www.cytosolve.com

Post - System Biologist

Job Description: Role of system biology is to design quantitative models of bimolecular networks and to study interactions between the components of biological systems, and how these interactions give rise to the function and behavior of that system (Enzyme, metabolites and pathway).

Qualification : B.Tech or M.Sc in Bioinformatics

Required Skills:

1) Basic knowledge of cell signaling pathways, chemical/enzyme kinetics, and differential equation based modeling approach.
2) Previous laboratory experience could be an advantage
3) Good Communication skills.

santhiya.ram@mproductions.com and 044-42946555.

Under   a   NEPAD   initiative,   the   Biosciences   Eastern   and   Central   Africa   (BECA)  (www.biosciencesafrica.org) was established at ILRI. BECA consists of a hub, regional nodes, and  other affiliated laboratories and partner institutes. A state of the art joint Bioinformatics Platform  (www.becabioinfo.org), whose overall goal is to provide a coherent and powerful bioinformatics  infrastructure for use by all scientists in East and central Africa. The Platform goal requires both  physical and intellectual developments that together provide researchers with access to diverse  infrastructure in a wide­area network, thereby addressing four important aspects of bioinformatics: 

1) Science: bioinformatics tools for data integration and visualization, standardization of data  formats and data analysis strategies, and distribution of analysis tasks over local­ and widearea networks are in development; 

2)  Bioinformatics Support Facility: provides assistance and custom programming to projects  and those unable to establish a bioinformatics support function intrinsic to their project due  to shortage of qualified personnel or lack of funding; 

3) Hardware Platform: provide a powerful high performance computing platform capable of  handling the largest analysis needs for projects; 

4) Bioinformatics Training for East and central African scientists: While many Web­based  tools are available to the wet­lab researcher, the Web is not well suited for tasks beyond  single­sequence annotation. Researchers need to become productive in a server­based Unix  environment with its wealth of scripting and automation tools. Even at an entry­level, this  can be an intimidating task if proper guidance is not available.

International Centre of Insect Physiology and Ecology (ICIPE): ICIPE’s research focus is on insect biology, in order to improve the wellbeing of the peoples of the  tropics through insect science. There is a commitment to utilise contemporary science in order to  limit the impact of disease vectors, and agricultural pests. The understanding of the mechanisms  associated with behaviour (e.g. attraction and repellency) is crucial. ICIPE seeks to enhance its  bioinformatics capacity in order to support data from various EST projects designed to gain insights  into the insect ecology and plant pathogen interactions though studies of metabolic pathways  associated with production of all elochemicals. 

Long­term training activities:

Kenyatta University: An introductory course in Bioinformatics is offers to MSc Biotechnology  students. This comprises of 35 hours of lectures and practicals.

University of Nairobi: A centre for Biotechnology and Bioinformatics (CEBIB), which will offer  postgraduate training (diplomas, MSc and PhD) in areas of biotechnology and bioinformatics has  recently been launched. Other universities in Kenya, including Egerton, Maseno and the Jomo Kenyatta University of  Agriculture and Technology offer introductory courses to undergraduates in biomedical sciences. In addition, under the BECA platform MSc and PhD fellowships are being made available for  Bioinformatics students. ILRI is forging links with Universities in South Africa and the United  Kingdom to provide access to courses and training material. 

Research Interest and Activities:

The following are the present areas of research interest: 1. EST clustering 2. Genome sequencing and annotation 3. Functional genomics and proteomics (including key tropical pathogens) 4. Structural bioinformatics 5. Development of Bioinformatics Data Management Systems 6. Gene Mining 7. High Throughput Genotyping 8. Microarray data management and analysis 9. Metagenomics 10. Immunoinformatics 11. Host­pathogen interaction 12. High performance computing and grid development 13. Parasite transfection technologies 14. Cell cycle regulation 15. Population genetics 16. Vector genomics 17. Drug, vaccine and diagnostic target discovery

More at Web site and links:

http://www.ilri.cgiar.org/

http://www.icipe.org/    

http://www.uonbi.ac.ke/cebib

A walk-in Interview for the following position tenable at the Bioinformatics Infrastructure Facility (BIF), Department of Biotechnology, Alagappa University will be held at the Department of Biotechnology, Science Campus, Alagappa University, Karaikudi 630 004 on 03.08.2013 (Saturday) at 12:30 PM. This national facility is funded by the Department of Biotechnology, Ministry of Science and Technology, Government of India, New Delhi. The main objectives of the Centre involve teaching and research activities in bioinformatics/biotechnology.

