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	<title><![CDATA[BOL: Related items]]></title>
	<link>https://bioinformaticsonline.com/related/26309?offset=1450</link>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/pages/view/1332/bioinformatics-companies-in-india</guid>
	<pubDate>Mon, 05 Aug 2013 20:20:07 -0500</pubDate>
	<link>https://bioinformaticsonline.com/pages/view/1332/bioinformatics-companies-in-india</link>
	<title><![CDATA[Bioinformatics Companies in India]]></title>
	<description><![CDATA[<p>Following are the list of top 30 bioinformatics companies in India. The companies name order does not follow any specific pattern.</p><p>1. Accelrys Software Solution Pvt Ltd.<br />12th Floor, Discover, ITPL, White Field, Bangalore-65.<br /><a href="http://www.accelrys.com/">www.accelrys.com</a></p><p>2. Apticraft Systems (P) Ltd.<br />142, Electronics Complex, Pardeshipura, Indore &ndash; 452010 (M.P.), India<br /><a href="http://www.apticraft.com/">www.apticraft.com</a></p><p>3. Aptuit Informatics<br />Plot No. 100-103, Export Promotion Industrial Park, White Field, Bangalore-560066<br /><a href="http://www.aptiuit.com/">www.aptiuit.com</a></p><p>4. Bigtec<br />J. K. Towers, 8th Block, Sangam Circle,46th Cross, Bangalore-560082.<br /><a href="http://www.bigtec.org/">www.bigtec.org</a></p><p>5. Bijam Biosciences Private Limited<br />Nagarjuna Hills, Hyderabad 500 082, India<br /><a href="http://www.nagarjunagroup.com/">www.nagarjunagroup.com</a></p><p>6. Bio Base Databases India Pvt Ltd.<br />Crescent Towers, 4th Floor, No : 32/1, Crescent Road, Bnagalore &ndash; 560 001<br /><a href="http://www.biobase-international.com/">www.biobase-international.com</a></p><p>7. BioImagene India Pvt. Ltd.<br />4th floor, C-Wing, Godrej Eternia, Shivajinagar, Pune-411005<br /><a href="http://www.bioimagene.com/">www.bioimagene.com</a></p><p>8. BioInformatics Institute Of India &ndash; Noida<br />C-56 A/28, Sector -62, Noida &ndash; 201 301<br /><a href="http://www.bii.in/">www.bii.in</a></p><p>9. CLC bio India Pvt Ltd<br />#Plot No. 51, H.No. 8-3-214/51, Srinivasa Nagar (West) Ameerpet Hyderabad &ndash; 500 038<br /><a href="http://www.clcbio.com/india">www.clcbio.com/india</a></p><p>10. CytoGenomics India (P) Ltd.<br />#3004, 12A Main HAL 2nd Stage, Bangalore 560008<br /><a href="http://www.silicocyte.com/">www.silicocyte.com</a></p><p>11. Genotypic Technology<br />211, 6th Cross, 80ft Road, RMV II Stage, Bangalore 560094<br /><a href="http://www.genotypic.co.in/">www.genotypic.co.in</a></p><p>12. Genvea Biosciences<br />Dr. D. T. Singh, CSO, 53, Craig Rd. #04-01, Singapore-089691<br /><a href="http://www.genvea.com/">www.genvea.com</a></p><p>13. Helix Info Systems<br />132 A, II Floor, Sterling Towers, IV Cross Street, Sterling Road, Nungambakkam, Chennai.<br /><a href="http://www.helixinfosystems.com/">www.helixinfosystems.com</a></p><p>14. Jalaja Technologies Pvt. Ltd.,<br />21/1,Victoria Layout, Victoria Road, Bangalore-47<br /><a href="http://www.jalaja.com/">www.jalaja.com</a></p><p>15. Jubilant Biosys Ltd<br />#96, Industrial Subrub, 2nd Stage, Yeshwanthpur, Bangalore- 560022<br />Jubilant Organosys Ltd.<br />1A, Sector 16A, Noida &ndash; 201 301 (India)<br /><a href="http://www.jubl.com/">www.jubl.com</a></p><p>16. Kshema Technologies<br />#1, Global Village, Mylasandra, Mysore Road, Bangalore-560 059.<br /><a href="http://www.mphasis.com/">www.mphasis.com</a></p><p>17. LabNetworx<br />B-704, Gitanjali Apartments, Vikas Marg Extension, New Delhi &ndash; 110 092<br /><a href="http://www.labnetworx.com/">www.labnetworx.com</a></p><p>18. LabVantage Solutions Pvt. Ltd.