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	<title><![CDATA[BOL: Related items]]></title>
	<link>https://bioinformaticsonline.com/related/22388?offset=550</link>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/pages/view/27038/worldwide-funding-agencies-to-fund-your-bioinformatics-research</guid>
	<pubDate>Tue, 19 Apr 2016 13:04:44 -0500</pubDate>
	<link>https://bioinformaticsonline.com/pages/view/27038/worldwide-funding-agencies-to-fund-your-bioinformatics-research</link>
	<title><![CDATA[Worldwide funding agencies to fund your bioinformatics research !!]]></title>
	<description><![CDATA[<p>Are you seeking funding for research or training in a particular area? Check out the following agencies ...</p><ol>
<li><a href="http://www.nsf.gov/funding/" target="_blank">National Science Foundation</a>:&nbsp;For the love of science! Head here when searching for ways to pay for that gargantuan geology or bigtime biology project. And other disciplines, of course.</li>
<li><a href="http://www.humboldt-foundation.de/web/sponsorship.html" target="_blank">Alexander von Humboldt Foundation</a>:&nbsp;Humbolt fellows embody the spirit of science and leadership alike, and the organization sponsors thinkers in Germany and abroad alike.</li>
<li><a href="http://www.nationalparks.org/our-work/grant-applications" target="_blank">National Parks Foundation</a>:&nbsp;Americans who want to preserve their country&rsquo;s gorgeous parks and trails pitch projects to this governing body, concerned largely with ecology and accessibility issues.</li>
<li><a href="http://www.sloan.org/apply-for-grants/" target="_blank">Alfred P. Sloan Foundation</a>:&nbsp;Money is available here throughout the year, covering science and engineering and their overlaps with civics, education, and economics.</li>
<li><a href="http://www.whitehall.org/about/" target="_blank">The Whitehall Foundation</a>:&nbsp;The Whitehall Foundation, through its program of grants and grants-in-aid, assists scholarly research in the life sciences. It is the Foundation&rsquo;s policy to assist those dynamic areas of basic biological research that are not heavily supported by Federal Agencies or other foundations with specialized missions.</li>
<li><a href="http://www.hfsp.org/funding/research-grants" target="_blank">Human Frontier Science Program</a>:&nbsp;Research grants from the Human Frontier Science Program are provided for teams of scientists from different countries who wish to combine their expertise in innovative approaches to questions that could not be answered by individual laboratories.</li>
<li><a href="http://www.sba.gov/content/research-grants-small-businesses" target="_blank">The U.S. Small Business Administration</a>:&nbsp;The U.S. Small Business Administration offers research grants to small businesses that are engaged in scientific research and development projects that meet federal R&amp;D objectives and have a high potential for commercialization.</li>
<li><a href="http://www.welch1.org/grants-and-programs/research-grants">The Welch Foundation</a>:&nbsp;The Welch Foundation provides grants for a minimum of $60,000 in funding to support research in chemistry by a full-time tenured or tenure-track faculty member who serves as principal investigator. Applications are restricted to universities, colleges, or other educational institutions located within the state of Texas.</li>
<li><a href="http://leakeyfoundation.org/research-grants/">The Leakey Foundation</a>:&nbsp;The Leakey Foundation offers research grants of up to $25,000 to doctoral and post-doctoral students as well as senior scientists, for research related specifically to human origins.</li>
<li><a href="http://www.acsm.org/find-continuing-education/awards-grants/research-grants">American College of Sports Medicine</a>:&nbsp;The American College of Sports Medicine offers several possible grants to research students in the areas of general and applied science.</li>
<li><a href="http://www.bdbiosciences.com/research/grant/">BD Biosciences</a>:&nbsp;BD Biosciences Research Grants* aim to reward and enable important research by providing vital funding to scientists pursuing innovative experiments that advance the scientific understanding of disease. This ongoing program includes grants for immunology and stem cell research, totaling $240,000 annually in BD Biosciences research reagents.</li>
<li><a href="http://www.sigmaxi.org/programs/giar/">Sigma Xi</a>:&nbsp;The Sigma Xi program awards grants for research in areas of science, engineering, astronomy and vision.</li>
<li><a href="http://www.uefoundation.org/grants.html">The United Engineering Foundation</a>:&nbsp;The United Engineering Foundation advances the engineering arts and sciences for the welfare of humanity. It supports engineering and education by, among other means, making grants.</li>
<li><a href="http://grants.nih.gov/grants/oer.htm" target="_blank">National Institutes of Health</a>:&nbsp;Foreign and American medical professionals hoping to advance their research might want to consider one of these prestigious (and generous) endowments.</li>
<li><a href="http://www.whitaker.org/grants/overview" target="_blank">Whitaker International Program</a>:&nbsp;Biomedical engineering&rsquo;s global reach serves as this organization&rsquo;s focus, so applications here need to open themselves up to international institutions and applications.</li>
<li><a href="http://www.nlm.nih.gov/grants.html" target="_blank">U.S. National Library of Medicine</a>:&nbsp;From tech to small businesses, the USNLM&rsquo;s funding programs cover a diverse range of fields that feed into medicine.</li>
