BOL: Related items

JRF Bioinformatics at NIPGR

Thu, 14 Apr 2016 13:12:42 -0500

JRF Bioinformatics job position in National Institute of Plant Genome Research (NIPGR)

Title : “Short-Term Research Fellowship”

Qualification : Candidates having M.Sc./M.Tech degree (with minimum of 60% marks overall) or equivalent in Bioinformatics/Biotechnology or any other related field, are eligible to apply. Candidate having prior experience in the area of next-generation sequencing data analysis, bioinformatics, molecular analysis of plant genes, and structural data analysis will be preferred.

No.of Post : 01
How to apply

Application should sent to Dr. Gitanjali Yadav, Staff Scientist-IV, National Institute of Plant Genome Research (NIPGR), Aruna Asaf Ali Marg, P.O. Box NO. 10531, New Delhi - 110067 on or before 26th April 2016

More at http://www.nipgr.res.in/careers/vacancies_latest.php#

DISCOVAR

Abhimanyu Singh — Mon, 18 Apr 2016 11:59:16 -0500

DISCOVAR is a new variant caller and DISCOVAR de novo a new genome assembler, both designed for state-of-the-art data. Their inputs are chosen to optimize quality while keeping costs low. Currently it takes as input Illumina reads of length 250 or longer — produced on MiSeq or HiSeq 2500 — and from a single PCR-free library. These data enable a level of completeness and continuity that was not previously possible.

DISCOVAR can call variants on a region by region basis, potentially tiling an entire large genome. DISCOVAR variant calling is under active development and transitioning to VCF.

DISCOVAR de novo can generate de novo assemblies for both large and small genomes. It currently does not call variants.

More at https://www.broadinstitute.org/software/discovar/blog/?page_id=14

Address of the bookmark: https://www.broadinstitute.org/software/discovar/blog/

Research Associate Bioinformatics recruitment in National Bureau of Plant Genetic Resources

Fri, 10 Mar 2017 06:50:51 -0600

Name of Project : Indo-UK Centre for improvement of Nitrogen use efficiency in wheat Dr. Soma S. Marla, Pr. Scientist (Bioinformatics), Division of Genomic Resources, ICAR, NBPGR, ND.

No. of Post : 01

Qualification : A doctoral (Ph.D). Degree in Bioinformatics OR 1. Masters degree in Bioinformatics or Computer Sciences having 1st division or 60% marks or equivalent overall grade point with at least two years of research experience as evidenced from Fellowship/ Associate ship. 2. NET or equivalent national level examination qualification is essential for the candidates with 3+2 years (B.Sc.+ M.Sc) pattern. Desirable: Demonstrated experience & skills in database design, management, UNIX OS, HPC environment inbased NGS data analysis. Experience substantiated by publications of high quality will be preferred.

Emoluments : Rs. 40,000 (Ph.D)/ Rs + 30 % HRA; 38,000 (Masters) Degree + 30 % HRA.
Hiring Process : Walk - In
Job Role: Research/JRF/SRF

Candidates should appear by 10.00 AM on 16.03.2016 for registration with relevant documents in the room B4, Bioinformatics Lab, ICAR.NBPGR. old campus, Inderpuri, New Delhi.

The candidates who wish to attend the walk-in interview are requested to bring with them five copies of the CV (one copy with photograph) as per the format given below. Also, the candidates should bring the original documents such as DOB, degree certificates, marks sheets, publications, thesis, experience certificate etc. for verification.

http://www.nbpgr.ernet.in/Downloadfile.aspx?EntryId=7284

Smash: An alignment-free method to find and visualise rearrangements between pairs of DNA sequences

Jit — Tue, 26 Apr 2016 12:18:49 -0500

Smash is a completely alignment-free method/tool to find and visualise genomic rearrangements. The detection is based on conditional exclusive compression, namely using a FCM (Markov model), of high context order (typically 20). For visualisation, Smash outputs a SVG image, with an ideogramoutput architecture, where the patterns are represented with several HSV values (only value varies). The method can perform both in small- and large-scale. Nevertheless is more directed to large-scale since that the main aim of the research is to know where the large-scale [chromosomal by chromosome] of several primates was equal/different, having at a glance a map of the entire genomes.

