BOL: August 2013

User Dashboard

Jitendra Narayan — Sat, 24 Aug 2013 05:13:10 -0500

Added a new feature "User Dashboard" that lets you track the activity and content on this site that matters to you.

Now you can customized your BOL website view on your own dashboard.

Cheers

Mom Knows Best

Jitendra Narayan — Thu, 22 Aug 2013 13:30:43 -0500

We always get instructions to wash our hands, sterilize kitchen stuff and bla bla. However, recent findings suggest something else. Perhaps we can't survive, or will face lots of problems if bacteria’s colonies are absent in mother womb. Please find the detail sources of microbial transmission in humans from mother to child in recently published PLOS paper.

http://www.plosbiology.org/article/info%3Adoi%2F10.1371%2Fjournal.pbio.1001631

DNA Bending Propensity in the Presence of Base Mismatches: Implications for DNA Repair

Jitendra Narayan — Mon, 19 Aug 2013 16:01:44 -0500

Understanding how the human body recognizes damaged DNA and initiates repair fascinates Michael Feig, professor of biochemistry and molecular biology at Michigan State University. Feig studies the proteins MutS and MSH2-MSH6, which recognize defective DNA and initiate DNA repair. Natural DNA repair occurs when proteins like MutS (the primary protein responsible for recognizing a variety of DNA mismatches) scan the DNA, identify a defect, and recruit other enzymes to carry out the actual repair.

Results from computer simulations show that it is energetically less expensive to bend mismatch-containing, defective DNA (G:T, C:C, C:T, G:A, G:G, T:T, A:A, A+:C) vs. non-defective DNA (containing A:T or G:C base pairs). DNA repair mechanisms likely take advantage of this feature to detect defective DNA based on an increased bending propensity.

http://www.tacc.utexas.edu/news/feature-stories/2013/how-dna-repair-helps-prevent-cancer

http://pubs.acs.org/doi/abs/10.1021/jp403127a

Cancer's origins revealed

Jitendra Narayan — Thu, 15 Aug 2013 13:06:56 -0500

Researchers have provided the first comprehensive compendium of mutational processes that drive tumour development. Together, these mutational processes explain most mutations found in 30 of the most common cancer types. This new understanding of cancer development could help to treat and prevent a wide-range of cancers.

More at >> http://www.sanger.ac.uk/about/press/2013/130814.html

Added video feature in BOL

Jitendra Narayan — Tue, 13 Aug 2013 17:42:16 -0500

Just in: Added video features in BOL, now you can watch and share your favourite bioinformatics video tutorials.

Share your favourite video tutorial or lectures on BOL at http://bioinformaticsonline.com/videolist/all . You can also add video in you groups.

Note: Other than bioinformatics video material/tutorial will be deleted without any prior warning.

Webinar: Wednesday 21 August 2013 at Noon EDT

Jitendra Narayan — Sun, 11 Aug 2013 19:31:56 -0500

This webinar will describe the use of combinatorial pooling to reconstruct gene sequences within BACs. Recent work in barley has shown that this level of sequence knowledge is sufficient to support critical end-point objectives such as map-based cloning and marker-assisted breeding.

http://www.extension.org/pages/67926/upcoming-webinar:-selective-sequencing-through-combinatorial-pooling#.UggsVuHyPqU

InterpretOmics

Jitendra Narayan — Sun, 11 Aug 2013 10:24:33 -0500

InterpretOmics, a big data analytics startup that focuses on life sciences, has received angel funding of around Rs 10 crore from a group of investors including Singapore's information technology and shipping company, Amarante.

http://www.interpretomics.co/

2.4 Mb Genome Size for World's Biggest Virus

Jitendra Narayan — Thu, 08 Aug 2013 10:05:37 -0500

The genome size of new discovered Pandoraviruses have roughly twice the size of the record-holding Megavirus genomic code. Interestingly only 6 percent of its genes resembled the genes other organisms. It is assume that it may come from a different origin.

For detail : http://www.sciencemag.org/content/341/6143/281

http://www.npr.org/blogs/health/2013/07/18/203298244/worlds-biggest-virus-may-have-ancient-roots

Prime Minister’s 100k Genome Project

Jitendra Narayan — Thu, 08 Aug 2013 09:40:39 -0500

Genomics Ebgland is destined to sequence 100,000 patients over the next five year in England. A landmark project by british government.

Genomics England will play a key role in building on the UK’s long track record as leader in medical science advances to push the boundaries by unlocking the power of DNA data. The UK will become the first ever country to introduce this technology in its mainstream health system – leading the global race for better tests, better drugs and above all better, more personalised care.

http://www.genomicsengland.co.uk/100k-genome-project/

100K Foodborne Pathogen Genome Project

Jitendra Narayan — Thu, 08 Aug 2013 09:33:36 -0500

The 100K Genome Project, led by the University of California, Davis, the U.S. Food and Drug Administration’s Center for Food Safety and Applied Nutrition, and Agilent Technologies, today announced that it has added 20 newly completed genome sequences of foodborne disease-causing microorganisms to its public database at the National Center for Biotechnology Information.

100K Genome Project, aims to sequence the genomes of 100,000 bacterial and viral genomes.

http://100kgenome.vetmed.ucdavis.edu/