<li><a href="http://my.americanheart.org/professional/Research/Research_UCM_316889_SubHomePage.jsp" target="_blank">American Heart Association</a>:&nbsp;Most of the AHA&rsquo;s research involves cardiovascular disease and stroke, with funding in these areas available in the winter and the summer.</li>
<li><a href="http://swhr.org/initiatives/grants-awards/" target="_blank">Society for Women&rsquo;s Health Research</a>:&nbsp;Female engineers and scientists benefit from these grants meant to support anything that improves women&rsquo;s health and education on a global scale.</li>
<li><a href="http://www.damonrunyon.org/research_results/categories/category/award_programs/" target="_blank">Damon Runyon Cancer Research Foundation</a>:&nbsp;Every cent donated to the DRCRF directly feeds into fellowships and awards bringing humanity closer to cancer cures and improved prevention regimens.</li>
<li><a href="http://www.bwfund.org/pages/52/Grant-Programs/" target="_blank">Burroughs Wellcome Fund</a>:&nbsp;Emerging scientists working in largely underrecognized and underfunded biomedical fields are the main recipients of this private foundation&rsquo;s money.</li>
<li><a href="http://www.abmrf.org/appyling_grant.asp" target="_blank">The Foundation for Alcohol Research</a>:&nbsp;As one can probably assume from the name, The Foundation for Alcohol Research contributes to projects studying how alcohol impacts human physical and mental health.</li>
<li><a href="http://www.alexslemonade.org/grants" target="_blank">Alex&rsquo;s Lemonade Stand</a>:&nbsp;These grants go towards doctors, nurses, and medical researchers concerned with curing childhood cancer.</li>
<li><a href="http://www.cancer.gov/grants-training/grants" target="_blank">National Cancer Institute</a>:&nbsp;Thanks to a little help from their friends in Congress, the National Cancer Institute have $4.9 billion to share with medical science.</li>
<li><a href="http://www.bushfoundation.org/solutions/building-leadership-capacity/bush_fellowship" target="_blank">Bush Foundation Fellowship Program</a>:&nbsp;Leadership&rsquo;s many forms are the main focus of the BFFP, who give money to folks dedicated to improving their communities.</li>
<li><a href="http://oedb.org/financial-aid/grants/" target="_blank">The David &amp; Lucile Packard Foundation</a>:&nbsp;Nonprofit organizations dedicated to growing education, charities, health, and other social justice causes should consider seeing what money they can land through this foundation.</li>
<li><a href="http://www.afar.org/research/funding/afar-research-grants/" target="_blank">American Federation for Aging Research</a>:&nbsp;AFAR provides up to $100,000 for a one- to two-year award to junior faculty (M.D.s and Ph.D.s) to conduct research that will serve as the basis for longer term research efforts in the areas of Biomedical and clinical research.</li>
<li><a href="http://mda.org/research2/grant-types">The Muscular Dystrophy Association</a>:&nbsp;The MDA is pursuing the full spectrum of research approaches that are geared toward combating neuromuscular diseases. MDA also helps spread this scientific knowledge and train the next generation of scientific leaders by funding national and international research conferences and career development grants.</li>
<li><a href="http://oedb.org/ilibrarian/100_places_to_find_funding_your_research/%22http://www.cff.org/research/ForResearchers/FundingOpportunities/ResearchGrants/%3C/a">The Cystic Fibrosis Foundation</a>:&nbsp;The CF Foundation offers competitive awards for research related to cystic fibrosis. Studies may be carried out at the subcellular, cellular, animal, or patient levels. Two of these funding mechanisms include Pilot and Feasibility Awards and Research Grants.</li>
<li><a href="http://www.ataxia.org/research/ataxia-research-grants.aspx">The National Ataxia Foundation</a>:&nbsp;The National Ataxia Foundation (NAF) is committed to funding the best science relevant to hereditary and sporadic types of ataxia in both basic and translational research. NAF invites research applications from U.S.A. and International non-profit and for-profit institutions.</li>
<li><a href="http://www.marchofdimes.com/research-grants.aspx">The March of Dimes</a>:&nbsp;In keeping with its mission the March of Dimes research portfolio funds many different areas of research on topics related to preventing birth defects, premature birth and infant mortality.</li>
<li><a href="https://www.ata.org/research-toward-cure">The American Tinnitus Association</a>:&nbsp;The American Tinnitus Association Research Grant Program financially supports scientific studies investigating tinnitus. Studies must be directly concerned with tinnitus and contribute to ATA&rsquo;s goal of finding a cure.</li>
<li><a href="http://www.abta.org/brain-tumor-research/research-grants/">American Brain Tumor Association</a>:&nbsp;The American Brain Tumor Association provides multiple grants for scientists doing research in or around the field of brain tumor research.</li>
<li><a href="http://www.cancer.org/research/applyforaresearchgrant/">American Cancer Society</a>:&nbsp;The American Cancer Society also offers grants that support the clinical and/or research training of health professionals. These Health Professional Training Grants promote excellence in cancer prevention and control by providing incentive and support for highly qualified individuals in outstanding training programs or responsible for training.</li>