Address of the bookmark: http://bioinformatics.ua.pt/software/smash/

Scientists post at Monsanto

Wed, 11 May 2016 07:58:44 -0500

Sustainable agriculture is at the core of Monsanto. We develop technologies that enable farmers to produce more crops while conserving natural resources. Monsanto scientists are conducting research and development (R&D) to revolutionize plant breeding and biotechnology.

Monsanto is seeking a very talented Genomics Scientistto become an integral member of our Global Pipeline Analytics team with a focus on quantitative genetics. The ideal candidate will have familiarity with modeling and analysis of genetic data sets using a variety of statistical techniques.

Major Responsibilities:
- Provide guidance on experimental design for genomic-related experiments
- Familiarity with analysis of the following methods: GWS, QTL, eQTL, RNA-Seq
- Provide written and oral presentations of methods, results, conclusions, and recommendations to peer and management groups.
- Ensure timely delivery and clear communication of results
- Develop strong and successful collaborations among various Monsanto enabling teams.

Required Skills:

- PhD degree in Statistics, Biostatistics, Statistical Genetics, Quantitative Genetics, Breeding, Bioinformatics or a related field with 2 years of experience
- Working knowledge and experience with one of the following quantitative languages:R, Python, Perl, SAS
- Background in Windows and Linux operating systems
- Very strong problem solving skills will be required to work well as a member of a dynamic team
- Strong verbal and written communication skills.
- Demonstrated ability to deliver timely results and be results oriented.
- Extensive knowledge of quantitative genetics and experimental design.
- Demonstrated track record of solving challenging and complex problems.

Desired Skills/Experience:

- Excellent communication skills, with the ability to summarize complex concepts in language understandable by scientists from a variety of disciplines.
- Experience in agronomy and/or plant breeding in vegetables or row crops.

Please apply to
https://jobs.monsanto.com/job/st-louis/genomics-scientist/769/2081771

Sample BINC question paper 2016 - part2

Radha Agarkar — Fri, 13 May 2016 03:42:56 -0500

Download the sample question paper for BINC 2016 - paer II

SATSUMA : Highly sensitive whole-genome synteny alignments.

Jit — Fri, 13 May 2016 05:25:26 -0500

Satsuma is a whole-genome synteny alignment program. It takes two genomes, computes alignments, and then keeps only the parts that are orthologous, i.e. following the conserved order and orientation of features, such as protein coding genes, non-coding genes, or neutral sequences. Satsuma does not require any pre-processing, such as repeat masking, since it will automatically detect ambiguous mappings.

Satsuma has parallelization built-in and is designed to run on multi-core architectures. The run-time for aligning two bird-size genomes (~1.2 Gb) is around two days on 24 CPUs.

You can find the manual here.
Download the latest source code from here.
Stable versions can also be downloaded from the Broad Institute's web site.

An incomplete list of questions and answers (yes, these have really been asked by our users! Please feel free to add your own by e-mailing us) is here.

If you use Satsuma in your research, please cite:
Grabherr, M. G., Russell, P., Meyer, M., Mauceli, E., Alföldi, J., Di Palma, F., & Lindblad-Toh, K. (2010). Genome-wide synteny through highly sensitive sequence alignment: Satsuma. Bioinformatics, 26(9), 1145-51.

Tutorial at http://evomics.org/learning/genomics/satsuma/

Address of the bookmark: http://satsuma.sourceforge.net/

Hagfish - assess an assembly through creative use of coverage plots

Abhi — Fri, 20 May 2016 19:08:17 -0500

Hagfish is a tool that is to be used in data analysis of Next Generation Sequencing (NGS) experiments. Hagfish builds on the concept of coverage plots and aims to assist (amongst others) in quality control of de novo genome assembly or identification of structural variation in a genome re-sequencing experiment.

Hagfish requires a reference sequence and a paired end re-sequencing data set. Hagfish has more power the larger the insert size of the paired end library is.

Quick links: Installation,Operation, Read mappers, Hagfish scripts, Hagfish plots

Address of the bookmark: https://github.com/mfiers/hagfish

Stampy

Abhi — Fri, 20 May 2016 19:13:32 -0500

Stampy is a package for the mapping of short reads from illumina sequencing machines onto a reference genome. It's recommended for most workflows, including those for genomic resequencing, RNA-Seq and Chip-seq. Stampy excels in the mapping of reads containing that contain sequence variation relative to the reference, in particular for those containing insertions or deletions.