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	<title><![CDATA[BOL: Related items]]></title>
	<link>https://bioinformaticsonline.com/related/23680?offset=70</link>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/44727/postdoctoral-scholar-in-bacterial-evolution-at-pathogen-and-microbiome-institute-at-northern-arizona-university</guid>
  <pubDate>Fri, 13 Dec 2024 12:49:16 -0600</pubDate>
  <link></link>
  <title><![CDATA[Postdoctoral Scholar in Bacterial Evolution at Pathogen and Microbiome Institute at Northern Arizona University]]></title>
  <description><![CDATA[
<p>We are pleased to announce a Postdoctoral Scholar position to study<br />bacterial evolution at the Pathogen and Microbiome Institute at<br />Northern Arizona University with Professor Paul Keim. The scholar<br />will have the opportunity also work with Professor Sam Sheppard at<br />The University of Oxford on joint projects. See our recent paper<br />on interspecific gene flow in Campylobacter. (DOI:<br />https://doi.org/10.1128/mbio.00581-24)</p>

<p>The job description: "This research position focuses on the science<br />of bacterial evolution. It will consist of researching theoretical<br />principles, but could include translational applications. Phylogenomic<br />and bioinformatic analysis of bacterial populations in nature or<br />in laboratory experiments will be a key component of the work. Prior<br />experience is an asset though training will be possible at PMI.<br />Likewise, laboratory microbiological, molecular, and biochemical<br />skills are an asset though not essential. Communication and critical<br />thinking skills are essential for performing the work and for<br />communicating to the local and international scientific communities.<br />Participating in team or independent grant writing to obtain research<br />funding will be required. Student mentoring is a part of the NAU<br />mission and is a partial expectation."</p>

<p>https://hr.peoplesoft.nau.edu/psp/ph92prta/EMPLOYEE/HRMS/c/HRS_HRAM.HRS_APP_SCHJOB.GBL?Page=HRS_APP_JBPST&amp;Action=U&amp;FOCUS=Applicant&amp;SiteId=1&amp;JobOpeningId=608024&amp;PostingSeq=1</p>

<p>Northern Arizona University is located in Flagstaff, Arizona, a<br />beautiful mountain town with a surprisingly vibrant restaurant<br />scene. Located a little over an hour from the Grand Canyon and ~45<br />min from Sedona, Flagstaff is a hiker's paradise. In fact, the city<br />of Flagstaff operates more than 50 miles of unpaved trails and there<br />are, on average, 266 sunny days per year with which to enjoy them.<br />At 7000 ft in elevation, Flagstaff experiences all four seasons,<br />but thesummers are mild and, in the winter, you can be on the ski<br />slopes within 30 min! https://www.flagstaffarizona.org/</p>

<p>As mentioned, joint projects with Professor Sheppard at Oxford<br />University are possible, including travel to his laboratory in the<br />United Kingdom. https://www.biology.ox.ac.uk/people/samuel-sheppard</p>

<p>Contact Information:<br />Paul.Keim@nau.edu</p>

<p>Paul S. Keim, Ph.D.<br />Regents Professor, &amp;<br />Cowden Endowed Chair of Microbiology<br />Northern Arizona University<br />Flagstaff, AZ 86011-4073</p>

<p>Paul S Keim</p>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/researchlabs/view/5422/shendure-lab</guid>
  <pubDate>Wed, 09 Oct 2013 14:21:58 -0500</pubDate>
  <link></link>
  <title><![CDATA[Shendure Lab]]></title>
  <description><![CDATA[
<p>The Shendure Lab is part of the Department of Genome Sciences at the University of Washington (Seattle, WA). The mission of the lab is to develop and apply new technologies in genomics and molecular biology. Most projects in the lab exploit new DNA sequencing technologies (Shendure et al., Nature Reviews Genetics 2004; Shendure &amp; Ji, Nature Biotechnology 2008; Shendure &amp; Lieberman Aiden, Nature Biotechnology 2012), and generally fall into one of six areas: 1) next-generation human genetics; 2) genome contiguity &amp; completeness; 3) massively parallel functional analysis; 4) molecular tagging; 5) synthetic biology; 6) translational genomics. Our interests in each of these areas are outlined briefly below, and a full list of publications is available via PubMed. http://www.ncbi.nlm.nih.gov/pubmed?cmd=search&amp;term=shendure<br />More http://krishna.gs.washington.edu/research.html</p>