<li><a href="https://www.thrasherresearch.org/default.aspx">Thrasher Research Fund</a>:&nbsp;The Thrasher Research Fund provides grants for pediatric medical research. The Fund seeks to foster an environment of creativity and discovery aimed at finding solutions to children&rsquo;s health problems. The Fund awards grants for research that offers substantial promise for meaningful advances in prevention and treatment of children&rsquo;s diseases, particularly research that offers broad-based​ applications.</li>
<li><a href="http://foundation4pt.org/apply-for-funding/research-grants/">Foundation for Physical Therapy</a>:&nbsp;The Foundation supports research projects in any patient care specialty.</li>
<li><a href="http://www.ocfoundation.org/research.aspx">International OCD Foundation</a>:&nbsp;The IOCDF awards grants to investigators whose research focuses on the nature, causes and treatment of OCD and related disorders.</li>
<li><a href="http://ww5.komen.org/ResearchGrants/FundingOpportunities.html">Susan G. Komen</a>:&nbsp;Susan G. Komen sustains a strong commitment to supporting research that will identify and deliver cures for breast cancer.</li>
<li><a href="http://www.aacr.org/research/research/Pages/Default.aspx#.VRsCCTvF-OM">American Association for Cancer Research</a>:&nbsp;The AACR promotes and supports the highest quality cancer research. The AACR has been designated as an organization with an approved NCI* peer review and funding system.</li>
<li><a href="http://www.thyroid.org/thyroid-physicians-professionals/research-grants-thyroidology/">American Thyroid Foundation</a>:&nbsp;The ATA is committed to supporting research into better ways to diagnose and treat thyroid disease.</li>
<li><a href="http://faer.org/research-grants/">The Foundation for Anesthesia Education and Research</a>:&nbsp;The FAER provides research grant funding for anesthesiologists and anesthesiology trainees to gain additional training in basic science, clinical and translational, health services and education research.</li>
<li><a href="http://www.alz.org/research/alzheimers_grants/types_of_grants.asp">The Alzheimer&rsquo;s Association</a>:&nbsp;The Alzheimer&rsquo;s Association funds a wide variety of investigations by scientists at every stage of their careers. Each grant is designed to meet the needs of the field and to introduce fresh ideas in Alzheimer&rsquo;s research.</li>
<li><a href="http://www.curearthritis.org/research-grant-application/">The Arthritis National Research Foundation</a>:&nbsp;The Arthritis National Research Foundation seeks to move arthritis research forward to find new treatments and to cure arthritis.</li>
<li><a href="http://www.hdfoundation.org/funding/grants.php">Hereditary Disease Foundation</a>:&nbsp;The focus of the Hereditary Disease Foundation is on Huntington&rsquo;s disease. Support will be for research projects that will contribute to identifying and understanding the basic defect in Huntington&rsquo;s disease. Areas of interest include trinucleotide expansions, animal models, gene therapy, neurobiology and development of the basal ganglia, cell survival and death, and intercellular signaling in striatal neurons.</li>
<li><a href="http://www.childrensleukemia.org/researchgrants.html">The Childrens Leukemia Research Association</a>:&nbsp;The objective of the CLRA is to direct the funds of the Association into the most promising leukemia research projects, and where funding would not duplicate other funding sources.</li>
<li><a href="http://www.apdaparkinson.org/research/research-grant/">The American Parkinson Disease Association</a>:&nbsp;The APDA offers grants of up to $50,000 for Parkinson disease research to scientists affiliated with U.S. research institutions.</li>
<li><a href="http://www.marykayfoundation.org/pages/CancerGrantProgram.aspx">The Mary Kay Foundation</a>:&nbsp;The Mary Kay Foundation offers grants to select doctors and medical scientists for research focusing on curing cancers that affect women.</li>
<li><a href="http://www.ccfa.org/science-and-professionals/research/grants-fellowships/">The Crohn&rsquo;s &amp; Colitis Foundation of America</a>:&nbsp;The CCFA is a leading funder of basic and clinical research in Inflammatory Bowel Diseases. CCFA supports research that increases understanding of the etiology, pathogenesis, therapy, and prevention of Crohn&rsquo;s disease and ulcerative colitis.</li>
<li><a href="http://www.avonfoundation.org/grants/breast-cancer/research-grant-guidelines/">The Avon Foundation for Women</a>:&nbsp;Grants from the Avon Foundation go to develop new strategies to prevent breast cancer and to researching the science behind breast cancer to increase understanding.</li>
<li><a href="http://www.pdf.org/en/grant_funding_irg">The International Research Grants Program</a>:&nbsp;The IRGP seeks to promote research that will have a major impact in developing knowledge of Parkinson&rsquo;s disease. Effort is made to promote projects that have little hope of securing traditional funding.</li>
<li><a href="http://www.gastro.org/research-funding">American Gastroenterological Association</a>:&nbsp;The AGA offers multiple grants for research advancing the science and practice of Gastroenterology.</li>
<li><a href="http://www.wilsonsociety.org/awards/wosawards.html">Wilson Ornithological Society Research Grants</a>:&nbsp;The Wilson Ornithological Society Research Grants offers up to four grants of $1500 dollars for work in any area of ornithology.</li>
<li><a href="http://www.obesity.org/about-us/early-career-research-grants.htm">The Obesity Society</a>:&nbsp;The Obesity Society offers grants of up to $25,000 dollars to members doing research in areas related to obesity.</li>
