BOL: Related items

Bioinformatics -- Understanding of living systems through information science

Wed, 14 Aug 2013 11:50:17 -0500

Recently, the progress of the Human Genome Project, aiming to decode all human DNA sequences, has highlighted a research field called bioinformatics. In this new field, computers and techniques from information science are not just used as tools to advance life science research; they're expected to have a major impact on how we think about the life sciences. Q. The main feature of bioinformatics is, it utilizes computers to analyze life. One is example is the genome. In all organisms, DNA contains genetic information, and this is called the genome. But the amount of information involved is huge, so recently, it's been read using next-generation sequencers, and analyzed by computers. In bioinformatics research, what we do is utilize those genome information to investigate the principles of life. As an organism evolves, its genome sequence changes through sudden mutations. Additionally, at the genome level, mutations called rearrangements, such as inversions, transpositions, and duplications, occur. The genome comparison system developed by the Sakakibara Lab calculates homologous sequences called anchors, which are conserved between species. If the genome is considered as a long text, then anchors can be thought of as words. Q. We're coming to understand the genomes of various organisms - not just humans, but monkeys, chimpanzees, bacteria, and so on. The first method used to analyze a genome is comparing it with the genomes of other organisms, to see where it's the same and where it's different. In that way, the content of the genome is decoded bit by bit, using computers. By contrast, in our method, we've developed software called Murasaki, which we also use to analyze large genomes, by comparing them with those of other organisms. The Sakakibara Lab uses a next-generation sequencer at Keio University, along with a cluster machine with hundreds of CPUs. In this way, the Lab is analyzing genome mutations that cause cancer, and the genome of the natto production strain Bacillus subtilis. Until now, genome analysis could only be done in national-scale projects. But now, next-generation sequencer development has made genome analysis possible in an ordinary lab. In a world-first achievement, the Sakakibara Lab has decoded the natto bacillus genome, through analysis using Keio's next-generation sequencer. Q. In the future, biology and the life sciences may become almost entirely information science and computer science. And in healthcare, that may enable us, for example, to predict whether individuals are susceptible to cancer, or to certain lifestyle-related diseases, by understanding their personal genome data. So, I think it's amply possible that we can make use of such information effectively, to help people live longer and be free from disease, by thinking about their lifestyle habits. Bioinformatics is only two decades old. In this field, many areas are still unknown. Professor Sakakibara, having been involved since the beginning, will continue tackling new, challenging research projects.

Bioinformatician for a lab at the Weizmann Institute of Science, Israel

Mon, 13 Oct 2014 04:38:28 -0500

We are looking for enthusiastic, motivated and talented people, at all career stages (MSc, PhD, postdoctoral fellows), to join the lab! Bioinformatics in particular are invited to apply.
Our lab focuses on understanding molecular mechanisms of protein modifications in cancer and immune regulation.
We employ advanced high-throughput proteomic and genomic methods, cell biology, biochemistry, immunology, in-vivo models as well as systems biology and bioinformatics to study the biology of PTMs in health and disease. Read more here: http://yifatmerbl.com.

Bioinformatics Infrastructure Facility

Sun, 15 Sep 2013 09:22:25 -0500

The Bioinformatics Infrastructure Facility has started working in the year 2007 at Presidency College, Kolkata. It is one of the premier institutes of India and boasts of a rich heritage and great alumni. The Infrastructure Facility has a dedicated team headed by Sayak Ganguli and ably supported by Priayanka Dhar. The coordinator of the facility is Abhijit Datta of the Post Graduate Department of Botany. The lab mainly focusses on the analysis of the RNA Induced Silencing Complex. Recent highlights include the presentation of a paper at the RNAi World Congress.

More @ http://bioinfo-presiuniv.edu.in/index.php

PIT Bioinformatics Group

Tue, 16 Jun 2015 14:34:26 -0500

PIT Bioinformatics Group solves problems in bioinformatics and computational biology. Recent developed online tools:

- Budapest Reference Connectome: View a parametrizable connectome (brain graph).
- AmphoraNet: The webserver implementation of the AMPHORA2 workflow for phylogenetic analysis of metagenomic shotgun sequencing data.
- AmphoraVizu: Chart visualization for metagenomics analysis tools AMPHORA2 and AmphoraNet.
- SCARF: Free online association rule mining tool.

More at: http://pitgroup.org

Algorithms for DNA Sequencing (course offered each month)

Rahul Agarwal — Sun, 26 Jul 2015 01:57:02 -0500

"We will learn computational methods -- algorithms and data structures -- for analyzing DNA sequencing data. We will learn a little about DNA, genomics, and how DNA sequencing is used. We will use Python to implement key algorithms and data structures and to analyze real genomes and DNA sequencing datasets."