<p>Lab page @ http://krishna.gs.washington.edu/index.html</p>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/researchlabs/view/5661/shankar-lab</guid>
  <pubDate>Wed, 16 Oct 2013 07:02:22 -0500</pubDate>
  <link></link>
  <title><![CDATA[Shankar Lab]]></title>
  <description><![CDATA[
<p>Research Interest:</p>

<p>(A) Regulatory System Analysis with respect to microRNAs</p>

<p>(B) Computational Epigenomics &amp; Regulomics:</p>

<p>(C) Computational issues with Next Generation Sequencing:</p>

<p>Department of Biotechnology, <br />Institute of Himalyan Bioresources Technology<br />CSIR, Palampur(Himachal Pradesh), India.<br />Email: ravishihbt.res.in; ravish9gmail.com</p>

<p>More @ http://scbb.ihbt.res.in/SCBB_dept/Lab_Member.php</p>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/researchlabs/view/5747/dbbrowser-attwood-lab</guid>
  <pubDate>Fri, 18 Oct 2013 10:48:19 -0500</pubDate>
  <link></link>
  <title><![CDATA[DbBrowser: Attwood Lab]]></title>
  <description><![CDATA[
<p>DbBrowser: Attwood Lab research concerns protein sequence analysis, primarily using the method of protein 'fingerprinting'. DbBrowser: Attwood Lab maintain a diagnostic fingerprint database (PRINTS), one of the founding partner of InterPro. We also design software to display sequence and structural data in visually-striking ways (e.g., Ambrosia, CINEMA); DbBrowser: Attwood Lab are building re-usable software components to create semantically integrated bioinformatics applications through UTOPIA, including a 'smart' PDF reader that links bioinformatics databases and tools directly with scientific articles (Utopia Documents); and have developed a number of tools for automatic annotation and text mining (e.g., MINOTAUR, PRECIS, METIS). </p>

