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	<title><![CDATA[BOL: Related items]]></title>
	<link>https://bioinformaticsonline.com/related/2492?offset=1330</link>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/37259/epiviz-an-interactive-visualization-tool-for-functional-genomics-data</guid>
	<pubDate>Mon, 09 Jul 2018 05:27:39 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/37259/epiviz-an-interactive-visualization-tool-for-functional-genomics-data</link>
	<title><![CDATA[Epiviz: an interactive visualization tool for functional genomics data.]]></title>
	<description><![CDATA[<p><span>Epiviz is an interactive visualization tool for functional genomics data. It supports genome navigation like other genome browsers, but allows multiple visualizations of data within genomic regions using scatterplots, heatmaps and other user-supplied visualizations. It also includes data from the&nbsp;</span><a href="http://barcode.luhs.org/" target="_blank">Gene Expression Barcode project</a><span>&nbsp;for transcriptome visualization. It has a flexible plugin framework so users can add</span><a href="http://d3js.org/" target="_blank">d3</a><span>&nbsp;visualizations. You can see a video tour&nbsp;</span><a href="http://youtu.be/099c4wUxozA" target="_blank">here</a><span>.</span></p>
<p><span>https://bioconductor.org/packages/release/bioc/html/epivizr.html</span></p>
<p><span>https://github.com/epiviz</span></p>
<p><span>https://github.com/epiviz/epiviz</span></p><p>Address of the bookmark: <a href="https://epiviz.github.io/" rel="nofollow">https://epiviz.github.io/</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/40369/phyloxml-xml-for-evolutionary-biology-and-comparative-genomics</guid>
	<pubDate>Sun, 08 Dec 2019 09:41:18 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/40369/phyloxml-xml-for-evolutionary-biology-and-comparative-genomics</link>
	<title><![CDATA[phyloXML: XML for evolutionary biology and comparative genomics]]></title>
	<description><![CDATA[<p><a href="http://www.biomedcentral.com/1471-2105/10/356/">phyloXML</a><span>&nbsp;(</span><a href="http://www.phyloxml.org/examples_syntax/phyloxml_syntax_example_1.html">example</a><span>) is an&nbsp;</span><a href="http://en.wikipedia.org/wiki/XML">XML</a><span>&nbsp;language designed to describe phylogenetic trees (or networks) and associated data. PhyloXML provides elements for commonly used features, such as taxonomic information, gene names and identifiers, branch lengths, support values, and gene duplication and speciation events. Using these standardized elements allows interoperability between various applications and databases. Furthermore, both due to extensible nature of XML itself and the provision of &lt;property&gt; elements by phyloXML, extensibility as well as domain specific applications are ensured. The structure of phyloXML is described by&nbsp;</span><a href="http://en.wikipedia.org/wiki/XML_Schema_%28W3C%29">XML Schema Definition (XSD)</a><span>&nbsp;language.</span></p>
<p><a href="http://www.phyloxml.org/archaeopteryx-js/adh.html">http://www.phyloxml.org/archaeopteryx-js/adh.html</a></p><p>Address of the bookmark: <a href="http://www.phyloxml.org/" rel="nofollow">http://www.phyloxml.org/</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/41459/jcvipython-utility-libraries-on-genome-assembly-annotation-and-comparative-genomics</guid>
	<pubDate>Tue, 17 Mar 2020 06:19:06 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/41459/jcvipython-utility-libraries-on-genome-assembly-annotation-and-comparative-genomics</link>
	<title><![CDATA[JCVI:Python utility libraries on genome assembly, annotation and comparative genomics]]></title>
	<description><![CDATA[<p>Collection of Python libraries to parse bioinformatics files, or perform computation related to assembly, annotation, and comparative genomics.</p>
<p>https://github.com/tanghaibao/jcvi</p>
<p>More at https://github.com/tanghaibao/jcvi/wiki</p><p>Address of the bookmark: <a href="https://github.com/tanghaibao/jcvi" rel="nofollow">https://github.com/tanghaibao/jcvi</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/17926/orange-bioinformatics-2534</guid>
	<pubDate>Mon, 06 Oct 2014 12:51:37 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/17926/orange-bioinformatics-2534</link>
	<title><![CDATA[Orange-Bioinformatics 2.5.34]]></title>
	<description><![CDATA[<p>Orange Bioinformatics extends <a href="http://orange.biolab.si/">Orange</a>, a data mining software package, with common functionality for bioinformatics. The provided functionality can be accessed as a Python library or through a visual programming interface (Orange Canvas). The latter is also suitable for non-programmers.</p>
<p>Orange Bioinformatics provides access to publicly available data, like GEO data sets, Biomart, GO, KEGG, Atlas, ArrayExpress, and PIPAx database. As for the analytics, there is gene selection, quality control, scoring distances between experiments with multiple factors. All features can be combined with powerful visualization, network exploration and data mining techniques from the Orange data mining framework.</p><p>Address of the bookmark: <a href="https://pypi.python.org/pypi/Orange-Bioinformatics/2.5.34" rel="nofollow">https://pypi.python.org/pypi/Orange-Bioinformatics/2.5.34</a></p>]]></description>
	<dc:creator>Robert M Willioms</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/42713/gggenomes-a-grammar-of-graphics-for-comparative-genomics</guid>
	<pubDate>Mon, 01 Feb 2021 14:47:32 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/42713/gggenomes-a-grammar-of-graphics-for-comparative-genomics</link>
	<title><![CDATA[gggenomes: A grammar of graphics for comparative genomics]]></title>
	<description><![CDATA[<p><span>gggenomes is a versatile graphics package for comparative genomics. It extends the popular R visualization package</span><a href="https://ggplot2.tidyverse.org/">ggplot2</a><span>&nbsp;by adding dedicated plot functions for genes, syntenic regions, etc. and verbs to manipulate the plot to, for example, quickly zoom in into gene neighborhoods.</span></p><p>Address of the bookmark: <a href="https://github.com/thackl/gggenomes" rel="nofollow">https://github.com/thackl/gggenomes</a></p>]]></description>
	<dc:creator>Surabhi Chaudhary</dc:creator>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/18380/jrfsrf-at-university-of-hyderabad</guid>
  <pubDate>Fri, 17 Oct 2014 01:55:44 -0500</pubDate>
  <link></link>
  <title><![CDATA[JRF/SRF at University of Hyderabad]]></title>
  <description><![CDATA[
<p>Applications are invited for the following post of Junior Research Fellow (temporary position coterminous with the project) under DBT funded research project on ““Understanding the functions of α1β1γ1/α2β1γ1 selective AMPK Modulators in dissecting the pharmacological role of these isozymes in metabolic diseases”</p>