<br />Bengal Intelligent Park, Building C, 2nd Floor, Sector V, Salt Lake Electronics Complex, Kolkata &ndash; 700 091<br /><a href="http://www.labvantage.com/">www.labvantage.com</a></p><p>19. LeadInvent,&nbsp;<br />2nd Floor, Biotech Centre, University of Delhi, South Campus, Benito Juarez Road, New Delhi 110021, India<br />Contact no: +91 11 24119241<br />Email: contact@leadinvent.com<br /><a href="http://www.leadinvent.com">www.leadinvent.com</a></p><p>20. Mascon Life Sciences<br />B &ndash; 8/ 10, Vasant Vihar, New Delhi 110057, India<br /><a href="http://www.masconlifesciences.com/">www.masconlifesciences.com</a></p><p>21. Molecular Connections P Ltd<br />Kandala Mansion, 2/2 Kariappa Road, Near Krishna Rao Park, Basavangudi, Bangalore &ndash; 4<br /><a href="http://www.molecularconnections.com/">www.molecularconnections.com</a></p><p>22.Novo Informatics Pvt. Ltd.<br />TBIU, 2nd Floor, Synergy Building, Indian Institute of Technology,&nbsp;Hauz Khas, New Delhi-16.<br />Contact: 91-11-26581524, 91-11-26581766(Extension: 28)<br />Email: info@novoinformatics.com<br /><a href="http://www.novoinformatics.com">www.novoinformatics.com</a></p><p>23. Ocimum Biosolutions (India) Ltd<br />6th Floor, Reliance Classic, Road No.1 Banjara Hills, Hyderabad 500 034, India.<br /><a href="http://www.ocimumbio.com/">www.ocimumbio.com</a></p><p>24. Scube Scientific Software Solutions<br />613, Hemkunt Chambers, 89, Nehru Place, New Delhi -110 019<br /><a href="http://www.scribeindia.com/">www.scribeindia.com</a></p><p>25. Siri Technologies Pvt Ltd.<br />38/C -23, South End Road, Basavanagudi, Bangalore-56004.<br /><a href="http://www.siritech.com/">www.siritech.com</a></p><p>26. Strand Life Sciences Pvt. Ltd.<br />#237, Sir C. V. Raman Avenue, Raj Mahal Vilas, Bangalore 560 080 INDIA<br /><a href="http://www.strandls.com/">www.strandls.com<br /></a><br />27. SooryaKiran Bioinformatics (P) Ltd<br />TBIC-13, Tejaswini Building, Technopark, Thriruvananthapuram- 695 584, Keralam, India</p><p>Ph: +91 471 4060979,+91 9895404104<br />Email:&nbsp;<a href="mailto:reachus@sooryakiran.com">reachus@sooryakiran.com</a><br /><a href="http://www.sooryakiran.com/">http://www.sooryakiran.com</a></p><p>28. Systat Software Asia Pacific<br />4th Floor, Block 1, Shankar Narayan Building, No.25, MG Road, Bangalore &ndash; 560001<br /><a href="http://www.systat.com/">www.systat.com</a></p><p>29. ABC Genomics (India) Pvt. Ltd.<br />Biotech Park, Sector G, Jankipuram, Kursi Road, Lucknow-226021, U.P., INDIA<br />Tel +91-522-4068579, Email: director@abcgenomics.com<br /><a href="http://www.abcgenomics.com/">www.abcgenomics.com</a></p><p>30. en-GENE-ier's Core Technology Services,<br />1/340, Virat Khand, Gomtinagar,&nbsp;<br />(Near Maharaja Agrasen Public School)<br />lucknow-226010, U.P., India.<br /><a href="http://www.bio.egicore.com/"></a><a href="http://www.bio.egicore.com/">http://www.bio.egicore.com/</a></p><p>&nbsp;</p><p>Best of luck for your job hunts :).</p>]]></description>
	<dc:creator>Jitendra Narayan</dc:creator>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/44294/opportunity-at-mcdermott-center-bioinformatics-lab</guid>
  <pubDate>Sat, 01 Apr 2023 09:56:39 -0500</pubDate>
  <link></link>
  <title><![CDATA[Opportunity at McDermott Center Bioinformatics Lab]]></title>
  <description><![CDATA[
<p>Our team, composed of experts from diverse backgrounds including genetics, cancer biology, computer science, bioinformatics, and microbiology, stays current with evolving bioinformatics techniques. We offer consulting, customized service, and collaboration opportunities. We suggest visiting us to discuss your experiment design and results, as we can tailor our assistance to meet your specific research goals.</p>

