is craft, not a click,<br />It&rsquo;s science with scars, not just a quick fix.</p><p><strong>To all who debug at 3AM light,</strong><br />Who ghostwrite figures through sleepless night&mdash;<br />You are the backbone, silent and true,<br />First-author-worthy, if only they knew.<br /><br /></p><hr><p><em><br />"कल मेरी प्रेज़ेंटेशन है,"</em>&nbsp;वो कहते हैं,</p></div></div><div><div dir="auto"><p>आशा भरी आँखों से, जैसे सब सहज है।<br />जैसे परिणाम रातोंरात प्रकट हो जाएं&mdash;<br />ना कि डेटा की भूलभुलैया से उखाड़े जाएं।</p><p><strong>आओ बैठो, एक किस्सा सुनाता हूँ,</strong><br />जहाँ पाइपलाइन टूटती है, और सर्वर भी थक जाते हैं।<br />कहानी शुरू होती है: &ldquo;डेटा तो है&mdash;<br />बस S3 बकेट में, एकदम पास में कहीं।&rdquo;</p><p>अब&nbsp;<code>awscli</code>&nbsp;बुलाता हूँ डरते हुए,<br />कुंजी सेट करूँ, क्रेडेंशियल जोड़ूं, रीजन भरूँ।<br />इतनी मशक्कत, फिर भी डेटा नहीं मिला,<br />बस सेटअप में ही पूरा दिन चला।</p><p>फिर आता है टूल: &ldquo;ओपन-सोर्स है!&rdquo;<br />GitHub पर है, 2019 से सूखा पड़ा है।<br />Python 2.7 चाहिए, एक पुराना कम्पाइलर,<br />और साथ में थोड़ी सी दुआ की ताकत।</p><p>आख़िरकार टूल चला, खुशी सी हुई,<br />लेकिन रन करते ही, मेमोरी ने हार मानी।<br />और मेटाडेटा? एक एक्सेल की आफ़त,<br />मर्ज़ किए हुए सेल, बस और क्या चाहिए काफ़ियत?</p><p>सैंपल आईडी? बस भगवान ही जाने&mdash;<br /><code>Sample_1</code>,&nbsp;<code>sample-1</code>,&nbsp;<code>S1</code>, और&nbsp;<code>control1</code>&mdash;<br />ये सब एक ही सैंपल हैं क्या?<br />पता तब चलता है जब पूछो दो-तीन बार।</p><p>काउंट मैट्रिक्स तैयार, अब R या Python की बारी,<br />QC करो, PCA प्लॉट&mdash;पर कुछ गड़बड़ भारी।<br />ट्यूमर और नॉर्मल का अदला-बदली खेल,<br />बार-बार, वही पुरानी झमेल।</p><p>आख़िर में आया मॉडलिंग का समय,<br />स्टैट्स, प्लॉट्स, डिफरेंशियल एक्सप्रेशन का श्रम।<br />लेकिन घड़ी में 5 बज चुके हैं जनाब,<br />और 8 बजे तक UMAP चाहिए, साफ़-सुथरा जबाब।</p><p>तो मैं कोड लिखता हूँ रात भर बैठ कर,<br />कलर पैलेट, जीन लेबल, लीजेंड बाहर रख कर।<br />फ़ॉन्ट, पैनल, एक्सिस सब सुधार,<br />एक्सपोर्ट करता हूँ... और लैपटॉप कहता है&mdash;"अब नहीं यार!"</p><p>इसीलिए बायोइन्फॉर्मेटिक्स में लगता है समय,<br />ये &ldquo;बस सीरत चलाओ&rdquo; या &ldquo;वोल्कैनो प्लॉट बनाओ&rdquo; नहीं है।<br />ये है सिस्टम एडमिन का काम, डेटा की सफ़ाई,<br />QC, डिबगिंग, और सांइस की सच्ची लड़ाई।</p><p><strong>तो कुछ सीखें इस व्यथा से आप भी आज:</strong><br />24 घंटे पहले चमत्कार मत माँगिए।<br />अच्छे फ़िगर साफ़ डेटा से बनते हैं।<br />बायोइन्फॉर्मेटिक्स जादू नहीं, विज्ञान है।<br />समय से बात कीजिए, प्रक्रिया का सम्मान कीजिए।</p><p><strong>और उन सभी बायोइन्फॉर्मेटिशियनों को सलाम,</strong><br />जो दूसरों की प्रेज़ेंटेशन के लिए रातों में जागते हैं&mdash;<br />तुम हो फ़िगर्स के भूत लेखक,<br />तुम हो बिना नाम के सह-लेखक।<br />तुम पहले लेखक बनने के हक़दार हो&mdash;<br />और एक लंबी नींद के भी।</p><p>Note: Written with the help of AI/LLM Tools !</p></div></div>]]></description>
	<dc:creator>LEGE</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/fun/view/42877/bioinformatician-on-valentines-day</guid>
	<pubDate>Sun, 14 Feb 2021 11:36:32 -0600</pubDate>
	<link>https://bioinformaticsonline.com/fun/view/42877/bioinformatician-on-valentines-day</link>
