BOL: Related items

Sundar Lab

Mon, 23 Sep 2013 11:10:16 -0500

Area of interest

Understanding DNA-protein interactions, genome engineering
Computational Genomics and Bioinformatics
Secondary metabolite biosynthesis, metabolic engineering

Ongoing Projects:

"Betraying the parasite’s redox system: Studies on spermidine synthase of Leishmania donovani "

"Towards modifying nature's DNA-recognition system"

"Yield enhancement strategies for production of therapeutic compounds by cell and tissue cultures of Tinospora cordifolia (willd.) Miers ex Hook. F. & Thoms"

"Program support for Computational Genomics"

More at http://web.iitd.ac.in/~sundar/

PhD positions on integrative omics and phylogenomics

Wed, 19 Oct 2022 05:11:11 -0500

Would you like to participate in an exciting interdisciplinary research project to discover the hidden chemistry of plants and its evolution using computational omics approaches? Do you enjoy collaboration and teamwork while being at the cutting edge of scientific progress? We are looking for two PhD candidates with complementary skills to pioneer new technologies to analyze, explore and leverage the diversity of plant chemistry hidden in plant genomes.

Plants represent an untapped resource of natural bioactive compounds that significantly contribute to plant resilience to pathogens, herbivores, and abiotic stresses, and may be applied for medicine or crop protection. In this project, you will design and/or apply innovative omics integration strategies for genomics, transcriptomics, and metabolomics data, to discover plant specialized metabolite biosynthetic pathways and study their evolution. You will work together with the other PhD candidate in this project, which will entail a combination of algorithm development, greenhouse experiments, integrative omics analysis, and evolutionary genomics. Extensive local and international collaboration is foreseen, including possibilities for a foreign research visit as part of your PhD project.

The research is embedded within the chairs of Bioinformatics and Biosystematics. The projects will be (co-)supervised by Dr. Marnix Medema, Dr. Justin van der Hooft, Dr. Klaas Bouwmeester and Prof. Dr. Eric Schranz.

We ask

We are looking for two enthusiastic and complementary team players with all or a subset of the following skills:

a solid academic record (MSc) in bioinformatics, biology, or biotechnology
experience in computational omics analysis and proficiency in programming (in, e.g., Python)
at least basic to intermediate statistical and mathematical skills
demonstrable experience in working with next-generation sequencing data or with greenhouse experiments with plants
affinity with plant science, metabolism and/or biosynthetic pathways
you meet all the entry requirements of the WUR PhD programme.
More information

For more information about this position, please contact Marnix Medema, Associate Professor Bioinformatics, by email (marnix.medema@wur.nl).
For more information about the procedure, please contact vacaturemeldingen.psg@wur.nl.

Sandelin group

Mon, 30 Sep 2013 19:12:58 -0500

Sandelin group have a deep interest in most biology, but focus on gene regulation and the many areas that are connected with this, including transcriptomics, epigenetics and technological and informatics aspects.

The group is both computational and experimental.

We ask biological questions to large datasets made using novel genomics techniques, with the help of computers. One of the strengths in the group are the many connections to high-profile experimental laboratories which supply data to be analyzed.

Lab webpage @ http://people.binf.ku.dk/albin/Sandelin_group_at_the_Bioinformatic_Centre/The_Sandelin_group.html

Bioinformatics Chat !

BioStar — Mon, 13 Mar 2023 13:20:27 -0500

The bioinformatics chat is a podcast about computational biology, bioinformatics, and next generation sequencing.

The bioinformatics chat is produced by Roman Cheplyaka and hosted by Roman and Jacob Schreiber.

Address of the bookmark: https://bioinformatics.chat/

National Training on Bioinformatics Computational Tools for Microbial Research Nov 19 to 30, 2013

Fri, 27 Sep 2013 10:49:34 -0500

Agricultural research in modern scientific arena is being represented by proper integration among various research fields of biological, chemical and physical sciences, because this field encompasses many more complexities of biology in nature. In the era of fast accumulating biological data coming out from the research on many crop plants, live stocks and microbes and the impact of changing climate, habitat and other interrelations on these biological entities, bioinformatics has come forward across the globe to solve the problems of analysis, prediction, storage, management, pattern recognition, submission, retrieval and storage of the data to find out a fruitful outcome. This area is becoming increasingly important in the context of systems biology approach where a holistic approach is required to understand the biology and chemistry of the biological entities and their behavior during environmental interactions to resolve the harmful impact of biotic or abiotic causes on crop plants, animals, fishes, livestock sector, beneficial insects as well as microbes. The National Training program on ‘Computational Tools for Microbial Research” is an initiative for the capacity building of NARS scientists/researchers in this most emerging area and fast developing area of i.e. agricultural bioinformatics.

Contact The Director, National Bureau of Agriculturally Important Microorganisms, Kusmaur, Maunath Bhanjan-275101 (U.P.); Phone: 0547-2530080, Fax: 0547-2530358, e mail: nbaimicar@gmail.com; website: www.nbaim.org.in OR

Dr. Dhananjaya P. Singh, Senior Scientist & CCPI, NABG project, NBAIM, Maunath Bhanjan, 275101; Mob.- 09415291703; e mail - dpsfarm@rediffmail.com, nabg.nbaim@gmail.com

More at http://www.nbaim.org.in/Announc.aspx?cd=36

Important Bioinformatics Tools !