<li><a href="http://www.sjogrens.org/home/research-programs/research-grants">The Sj&ouml;gren&rsquo;s Syndrome Foundation</a>:&nbsp;The SSF Research Grants Program places a high priority on both clinical and basic scientific research into the cause, prevention, detection, treatment, and cure of Sj&ouml;gren&rsquo;s.</li>
<li><a href="http://www.melanoma.org/research-center/research-grants/the-grant-process">The Melanoma Research Foundation</a>:&nbsp;The MRF&rsquo;s Research Grant Program emphasizes both basic and clinical research projects that explore innovative approaches to understanding melanoma and its treatment.</li>
<li><a href="http://www.aascu.org/GRCinfo/Grant_Search/" title="Grant Resource Center (GRC)">GRC</a>&nbsp;- Run by the American Association of State Colleges and Universities (AASCU), the Grant Resource Center includes a database "customized to smaller institutions, and staff assistance," according to one user. A paid institutional membership is required for access.</li>
<li><a href="http://www.library.illinois.edu/iris/" title="IRIS">IRIS</a>&nbsp;- The Illinois Research Information Service is free for the University of Illinois (UI) community. Outside the UI system, a paid institutional subscription is needed for access.</li>
<li><a href="http://www.infoed.org/new_spin/spin.asp" title="Sponsored Programs Information Network (SPIN)">SPIN</a>&nbsp;- Run by InfoEd International, SPIN (the Sponsored Programs Information Network) claims to be the most widely used funding opportunity database in the world. An institutional subscription is required for access.</li>
<li><a href="http://fundingopps.cos.com/" title="Community of Science (COS )">COS</a>&nbsp;- Funding Opportunities. Community of Science claims the "largest, most comprehensive database of available funding," with 700 member institutions. Individuals can register free, but this won't get you access to the funding database.</li>
<li><a href="http://www.researchresearch.com/" title="ResearchResearch">ResearchResearch</a>&nbsp;- Based in London, ResearchResearch provides an international option for people seeking research-funding programs. A paid subscription is required for access.</li>
</ol>]]></description>
	<dc:creator>Jitendra Prajapati</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/27070/venn-diagrams-on-r-studio</guid>
	<pubDate>Mon, 25 Apr 2016 16:22:28 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/27070/venn-diagrams-on-r-studio</link>
	<title><![CDATA[Venn Diagrams on R Studio]]></title>
	<description><![CDATA[<h3>First step: Install &amp; load &ldquo;VennDiagram&rdquo; package.</h3>
<pre><code><span># install.packages('VennDiagram')</span>
<span>library</span><span>(</span><span>VennDiagram</span><span>)</span>
</code></pre>
<h3>Second step: Load data</h3>
<p>Add filepath if &ldquo;catdoge.csv&rdquo; is not in working-directory.</p>
<pre><code><span>d</span> <span>&lt;-</span> <span>read.csv</span><span>(</span><span>"catdoge.csv"</span><span>)</span></code><br><br></pre><p>Address of the bookmark: <a href="http://rstudio-pubs-static.s3.amazonaws.com/13301_6641d73cfac741a59c0a851feb99e98b.html" rel="nofollow">http://rstudio-pubs-static.s3.amazonaws.com/13301_6641d73cfac741a59c0a851feb99e98b.html</a></p>]]></description>
	<dc:creator>Jitendra Prajapati</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/27463/bpipe-a-tool-for-running-and-managing-bioinformatics-pipelines</guid>
	<pubDate>Sat, 21 May 2016 22:42:16 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/27463/bpipe-a-tool-for-running-and-managing-bioinformatics-pipelines</link>
	<title><![CDATA[Bpipe - a tool for running and managing bioinformatics pipelines]]></title>
	<description><![CDATA[<p>Bpipe provides a platform for running big bioinformatics jobs that consist of a series of processing stages - known as 'pipelines'.</p>
<ul>
<li>January 20th, 2016 - New! Bpipe 0.9.9 released!</li>
<li>Download <a href="http://download.bpipe.org/versions/bpipe-0.9.9.tar.gz">latest</a>, <a href="http://download.bpipe.org">all</a></li>
<li><a href="http://docs.bpipe.org">Documentation</a></li>
<li><a href="https://groups.google.com/forum/#%21forum/bpipe-discuss">Mailing List</a> (Google Group)</li>
</ul>
<p>Bpipe has been published in <a href="http://bioinformatics.oxfordjournals.org/content/early/2012/04/11/bioinformatics.bts167.abstract">Bioinformatics</a>! If you use Bpipe, please cite:</p>
<p><em>Sadedin S, Pope B &amp; Oshlack A, Bpipe: A Tool for Running and Managing Bioinformatics Pipelines, Bioinformatics</em></p><p>Address of the bookmark: <a href="http://docs.bpipe.org/" rel="nofollow">http://docs.bpipe.org/</a></p>]]></description>
	<dc:creator>Radha Agarkar</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/30696/many-core-engine-mce-for-perl-example</guid>
	<pubDate>Tue, 31 Jan 2017 05:37:50 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/30696/many-core-engine-mce-for-perl-example</link>
	<title><![CDATA[Many-Core Engine (MCE) for Perl example]]></title>
	<description><![CDATA[<p><span>MCE spawns a pool of workers and therefore does not fork a new process per each element of data. Instead, MCE follows a bank queuing model. Imagine the line being the data and bank-tellers the parallel workers. MCE enhances that model by adding the ability to chunk the next n elements from the input stream to the next available worker.</span></p>
<p>CORE MODULES</p>
<p>Three modules make up the core engine for MCE.</p>
<dl><dt id="MCE::Core"><a href="https://metacpan.org/pod/MCE#MCE::Core"><span></span></a><a></a><a href="https://metacpan.org/pod/distribution/MCE/lib/MCE/Core.pod">MCE::Core</a></dt><dd>
