To install the stable version: pip3 install --user tinycov

To install the development version:

git clone https://github.com/cmdoret/tinycov.git
cd tinycov
pip install .

Address of the bookmark: https://github.com/cmdoret/tinycov

https://wlcb.oit.uci.edu/modules/index.html

Address of the bookmark: https://wlcb.oit.uci.edu/NG-Circos

Recently useR! conference have been organized University of Castilla-La Mancha, Albacete, Spain.

http://www.edii.uclm.es/~useR-2013//

First cover a full workflow from preparation, reads counting, data preprocessing, gene set test, to pathway visualization in about 40 lines of codes. The same workflow can be used for GO analysis or other types of gene set analysis too. We also describe joint workflows, i.e. to do gene-level analysis using one of the major RNA-Seq analysis tools, DEseq/DEseq2, edgeR, limma and Cufflinks, and feed the results into GAGE/Pahview for pathway analysis or visualization. All these workflows are implemented in R/Bioconductor.

The work ows cover the most common situations and issues for RNA-Seq data pathway analysis. Issues like data quality assessment are relevant for data analysis in general yet out the scope of this tutorial. Although we focus on RNA-Seq data here, but pathway analysis work ow remains similar for microarray, particularly step 3-4 would be the same. Please check gage and pathview vigenttes for details.

Note: You need to update to current release versions of R(3.0.2)/ Bioconductor(2.13) to use all the features. 

Reference: 

Please check it out:
http://bioconductor.org/packages/release/bioc/html/gage.html
http://bioconductor.org/packages/release/bioc/vignettes/gage/inst/doc/RNA-seqWorkflow.pdf

Address of the bookmark: http://www.biostat.jhsph.edu/~iruczins/teaching/

https://flowingdata.com/

Address of the bookmark: https://flowingdata.com/

These examples are taken from the googleVis demo. You can execute the demo via

library(googleVis)
demo(googleVis)

For more details about the charts and further examples see the helpfiles of the individual googleVis function and review the Google Charts API documentation and Terms of Service.

Address of the bookmark: https://cran.r-project.org/web/packages/googleVis/vignettes/googleVis_examples.html

Since you can create Power BI custom visuals using R, that means you'll be able to design a custom R-based chart, and make it available to people using Excel — even if they don't know how to use R themselves. There also many pre-defined custom visuals available, including some familiar R charts like decision trees, calendar heatmaps, and hexbin scatterplots.

For more details on how you'll be able to use custom R visuals in Excel, check out the blog post linked below.

PowerBI Blog: Excel announces new data visualization capabilities with Power BI custom visuals

Most people who have a balanced translocation have the right amount of chromosome material but it has been rearranged in some way. This may happen if two chromosomes swap pieces (a reciprocal translocation). In other cases two whole chromosomes may become stuck together (a Robertsonian translocation). This page describes what happens when someone has a reciprocal translocation.

Reciprocal chromosomal translocations occur following double-strand breaks (DSBs) in DNA when a section of one chromosome is exchanged with that of another, non-homologous chromosome. These exchanges may produce a dysfunctional fusion gene that disrupts cell growth and survival pathways, such as the translocations seen in leukemia and childhood sarcomas.

Chromosomal translocations have been well studied in cancer cell lines which are associated with two types of cancer, acute myeloid leukemia and Ewing's sarcoma, but determining how they contribute to cancer development is complicated by additional mutations and altered gene expression profiles in these cultured cells. Now, Juan Carlos Ramirez, head of the Viral Vector Facility at the Fundacion Centro Nacional de Investigaciones Cardiovasculares (CNIC) and his colleagues Raul Torres at CNIC and Sandra Rodriguez-Peralez at the Spanish National Cancer Center (CNIO) in Madrid, Spain have used a new genome editing tool, CRISPR-Cas9, to induce chromosomal translocations for the first time in a human cell line and in primary cells. The study's authors conclude by stating that the use of this technology will allow for the clarification of how and why chromosomal translocation occurs, which without doubt will allow new anti-cancer therapeutic strategies to be tackled.

Using RNA-Guided Endonuclease (RGEN) technology or CRISPR/Cas9 genome engineering technology, CNIO and CNIC researchers have shown that it is possible to obtain such chromosomal translocations. The CRISPR-Cas9 system is extremely simple to introduce a cut at the desired locus, easier to design, and cheaper than many other systems. Using the CRISPR-Cas9 system, Ramirez and his colleagues reproduced the translocations observed in Ewing’s Sarcoma (ES) and Acute Myeloid Leukemia (AML) patient cell lines in HEK293 cells and also generated the ES translocation in human mesenchymal stem cells and the AML translocation in umbilical cord blood cells.

By focusing on chromosomal translocation without the confounding characteristics of established cell lines, these new cells lines should help answer the fundamental question of what causes a cell to become cancerous. Ramirez and his team now look forward to modeling other chromosome translocations in a variety of cell types.

Reference:

http://en.wikipedia.org/wiki/Chromosomal_translocation

http://www.nature.com/ncomms/2014/140603/ncomms4964/abs/ncomms4964.html

1. greatly improve resolution of the visualization fron n to √nn;
2. easy to visualize clusters because generally data points in the axis will also be close in the 2D space.

This package aims to provide an easy and flexible way to visualize data through Hilbert curve. The implementation and example figures are based on following sources:

• http://mkweb.bcgsc.ca/hilbert/
• http://corte.si/posts/code/hilbert/portrait/index.html
• http://bioconductor.org/packages/devel/bioc/html/HilbertVis.html

Address of the bookmark: https://bioconductor.org/packages/devel/bioc/vignettes/HilbertCurve/inst/doc/HilbertCurve.html