<p>https://labs.utsouthwestern.edu/bioinformatics-lab/positions</p>
]]></description>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/1490/bioinformatics-jrf-at-iiser-mohali</guid>
  <pubDate>Thu, 08 Aug 2013 15:56:02 -0500</pubDate>
  <link></link>
  <title><![CDATA[Bioinformatics JRF at IISER MOHALI]]></title>
  <description><![CDATA[
<p>Applications are invited for a Junior Research Fellow (JRF) in Innovative Young Biotechnologist Award (IYBA) research project funded by Department of Biotechnology (DBT).</p>

<p>The project involves identification and characterization of transcription factors (TFs) from the Arabidopsis shoot apical meristem stem cell niche using genomic approaches and construction of a gene regulatory network for the identified TFs.</p>

<p>Positions: 1</p>

<p>Duration: 1 year but extendable up to three years based on performance and availability of funds.</p>

<p>Emoluments: As per DST rules.</p>

<p>Essential Qualifications: M.Sc. in any branch of life sciences with excellent academic record with CSIR-UGC NET or DBT-JRF. Candidate having previous work experience in the area of bioinformatics, molecular biology and genetics is preferred, but not required.</p>

<p>How to Apply: Applicants are requested to send a cover letter outlining previous research experiences and reasons for joining this position. Please send your complete bio-data including the cover letter as PDF attachment by email to Dr. Ram Yadav at ryadav@iisermohali.ac.in</p>

<p>Last date of submission is 17.00 IST, August 10, 2013.</p>

<p>Advertisement: www.iisermohali.ac.in/project_openings.html#29</p>
]]></description>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/44624/bioinformatics-workshops</guid>
	<pubDate>Wed, 31 Jul 2024 02:16:53 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/44624/bioinformatics-workshops</link>
	<title><![CDATA[Bioinformatics Workshops !]]></title>
	<description><![CDATA[<p>When delving into bioinformatics, having access to reliable resources is crucial for effective research and analysis. Key online resources include the National Center for Biotechnology Information (NCBI), which offers tools like BLAST for sequence alignment and comprehensive gene databases. For presentations and educational materials, exploring SlideShare for introductory and advanced bioinformatics topics can provide valuable insights and learning aids.</p>
<p>https://evomics.org/2024-workshop-on-genomics/</p><p>Address of the bookmark: <a href="https://evomics.org/2024-workshop-on-genomics/" rel="nofollow">https://evomics.org/2024-workshop-on-genomics/</a></p>]]></description>
	<dc:creator>Abhi</dc:creator>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/44669/bioinformatician-at-qub-uk</guid>
  <pubDate>Tue, 01 Oct 2024 21:43:23 -0500</pubDate>
  <link></link>
  <title><![CDATA[Bioinformatician at QUB, UK]]></title>
  <description><![CDATA[
<p>The post-holder will work under the direction of the Precision Medicine Centre of Excellence's (PMC) Bioinformatics lead and collaborate closely with the Scientific and Clinical leads. The primary responsibilities will be to develop, validate and maintain data analysis pipelines and algorithms that enable the comprehensive analysis of genomic information derived from cancer specimens, within the context of clinical studies. The PMC is an ISO 15189:2012 accredited medical laboratory (Ref 20634), providing an integrated cancer diagnostic and clinical research service that combines high throughput genomics and digital pathology (www.qub.ac.uk/research-centres/PMC).</p>

