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	<title><![CDATA[BOL: Related items]]></title>
	<link>https://bioinformaticsonline.com/related/14215?offset=240</link>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/43722/crossmap-program-for-genome-coordinates-conversion-between-different-assemblies</guid>
	<pubDate>Tue, 25 Jan 2022 17:59:32 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/43722/crossmap-program-for-genome-coordinates-conversion-between-different-assemblies</link>
	<title><![CDATA[CrossMap: program for genome coordinates conversion between different assemblies]]></title>
	<description><![CDATA[<p><span>CrossMap is a program for genome coordinates conversion between&nbsp;</span><em>different assemblies</em><span>&nbsp;(such as&nbsp;</span><a href="http://www.ncbi.nlm.nih.gov/assembly/2928/">hg18 (NCBI36)</a><span>&nbsp;&lt;=&gt;&nbsp;</span><a href="http://www.ncbi.nlm.nih.gov/assembly/2758/">hg19 (GRCh37)</a><span>). It supports commonly used file formats including&nbsp;</span><a href="https://samtools.github.io/hts-specs/SAMv1.pdf">BAM</a><span>,&nbsp;</span><a href="https://en.wikipedia.org/wiki/CRAM_(file_format)">CRAM</a><span>,&nbsp;</span><a href="https://en.wikipedia.org/wiki/SAM_(file_format)">SAM</a><span>,&nbsp;</span><a href="https://genome.ucsc.edu/goldenPath/help/wiggle.html">Wiggle</a><span>,&nbsp;</span><a href="https://genome.ucsc.edu/goldenPath/help/bigWig.html">BigWig</a><span>,&nbsp;</span><a href="https://genome.ucsc.edu/FAQ/FAQformat.html#format1">BED</a><span>,&nbsp;</span><a href="https://genome.ucsc.edu/FAQ/FAQformat.html#format3">GFF</a><span>,&nbsp;</span><a href="https://genome.ucsc.edu/FAQ/FAQformat.html#format4">GTF</a><span>,&nbsp;</span><a href="https://docs.gdc.cancer.gov/Data/File_Formats/MAF_Format/">MAF</a><span>&nbsp;</span><a href="https://samtools.github.io/hts-specs/VCFv4.2.pdf">VCF</a><span>, and&nbsp;</span><a href="https://sites.google.com/site/gvcftools/home/about-gvcf">gVCF</a><span>.</span></p><p>Address of the bookmark: <a href="http://crossmap.sourceforge.net/" rel="nofollow">http://crossmap.sourceforge.net/</a></p>]]></description>
	<dc:creator>Rahul Nayak</dc:creator>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/researchlabs/view/19979/zhang-lab</guid>
  <pubDate>Sun, 28 Dec 2014 12:43:08 -0600</pubDate>
  <link></link>
  <title><![CDATA[Zhang Lab]]></title>
  <description><![CDATA[
<p>We develop and use integrative bioinformatics approaches to extract biological meanings from experimental data and generate hypotheses for experimental validation. Please explore our website to learn more about our people and our research.</p>