<p>More @ http://www.bioinf.manchester.ac.uk/dbbrowser/index.php</p>
]]></description>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/blog/view/44751/large-language-models-in-bioinformatics-transforming-data-analysis-and-interpretation</guid>
	<pubDate>Thu, 02 Jan 2025 11:26:29 -0600</pubDate>
	<link>https://bioinformaticsonline.com/blog/view/44751/large-language-models-in-bioinformatics-transforming-data-analysis-and-interpretation</link>
	<title><![CDATA[Large Language Models in Bioinformatics: Transforming Data Analysis and Interpretation]]></title>
	<description><![CDATA[<p>The integration of artificial intelligence (AI) into bioinformatics has ushered in a new era of computational biology. Among the most transformative advancements are large language models (LLMs), such as GPT and BERT, which leverage deep learning to process and interpret vast amounts of text data. These models are reshaping bioinformatics by enhancing data analysis, hypothesis generation, and literature mining.</p><h3>Understanding Large Language Models</h3><p>LLMs are AI systems trained on extensive datasets of natural language. Their ability to model context, identify patterns, and generate coherent language has proven invaluable across domains, including bioinformatics. By fine-tuning these models on biological datasets, researchers can unlock insights into molecular biology, systems biology, and beyond.</p><h3>Key Applications of LLMs in Bioinformatics</h3><h4>1. <strong>Annotating Biological Data</strong></h4><p>Annotating genomic and proteomic data is fundamental yet labor-intensive. LLMs streamline this process by extracting functional annotations from literature and databases, predicting gene and protein functions, and providing automated insights.</p><h4>2. <strong>Mining Scientific Literature</strong></h4><p>The exponential growth of publications presents a challenge for researchers to stay updated. LLMs can process large volumes of text to extract key findings, summarize papers, and identify trends, thereby facilitating efficient literature reviews.</p><h4>3. <strong>Predicting Gene and Protein Functions</strong></h4><p>By leveraging sequence data and annotations, LLMs can predict the functions of uncharacterized genes and proteins. This capability is particularly useful for studying non-model organisms and orphan genes.</p><h4>4. <strong>Drug Discovery and Repurposing</strong></h4><p>LLMs enable pattern recognition across chemical, genomic, and clinical datasets, identifying novel drug candidates and repurposing existing drugs for new therapeutic targets. They can simulate interactions between drugs and biological molecules, accelerating the discovery pipeline.</p><h4>5. <strong>Generating Hypotheses for Research</strong></h4><p>LLMs analyze complex datasets to propose testable hypotheses. For example, they can predict protein-protein interactions, identify regulatory motifs, or model evolutionary processes in genomes.</p><h3>Advantages of LLMs in Bioinformatics</h3><ul>
<li>
<p><strong>Scalability:</strong> LLMs process massive datasets rapidly, reducing the time required for data analysis.</p>
</li>
<li>
<p><strong>Versatility:</strong> These models adapt to diverse bioinformatics tasks, from genomic annotation to network analysis.</p>
</li>
<li>
<p><strong>Contextual Insights:</strong> By synthesizing information across disparate datasets, LLMs provide integrative insights into biological systems.</p>
</li>
</ul><h3>Challenges in Applying LLMs</h3><p>Despite their promise, LLMs face limitations:</p><ul>
<li>
<p><strong>Data Quality and Bias:</strong> Inaccurate or biased datasets can affect model predictions, necessitating rigorous data curation.</p>
</li>
<li>
<p><strong>Interpretability:</strong> Understanding the decision-making process of LLMs remains a critical challenge, especially in high-stakes fields like genomics and medicine.</p>
</li>
<li>
<p><strong>Resource Intensity:</strong> Training and deploying LLMs require substantial computational power, which can limit accessibility.</p>
</li>
<li>
<p><strong>Ethical Concerns:</strong> Handling sensitive genomic data raises privacy and security issues, emphasizing the need for ethical guidelines.</p>
</li>
</ul><h3>Future Prospects</h3><p>The continued development of LLMs tailored for bioinformatics promises exciting advancements. Specialized models trained on omics data, open-access platforms, and interdisciplinary collaborations will expand the utility of LLMs. Moreover, integrating LLMs with other AI technologies, such as graph neural networks and reinforcement learning, can unlock deeper biological insights.</p><h3>Conclusion</h3><p>Large language models are revolutionizing bioinformatics by addressing longstanding challenges in data annotation, literature mining, and function prediction. Their ability to analyze complex biological datasets efficiently positions them as indispensable tools for modern research. As bioinformatics embraces AI, the synergy between LLMs and biological sciences holds the potential to unravel the complexities of life with unprecedented precision and scale.</p>]]></description>
	<dc:creator>LEGE</dc:creator>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/6012/project-junior-research-fellow-ccmb</guid>
  <pubDate>Fri, 01 Nov 2013 10:38:22 -0500</pubDate>
  <link></link>
  <title><![CDATA[Project Junior Research Fellow @ CCMB]]></title>
  <description><![CDATA[
<p>Temporary Project positions available purely on temporary basis - Oct/2013</p>

<p>1. Project Junior Research Fellow / Project Assistant</p>

<p>Last Date: 11th Nov 2013</p>

<p>Qualification B.Tech (Comp. Sci.), B.Tech/M.Tech (Bioinformatics), MCA,  M.Sc. (Mathematics/Statistics)</p>

<p>Desirable Qualifications: Programming in FORTRAN/ C /PERL, Web application technologies</p>