	<title><![CDATA[Bioinformatician on Valentine's Day]]></title>
	<description><![CDATA[<p>Once asked to a bioinformatician "How is ur Valentine's Day?"</p><blockquote><p>Bioinformatician replied:</p><p>if ($date == "Valentine's Day" &amp;&amp; $me =! Bioinformatician) {</p><p>rose_day(); promise_day(); kiss_day();</p><p>}</p><p>else {</p><p>hack_genome(); ko-fi(); youtube(); do_scripting(); sleep();</p><p>)</p></blockquote>]]></description>
	<dc:creator>BioQueen</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/fun/view/39329/you-cant-install-david-brownlee</guid>
	<pubDate>Wed, 01 May 2019 21:47:36 -0500</pubDate>
	<link>https://bioinformaticsonline.com/fun/view/39329/you-cant-install-david-brownlee</link>
	<title><![CDATA[You can't install David Brownlee ;-)]]></title>
	<description><![CDATA[<p>By mistake I ask cpan to install abs, and it return this message.</p><blockquote><p>jitendra@jitendra-Aspire-S3-391[parallelLastz] sudo cpan install abs&nbsp; [ 4:43AM]<br />Going to read '/home/jitendra/.cpan/Metadata'<br />&nbsp; Database was generated on Thu, 02 May 2019 00:08:06 GMT<br />Don't be silly, you can't install David Brownlee ;-)</p></blockquote>]]></description>
	<dc:creator>Jit</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/fun/view/23959/bioinformatics-jokes</guid>
	<pubDate>Fri, 21 Aug 2015 01:26:54 -0500</pubDate>
	<link>https://bioinformaticsonline.com/fun/view/23959/bioinformatics-jokes</link>
	<title><![CDATA[Bioinformatics Jokes !!]]></title>
	<description><![CDATA[<p>Why was the Bioinformatics fired from his job?</p><p>A: He was getting too Sassy.</p><p>&nbsp;</p><p>What did the bioinformatician say when he found out his team stopped using version control?</p><p>A: Y&rsquo;all better Git!</p><p>&nbsp;</p><p>Why did the computational biologist stay home from work?</p><p>A: He had a code!</p><p>&nbsp;</p><p>Why was the bioinformatician's paper was rejected?</p><p>A: Journal thought it seemed scripted.</p><p>&nbsp;</p><p>How can you tell that a Bioinformatics is working?</p><p>A: You can hear him Grunting!</p><p>&nbsp;</p><p>Why bioinformatician always silence?</p><p>A: Because bioinformatician calmly whisper, &ldquo;SSH&rdquo;</p><p>&nbsp;</p><p>Why was the bioinformatician always so sleepy?</p><p>A: He/She wasn&rsquo;t given any Java.</p><p>&nbsp;</p><p>Why did the program/software hanged?</p><p>A: Because genome float.</p><p>&nbsp;</p><p>Why was the class upset that its parent died?</p><p>A: Because it wouldn&rsquo;t be getting the inheritance!</p><p>&nbsp;</p><p>Why did bioinformatician always works on the command line?</p><p>A: Because they don't want to scare you with huge amount of data!</p><p>&nbsp;</p><p>Why did the bioinformatician attend the gay pride parade?</p><p>A: They supported polymorphism.</p><p>&nbsp;</p><p>Why did bioinformatician prefer awk, PerlOneliner?</p><p>A: Because even computer can't handle to load the data.</p><p>&nbsp;</p><p>Why don&rsquo;t bioinformatician get along with others?</p><p>A: They&rsquo;re too MEAN.</p><p>&nbsp;</p><p>Why computational biologist are cool?</p><p>A: Because they are scripted!!</p><p>&nbsp;</p><p>Why they talk $ unzip; strip; touch; finger; grep; mount; fsck; more; yes; fsck; fsck; umount; clean; sleep;</p><p>A: Ah, Ohhh, dude, these are *NIX commands</p><p>&nbsp;</p><p>Did they really hack genome?</p><p>A: Yes, I guess so.</p>]]></description>