<p>More at http://bioinfo.vanderbilt.edu/zhanglab/</p>
]]></description>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/43791/comparative-genomics-visualisation-tools</guid>
	<pubDate>Thu, 17 Feb 2022 05:37:55 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/43791/comparative-genomics-visualisation-tools</link>
	<title><![CDATA[Comparative genomics visualisation tools !]]></title>
	<description><![CDATA[<p>Comparative genomics visualisation tools !</p><p>Address of the bookmark: <a href="https://cmdcolin.github.io/awesome-genome-visualization/?latest=true&amp;selected=%23BRIG&amp;tag=Comparative" rel="nofollow">https://cmdcolin.github.io/awesome-genome-visualization/?latest=true&amp;selected=%23BRIG&amp;tag=Comparative</a></p>]]></description>
	<dc:creator>Neel</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/news/view/20015/illumina-smartphone-chip</guid>
	<pubDate>Tue, 30 Dec 2014 23:19:54 -0600</pubDate>
	<link>https://bioinformaticsonline.com/news/view/20015/illumina-smartphone-chip</link>
	<title><![CDATA[Illumina Smartphone Chip !!!]]></title>
	<description><![CDATA[<p>Illumina, the company that claims it brought human genome sequencing down to $1000 prices, has now turned its attention to a consumer product - a chip that you can plug into your smartphone and have it read your genetic information.<br /><br />The biggest challenge ahead of Illumina is simplifying the process of genetic sequencing. Currently, Illumina&rsquo;s DNA sequencers are gigantic machines that use techinques like colorimetry to work, but while the core technology is computational, it takes some 30 steps to extract genetic data and run it through. This process will likely have to be hugely simplified on mobile devices, given the fact that some studies require extracting 10 mililiters of blood. Illumina researchers are also working on finding the optimal technology for this on-chip DNA sequencing - be it electrical, optical, or other.<br /><br />Illumina is one of the most prominent names in genetics, often said to be the Intel of genetic sequencing, as just like Intel it provides the algorithms, the processing brain that runs a DNA reading task.<br /><br />In other recent smartphone-related biotech news, drug company Pfizer launched its REMOTE project, a new type of clinical trial that does not require going to a hospital for checks - targeted at patients with overactive bladder problems, the FDA-approved REMOTE project allowed to gather data from patients from over 10 states remotely, via mobile devices.<br /><br /></p><p>This is indeed the Illumina answer to Apple's Health app, HealthBook, Google HealthFit.</p>]]></description>
	<dc:creator>Robert M Willioms</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/43923/monkeypox-virus-isolate-mpxv-usa-2022-ma001-complete-genome</guid>
	<pubDate>Tue, 26 Jul 2022 06:21:07 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/43923/monkeypox-virus-isolate-mpxv-usa-2022-ma001-complete-genome</link>
	<title><![CDATA[Monkeypox virus isolate MPXV_USA_2022_MA001, complete genome]]></title>
	<description><![CDATA[<pre>LOCUS       ON563414              197205 bp    DNA     linear   VRL 30-MAY-2022
DEFINITION  Monkeypox virus isolate MPXV_USA_2022_MA001, complete genome.
ACCESSION   ON563414
VERSION     ON563414.3
KEYWORDS    .
SOURCE      Monkeypox virus (monkeypox)
  ORGANISM  <a href="https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10244">Monkeypox virus</a>
            Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota;
            Pokkesviricetes; Chitovirales; Poxviridae; Chordopoxvirinae;
            Orthopoxvirus.</pre><p>Address of the bookmark: <a href="https://www.ncbi.nlm.nih.gov/nuccore/ON563414" rel="nofollow">https://www.ncbi.nlm.nih.gov/nuccore/ON563414</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/20449/walk-in-interview-for-the-post-of-jrf-and-project-assistant-cift</guid>
  <pubDate>Tue, 20 Jan 2015 23:03:20 -0600</pubDate>
  <link></link>
  <title><![CDATA[WALK-IN-INTERVIEW for the post of JRF and Project Assistant @ CIFT]]></title>
  <description><![CDATA[
<p>Eligible candidates are invited to attend a walk-in-Interview with all relevant documents for the following positions of Project Fellows (on contractual basis) to work in the Project “ Genetic Diversity of Clostridium botulinum in seafood and Development of Lateral Flow Immuno Assay (LFIA) for toxinotyping  funded by Department of Biotechnology.   The duration of the project is 3 years / co-terminus with the scheme.</p>

<p>Jr. Research Fellow – 2 posts</p>

<p>    Fellowship    :   Rs. 25000/- + 20% HRA pm  for Ist &amp; 2nd year and Rs.28000/- + HRA on 3rd year</p>

<p>    Qualification :    Ist class Masters Degree in Microbiology/Fishery Microbiology/Bio-technology.</p>

<p>    Desirable        :  </p>

<p>    1. CSIR/UGC NET/JRF qualified</p>

<p>    2. Excellent analytical skills and computer documentation</p>

<p>    3. Prior experience in handling microbial cultures and molecular techniques</p>

<p>Project Assistant – 1 post</p>

<p>Fellowship    :    Rs.8000/- p.m (consolidated)</p>

<p>Qualification:   Masters degree in Microbiology/Biotechnology with skill in Bioinformatics</p>

<p>Desirable:   Excellent analytical skills in Bioinformatics and computer documentation</p>

<p>Terms &amp; Conditions:</p>

<p>Registration will begin at 8.30 a.m and will close at 11.00 am<br />Age limit (as on 29.1.2015):  Below 35 years for men and 40 years for women.<br />Age relaxation of 3 year for OBC candidates and 5 years for SC/ST candidates is permissible.<br />Candidates are required to submit self-attested copies of all the Certificates in support of their claims    regarding age, educational qualifications, scheduled caste/scheduled tribe/OBC etc.  The original certificates shall be produced for verification before the interview.<br />Candidates should bring detailed bio-data (in the enclosed format)  affixing a recent passport size photograph.<br />The selected candidate will be recruited on contract basis under ICAR norms.  The post is purely temporary and is co-terminus with the project.<br />The candidates attending the interview should ensure that they fulfil all the eligibility conditions.  No correspondence will be entertained from the candidates for selection/test/appointment.<br />No TA/DA will be paid to attend the interview.<br />Canvassing in any form will render the candidate disqualified for the post.<br />The Director’s decision will be final and binding in all aspects regarding the selection to the post.</p>

<p>Venue: CIFT, Matsyapuri.P.O, Cochin                  Date of interview:  29.01.2015          Time:  10.00 am</p>