<p>Upper Age limit 28</p>

<p>Rs.12000 / Rs.16000 (as sanctioned by the funding agency)</p>

<p>General terms and conditions:</p>

<p>    Positions are purely temporary and co-terminus with the project.</p>

<p>    HRDG (CSIR) prevailing guidelines are applicable these positions.</p>

<p>    All categories of applicants are required to submit online application.</p>

<p>    Enhancement of stipend to Project JRF to Project SRF will be with the due recommendation of Principal Investigator and approval of the Director on the evaluation of the 3 member Standing Committee consisting of Chairperson at the level of Chief Scientist, Coordinator of the JRFs/RAs/PDFs and the Principal Investigator of the Project.</p>

<p>    The age relaxation as per HRDG (CSIR) norms: SC/ST/OBC/Women/Physically Handicapped persons – five years.</p>

<p>    The Stipend normally be fixed at Rs.22000/- for Research Associates/Post Doc. Fellows. However, a selected RA/PDF may be placed in the higher start of stipend if there is ample justification and such recommendation is made by the Selection Committee. Based on the recommendation with justification by the PI and approval of the Director, person getting stipend at lower rate may be elevated to higher rate subject to availability of the funds in the project.</p>

<p>    Recruitment will be based on initial screening based on qualifications and experience criteria and also based on suitability of the candidates to the nature of research project. This screening will be followed by written test followed / interview. After completing this process, candidates will be shortlisted and appointed in specific project subjects as and when appropriate positions become available. The pool of selected candidates will be valid for six months.</p>

<p>    Remunerations indicate are maximum admissible and will depend upon the availability of funds and subject to conditions applicable to projects from different funding agencies at the time of recruitment.</p>