<p>Provides the Core API for Many-Core Engine. The various MCE options are described here.</p>
</dd><dt id="MCE::Signal"><a href="https://metacpan.org/pod/MCE#MCE::Signal"><span></span></a><a></a><a href="https://metacpan.org/pod/MCE::Signal">MCE::Signal</a></dt><dd>
<p>Temporary directory creation, cleanup, and signal handling.</p>
</dd><dt id="MCE::Util"><a href="https://metacpan.org/pod/MCE#MCE::Util"><span></span></a><a></a><a href="https://metacpan.org/pod/MCE::Util">MCE::Util</a></dt><dd>
<p>Utility functions for Many-Core Engine.</p>
</dd></dl>
<p><a href="https://metacpan.org/pod/MCE#MCE-EXTRAS"><span></span></a><a></a>MCE EXTRAS</p>
<p>There are 4 add-on modules for use with MCE.</p>
<dl><dt id="MCE::Candy"><a href="https://metacpan.org/pod/MCE#MCE::Candy"><span></span></a><a></a><a href="https://metacpan.org/pod/MCE::Candy">MCE::Candy</a></dt><dd>
<p>Provides a collection of sugar methods and output iterators for preserving output order.</p>
</dd><dt id="MCE::Mutex"><a href="https://metacpan.org/pod/MCE#MCE::Mutex"><span></span></a><a></a><a href="https://metacpan.org/pod/MCE::Mutex">MCE::Mutex</a></dt><dd>
<p>Provides a simple semaphore implementation supporting threads and processes.</p>
</dd><dt id="MCE::Queue"><a href="https://metacpan.org/pod/MCE#MCE::Queue"><span></span></a><a></a><a href="https://metacpan.org/pod/MCE::Queue">MCE::Queue</a></dt><dd>
<p>Provides a hybrid queuing implementation for MCE supporting normal queues and priority queues from a single module. MCE::Queue exchanges data via the core engine to enable queuing to work for both children (spawned from fork) and threads.</p>
</dd><dt id="MCE::Relay"><a href="https://metacpan.org/pod/MCE#MCE::Relay"><span></span></a><a></a><a href="https://metacpan.org/pod/MCE::Relay">MCE::Relay</a></dt><dd>
<p>Enables workers to receive and pass on information orderly with zero involvement by the manager process while running.</p>
</dd></dl>
<p><a href="https://metacpan.org/pod/MCE#MCE-MODELS"><span></span></a><a></a>MCE MODELS</p>
<p>The models take Many-Core Engine to a new level for ease of use. Two options (chunk_size and max_workers) are configured automatically as well as spawning and shutdown.</p>
<dl><dt id="MCE::Loop"><a href="https://metacpan.org/pod/MCE#MCE::Loop"><span></span></a><a></a><a href="https://metacpan.org/pod/MCE::Loop">MCE::Loop</a></dt><dd>
<p>Provides a parallel loop utilizing MCE for building creative loops.</p>
</dd><dt id="MCE::Flow"><a href="https://metacpan.org/pod/MCE#MCE::Flow"><span></span></a><a></a><a href="https://metacpan.org/pod/MCE::Flow">MCE::Flow</a></dt><dd>
<p>A parallel flow model for building creative applications. This makes use of user_tasks in MCE. The author has full control when utilizing this model. MCE::Flow is similar to MCE::Loop, but allows for multiple code blocks to run in parallel with a slight change to syntax.</p>
</dd><dt id="MCE::Grep"><a href="https://metacpan.org/pod/MCE#MCE::Grep"><span></span></a><a></a><a href="https://metacpan.org/pod/MCE::Grep">MCE::Grep</a></dt><dd>
<p>Provides a parallel grep implementation similar to the native grep function.</p>
</dd><dt id="MCE::Map"><a href="https://metacpan.org/pod/MCE#MCE::Map"><span></span></a><a></a><a href="https://metacpan.org/pod/MCE::Map">MCE::Map</a></dt><dd>
<p>Provides a parallel map model similar to the native map function.</p>
</dd><dt id="MCE::Step"><a href="https://metacpan.org/pod/MCE#MCE::Step"><span></span></a><a></a><a href="https://metacpan.org/pod/MCE::Step">MCE::Step</a></dt><dd>
<p>Provides a parallel step implementation utilizing MCE::Queue between user tasks. MCE::Step is a spin off from MCE::Flow with a touch of MCE::Stream. This model, introduced in 1.506, allows one to pass data from one sub-task into the next transparently.</p>
</dd><dt id="MCE::Stream"><a href="https://metacpan.org/pod/MCE#MCE::Stream"><span></span></a><a></a><a href="https://metacpan.org/pod/MCE::Stream">MCE::Stream</a></dt><dd>
<p>Provides an efficient parallel implementation for chaining multiple maps and greps together through user_tasks and MCE::Queue. Like with MCE::Flow, MCE::Stream can run multiple code blocks in parallel with a slight change to syntax from MCE::Map and MCE::Grep.</p>
</dd></dl>
<p><a href="https://metacpan.org/pod/MCE#MISCELLANEOUS"><span></span></a>MISCELLANEOUS</p>
<p>Miscellaneous additions included with the distribution.</p>
<dl><dt id="MCE::Examples"><a href="https://metacpan.org/pod/MCE#MCE::Examples"><span></span></a><a></a><a href="https://metacpan.org/pod/distribution/MCE/lib/MCE/Examples.pod">MCE::Examples</a></dt><dd>
<p>Describes various demonstrations for MCE including a Monte Carlo simulation.</p>
</dd><dt id="MCE::Subs"><a href="https://metacpan.org/pod/MCE#MCE::Subs"><span></span></a><a></a><a href="https://metacpan.org/pod/MCE::Subs">MCE::Subs</a></dt><dd>
<p>Exports functions mapped directly to MCE methods; e.g. mce_wid. The module allows 3 options; :manager, :worker, and :getter.</p>
</dd></dl>
<p><a href="https://metacpan.org/pod/MCE#REQUIREMENTS"><span></span></a>REQUIREMENTS</p>
<p>Perl 5.8.0 or later. PDL::IO::Storable is required in scripts running PDL.</p>
<p><a href="https://metacpan.org/pod/MCE#SOURCE-AND-FURTHER-READING"><span></span></a><a></a>SOURCE AND FURTHER READING</p>
<p>The source, cookbook, and examples are hosted at GitHub.</p>
<ul>
<li>
<p><a href="https://github.com/marioroy/mce-perl">https://github.com/marioroy/mce-perl</a></p>
</li>
<li>
<p><a href="https://github.com/marioroy/mce-cookbook">https://github.com/marioroy/mce-cookbook</a></p>
</li>
<li>