<p>About the person:</p>

<p>Essential criteria:</p>

<p>Hold or be about to obtain* a PhD in Computational biology, Bioinformatics, computing science or related subjects. (*must be obtained within 3 months of the closing date for the post) or MSc equivalent with at least 3 years' work experience in a relevant role.<br />Significant relevant research experience in genomics or work experience in a relevant technical/scientific role.<br />Significant experience in managing and analysing NGS data and other big data.<br />Experience in developing and maintaining analysis pipelines.<br />Experience working with Linux/UNIX environments.<br />Proficiency with python, bash, R and/or equivalent languages.<br />To be successful at shortlisting stage, please ensure you clearly evidence in your application how you meet the essential and, where applicable, desirable criteria listed in the Candidate Information document linked on our website.</p>

<p>More at https://hrwebapp.qub.ac.uk/tlive_webrecruitment/wrd/run/ETREC107GF.open</p>
]]></description>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/44702/postdoc-in-comparative-single-cell-genomics-at-university-of-basel</guid>
  <pubDate>Fri, 06 Dec 2024 23:41:20 -0600</pubDate>
  <link></link>
  <title><![CDATA[Postdoc in Comparative Single Cell Genomics at University of Basel]]></title>
  <description><![CDATA[
<p>A fully funded 4-year Postdoc position is available in the lab of Patrick<br />Tschopp at the University of Basel, Switzerland, study the molecular and<br />tissue-scale dynamics during the embryonic formation of the vertebrate<br />skeleton and compare it across different vertebrate species with distinct<br />habitats.</p>

<p>We are looking for a highly motivated candidate with a PhD degree in<br />Bioinformatics or a related field. Candidates are expected to have a<br />strong background in evolutionary biology and/or comparative functional<br />genomics. Additional experiences in single cell functional genomics<br />analyses, statistics and computational data analyses are a plus, as is<br />an interest in comparative developmental (EvoDevo) questions.</p>

<p>We offer a dynamic and interactive research environment with state-of-the<br />art research facilities, good research funding and internationally<br />competitive salaries.</p>

<p>The Tschopp lab (www.evolution.unibas.ch/tschopp/research/)<br />studies the gene regulatory mechanisms of cell type<br />specification and evolution in vertebrates. See also our<br />preprints at https://doi.org/10.1101/2024.03.26.586769 and<br />https://doi.org/10.1101/2024.11.28.625862 Applications should include<br />a motivation letter, a CV, a list of publications, a statement about<br />research interests, as well as the names and contact details of at<br />least two referees. Applications (in the form of a single .pdf file)<br />should be sent to Patrick Tschopp (patrick.tschopp@unibas.ch); review<br />of applications will begin on January 1st 2025, and will continue until<br />the position is filled.</p>

<p>Patrick Tschopp</p>
]]></description>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/researchlabs/view/4551/au-kbc-lab</guid>
  <pubDate>Sun, 15 Sep 2013 09:33:59 -0500</pubDate>
  <link></link>
  <title><![CDATA[AU-KBC Lab]]></title>
  <description><![CDATA[
<p>Conducting Clinical Trial Management Course combined with the Apollo Hospitals. Major Research in bioinformatics as Drug Discovery, Functional Genomics, Comparative genomics, Data Mining </p>