1. Studentship (One Post):

Stipend : Rs. 5000 p.m. (consolidated)

Qualification: M.Sc., in Bioinformatics/Biotechnology/Biophysics/Biochemistry/
Life Sciences

Interested candidates are encouraged to send their Curriculum Vitae by email to alagappauniv.btisnet@nic.in in advance. On the day of interview, the candidates must produce original certificates in proof of their educational qualification and experience and a recommendation letter from the Head of the Department/Institution where last studied/worked. Candidates who have already passed the required Degree alone are eligible to appear for interview. No TA&DA will be given for attending the interview.

Advertisement: http://www.alagappabiotech.org/Notification.pdf

1. Accelrys Software Solution Pvt Ltd.
12th Floor, Discover, ITPL, White Field, Bangalore-65.
www.accelrys.com

2. Apticraft Systems (P) Ltd.
142, Electronics Complex, Pardeshipura, Indore – 452010 (M.P.), India
www.apticraft.com

3. Aptuit Informatics
Plot No. 100-103, Export Promotion Industrial Park, White Field, Bangalore-560066
www.aptiuit.com

4. Bigtec
J. K. Towers, 8th Block, Sangam Circle,46th Cross, Bangalore-560082.
www.bigtec.org

5. Bijam Biosciences Private Limited
Nagarjuna Hills, Hyderabad 500 082, India
www.nagarjunagroup.com

6. Bio Base Databases India Pvt Ltd.
Crescent Towers, 4th Floor, No : 32/1, Crescent Road, Bnagalore – 560 001
www.biobase-international.com

7. BioImagene India Pvt. Ltd.
4th floor, C-Wing, Godrej Eternia, Shivajinagar, Pune-411005
www.bioimagene.com

8. BioInformatics Institute Of India – Noida
C-56 A/28, Sector -62, Noida – 201 301
www.bii.in

9. CLC bio India Pvt Ltd
#Plot No. 51, H.No. 8-3-214/51, Srinivasa Nagar (West) Ameerpet Hyderabad – 500 038
www.clcbio.com/india

10. CytoGenomics India (P) Ltd.
#3004, 12A Main HAL 2nd Stage, Bangalore 560008
www.silicocyte.com

11. Genotypic Technology
211, 6th Cross, 80ft Road, RMV II Stage, Bangalore 560094
www.genotypic.co.in

12. Genvea Biosciences
Dr. D. T. Singh, CSO, 53, Craig Rd. #04-01, Singapore-089691
www.genvea.com

13. Helix Info Systems
132 A, II Floor, Sterling Towers, IV Cross Street, Sterling Road, Nungambakkam, Chennai.
www.helixinfosystems.com

14. Jalaja Technologies Pvt. Ltd.,
21/1,Victoria Layout, Victoria Road, Bangalore-47
www.jalaja.com

15. Jubilant Biosys Ltd
#96, Industrial Subrub, 2nd Stage, Yeshwanthpur, Bangalore- 560022
Jubilant Organosys Ltd.
1A, Sector 16A, Noida – 201 301 (India)
www.jubl.com

16. Kshema Technologies
#1, Global Village, Mylasandra, Mysore Road, Bangalore-560 059.
www.mphasis.com

17. LabNetworx
B-704, Gitanjali Apartments, Vikas Marg Extension, New Delhi – 110 092
www.labnetworx.com

18. LabVantage Solutions Pvt. Ltd.
Bengal Intelligent Park, Building C, 2nd Floor, Sector V, Salt Lake Electronics Complex, Kolkata – 700 091
www.labvantage.com

19. LeadInvent, 
2nd Floor, Biotech Centre, University of Delhi, South Campus, Benito Juarez Road, New Delhi 110021, India
Contact no: +91 11 24119241
Email: contact@leadinvent.com
www.leadinvent.com