<p><a href="https://github.com/marioroy/mce-examples">https://github.com/marioroy/mce-examples</a></p>
</li>
</ul>
<p><a href="https://metacpan.org/pod/MCE#SEE-ALSO"><span></span></a><a></a>SEE ALSO</p>
<p><code>MCE::Shared</code>&nbsp;provides data sharing capabilities for&nbsp;<code>MCE</code>. It includes&nbsp;<code>MCE::Hobo</code>&nbsp;for running code asynchronously.</p>
<ul>
<li>
<p><a href="https://metacpan.org/pod/MCE::Shared">MCE::Shared</a></p>
</li>
<li>
<p><a href="https://metacpan.org/pod/MCE::Hobo">MCE::Hobo</a></p>
</li>
</ul><p>Address of the bookmark: <a href="https://github.com/marioroy/mce-examples" rel="nofollow">https://github.com/marioroy/mce-examples</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/30897/finestructure-v2-globetrotter</guid>
	<pubDate>Mon, 13 Feb 2017 08:40:23 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/30897/finestructure-v2-globetrotter</link>
	<title><![CDATA[fineSTRUCTURE v2 &amp; GLOBETROTTER]]></title>
	<description><![CDATA[<p>Software available at this site</p>
<div>
<ul>
<li><a href="https://people.maths.bris.ac.uk/%7Emadjl/finestructure/finestructure_info.html">FineSTRUCTURE version 2</a>, a pipeline for running ChromoPainter and FineSTRUCTURE for population inference. A GUI is available for interpretation. Download from the <a href="https://people.maths.bris.ac.uk/%7Emadjl/finestructure/finestructure.html">Downloads</a> page.</li>
<li><a href="https://people.maths.bris.ac.uk/%7Emadjl/finestructure/finestructureR.html">FineSTRUCTURE R scripts</a>, a facility for exploring the results when the GUI is unavailable.</li>
<li><a href="https://people.maths.bris.ac.uk/%7Emadjl/finestructure/globetrotter.html">GLOBETROTTER</a>, the admixture dating method based on ChromoPainter. Download from the <a href="https://people.maths.bris.ac.uk/%7Emadjl/finestructure/finestructure.html">Downloads</a> page.</li>
<li><a href="https://people.maths.bris.ac.uk/%7Emadjl/finestructure/admixture.html">AdmixturePainting</a>, A set of R tools to inmterpret the results of ADMIXTURE and STRUCTURE-like mixture models.</li>
<li><a href="https://people.maths.bris.ac.uk/%7Emadjl/finestructure/radpainter.html">RADpainter</a>, finestructure and ChromoPainter for RAD tag data used for non-model organisms.</li>
<li>Scripts to perform many types of conversion. Included in the main software download from the <a href="https://people.maths.bris.ac.uk/%7Emadjl/finestructure/finestructure.html">Downloads</a> page.</li>
</ul>
What this page is This page provides information about and downloads for <strong>methodology for Chromosome Painting</strong>. It is not a facility to analyse your genome. Sorry if you were misled by the punchy name!<br> About Chromosome Painting Painting is an efficient way of identifying important haplotype information from dense genotype data. It describes ancestry in an efficient way suitable for a range of further analyses, including population identification and admixture dating.</div><p>Address of the bookmark: <a href="http://paintmychromosomes.com/" rel="nofollow">http://paintmychromosomes.com/</a></p>]]></description>
	<dc:creator>Shruti Paniwala</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/blog/view/35923/basic-command-line-to-run-blast</guid>
	<pubDate>Wed, 14 Mar 2018 05:10:34 -0500</pubDate>
	<link>https://bioinformaticsonline.com/blog/view/35923/basic-command-line-to-run-blast</link>
	<title><![CDATA[Basic command-line to run BLAST]]></title>
	<description><![CDATA[<p>&nbsp;</p><p>The goal of this tutorial is to run you through a demonstration of the command line, which you may not have seen or used much before.</p><p>All of the commands below can copy/pasted.</p><div id="install-software"><h2>Install software<a href="http://angus.readthedocs.io/en/2016/running-command-line-blast.html#install-software" title="Permalink to this headline"></a></h2><p>Copy and paste the following commands</p><div><div><pre>sudo apt-get update &amp;&amp; sudo apt-get -y install python ncbi-blast+
</pre></div></div><p>This updates the software list and installs the Python programming language and NCBI BLAST+.</p></div><div id="get-data"><h2>Get Data<a href="http://angus.readthedocs.io/en/2016/running-command-line-blast.html#get-data" title="Permalink to this headline"></a></h2><p>Grab some data to play with. Grab some cow and human RefSeq proteins:</p><div><div><pre>wget ftp://ftp.ncbi.nih.gov/refseq/B_taurus/mRNA_Prot/cow.1.protein.faa.gz
wget ftp://ftp.ncbi.nih.gov/refseq/H_sapiens/mRNA_Prot/human.1.protein.faa.gz
</pre></div></div><p>This is only the first part of the human and cow protein files - there are 24 files total for human.</p><p>The database files are both gzipped, so lets unzip them</p><div><div><pre>gunzip *gz
ls
</pre></div></div><p>Take a look at the head of each file:</p><div><div><pre>head cow.1.protein.faa
head human.1.protein.faa
</pre></div></div><p>These are protein sequences in FASTA format. FASTA format is something many of you have probably seen in one form or another &ndash; it&rsquo;s pretty ubiquitous. It&rsquo;s just a text file, containing records; each record starts with a line beginning with a &lsquo;&gt;&rsquo;, and then contains one or more lines of sequence text.</p><p>Note that the files are in fasta format, even though they end if &rdquo;.faa&rdquo; instead of the usual &rdquo;.fasta&rdquo;. This NCBI&rsquo;s way of denoting that this is a fasta file with amino acids instead of nucleotides.</p><p>How many sequences are in each one?</p><div><div><pre>grep -c '^&gt;' cow.1.protein.faa
grep -c '^&gt;' human.1.protein.faa