<p>More @ http://www.au-kbc.org/</p>
]]></description>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/blog/view/44716/exploring-rna-sequence-analysis-tools-for-every-bioinformatician</guid>
	<pubDate>Fri, 13 Dec 2024 04:03:04 -0600</pubDate>
	<link>https://bioinformaticsonline.com/blog/view/44716/exploring-rna-sequence-analysis-tools-for-every-bioinformatician</link>
	<title><![CDATA[Exploring RNA Sequence Analysis: Tools for Every Bioinformatician]]></title>
	<description><![CDATA[<p>RNA sequence analysis has become an essential part of modern biological research. From RNA-seq pipelines to specialized tools for specific RNA types, here's a comprehensive guide to tools you can use to make sense of RNA data.</p><h4><strong>1. RNA-Seq Analysis Pipelines</strong></h4><p>RNA-seq is one of the most popular techniques for studying RNA. These tools streamline processing raw sequence data:</p><ul>
<li><strong>FASTQC</strong>: For quality control of raw RNA-seq reads.</li>
<li><strong>Trimmomatic</strong>: For trimming and filtering RNA-seq reads.</li>
<li><strong>HISAT2/STAR</strong>: High-performance aligners for RNA-seq reads.</li>
<li><strong>FeatureCounts</strong>: For quantifying gene expression.</li>
<li><strong>DESeq2/EdgeR</strong>: For differential expression analysis.</li>
</ul><h4><strong>2. Transcriptome Assembly and Annotation</strong></h4><p>For analyzing transcriptomes from non-model organisms or assembling novel transcripts:</p><ul>
<li><strong>Trinity</strong>: For de novo transcriptome assembly.</li>
<li><strong>StringTie</strong>: For transcript assembly and quantification from RNA-seq alignments.</li>
<li><strong>TransDecoder</strong>: To predict coding regions within assembled transcripts.</li>
<li><strong>TAU</strong>: Tools for annotating non-coding and coding RNAs.</li>
</ul><h4><strong>3. Exploring Non-Coding RNA (ncRNA)</strong></h4><p>Non-coding RNAs play critical regulatory roles. Dedicated tools for studying them include:</p><ul>
<li><strong>Infernal</strong>: For identifying ncRNA sequences based on covariance models.</li>
<li><strong>Rfam</strong>: Database and tools for ncRNA families.</li>
<li><strong>miRDeep</strong>: For identifying microRNAs in RNA-seq datasets.</li>
</ul><h4><strong>4. RNA Structure and Motif Analysis</strong></h4><p>Structural biology of RNA helps in understanding its function:</p><ul>
<li><strong>RNAfold (ViennaRNA)</strong>: Predicts secondary structures from RNA sequences.</li>
<li><strong>RNAstructure</strong>: Tools for RNA secondary structure prediction and analysis.</li>
<li><strong>MEME Suite</strong>: For identifying motifs in RNA sequences.</li>
<li><strong>IntaRNA</strong>: For RNA-RNA interaction prediction.</li>
</ul><h4><strong>5. RNA Editing and Modifications</strong></h4><p>Epitranscriptomics is a growing field focusing on RNA modifications:</p><ul>
<li><strong>REDItools</strong>: For RNA editing analysis.</li>
<li><strong>m6Aboost</strong>: For identifying m6A modifications in RNA.</li>
</ul><h4><strong>6. Long-Read RNA Sequencing Analysis</strong></h4><p>Long-read technologies like Nanopore and PacBio are transforming RNA research:</p><ul>
<li><strong>FLAIR</strong>: For isoform-level analysis of long-read RNA-seq data.</li>
<li><strong>NanoMod</strong>: For detecting modifications in RNA from Nanopore sequencing.</li>
</ul><h4><strong>7. RNA-Protein Interactions</strong></h4><p>To study RNA-protein interactions and complexes:</p><ul>
<li><strong>RBPmap</strong>: For identifying RNA-binding protein motifs.</li>
<li><strong>PARalyzer</strong>: For analyzing PAR-CLIP data.</li>
</ul><h4><strong>8. Functional Enrichment Analysis</strong></h4><p>Understanding biological functions and pathways from RNA-seq data:</p><ul>
<li><strong>getENRICH</strong>: A tool designed for pathway enrichment analysis of non-model organisms (hypergeometric P-value calculation with FDR correction).</li>
<li><strong>ClusterProfiler</strong>: For GO and KEGG pathway enrichment analysis.</li>
</ul><h4><strong>9. Visualization and Data Sharing</strong></h4><p>Presenting and sharing RNA sequence analysis results effectively:</p><ul>
<li><strong>IGV</strong>: Genome browser for visualizing RNA-seq alignments.</li>
<li><strong>Circos</strong>: Circular visualization of RNA-seq data.</li>
<li><strong>DashBio</strong>: A Python library for creating bioinformatics visualizations.</li>
</ul><h4><strong>Conclusion</strong></h4><p>The bioinformatics landscape for RNA sequence analysis is vast, with tools catering to specific needs. Whether you&rsquo;re studying coding RNAs, non-coding RNAs, or exploring RNA-protein interactions, the right tools can transform your data into biological insights.</p>]]></description>
	<dc:creator>Neel</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/blog/view/44744/life-as-a-bioinformatician-%E2%80%93-expectation-vs-reality</guid>
	<pubDate>Mon, 23 Dec 2024 19:32:36 -0600</pubDate>
	<link>https://bioinformaticsonline.com/blog/view/44744/life-as-a-bioinformatician-%E2%80%93-expectation-vs-reality</link>
	<title><![CDATA[Life as a Bioinformatician – Expectation vs. Reality]]></title>
