<![CDATA[BOL: January 2020]]> https://bioinformaticsonline.com/news/archive/biojoker/1577858400/1580536800? https://bioinformaticsonline.com/news/view/40596/igblast-a-popular-ncbi-package-for-classifying-and-analyzing-immunoglobulin-ig-and-t-cell-receptor-tcr-variable-domain-sequences Thu, 23 Jan 2020 11:34:37 -0600 https://bioinformaticsonline.com/news/view/40596/igblast-a-popular-ncbi-package-for-classifying-and-analyzing-immunoglobulin-ig-and-t-cell-receptor-tcr-variable-domain-sequences <![CDATA[IgBLAST: a popular NCBI package for classifying and analyzing immunoglobulin (IG) and T cell receptor (TCR) variable domain sequences]]> NCBI team released a new version of IgBLAST with four new improvements. IgBLAST is a popular NCBI package for classifying and analyzing immunoglobulin (IG) and T cell receptor (TCR) variable domain sequences. Improvements are:

    1. Support for the new FWR4 annotation feature in the AIRR format, both in standard format and in the AIRR alignment format.

    2. The previous “-penalty” parameter was renamed as -V_penalty to be consistent with other IgBLAST penalty options.

    3. Restored constant internal BLAST search parameters for domain annotation (i.e., FWR/CDR) such that this process is not influenced by user parameters.

    4. Corrected FWR/CDR annotations for certain mouse VK and rat VH germline genes. 

IgBLAST 1.15.0 is available for download from the BLAST FTP area. See the the new manual on GitHub for information about setting up and running IgBLAST.

 If you have any questions or concerns, please contact blast-help@ncbi.nlm.nih.gov

 

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