</pre></div></div><p>This grep command uses the c flag, which reports a count of lines with match to the pattern. In this case, the pattern is a regular expression, meaning match only lines that begin with a &gt;.</p><p>This is a bit too big, lets take a smaller set for practice. Lets take the first two sequences of the cow proteins, which we can see are on the first 6 lines</p><div><div><pre>head -6 cow.1.protein.faa &gt; cow.small.faa
</pre></div></div></div><div id="blast"><h2>BLAST<a href="http://angus.readthedocs.io/en/2016/running-command-line-blast.html#blast" title="Permalink to this headline"></a></h2><p>Now we can blast these two cow sequences against the set of human sequences. First, we need to tell blast about our database. BLAST needs to do some pre-work on the database file prior to searching. This helps to make the software work a lot faster. Because you installed your own version of the sotware, you need to tell the shell where the software is located. Use the full path and the makeblastdb command:</p><div><div><pre>makeblastdb -in human.1.protein.faa -dbtype prot
ls
</pre></div></div><p>Note that this makes a lot of extra files, with the same name as the database plus new extensions (.pin, .psq, etc). To make blast work, these files, called index files, must be in the same directory as the fasta file.</p><p><br /> blastp [-h] [-help] [-import_search_strategy filename]<br /> [-export_search_strategy filename] [-task task_name] [-db database_name]<br /> [-dbsize num_letters] [-gilist filename] [-seqidlist filename]<br /> [-negative_gilist filename] [-negative_seqidlist filename]<br /> [-entrez_query entrez_query] [-db_soft_mask filtering_algorithm]<br /> [-db_hard_mask filtering_algorithm] [-subject subject_input_file]<br /> [-subject_loc range] [-query input_file] [-out output_file]<br /> [-evalue evalue] [-word_size int_value] [-gapopen open_penalty]<br /> [-gapextend extend_penalty] [-qcov_hsp_perc float_value]<br /> [-max_hsps int_value] [-xdrop_ungap float_value] [-xdrop_gap float_value]<br /> [-xdrop_gap_final float_value] [-searchsp int_value]<br /> [-sum_stats bool_value] [-seg SEG_options] [-soft_masking soft_masking]<br /> [-matrix matrix_name] [-threshold float_value] [-culling_limit int_value]<br /> [-best_hit_overhang float_value] [-best_hit_score_edge float_value]<br /> [-window_size int_value] [-lcase_masking] [-query_loc range]<br /> [-parse_deflines] [-outfmt format] [-show_gis]<br /> [-num_descriptions int_value] [-num_alignments int_value]<br /> [-line_length line_length] [-html] [-max_target_seqs num_sequences]<br /> [-num_threads int_value] [-ungapped] [-remote] [-comp_based_stats compo]<br /> [-use_sw_tback] [-version]</p><p>Now we can run the blast job. We will use blastp, which is appropriate for protein to protein comparisons.</p><div><div><pre>blastp -query cow.small.faa -db human.1.protein.faa
</pre></div></div><p>This gives us a lot of information on the terminal screen. But this is difficult to save and use later - Blast also gives the option of saving the text to a file.</p><div><div><pre>    blastp -query cow.small.faa -db human.1.protein.faa -out cow_vs_human_blast_results.txt
ls
</pre></div></div><p>Take a look at the results using less. Note that there can be more than one match between the query and the same subject. These are referred to as high-scoring segment pairs (HSPs).</p><div><div><pre>less cow_vs_human_blast_results.txt
</pre></div></div><p>So how do you know about all the options, such as the flag to create an output file? Lets also take a look at the help pages. Unfortunately there are no man pages (those are usually reserved for shell commands, but some software authors will provide them as well), but there is a text help output</p><div><div><pre>blastp -help
</pre></div></div><p>To scroll through slowly</p><div><div><pre>blastp -help | less
</pre></div></div><p>To quit the less screen, press the q key.</p><p>Parameters of interest include the -evalue (Default is 10?!?) and the -outfmt</p><p>Lets filter for more statistically significant matches with a different output format:</p><div><div><pre>blastp \
-query cow.small.faa \
-db human.1.protein.faa \
-out cow_vs_human_blast_results.tab \
-evalue 1e-5 \
-outfmt 7
</pre></div></div><p>I broke the long single command into many lines with by &ldquo;escaping&rdquo; the newline. That forward slash tells the command line &ldquo;Wait, I&rsquo;m not done yet!&rdquo;. So it waits for the next line of the command before executing.</p><p>Check out the results with less.</p><p>Lets try a medium sized data set next</p><div><div><pre>head -199 cow.1.protein.faa &gt; cow.medium.faa
</pre></div></div><p>What size is this db?</p><div><div><pre>grep -c '^&gt;' cow.medium.faa
</pre></div></div><p>Lets run the blast again, but this time lets return only the best hit for each query.</p><div><div><pre>blastp \
-query cow.medium.faa \
-db human.1.protein.faa \
-out cow_vs_human_blast_results.tab \
-evalue 1e-5 \
-outfmt 6 \
-max_target_seqs 1
</pre></div></div></div><div id="summary"><h2>Summary<a href="http://angus.readthedocs.io/en/2016/running-command-line-blast.html#summary" title="Permalink to this headline"></a></h2><p>Review:</p><ul>
<li>command line programs such as blast use flags to get information about how and what to do</li>
<li>blast options can be found by typing&nbsp;<cite>blastp -help</cite></li>
<li>break a command up over many lines by using&nbsp;<a href="http://angus.readthedocs.io/en/2016/running-command-line-blast.html#id1">`</a>` to &ldquo;escape&rdquo; the new line</li>