<p>Qualified and interested candidates can send their curriculum vitae by e-mail to hr@drils.org on or before 27th October 2014 mention in the subject line of the mail the following code: AMPK-Biology.</p>

<p>Selected candidates will be called for a personal interview to Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad. The selected candidate is expected to report within two weeks from the date of selection to start work on the project.</p>

<p>Junior Research Fellowship (Molecular Modeling/Biology) for two years and Senior Research fellowship for one year</p>

<p>Junior Research Fellowship: Rs. 15,600/- (consolidated) per month for first two years.<br />Senior Research Fellowship: Rs. 18,200/-(consolidated) per month for the 3rd year.</p>

<p>Duration: The duration of the fellowship is for three years. However, the performance of the candidate will be reviewed after the completion of every year and the fellowship will be renewed only upon satisfactory performance.</p>

<p>Responsibilities:</p>

<p>1) Literature search.<br />2) Design, plan and execute experiments under the supervision of the scientist.<br />3) Provide scientific support to the scientist in his/her research activities.<br />4) Book keeping and maintenance of stocks and consumables.</p>

<p>Essential Qualifications:</p>

<p>Required: M.Sc. in Microbiology/Biotechnology/Bioinformatics or any other related branch of basic Sciences from a recognized university/institute with a consistent academic record of minimum 60% aggregate in all qualifying examinations. The candidate should be NET qualified for lectureship. The candidate should be motivated to work with dedication.</p>