	<dc:creator>Jitendra Prajapati</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/fun/view/14036/introduction-to-programming-write-short-programs-that-generate-graphics-and-animation</guid>
	<pubDate>Thu, 14 Aug 2014 23:29:04 -0500</pubDate>
	<link>https://bioinformaticsonline.com/fun/view/14036/introduction-to-programming-write-short-programs-that-generate-graphics-and-animation</link>
	<title><![CDATA[Introduction to programming. Write short programs that generate graphics and animation.]]></title>
	<description><![CDATA[<p>Introduction to programming. Write short programs that generate graphics and animation.</p><p>http://funprogramming.org/</p>]]></description>
	<dc:creator>Ram Yash Pal</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/fun/view/9207/biogeek-fun</guid>
	<pubDate>Sun, 16 Mar 2014 06:33:31 -0500</pubDate>
	<link>https://bioinformaticsonline.com/fun/view/9207/biogeek-fun</link>
	<title><![CDATA[BioGeek Fun]]></title>
	<description><![CDATA[<p>1. A futuristic computational biology student was told to write "It is in my gene!!!" on the board 100 times as a punishment. here's his response -<br /><br />use warnings;<br />for ($count=1; $count &lt;=100; $count++) { print "It is in my gene!!!";}<br /><br />I guess, he is gonna to be a real biogeek. Nice try though. Smart kid.</p><p>&nbsp;</p><p>2. In some perl script I found this <br />&nbsp;. . . . . .<br />&nbsp;. . . . . .<br /># It works for me, only God understood how it is working<br />while (/(&lt;\/[^&gt;]+&gt;)|(&lt;[^&gt;]+&gt;)|(&lt;[^&gt;]+&gt;)$|([^&gt;&lt;]+)/go) {<br />&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; $startGene=$1;<br />&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; $beginChromosome=$2;<br />&nbsp;&nbsp; &nbsp;<br />. . . . . .<br />&nbsp;.. . . . . .<br />}</p><p>&nbsp;</p><p>3. One more interesting message in Perl found &hellip;. It will must tickle you bone :) <br />open(my $fh, "&lt;", "gene.txt")&nbsp;&nbsp; &nbsp;or kill " Me if you think this is a mistake :$!";<br /><br /></p><p>&nbsp;</p><p>4. From the Perl <br /><br />&nbsp; while () {&nbsp; # "The Mothership Connection is here!"<br />&nbsp;&nbsp; &nbsp;print &ldquo;$_\n&rdquo;; # Printing the offspring :)</p><p>&nbsp;</p><p>5. Perl message<br />if ($1) { print &ldquo;Just found a the error in chromosome !!!, yahoo&hellip;&rdquo;; else { &ldquo;That is not error, but mutation you moron!&rdquo;;</p><p>&nbsp;</p><p>6. One genome database curator walk in wine bar asked the bartender:<br />CREATE TABLE gene IF NOT EXISTS SexOnTheBeach;</p>]]></description>
	<dc:creator>Jit</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/fun/view/8509/the-best-bioinformatics-computational-biology-quotes</guid>
	<pubDate>Wed, 26 Feb 2014 17:50:59 -0600</pubDate>
	<link>https://bioinformaticsonline.com/fun/view/8509/the-best-bioinformatics-computational-biology-quotes</link>