20. Mascon Life Sciences
B – 8/ 10, Vasant Vihar, New Delhi 110057, India
www.masconlifesciences.com

21. Molecular Connections P Ltd
Kandala Mansion, 2/2 Kariappa Road, Near Krishna Rao Park, Basavangudi, Bangalore – 4
www.molecularconnections.com

22.Novo Informatics Pvt. Ltd.
TBIU, 2nd Floor, Synergy Building, Indian Institute of Technology, Hauz Khas, New Delhi-16.
Contact: 91-11-26581524, 91-11-26581766(Extension: 28)
Email: info@novoinformatics.com
www.novoinformatics.com

23. Ocimum Biosolutions (India) Ltd
6th Floor, Reliance Classic, Road No.1 Banjara Hills, Hyderabad 500 034, India.
www.ocimumbio.com

24. Scube Scientific Software Solutions
613, Hemkunt Chambers, 89, Nehru Place, New Delhi -110 019
www.scribeindia.com

25. Siri Technologies Pvt Ltd.
38/C -23, South End Road, Basavanagudi, Bangalore-56004.
www.siritech.com

26. Strand Life Sciences Pvt. Ltd.
#237, Sir C. V. Raman Avenue, Raj Mahal Vilas, Bangalore 560 080 INDIA
www.strandls.com

27. SooryaKiran Bioinformatics (P) Ltd
TBIC-13, Tejaswini Building, Technopark, Thriruvananthapuram- 695 584, Keralam, India

Ph: +91 471 4060979,+91 9895404104
Email: reachus@sooryakiran.com
http://www.sooryakiran.com

28. Systat Software Asia Pacific
4th Floor, Block 1, Shankar Narayan Building, No.25, MG Road, Bangalore – 560001
www.systat.com

29. ABC Genomics (India) Pvt. Ltd.
Biotech Park, Sector G, Jankipuram, Kursi Road, Lucknow-226021, U.P., INDIA
Tel +91-522-4068579, Email: director@abcgenomics.com
www.abcgenomics.com

30. en-GENE-ier's Core Technology Services,
1/340, Virat Khand, Gomtinagar, 
(Near Maharaja Agrasen Public School)
lucknow-226010, U.P., India.
http://www.bio.egicore.com/

Best of luck for your job hunts :).

The project involves identification and characterization of transcription factors (TFs) from the Arabidopsis shoot apical meristem stem cell niche using genomic approaches and construction of a gene regulatory network for the identified TFs.

Positions: 1

Duration: 1 year but extendable up to three years based on performance and availability of funds.

Emoluments: As per DST rules.

Essential Qualifications: M.Sc. in any branch of life sciences with excellent academic record with CSIR-UGC NET or DBT-JRF. Candidate having previous work experience in the area of bioinformatics, molecular biology and genetics is preferred, but not required.

How to Apply: Applicants are requested to send a cover letter outlining previous research experiences and reasons for joining this position. Please send your complete bio-data including the cover letter as PDF attachment by email to Dr. Ram Yadav at ryadav@iisermohali.ac.in

Last date of submission is 17.00 IST, August 10, 2013.

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Address of the bookmark: https://astrobiomike.github.io/

https://www.mbl.edu/research/research-organisms/rotifer
https://gribblebiolab.org/

https://evirusbioinfc.notion.site/18e21bc49827484b8a2f84463cb40b8d?v=92e7eb6703be4720abf17a901bc9a947

Address of the bookmark: https://evirusbioinfc.notion.site/18e21bc49827484b8a2f84463cb40b8d?v=92e7eb6703be4720abf17a901bc9a947

More @ http://www.au-kbc.org/

What is Bacterial Comparative Genomics?

Comparative genomics involves the systematic comparison of genomes across different bacterial species or strains. This approach allows scientists to:

• Identify conserved and unique genes.

• Explore genetic determinants of pathogenicity.

• Understand bacterial evolution and phylogenetics.

• Investigate horizontal gene transfer and its role in antibiotic resistance.

Bioinformatics is central to these analyses, enabling the processing and interpretation of large-scale genomic data.

Key Steps in Bacterial Comparative Genomics

1. Genome Sequencing and Assembly: The process begins with obtaining high-quality bacterial genome sequences. Advances in next-generation sequencing (NGS) technologies have made it faster and more affordable to sequence bacterial genomes. Tools such as SPAdes and Velvet are commonly used for genome assembly.

