More @ http://www.guptalab.org/

Like other indel callers, Scalpel works by performing de novo assembly of regions of interest, so that misalignment to the reference genome cannot obscure the presence of an insertion or deletion. Scalpel's innovation is to repeatedly check its assembly before comparing to the reference genome, to account for simple sequence repeats that are a regular source of error in indel calling. When Scalpel assembles an exon, it collects reads that map to that exon (including partial matches), splits them into k-mers, and creates a de Bruijn graph to span the exon; however, if it detects repeats in the map, it iteratively increases the size of the k-mers by one base until the repeats are eliminated. This ensures that the final assembly of the exon is highly accurate while minimizing compute time.

The Cold Spring Harbor team's validation of Scalpel, published over the weekend in Nature Methods, compares Scalpel's performance on a live whole exome against HaplotypeCaller and SOAPindel. The donor is an individual with serious neurological disorders, which may be linked to a high incidence of indels. One thousand indels from this individual's exome, called by one or more of the informatics pipelines, were selected for focused resequencing. This resequencing revealed a 77% true positive rate for Scalpel calls, dramatically better than the rates for either of the competing tools; Scalpel performed especially well with indels longer than five base pairs, a traditional weak point for indel callers.

Finally, the authors demonstrate Scalpel's use on a large set of genetic data from nearly 600 families who donated samples to the Simons Simplex Collection, a project of the Simons Foundation Autism Research Initiative. Scalpel found a very high enrichment for indels in children affected by autism, compared with their unaffected siblings, a pattern that persisted even after excluding common variants.

The main purpose of OSDDLinux is to provide an in silico platform for computer-aided drug design. This is a collection and compilation of large number of software and web services which will be directly or indirectly useful for researches working in the field of drug design/discovery. Overall objective of OSDDlinux is to promote open source in drug discovery, crowdsourcing and network based collobrations. Following are major features of OSDDlinux ... 

Find more @ http://osddlinux.osdd.net/index.php

Algorithms scripts @ https://github.com/jschendel/bioinformatics-algorithms-coursera

Address of the bookmark: https://github.com/jorvis/biocode

With emphasis on research, the institute has large research centers with over 100 PhD & 250 MS by Research students working on wide ranging topics: Computer Science, Information Security, Software engineering, AI & Robotics, VLSI and Embedded Systems, Digital Signal Processing, Computer Aided Structural Engineering (CASE), Computational Natural Sciences, Bio informatics, Computational Linguistics, IT and social development, Exact Humanities, etc., IIIT-H provides a flexible environment which active industry collaborations for conducting research.

The institute is seeking Faculty Members at all levels in the following areas:
Computational & Theoretical Chemistry/Physics/Biology(CNS)
Bioinformatics(BI)
Computational Linguistics
Mathematics & Statistics
IT for Agriculture

We also encourage applications from other areas of national importance (such as, agriculture, health, e-governance, education, policy studies, arts, etc)wherein there is a strong need to come up with IT/ECE enabled solutions.

Academic & Research Programs at the institute:
BTech, MS by Research, PostBSc Dual Degree, MTech, MPhil and PhD.

Eligibility
Candidates should normally have a PhD and an outstanding research record and commitment to teaching. The position and level offered would be based on relevant experience in research and teaching. Candidates without a PhD but demonstrated research record can also be considered in special cases. The compensation (including HRA, LTA, Medical Reimbursement, Research Allowance, etc) is designed to reward the best talent and will not be a limiting factor for the right person.

International Institute of Information Technology
Gachibowli, Hyderabad - 500 032.
Fax:+91-40-6653 1413; e-mail: facultysearch@iiit.ac.in

Lectureship Program : Outstanding candidates with B.Tech/MCA or M.Tech and desirous of joining faculty can apply for lectureship position and enroll for PhD at the same time. Applications for this program can be sent to facultysearch@iiit.ac.in .

More at http://oldwww.iiit.ac.in/content/faculty-openings/

WALK IN INTERVIEW

A walk-in Interview for the following position tenable at the Bioinformatics Infrastructure Facility (BIF), Department of Biotechnology, Alagappa University will be held at the Department of Biotechnology, Alagappa University, Karaikudi 630 003 on 15.05.2014 (Thursday) at 01:00 PM. This national facility is funded by the Department of Biotechnology, Ministry of Science and Technology, Government of India, New Delhi. The main objectives of the Centre involve teaching and research activities in bioinformatics/biotechnology.

RA (One Post):

Salary : Rs. 11000 p.m. plus admissible HRA

Qualification: M.Sc., in Bioinformatics/Biotechnology/Biophysics/Biochemistry/ Life Sciences

Interested candidates are encouraged to send their Curriculum Vitae by email to “sk_pandian@rediffmail.com” in advance. On the day of interview, the candidates must produce original certificates in proof of their educational qualification and experience and a recommendation letter from the Head of the Department/Institution where last studied/worked. Candidates who have already passed the required Degree alone are eligible to appear for interview. No TA&DA will be given for attending the interview.

Advertisement: http://www.alagappabiotech.org/Walk%20in%20interview.pdf

More at http://bigd.big.ac.cn/databasecommons/stat

Pay scale: Pay Band of Rs. 37400-67000 with AGP of Rs. 9000.

i. Educational Qualification: Good academic record with a Ph.D. Degree in the concerned/allied/relevant disciplines.

ii. A Master's Degree with at least 55% marks (or an equivalent grade in a point scale wherever grading system is followed).

iii. A minimum of eight years of experience of teaching and/or research in an academic/research position equivalent to that of Assistant Professor in a University, College or Accredited Research Institution/industry excluding the period of Ph.D. research with evidence of published work and a minimum of 5 publications as books and/or research/policy papers.

iv. Contribution to educational innovation, design of new curricula and courses, and technology - mediated teaching learning process with evidence of having guided doctoral candidates and research students.

v. A minimum score as stipulated in the Academic Performance Indicator (API) based Performance Based Appraisal System (PBAS), set out in UGC Regulation.

Download application form from website: http://www.allduniv.ac.in/

Send your application to the Registrar, University of Allahabad, Allahabad-211002 (U.P.) on or before 30th April 2014

For more details: http://www.allduniv.ac.in/images/adv/backlog/advt-details.pdf OR http://www.allduniv.ac.in/images/news/extension-notice.pdf

Last Apply Date: 30 May 2014

Here are the list of all the research and development funding agencies in India.