</ul><p>&nbsp;</p><p>Blastn</p><p>blastn [-h] [-help] [-import_search_strategy filename]<br /> [-export_search_strategy filename] [-task task_name] [-db database_name]<br /> [-dbsize num_letters] [-gilist filename] [-seqidlist filename]<br /> [-negative_gilist filename] [-negative_seqidlist filename]<br /> [-entrez_query entrez_query] [-db_soft_mask filtering_algorithm]<br /> [-db_hard_mask filtering_algorithm] [-subject subject_input_file]<br /> [-subject_loc range] [-query input_file] [-out output_file]<br /> [-evalue evalue] [-word_size int_value] [-gapopen open_penalty]<br /> [-gapextend extend_penalty] [-perc_identity float_value]<br /> [-qcov_hsp_perc float_value] [-max_hsps int_value]<br /> [-xdrop_ungap float_value] [-xdrop_gap float_value]<br /> [-xdrop_gap_final float_value] [-searchsp int_value]<br /> [-sum_stats bool_value] [-penalty penalty] [-reward reward] [-no_greedy]<br /> [-min_raw_gapped_score int_value] [-template_type type]<br /> [-template_length int_value] [-dust DUST_options]<br /> [-filtering_db filtering_database]<br /> [-window_masker_taxid window_masker_taxid]<br /> [-window_masker_db window_masker_db] [-soft_masking soft_masking]<br /> [-ungapped] [-culling_limit int_value] [-best_hit_overhang float_value]<br /> [-best_hit_score_edge float_value] [-window_size int_value]<br /> [-off_diagonal_range int_value] [-use_index boolean] [-index_name string]<br /> [-lcase_masking] [-query_loc range] [-strand strand] [-parse_deflines]<br /> [-outfmt format] [-show_gis] [-num_descriptions int_value]<br /> [-num_alignments int_value] [-line_length line_length] [-html]<br /> [-max_target_seqs num_sequences] [-num_threads int_value] [-remote]<br /> [-version]</p><p>DESCRIPTION<br /> Nucleotide-Nucleotide BLAST 2.7.0+</p></div>]]></description>
	<dc:creator>Shruti Paniwala</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/31353/concoct-clustering-contigs-with-coverage-and-composition</guid>
	<pubDate>Mon, 06 Mar 2017 04:08:16 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/31353/concoct-clustering-contigs-with-coverage-and-composition</link>
	<title><![CDATA[CONCOCT: Clustering cONtigs with COverage and ComposiTion]]></title>
	<description><![CDATA[<p>A program for unsupervised binning of metagenomic contigs by using nucleotide composition, coverage data in multiple samples and linkage data from paired end reads.</p>
<p>Warning! This software is to be considered under development. Functionality and the user interface may still change significantly from one version to another. If you want to use this software, please stay up to date with the list of known issues:<a href="https://github.com/BinPro/CONCOCT/issues">https://github.com/BinPro/CONCOCT/issues</a></p><p>Address of the bookmark: <a href="https://github.com/BinPro/CONCOCT" rel="nofollow">https://github.com/BinPro/CONCOCT</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/file/view/87/linux-cheat-sheet</guid>
	<pubDate>Tue, 09 Jul 2013 17:30:04 -0500</pubDate>
	<link>https://bioinformaticsonline.com/file/view/87/linux-cheat-sheet</link>
	<title><![CDATA[Linux Cheat Sheet]]></title>
	<description><![CDATA[<p><span>In an attempt to find a good Linux reference for bioinformatician and BOL readers, I was unsuccessful at finding a decent one on the Internet. So, we decided to make a cheat sheet for biological programmers.</span></p>]]></description>
	<dc:creator>Jitendra Narayan</dc:creator>
	<enclosure url="https://bioinformaticsonline.com/file/download/87" length="81260" type="application/pdf" />
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/31382/seqmule-automated-human-exomegenome-variants-detection</guid>
	<pubDate>Tue, 07 Mar 2017 10:12:36 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/31382/seqmule-automated-human-exomegenome-variants-detection</link>
	<title><![CDATA[SeqMule: Automated human exome/genome variants detection]]></title>
	<description><![CDATA[<p><span>SeqMule takes single-end or paird-end FASTQ or BAM files, generates a script consisting of more than 10 popular alignment, analysis tools and runs the script line by line. Users can change the pipeline or fine-tune the parameters by modifying its configuration file. SeqMule also has some built-in functions, such as pooling consensus calls from various callers, plotting a Venn diagram showing intersection among different callers, and downloading databases. SeqMule can be used for both Mendelian disease study and cancer genome study.</span></p><p>Address of the bookmark: <a href="http://seqmule.openbioinformatics.org/en/latest/" rel="nofollow">http://seqmule.openbioinformatics.org/en/latest/</a></p>]]></description>
	<dc:creator>Abhimanyu Singh</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/31564/htslib</guid>
	<pubDate>Wed, 15 Mar 2017 11:38:05 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/31564/htslib</link>
	<title><![CDATA[HTSlib]]></title>
	<description><![CDATA[<p>Samtools is a suite of programs for interacting with high-throughput sequencing data. It consists of three separate repositories:</p>
<dl><dt>Samtools</dt><dd>Reading/writing/editing/indexing/viewing SAM/BAM/CRAM format</dd><dt>BCFtools</dt><dd>Reading/writing BCF2/VCF/gVCF files and calling/filtering/summarising SNP and short indel sequence variants</dd><dt>HTSlib</dt><dd>A C library for reading/writing high-throughput sequencing data</dd></dl>
<p>Samtools and BCFtools both use HTSlib internally, but these source packages contain their own copies of htslib so they can be built independently.</p><p>Address of the bookmark: <a href="http://www.htslib.org/" rel="nofollow">http://www.htslib.org/</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>

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