<p>Desirable: expertise/experience in both Molecular Modeling and Molecular Biology.</p>

<p>Experience: 0-2 years in the areas of Molecular Modeling and/or Molecular Biology and cell biology and Biochemistry.</p>

<p>Preferable: Relevant research experience as evident from thesis/dissertation/project work.</p>

<p>Advertisement: http://www.ilsresearch.org/userfiles/Junior%20REsearch%20Fellowship%20-%20AMPK(Biology).pdf</p>
]]></description>
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<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/43683/genview-a-phylogeny-based-comparative-genomics-software-to-analyze-the-genetic-environment-of-genes</guid>
	<pubDate>Tue, 28 Dec 2021 01:49:03 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/43683/genview-a-phylogeny-based-comparative-genomics-software-to-analyze-the-genetic-environment-of-genes</link>
	<title><![CDATA[GEnView: A phylogeny based comparative genomics software to analyze the genetic environment of genes]]></title>
	<description><![CDATA[<p><span>A phylogeny based comparative genomics software to analyze the genetic environment of genes. The user can select one or several taxa and provide one or several reference protein(s). Genomes and plasmids (based on user choice) will be downloaded from the NCBI Assembly/NR database and searched for the respective gene. Alternatively, custom genomes can be provided. User selected stretches (20kbp by default) of the genes genetic environment are extracted, annotated and aligned between all genomes. The sequences are then visualized, enabling comparison of synteny and gene content.</span></p>
<p><span>More at&nbsp;https://pubmed.ncbi.nlm.nih.gov/34951622/</span></p><p>Address of the bookmark: <a href="https://github.com/EbmeyerSt/GEnView" rel="nofollow">https://github.com/EbmeyerSt/GEnView</a></p>]]></description>
	<dc:creator>Abhi</dc:creator>
</item>

<item>
  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/18385/biinformamatics-lead-at-google-life-sciences</guid>
  <pubDate>Fri, 17 Oct 2014 02:24:55 -0500</pubDate>
  <link></link>
  <title><![CDATA[Biinformamatics Lead at Google Life Sciences]]></title>
  <description><![CDATA[
<p>Google Life Sciences is recruiting a technical lead with experience in bioinformatics and clinical bioinformatics, including for biomarker discovery projects such as the Baseline study.</p>

<p>Responsibilities</p>

<p>Lead teams of scientists in structuring, prototyping, and executing large-scale bioinformatic and other analysis.<br />Develop novel bioinformatics, statistical, data processing, pathway, data mining and other algorithms to identify biological signals and their clinical correlates in broad kinds of individual and population data.<br />Develop novel platform-level analytical tools for sequence-based assays (assembly, annotation, variant calling and interpretation, phasing, genome structure, etc.), expression assays (RNAseq and microarray), proteomics, and metabolomics.<br />Develop statistical models that robustly correlate complex laboratory-derived information with phenotypic and clinical information.<br />Create scientifically rigorous visualizations, communications, and presentations of results.</p>