	<description><![CDATA[<p>You enter the world of bioinformatics envisioning a sleek, high-tech career, surrounded by cutting-edge algorithms, advanced computational tools, and groundbreaking discoveries. You imagine a seamless integration of biology and data science, where every day you decode the mysteries of life at a molecular level. Your days will be spent analyzing elegant datasets, publishing in top-tier journals, and making significant contributions to human health and the environment. To top it off, you picture yourself working in a comfortable, quiet environment, with plenty of time to perfect your skills and learn new ones.</p><p>While the expectations are not entirely off base, the reality of life as a bioinformatician is a mix of exciting discoveries, troubleshooting, and, let&rsquo;s admit it, a fair amount of frustration. Here&rsquo;s what it&rsquo;s really like:</p><h4>1. <strong>Expectation: Seamlessly Working with Perfect Datasets</strong></h4><p><em>Reality:</em> You often receive messy, incomplete, or poorly annotated datasets. Hours are spent cleaning, normalizing, and validating data before you even begin your analysis. "Garbage in, garbage out" is a constant reminder in your workflow. Tools designed to handle these problems exist, but they require significant customization, which adds another layer of complexity.</p><h4>2. <strong>Expectation: Effortless Multidisciplinary Integration</strong></h4><p><em>Reality:</em> Bridging biology and computational science is far from straightforward. You need to be proficient in both domains while keeping up with advancements in genomics, machine learning, and statistics. Additionally, collaborating with biologists who might not be fluent in computational jargon requires patience and effective communication skills.</p><h4>3. <strong>Expectation: Rapid, Groundbreaking Results</strong></h4><p><em>Reality:</em> Analysis often involves waiting&mdash;waiting for scripts to run, pipelines to complete, or software to install. Bioinformatics projects are iterative; you analyze, debug, and refine repeatedly. A single project might take months to complete due to unforeseen challenges, like computational bottlenecks or the need for additional experiments.</p><h4>4. <strong>Expectation: Beautiful Visualizations with a Click</strong></h4><p><em>Reality:</em> While tools like R, Python, and specialized software can create stunning plots, generating a publication-ready visualization requires significant effort. You&rsquo;ll spend hours tweaking axes, labels, and color palettes, ensuring clarity and accuracy.</p><h4>5. <strong>Expectation: All Work, No Bugs</strong></h4><p><em>Reality:</em> Debugging is an integral part of the job. Whether it&rsquo;s a misconfigured server, a script throwing unexpected errors, or a pipeline breaking due to an update, you&rsquo;ll develop a knack for problem-solving under pressure.</p><h4>6. <strong>Expectation: Ample Time for Skill Development</strong></h4><p><em>Reality:</em> Bioinformatics moves fast. Juggling ongoing projects, tight deadlines, and the constant stream of new tools and algorithms leaves little time for leisurely learning. Staying updated requires proactive effort&mdash;evenings, weekends, or dedicated study breaks.</p><h4>7. <strong>Expectation: Publishing Papers Regularly</strong></h4><p><em>Reality:</em> Publishing in bioinformatics is a marathon, not a sprint. Your analysis needs to be thorough, reproducible, and supported by strong biological insights. Reviewers often demand additional experiments or clarifications, stretching the timeline even further.</p><h4>8. <strong>Expectation: A Clear Career Path</strong></h4><p><em>Reality:</em> Bioinformatics offers diverse career paths, from academia and industry to healthcare and government. However, the choice can be daunting, with each path requiring unique skill sets and presenting different challenges. Navigating these options takes time, research, and sometimes trial and error.</p><h3>Finding Joy in the Chaos</h3><p>Despite these challenges, being a bioinformatician is immensely rewarding. You are at the forefront of science, enabling discoveries that impact medicine, agriculture, and the environment. The thrill of uncovering insights hidden in complex datasets and the satisfaction of solving biological puzzles make the hard work worthwhile.</p><h3>Advice for Aspiring Bioinformaticians</h3><ul>
<li><strong>Embrace Learning:</strong> The field is ever-evolving. Stay curious and adaptable.</li>
<li><strong>Develop Communication Skills:</strong> Bridging the gap between biology and computation is as much about explaining your methods as it is about applying them.</li>
<li><strong>Find a Community:</strong> Collaborate with peers, join forums, and attend conferences to stay inspired and updated.</li>
<li><strong>Celebrate Small Wins:</strong> Every cleaned dataset, successful script, or informative plot is a step forward.</li>
</ul><p>Bioinformatics is a blend of science, technology, and artistry. While the reality might not match the polished expectations, the journey is nothing short of exhilarating. If you&rsquo;re ready to embrace the chaos and keep learning, the field of bioinformatics will never cease to amaze you.</p>]]></description>
	<dc:creator>Abhi</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/videolist/watch/2349/bioinformatics-understanding-of-living-systems-through-information-science</guid>
	<pubDate>Wed, 14 Aug 2013 11:50:17 -0500</pubDate>
	<link>https://bioinformaticsonline.com/videolist/watch/2349/bioinformatics-understanding-of-living-systems-through-information-science</link>
	<title><![CDATA[Bioinformatics -- Understanding of living systems through  information science]]></title>
	<description><![CDATA[<iframe width="" height="" src="https://www.youtube-nocookie.com/embed/6Ovd_GOM9-g" frameborder="0" allowfullscreen></iframe>Recently, the progress of the Human Genome Project, aiming to decode all human DNA sequences, has highlighted a research field called bioinformatics. In this new field, computers and techniques from information science are not just used as tools to advance life science research; they're expected to have a major impact on how we think about the life sciences.