Source : https://www.coursera.org/course/ads1

Address of the bookmark: https://www.coursera.org/course/ads1

PostDoc at Jaypee Institute of Information Technology (JIIT), Noida Department of Biotechnology

Fri, 02 Feb 2018 11:13:25 -0600

Lab of Dr. Rawal is supported by generous grants to build advanced applications in emerging areas of cancer genomics, network sciences, vaccine development and epidemiology. The lab has dedicated high end Xeon servers, desktops, & laptops for research purpose. Currently, there are several researchers (JRFs, B. Techs, M. Tech and PhDs) working on several challenging bioinformatics projects. In addition, Dr. Rawal has collaborations with reputed national and international research teams.

Dr. Rawal and his US based collaborators have recently secured grant for development of vaccine against an infectious disease agent. For this project, applications are invited for the posts of Post Doctoral Fellow/Research Scientist (One Position) for the following time-bound sponsored projects as per the details given below:

PI: Dr. Kamal Rawal, Biotechnology Department, JIIT, Noida.

Essential Qualification(s) for Post Doctoral Fellow/ Research Scientist:

We are seeking an individual with expertise in analyzing literature information, text mining, network biology, data integration, and modeling. Competitive candidates would also have programming experience in scripting languages with perl, C, C++, and R programming. This position requires a PhD in Computational Biology, Bioinformatics, Biostatistics, Physics or related fields, and evidence of scientific productivity through publications in international journals. Motivation to gain an in-depth understanding of biological phenomena is required. Applications should include a current CV and names of at least three references. Application packages and inquiries regarding this position can be sent to Dr. Kamal Rawal (bioinfocvatgmaildotcom and kamaldotrawalatgmaildotcom). Screening of applications will commence immediately and the position will remain open until filled. Candidates having master’s degree with extensive experience in IT industry or research can also be considered for this post.

Salary: Rs 50000 per month.

Duration: 2 years or upto the project duration.

Number of position: 1

Candidate may also fill the following form:

https://docs.google.com/…/1FAIpQLSdZoZ21ZoNRStEeL5…/viewform

http://tinyurl.com/bioinfocv2017

Bioinformatician Dreams

Jitendra Narayan — Wed, 21 Aug 2013 10:50:45 -0500

Bioinformatician life is interconnected, they always dream for a powerful server, little more space on server as they are generating lots of data per run, dream to publish results in good impact journals, meetings reminders :) and research analysis off course!!!

Learning Python Programming - a bioinformatician perspective !

Rahul Nayak — Mon, 14 May 2018 16:33:03 -0500

Python Programming is a general purpose programming language that is open source, flexible, powerful and easy to use. One of the most important features of python is its rich set of utilities and libraries for data processing and analytics tasks. In the current era of big biological data, python and biopython is getting more popularity due to its easy-to-use features which supports big data processing.

In this tutorial series article, I will explore features and packages of python which are widely used in the big data, NGS, and bioinformatics. I will also walk through a real biological example which shows NGS data processing with the help of python packages and programming.

Python has a couple of points to recommend it to biologists and scientists specifically:

It's widely used in the scientific community
It has a couple of very well designed libraries for doing complex scientific computing (although we won't encounter them in this book)
It lend itself well to being integrated with other, existing tools
It has features which make it easy to manipulate strings of characters (for example, strings of DNA bases and protein amino acid residues, which we as biologists are particularly fond of)

In general, following are some of the important features of python which makes it a perfect fit for rapid application development.

Python is interpreted language so the program does not need to be compiled. Interpreter parses the program code and generates the output.
Python is dynamically typed, so the variables types are defined automatically.
Python is strongly typed. So the developers need to cast the type manually.
Less code and more use makes it more acceptable.
Python is portable, extendable and scalable.

There are two major Python versions, Python 2 and Python 3. Python 2 and 3 are quite different. This tutorial uses Python 3, because it more semantically correct and supports newer features.

I will post tutorial on daily basis on this page. Check the sub-pages on right side.

R and Bioconductor Tutorial

Jitendra Narayan — Fri, 23 Aug 2013 08:23:59 -0500

This tutorial is intended to introduce users quickly to the basics of R, focusing on a few common tasks that biologists need to perform some basic analysis: load a table, plot some graphs, and perform some basic statistics. More extensive tutorials can be found on the project website and via bioconductor (not covered here).

You can add more tutorial links in comments if found new pages.

Address of the bookmark: http://manuals.bioinformatics.ucr.edu/home/R_BioCondManual

multiPhATE: bioinformatics pipeline for functional annotation of phage isolates

Abhimanyu Singh — Thu, 16 May 2019 00:17:39 -0500

multiple-genome Phage Annotation Toolkit and Evaluator (multiPhATE). multiPhATE is a throughput pipeline driver that invokes an annotation pipeline (PhATE) across a user-specified set of phage genomes. This tool incorporates a de novo phage gene-calling algorithm and assigns putative functions to gene calls using protein-, virus-, and phage-centric databases.

Address of the bookmark: https://github.com/carolzhou/multiPhATE