<p>Reference @ https://www.google.com/about/careers/search#!t=jo&amp;jid=62095001</p>
]]></description>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/blog/view/44799/unlocking-evolutionary-secrets-a-dive-into-comparative-genomics-methods</guid>
	<pubDate>Tue, 20 May 2025 00:25:09 -0500</pubDate>
	<link>https://bioinformaticsonline.com/blog/view/44799/unlocking-evolutionary-secrets-a-dive-into-comparative-genomics-methods</link>
	<title><![CDATA[Unlocking Evolutionary Secrets: A Dive into Comparative Genomics Methods]]></title>
	<description><![CDATA[<p>Comparative genomics is the art and science of comparing genomes&mdash;across species, within species, or even among individuals&mdash;to unravel evolutionary relationships, functional elements, and genetic adaptations. As sequencing technologies have advanced and genome databases have expanded, comparative genomics has become a cornerstone of modern biology, shedding light on everything from antibiotic resistance in bacteria to human disease genetics.</p><p>In this post, we&rsquo;ll explore the core methods used in comparative genomics, the questions they help answer, and how they&rsquo;re shaping our understanding of life.</p><p><strong>1. Whole-Genome Alignment</strong><br />Whole-genome alignment involves mapping the entire genome of one species to another. Tools like MUMmer, MAUVE, and LASTZ perform large-scale sequence alignments to detect conserved regions, rearrangements, insertions, and deletions.</p><p>Use Case:<br />Comparing human and chimpanzee genomes to identify evolutionary conserved sequences (ECS) and regions of divergence.</p><p>Key Challenges:<br />Handling repetitive sequences and genome rearrangements.</p><p>Computational complexity in large genomes.</p><p><strong>2. Synteny and Collinearity Analysis</strong><br />Synteny refers to conserved blocks of gene order across species. Tools like MCScanX, SynMap, or CHITRA (for visualizing synteny interactively) detect these blocks to understand chromosomal evolution.</p><p>Use Case:<br />Studying ancient genome duplications in plants.</p><p>Investigating chromosomal rearrangements in cancer genomes.</p><p><strong>3. Ortholog and Paralog Detection</strong><br />Orthologs are genes in different species that evolved from a common ancestor, while paralogs are genes duplicated within a genome. Identifying them is crucial for functional annotation and evolutionary studies.</p><p>Popular Tools:<br />OrthoFinder, Orthologous MAtrix (OMA), InParanoid, and EggNOG.</p><p>Use Case:<br />Functional prediction of uncharacterized genes based on orthologs in model organisms.</p><p>Tracing gene family evolution.</p><p><strong>4. Phylogenomic Analysis</strong><br />Phylogenomic methods combine phylogenetics and genomics to infer evolutionary trees based on genome-wide data. These methods can handle dozens to hundreds of genomes, using concatenated alignments or gene trees.</p><p>Tools:<br />RAxML, IQ-TREE, ASTRAL, Phylip, BEAST.</p><p>Use Case:<br />Resolving the evolutionary relationships between microbial species.</p><p>Studying speciation events.</p><p><strong>5. Pan-Genome Analysis</strong><br />The pan-genome consists of the core genome (shared by all strains) and the accessory genome (strain-specific genes). This is especially popular in microbial genomics.</p><p>Tools:<br />Roary, Panaroo, BPGA, PGAP.</p><p>Use Case:<br />Understanding virulence factor diversity in E. coli.</p><p>Designing broad-spectrum vaccines.</p><p><strong>6. Comparative Transcriptomics</strong><br />Comparing transcriptomes across species or conditions reveals conserved and unique expression patterns. RNA-seq data can be mapped to reference genomes to identify orthologous expression profiles.</p><p>Use Case:<br />Comparing stress response in extremophiles and model species.</p><p>Studying conserved regulatory networks.</p><p><strong>7. Functional Element Comparison</strong><br />Beyond genes, comparative genomics also targets non-coding regions&mdash;enhancers, promoters, miRNAs. Conservation across species often implies functional importance.</p><p>Tools:<br />PhastCons, GERP, phyloP (based on multiple alignments).</p><p>Use Case:<br />Detecting conserved non-coding elements in vertebrates.</p><p>Studying regulatory divergence in human evolution.</p><p><strong>8. Horizontal Gene Transfer (HGT) Detection</strong><br />In microbes, genes often jump across species boundaries. Comparative genomics can detect HGT by identifying genes that defy the expected phylogenetic pattern.