Q. The main feature of bioinformatics is, it utilizes computers to analyze life. One is example is the genome. In all organisms, DNA contains genetic information, and this is called the genome. But the amount of information involved is huge, so recently, it's been read using next-generation sequencers, and analyzed by computers. In bioinformatics research, what we do is utilize those genome information to investigate the principles of life.

As an organism evolves, its genome sequence changes through sudden mutations. Additionally, at the genome level, mutations called rearrangements, such as inversions, transpositions, and duplications, occur. 

The genome comparison system developed by the Sakakibara Lab calculates homologous sequences called anchors, which are conserved between species. If the genome is considered as a long text, then anchors can be thought of as words.

Q. We're coming to understand the genomes of various organisms - not just humans, but monkeys, chimpanzees, bacteria, and so on. The first method used to analyze a genome is comparing it with the genomes of other organisms, to see where it's the same and where it's different. In that way, the content of the genome is decoded bit by bit, using computers. By contrast, in our method, we've developed software called Murasaki, which we also use to analyze large genomes, by comparing them with those of other organisms.

The Sakakibara Lab uses a next-generation sequencer at Keio University, along with a cluster machine with hundreds of CPUs. In this way, the Lab is analyzing genome mutations that cause cancer, and the genome of the natto production strain Bacillus subtilis.

Until now, genome analysis could only be done in national-scale projects. But now, next-generation sequencer development has made genome analysis possible in an ordinary lab. In a world-first achievement, the Sakakibara Lab has decoded the natto bacillus genome, through analysis using Keio's next-generation sequencer.

Q. In the future, biology and the life sciences may become almost entirely information science and computer science. And in healthcare, that may enable us, for example, to predict whether individuals are susceptible to cancer, or to certain lifestyle-related diseases, by understanding their personal genome data. So, I think it's amply possible that we can make use of such information effectively, to help people live longer and be free from disease, by thinking about their lifestyle habits.
 
Bioinformatics is only two decades old. In this field, many areas are still unknown. Professor Sakakibara, having been involved since the beginning, will continue tackling new, challenging research projects.]]></description>
	
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