<p>http://www.cift.res.in/uploads/userfiles/file/file/srf%20appn.doc</p>
]]></description>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/44375/phyloherb-a-high%E2%80%90throughput-phylogenomic-pipeline-for-processing-genome-skimming-data</guid>
	<pubDate>Wed, 06 Sep 2023 00:14:28 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/44375/phyloherb-a-high%E2%80%90throughput-phylogenomic-pipeline-for-processing-genome-skimming-data</link>
	<title><![CDATA[PhyloHerb: A high‐throughput phylogenomic pipeline for processing genome skimming data]]></title>
	<description><![CDATA[<p dir="auto"><span>Phylo</span>genomic Analysis Pipeline for&nbsp;<span>Herb</span>arium Specimens</p>
<p dir="auto"><span>What is PhyloHerb</span>: PhyloHerb is a wrapper program to process&nbsp;<span>genome skimming</span>&nbsp;data collected from plant materials. The outcomes include the plastid genome (plastome) assemblies, mitochondrial genome assemblies, nuclear ribosomal DNAs (NTS+ETS+18S+ITS1+5.8S+ITS2+28S), alignments of gene and intergenic regions, and a species tree. It is designed to be a high throughput program dealing with lower quality data. Examples include&nbsp;<span>low-coverage (5x cpDNA) plastome phylogeny, recycling plastid genes from target enrichment data, retrieving low-copy nuclear genes from medium coverage (5x nucDNA) genome skimming</span>.</p>
<p dir="auto"><span>License</span>: GNU General Public License</p>
<p dir="auto"><span>Citation</span>:</p>
<ul dir="auto">
<li>Cai, Liming, Hongrui Zhang, and Charles C. Davis. 2022. PhyloHerb: A high‐throughput phylogenomic pipeline for processing genome‐skimming data. Applications in Plant Sciences 10(3): 1&ndash;9.&nbsp;<a href="https://doi.org/10.1002/aps3.11475">https://doi.org/10.1002/aps3.11475</a></li>
</ul><p>Address of the bookmark: <a href="https://github.com/lmcai/PhyloHerb/" rel="nofollow">https://github.com/lmcai/PhyloHerb/</a></p>]]></description>
	<dc:creator>Abhi</dc:creator>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/20387/walk-in-interview-for-project-assistant-bharathidasan-university</guid>
  <pubDate>Mon, 12 Jan 2015 21:54:10 -0600</pubDate>
  <link></link>
  <title><![CDATA[WALK-IN-INTERVIEW FOR PROJECT ASSISTANT @ BHARATHIDASAN UNIVERSITY]]></title>
  <description><![CDATA[
<p>BHARATHIDASAN UNIVERSITY<br />DEPARTMENT OF BIOINFORMATICS, SCHOOL OF LIFE SCIENCES, TIRUCHIRAPPALLI – 620024</p>

<p>Project title: “Genome-scale metabolic modeling and simulation of rumen methanogens An in silico attempt to methane attenuation”</p>

<p>Funding Agency: University Grants Commission, New Delhi</p>

<p>Tenure of the project: Two years or till the end of the project period.</p>

<p>Position: Project Assistant (1 no.)</p>

<p>Essential qualification: First class M.Sc. in Bioinformatics/Microbiology/ Biotechnology and other related discipline.</p>

<p>Desirable qualification: Experience in an area relevant (Molecular Systems Engineering) to the project.</p>

<p>Fellowship: Rs. 5000 per month as per the UGC norms.</p>

<p>Upper age limit: 28 years</p>

<p>Date of Venue of interview: 22.01.2015, Department of Bioinformatics, School of Life Sciences, Bharathidasan University, Tiruchirappalli -620 024, Tamil Nadu</p>

<p>The above post is purely temporary and will be terminated with three month notice.</p>

<p>The Terms and the condition of the appointment shall be governed according to UGC, Govt. of India. The eligible candidates will bring their original certificates and documents at the time of interview. No TA/DA will be paid for attending the interview.</p>

<p>Dr. P. CHELLAPANDI<br />UGC-Research Awardee,<br />Department of Bioinformatics,<br />School of Life Sciences,<br />Bharathidasan University,<br />Tiruchirappalli -620 024, Tamil Nadu</p>