	<title><![CDATA[The Best Bioinformatics / Computational Biology Quotes]]></title>
	<description><![CDATA[<p><img src="http://bioinformaticsonline.com/mod//photo/hahaha.png" style="border: 0; border: 0px;" alt="image"></p><p>Bioinformatician are not anti-social; We are just genome friendly.</p><p>Bioinformatician would love to change the biological world, but they won't give us the genetic code :P</p><p>If at first you don't succeed; call it version 1.0</p><p>The glass is neither half-full nor half-empty: it's actually have several genomes.</p><p>I'm BioGeek.</p><p>Fedup with LIPS, try God script.</p><p>Idiot, Go ahead, make my data!</p><p>Thank god, my genome just compiled.</p><p>Error message: "Out of space on genome drive:"</p><p>Shut up mobile elements, or i'll flush you out.</p><p>Never underestimate the internet bandwidth, u gotta incomplete.</p><p>Applied fuzzy logic to understand God's logic?</p><p>Warning! Overflow, delete chromosome !</p><p>Be nice to the BioGeek, for all you know they might be the next curator!</p><p>Beware of computational biologist they screw genes and protein.</p><p>Warning! Your genome is full of garbage, delete it !</p><p>Bad or missing mouse genome. Spank the cat? (Y/N)</p><p>Genome make very fast, very accurate mistakes.</p><p>Let's BLAST it.</p><p>Some genome never has transposons. It just develops random features.</p><p>Go watch CINEMA and have BLAST.</p>]]></description>
	<dc:creator>Jit</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/fun/view/4196/chemical-elements-of-bioinformatics</guid>
	<pubDate>Tue, 03 Sep 2013 16:35:39 -0500</pubDate>
	<link>https://bioinformaticsonline.com/fun/view/4196/chemical-elements-of-bioinformatics</link>
	<title><![CDATA[Chemical Elements of Bioinformatics]]></title>
	<description><![CDATA[<p>You must be familiar with periodic table and colour pattern, but this time you are going to amaze by new elements table by Eagle genomics. Just check it out and have fun :)</p><p><a href="http://elements.eaglegenomics.com/">http://elements.eaglegenomics.com/</a></p>]]></description>
	<dc:creator>Rahul Agarwal</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/fun/view/4194/what-a-bioinformatician-always-dream-for</guid>
	<pubDate>Tue, 03 Sep 2013 15:31:17 -0500</pubDate>
	<link>https://bioinformaticsonline.com/fun/view/4194/what-a-bioinformatician-always-dream-for</link>
	<title><![CDATA[What a bioinformatician always dream for ???]]></title>
	<description><![CDATA[<ol style="color: #000000; background-color: #ffffff;">
<li>Well established bioinformatics labs with SGI(silicon graphics interface)</li>
<li>License of all commercial softwares.</li>
<li>Complete, and&nbsp;fully assembled genome of the girl :P</li>
<li>A girl/boy with lesser E-values and higher compatibility score.</li>
<li>Horoscope Match should be significant (not less that 18).</li>
<li>Laptops with broadband connections.</li>
<li>Licence to almost all genomics and proteomics servers.</li>
<li>All eBooks of bioinformatics.</li>
<li>Ready passport and Study visa.</li>
</ol>]]></description>
	<dc:creator>Jit</dc:creator>
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