2. Genome Annotation: Annotating a genome involves identifying genes, regulatory elements, and other genomic features. Automated tools like Prokka and RAST provide functional annotations, allowing researchers to predict the roles of genes and proteins.

3. Genome Alignment: Aligning genomes is crucial for identifying conserved regions, single-nucleotide polymorphisms (SNPs), and structural variations. Tools like Mauve and progressiveMauve are commonly employed for whole-genome alignments.

4. Comparative Analyses:

   • Core and Pan-genome Analysis: The core genome consists of genes shared across all strains of a species, while the pan-genome includes all genes found in any strain. Software like Roary and BPGA can perform core and pan-genome analyses.

   • Phylogenetic Analysis: Comparative genomics often involves reconstructing evolutionary relationships. Tools such as MEGA and IQ-TREE facilitate phylogenetic tree construction based on genomic data.

   • Functional Enrichment Analysis: To understand the biological significance of unique or shared genes, functional enrichment analysis using databases like GO (Gene Ontology) and KEGG is essential.

Here are some additional bioinformatics tools that can aid bacterial comparative genomics:

• OrthoFinder: For accurate ortholog identification across multiple genomes.

• PanOCT: Specifically designed for pan-genome clustering and annotation.

• FASTANI: A tool for calculating Average Nucleotide Identity (ANI) for microbial genome comparisons.

• CIRCOS: For visually comparing genomic data through circular genome plots.

• Galaxy Platform: A user-friendly web-based platform offering numerous genomic analysis tools.

• BLAST: Essential for sequence alignment and similarity searches.

• PhyloSift: Focused on phylogenetic analysis of microbial genomes using marker genes.

These tools, in combination with the methods discussed, provide a robust framework for conducting comprehensive comparative genomic studies.

Applications of Bacterial Comparative Genomics

1. Understanding Pathogenicity: Comparative genomics helps identify virulence factors that distinguish pathogenic strains from non-pathogenic relatives. For instance, comparing genomes of Escherichia coli strains has revealed key genetic determinants of pathogenicity in enterohemorrhagic strains.

2. Antibiotic Resistance Research: The spread of antibiotic resistance genes through horizontal gene transfer is a major global concern. Comparative analyses can trace the origins and dissemination of resistance genes, aiding in the development of countermeasures.

3. Microbial Ecology and Evolution: By studying genomic variations, researchers can understand how bacteria adapt to different environments. This is particularly relevant for extremophiles and symbiotic bacteria.

4. Vaccine Development: Identifying conserved antigens across pathogenic strains is critical for vaccine design. Comparative genomics has been instrumental in developing vaccines against pathogens like Neisseria meningitidis.

5. Biotechnology Applications: Comparative studies can uncover unique metabolic pathways in bacteria, paving the way for applications in bioremediation, synthetic biology, and industrial microbiology.

Challenges in Bacterial Comparative Genomics

While the field has made significant strides, several challenges remain:

• Data Overload: The rapid growth of sequencing data requires robust computational infrastructure and efficient algorithms.

• Genome Plasticity: High rates of horizontal gene transfer and genome rearrangements in bacteria complicate comparative analyses.

• Annotation Accuracy: Automated annotation tools are not infallible, and manual curation is often needed for high-confidence results.

• Interpreting Non-Coding Regions: Understanding the functional significance of non-coding genomic regions remains a challenge.

Future Directions

The integration of bacterial comparative genomics with other ‘omics’ approaches—such as transcriptomics, proteomics, and metabolomics—promises a more comprehensive understanding of bacterial biology. Additionally, advancements in machine learning and artificial intelligence are likely to further enhance bioinformatics analyses, enabling the prediction of complex phenotypes from genomic data.

Conclusion

Bacterial comparative genomics, driven by bioinformatics, continues to unravel the complexities of bacterial life. From combating antibiotic resistance to uncovering the secrets of microbial evolution, this interdisciplinary field holds immense potential for addressing pressing challenges in microbiology and beyond. As technology advances, so too will our ability to harness the power of comparative genomics for scientific and societal benefit.