<p>Apply : http://www.ccmb.res.in/positions/projects/temp_positions.php</p>

<p>Form download : http://www.ccmb.res.in/positions/projects/oct-2013/pdf_download.php</p>
]]></description>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/blog/view/44852/what-is-data-science-%E2%80%94-a-bioinformatics-perspective</guid>
	<pubDate>Mon, 16 Jun 2025 01:44:34 -0500</pubDate>
	<link>https://bioinformaticsonline.com/blog/view/44852/what-is-data-science-%E2%80%94-a-bioinformatics-perspective</link>
	<title><![CDATA[What is Data Science? — A Bioinformatics Perspective]]></title>
	<description><![CDATA[<p>In today&rsquo;s era of big biology, we&rsquo;re generating more data than ever before&mdash;genomes, transcriptomes, proteomes, metabolomes, microbiomes&hellip; you name it. But raw biological data doesn&rsquo;t speak for itself. Making sense of it requires more than traditional biology. This is where data science steps in.</p><p><strong>So, What Is Data Science?</strong><br />At its core, data science is the interdisciplinary field that extracts knowledge and insights from data using programming, statistics, and domain expertise. In bioinformatics, data science enables us to turn gigabytes of sequence data into biological meaning.</p><p>Imagine trying to understand gene regulation in cancer by analyzing thousands of RNA-seq samples, or predicting antibiotic resistance from bacterial genomes&mdash;these challenges are not solvable through wet lab experiments alone. They require data-driven thinking.</p><p><strong>Data Science Meets Bioinformatics</strong><br />Bioinformatics is inherently a data science domain. From genomics to systems biology, every field in modern biology relies on data science techniques to:</p><p>Clean and process massive datasets</p><p>Discover patterns in high-dimensional data</p><p>Build predictive models (e.g., for disease classification)</p><p>Visualize complex biological networks and trends</p><p>Integrate diverse data types (e.g., transcriptomic + epigenomic data)</p><p><strong>The Bioinformatics Toolkit</strong><br />Here&rsquo;s what data science typically looks like in bioinformatics:</p><p>Task Data Science Role<br />Sequence alignment Efficient algorithms, indexing, parallel processing<br />Gene expression analysis Statistical modeling (e.g., DESeq2, limma)<br />Variant calling Data filtering, probabilistic models<br />Clustering of cells in single-cell data Unsupervised learning<br />Protein structure prediction Deep learning models (e.g., AlphaFold)<br />Metagenomics Data integration, classification, dimensionality reduction</p><p>Common tools include Python, R, Bioconductor, scikit-learn, Pandas, Seurat, and TensorFlow&mdash;often working together in reproducible workflows.</p><p><strong>It's Not Just About Coding</strong><br />A common misconception is that bioinformatics is just programming or scripting. But being a data scientist in bioinformatics also means:</p><p>Understanding experimental design</p><p>Asking biologically meaningful questions</p><p>Choosing the right statistical or machine learning models</p><p>Communicating findings effectively (e.g., plots, dashboards, papers)</p><p>In other words, data science in bioinformatics is where biology, statistics, and computer science converge.</p><p><strong>Why It Matters</strong><br />The real power of data science in bioinformatics is its ability to scale discovery.</p><p>Instead of studying one gene, we can study thousands.</p><p>Instead of analyzing one species, we can explore entire ecosystems.</p><p>Instead of waiting months for lab results, we can generate hypotheses in days.</p><p>From personalized medicine and cancer diagnostics to agricultural genomics and pandemic surveillance, data science is at the heart of the bioinformatics revolution.</p><p><strong>Final Thoughts</strong><br />If you&rsquo;re a biologist who&rsquo;s curious about code, or a data enthusiast fascinated by life sciences, bioinformatics is your playground&mdash;and data science is your toolkit.</p><p>In bioinformatics, data science isn&rsquo;t just useful. It&rsquo;s essential.</p><p>&nbsp;</p>]]></description>
	<dc:creator>Abhi</dc:creator>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/researchlabs/view/6233/edwards-lab</guid>
  <pubDate>Sun, 10 Nov 2013 15:07:08 -0600</pubDate>
  <link></link>
  <title><![CDATA[Edwards Lab]]></title>
  <description><![CDATA[
<p>We study the evolutionary biology of birds and relatives, combining field, museum and genomics approaches to understand the basis of avian diversity, evolution and behavior. Our guiding approaches include population genetics, which provides a quantitative framework for studying speciation, geographic variation and genome evolution; systematics, which acknowledges that the focal species of any study has relatives that are behaviorally and ecologically no less interesting; and natural history, which gives meaning to the genes and genomic patterns we study.</p>

<p>Lab page: http://www.oeb.harvard.edu/faculty/edwards/index.html</p>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/6559/ai-cadd-project-kerela-university</guid>
  <pubDate>Tue, 19 Nov 2013 17:48:15 -0600</pubDate>
  <link></link>
  <title><![CDATA[Ai-CADD Project @ Kerela University]]></title>
  <description><![CDATA[
<p>Applications are invited for the following Positions in the AiCADD project funded by MHRD Govt of India</p>

<p>Last Date for Submitting Application: 25th November 2013</p>

<p>1. Senior Scientist: (01 position)<br />Pay Scale: Rs.40, 000/-<br />Qualifications:  PhD/ Post Doctoral with Experience in CADD</p>

<p>2. Junior Scientist (10 positions)<br />Pay Scale: Rs. 22,000/-<br />Qualifications: MPhil / Masters Degree in Bioinformatics / Computational Biology / CADD / Ayurveda</p>

<p>3. Technical Assistant (01+01 positions)<br />Pay Scale: Rs.12,000/-<br />Qualifications: 1. BSc Computer Science/ MCA<br />Qualifications: 2. MSc Biotechnology / MSc Microbiology </p>

<p>4. Programmer (01 position)<br />Pay Scale: Rs.20,000/-<br />Qualifications: MSc Computer Science/ MCA / B Tech (Experience in MATLAB, C, C++) Industrial experience is desirable</p>