</p><p>Tools:<br />HGTector, DarkHorse, AlienHunter, SIGI-HMM.</p><p>Use Case:<br />Tracing antibiotic resistance genes.</p><p>Exploring microbial adaptability in extreme environments.</p><p><strong>Final Thoughts</strong><br />Comparative genomics is a powerful lens to observe the diversity and unity of life. With a broad toolkit&mdash;from aligners to orthology pipelines, phylogenetic engines to visualization tools&mdash;it allows scientists to ask big questions: How did genomes evolve? What makes species unique? Where do new genes come from?</p><p>Whether you're studying extremophiles, building better crops, or exploring human ancestry, comparative genomics offers the methods to connect the dots across the tree of life.</p><p>&nbsp;</p>]]></description>
	<dc:creator>LEGE</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/blog/view/33617/list-of-universities-offering-bachelor-or-master-bioinformatics-degree-in-pakistan</guid>
	<pubDate>Wed, 21 Jun 2017 04:20:43 -0500</pubDate>
	<link>https://bioinformaticsonline.com/blog/view/33617/list-of-universities-offering-bachelor-or-master-bioinformatics-degree-in-pakistan</link>
	<title><![CDATA[List of universities offering Bachelor or Master bioinformatics degree in Pakistan]]></title>
	<description><![CDATA[<p>There are a lot of universities offering Bachelor or Master degree in Pakistan. Following are the list of few intitute/universities</p><p>Bachelor/ BS Bioinformatics at<br />1. Al-khair University, Bhimber<br />2. Government College University, Faisalabad<br />3. University Of Agriculture, Faisalabad<br />4. Comsats Institute Of Information Technology [isb], Islamabad<br />5. International Islamic University, Islamabad<br />6. Quaid-e-azam University, Islamabad<br />7. Khushal Khan Khattak University, Karak<br />8. Virtual University Of Pakistan, Lahore<br />9. Virtual University Of Pakistan, Lahore<br />10. Hazara University, Mansehra<br />11. Shaheed Benazir Bhutto Women University, Peshawar<br />12. Comsats Institute Of Information Technology, Sahiwal<br />13. Capital University Of Science And Technology, Islamabad<br />14. Foundation University, Islamabad<br />15. Baqai Medical University/hospital, Karachi<br />16. Institute Of Business And Technology(main Campus), Karachi<br />17. Sir Syed University Of Engineering &amp; Technology, Karachi<br />18. Forman Christian College, Lahore<br />19. Qarshi University (lhr), Lahore<br />20. The Superior University, Lahore<br />21. University Of Management And Technology, Lahore<br />22. Federal Institute Of Health Sciences, Lahore<br />23. Shaheed Benazir Bhutto Women University Peshawar, Sub Campus, Swabi<br />24. Government Postgraduate College ( Mandian), Abbottabad<br />25. Federal Institute Of Health Sciences, Multan<br />26. Fedral Institute Of Health Sciences, Muzaffarabad<br />27. The Limit Institution Of Health Sciences, Sahiwal</p><p><br />Master/ MS Bioinformatics cources at<br />1. Government College University, Faisalabad<br />2. Comsats Institute Of Information Technology [isb], Islamabad<br />3. International Islamic University, Islamabad<br />4. National University Of Science &amp; Technology, Islamabad<br />5. Quaid-e-azam University, Islamabad<br />6. University Of Sindh, Jamshoro<br />7. Virtual University Of Pakistan, Lahore<br />8. Hazara University, Mansehra<br />9. Shaheed Benazir Bhutto Women University, Peshawar<br />10. Capital University Of Science And Technology, Islamabad<br />11. Cecos University Of Information Tech. &amp; Emerging Sciences, Peshawar</p><p>The real bioinformatics scope lies if there are research labs which work in this field. One has to take account of that. If so then try to get information of those labs and visit them to get a hang of the work they pursue.</p><p>There is a huge buzz of precision medicine in light of genomics all around the world. One should also try to see how genomics infrastructure is built up or standing in Pakistan. If research labs having collaboration with hospitals employ genomics then one must also visit such labs. This will bring new avenues in healthcare advances. Not only it opens up the wealth of knowledge one can make out of genomics study but will also advance the critical thinking of therapies.</p><p>So I would encourage to target research labs working in the fields and also get information of hospitals employing genomics, this will give you an overall understanding of the fields demand in your country.</p>]]></description>
	<dc:creator>Reshma Khatun</dc:creator>
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