<p>Advertisement: www.bdu.ac.in/adv/PA_UGC_Bioinformatics.pdf</p>
]]></description>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/blog/view/44773/genetic-basis-of-tail-loss-evolution</guid>
	<pubDate>Tue, 04 Mar 2025 12:12:36 -0600</pubDate>
	<link>https://bioinformaticsonline.com/blog/view/44773/genetic-basis-of-tail-loss-evolution</link>
	<title><![CDATA[Genetic basis of tail-loss evolution]]></title>
	<description><![CDATA[<p>The paper <em>"On the genetic basis of tail-loss evolution in humans and apes (https://www.nature.com/articles/s41586-024-07095-8)"</em>, published in <em>Nature</em>, investigates the genetic mechanisms that led to the loss of tails in humans and apes. The study suggests that a specific genetic mutation, involving the insertion of an <em>Alu</em> element (a type of transposable DNA sequence), played a critical role in the evolutionary transition from tailed primates to tailless hominoids.</p><h3><strong>Key Findings of the Study:</strong></h3><ol>
<li>
<p><strong>Alu Insertion and Tail Loss:</strong><br /> The researchers discovered an <em>Alu</em>-mediated genetic change in a common ancestor of modern apes and humans. This change disrupted the normal function of a gene involved in tail development, leading to the suppression of tail formation.</p>
</li>
<li>
<p><strong>Gene Disruption Mechanism:</strong><br /> The <em>Alu</em> insertion was found within a regulatory region of the <em>TBXT</em> gene (also known as <em>T</em> or <em>Brachyury</em>), which is crucial for tail development in vertebrates. This insertion likely altered the gene's expression patterns, leading to tail reduction over evolutionary time.</p>
</li>
<li>
<p><strong>Functional Evidence from Model Organisms:</strong><br /> To test their hypothesis, the researchers introduced similar genetic modifications in mice. The modified mice exhibited shortened or absent tails, supporting the idea that the identified mutation played a role in tail loss in hominoids.</p>
</li>
<li>
<p><strong>Evolutionary Implications:</strong><br /> The findings suggest that small, random genomic changes&mdash;such as transposable element insertions&mdash;can have profound effects on body morphology. This study provides evidence that mobile DNA elements (like <em>Alu</em>) can drive major evolutionary transitions.</p>
</li>
<li>
<p><strong>Relevance to Human Evolution:</strong><br /> Understanding the genetic basis of tail loss helps in reconstructing the evolutionary history of hominins (the lineage that includes humans and our extinct relatives). It also sheds light on how genetic variations contribute to anatomical diversity among primates.</p>
</li>
</ol><h3><strong>Significance of the Study:</strong></h3><p>This research highlights the role of transposable elements in shaping evolutionary traits and provides a concrete genetic explanation for a defining characteristic of humans and great apes. It also demonstrates how mutations in regulatory regions of developmental genes can lead to significant anatomical changes.</p>]]></description>
	<dc:creator>LEGE</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/news/view/20440/linux-operating-system-aimed-at-scientists</guid>
	<pubDate>Mon, 19 Jan 2015 08:30:49 -0600</pubDate>
	<link>https://bioinformaticsonline.com/news/view/20440/linux-operating-system-aimed-at-scientists</link>
	<title><![CDATA[Linux operating system aimed at scientists]]></title>
	<description><![CDATA[<p>The Bio-Linux operating system is based on Ubuntu 14.04 LTS (Trusty Tahr), and the previous version was using Ubuntu 12.04 LTS. The developers only use LTS releases and that means that upgrades for this distro don't come along all that often.<br /> <br /> This Linux distribution is aimed at scientists and it comes with more than 250 bioinformatics packages, 50 graphical applications and several hundred command line tools. And this is just skimming the surface of what the OS can do. Users have access to even more apps from the official repositories.</p><h3>Bio-Linux is using an Ubuntu LTS version as its base</h3><p>The fact that it uses Ubuntu LTS versions for the base is a good thing because it means its users won't have to worry about the support. Ubuntu 14.04 LTS is supported until 2019, so people who are using Bio-Linux shouldn't have a problem.<br /> <br /> "An updated Bio-Linux 8 version is now on the website in ISO and OVA versions. As usual, there is no need to download this version if you are an existing user. All updates to existing packages will be applied to your system through the update manager and new packages are all available via apt-get or Synaptic," reads the <a href="http://nebclists.nerc.ac.uk/pipermail/bio-linux-announce/2015-January/000020.html" target="_blank">announcement</a>.<br /> <br /> The changelog also states that a problem that was preventing the desktop to not start on VirtualBox has been fixed, the QIIME and Bowtie-Bio tools have been upgraded, the pandaseq paired end assembler has been added, and the beginners tutorial specific to Bio-Linux 8 has been improved.<br /> <br /> Check out the official announcement for a complete list of changes and updates. You can <a href="http://linux.softpedia.com/get/System/Operating-Systems/Linux-Distributions/Bio-Linux-45495.shtml" target="_blank"><strong>download Bio-Linux 8.0.5</strong></a> right now from Softpedia and give it a spin. It has the Unity desktop and now it runs very well in virtual environments.</p><p>Reference @ http://news.softpedia.com/news/Bioinformatics-Distro-Bio-Linux-8-0-5-Now-Available-for-Download-469867.shtml</p>]]></description>
	<dc:creator>Pranjali Yadav</dc:creator>
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