<p>5. Teaching Assistant (03 positions)<br />Pay Scale: Rs.10,000/-<br />Qualifications: MSc in Bioinformatics </p>

<p>6. Administration Assistant (02 positions)<br />Pay Scale: Rs.8,000/-<br />Qualifications: Degree + PGDCA</p>

<p>The Selection process comprises of written test and interview. Positions are purely temporary (initially for the period of one year) and co-terminus with the project. For more details mail to: cbi.uok [at] gmail.com</p>

<p>More detail @ https://sites.google.com/site/centreforbioinformatics/announcements/applicationsinvitedforapplicationforai-caddproject</p>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/45133/postdoctoral-position-in-evolutionary-genomics-and-bioinformatics-at-the-center-for-interdisciplinary-neuroscience-at-university-of-valparaiso-valparaiso-chile</guid>
  <pubDate>Wed, 22 Apr 2026 02:36:00 -0500</pubDate>
  <link></link>
  <title><![CDATA[Postdoctoral Position in Evolutionary Genomics and Bioinformatics, at the Center for Interdisciplinary Neuroscience at University of Valparaiso, Valparaiso, Chile.]]></title>
  <description><![CDATA[
<p>The Center for Interdisciplinary Neuroscience of Valparaiso (CINV)<br />in Valparaiso, Chile, invites postdoctoral researchers to apply for<br />a Postdoctoral Fellowship focusing on understanding the evolution of<br />genes and molecular pathways that play a role on inflammatory processes<br />driving diseases affecting the central nervous system.</p>

<p>The postdoctoral researcher will contribute to this project using<br />a combination of evolutionary and comparative genomics, as well as a<br />diverse set of bioinformatic approaches for data analysis and integration<br />(e.g., transcriptomics, genomics, phenotypic data). This position offers<br />a unique opportunity to integrate diverse state-of-the-art genomic and<br />phenotypic datasets across different model organisms to understand the<br />role of genes, molecular pathways in the origin of complex diseases.</p>

<p>CINV provides a highly collaborative and multidisciplinary environment<br />using a variety of computational and experimental approaches,<br />including genetically tractable animal models as well as expertise in<br />genetics, behavior, glia-neuron communication, metabolism, biophysics,<br />genomics, bioinformatics, host-microbe communication, and biomolecular<br />modelling. The new postdoc will be part of one of our labs which focuses<br />more generally on the intersection between molecular evolution and<br />disease biology.</p>

<p>Required qualifications are a PhD in evolutionary biology, computational<br />biology, bioinformatics, or closely related fields. Candidates must have<br />excellent verbal and written communication skills (working language<br />is English), as well as an established record of productivity (e.g.,<br />at least one previous peer-reviewed publication). Candidates with a<br />past record of publications in bioinfomatics, computational biology,<br />population genetics or evolutionary genomics are strongly preferred. Ideal<br />candidates should have experience in analyzing genomic and phenomic<br />data, performing comparative evolution or population genomic analyses,<br />as well as in collaborating with experimentalists.</p>

<p>Interested candidates should first contact Evandro Ferrada at<br />. Please include the following: (1) a cover<br />letter addressing your interest in the position and how your expertise<br />meets the position requirements, (2) a CV, (3) contact information of<br />at least 2 references. A short online interview will follow to discuss<br />specific proposals. Candidate materials will be reviewed as soon as<br />possible until the position is filled.</p>

<p>For further information, please visit:<br />https://cinv.uv.cl/cinv-postdoctoral-fellowship-program-2026/</p>

<p>Dr. Evandro Ferrada<br />Associate Profesor</p>

<p>Centro Interdisciplinario de Neurociencia (CINV)</p>

<p>Facultad de Ciencias, Universidad de Valpara�so.</p>

<p>Pasaje Harrington 287, Playa Ancha, Valpara�so, Chile.</p>

<p>Tel.  +56 (32) 250 8453</p>

<p>www.cinv.cl</p>
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