BioStar — Tue, 30 Jul 2024 05:03:29 -0500

1. Ktrim: An extra-fast, accurate adapter trimmer for sequencing data. It processes FASTQ files from multiple lanes with minimal mismatching and over-trimming of adapters.

2. BWA MEM: A reliable alignment tool (particularly for mapping ALT contigs and HLA genes, which are not fully addressed in BWA-MEM2).

3. Sambamba markdup: Quickly marks or removes duplicate reads using Picard's criteria.

4. ichorCNA: Estimates the tumor DNA fraction in cell-free DNA from ultra-low-pass whole genome sequencing (0.1x coverage) based on copy number alterations (CNA).

5. Fragle: A deep learning method for quantifying ctDNA levels from cell-free DNA fragmentomic profiles. It detects TF as low as ~1% ctDNA and works with targeted genomic panel sequencing data.

6. AlfredQC: A quality control tool for high-throughput sequencing data. It assesses metrics like read quality scores, GC content, and duplication rates, visualized through detailed plots and summary statistics.

7. Mosdepth: A fast tool for calculating sequencing coverage depth, offering a quicker alternative to samtools/sambamba depth by processing BAM and CRAM files.

8. Bedtools: A versatile toolkit for genomics, enabling operations like intersect, merge, count, and shuffle on genomic intervals across formats such as BAM, BED, GFF/GTF, and VCF.

9. Datamash: A command-line tool for basic numeric, textual, and statistical operations on input data streams. It supports operations such as grouping, sorting, transposing, and performing arithmetic calculations on tabular data.

10. gwf.app: A pragmatic alternative to Snakemake. Developed at Aarhus University, this flexible, generic workflow tool builds and runs large scientific workflows.

EMBL Postdoc position in Bacterial Gene Gain Loss

Thu, 20 Aug 2015 14:09:21 -0500

A post-doctoral fellowship is available in the research groups of Nick Goldman (EBI) and John Welch (Genetics Department, Cambridge University) under the EMBL-EBI / Cambridge Computational Biomedical Postdoctoral Fellowship scheme.

The project is on bacterial gene gain and loss and emerging pathogenicity, and is described in full here: https://www.ebi.ac.uk/research/postdocs/ebpods/projects/goldman-welch-2015 . The EMBL-EBI / Cambridge Computational Biomedical Postdoctoral (“EBPOD”)

The closing date for applications is 3 September 2015. Nick Goldman EMBL-European Bioinformatics Institute Nick Goldman

More at https://www.ebi.ac.uk/research/postdocs/ebpods/projects/goldman-welch-2015

Bioinformatics Lecture Notes

LEGE — Tue, 01 Oct 2024 03:45:26 -0500

Study Resources for

ECM3413 - Bioinformatics

Contents

General Information

Lecture Slides

Past Exam Paper

Continuous Assessments

Mike Ritchie Lab

Wed, 02 Oct 2013 15:25:45 -0500

Mike Ritchie Lab primary research focus is the detection of susceptibility genes for common diseases such as cancer, diabetes, hypertension, and cardiovascular disease, among others. The approaches will involve the development and application of new statistical methods with a focus on the detection of gene-gene interactions associated with human disease.

Gene expression and protein expression patterns between normal and non-normal tissues is a growing area of research that may lead to the identification of candidate genes for understanding the etiology of common, complex diseases.

Lab homepage @ http://ritchielab.psu.edu/ritchielab/

Professor/Senior Lecturer of Comparative Genomics @ University of Glasgow

Fri, 06 Dec 2024 05:16:09 -0600

University of Glasgow
College of Medical, Veterinary and Life Sciences
School of Biodiversity, One Health and Veterinary Medicine

Professor/Senior Lecturer of Comparative Genomics
Vacancy Ref: 153610
Salary: Professor, Grade 10 will be within the Professorial range and
subject to negotiation
Senior Lecturer, Grade 9, 57,696 - 64,914 per annum

The School of Biodiversity, One Health and Veterinary Medicine has an
exciting opportunity to appoint a Professor/Senior Lecturer in Comparative
Genomics. You will make a substantial and positive contribution to the
strategic direction of the School/College through leading and contributing
to research of international standard, high quality teaching at both
undergraduate and postgraduate level, securing research funding, and
providing academic leadership and management within the School/College.

Applications are invited from candidates of international standing with
an appropriate record of academic achievement in comparative genomics
and associated omics technologies. We are looking for a candidate who
will complement our existing strengths in clinical veterinary medicine,
evolutionary biology, and animal physiology, with a demonstrable interest
in using domestic mammals among their study systems. We are particularly
interested in applications from candidates with a track record of
studying health related traits and their underlying genomic basis in
companion animals. Traits of specific interest include those related
to metabolism, ageing, and disease (e.g. cancer, autoimmune diseases,
neuromuscular disorders).

The School of Biodiversity, One Health and Veterinary Medicine is home to
researchers studying organismal biology and animal health across a diverse
range of systems, approaches and disciplines with existing strengths
in infectious disease, physiology, ageing, veterinary epidemiology, and
evolution among others. You will be based on the University of Glasgow's
Garscube campus, where the majority of veterinary teaching and research
infrastructure is located. This includes the Small Animal Hospital (a
recent 15M investment) and our Veterinary Diagnostic Services, offering
excellent opportunities for collaborative research at the clinical and
translational interface, especially with respect to companion animals.

We welcome applications from candidates with a Scottish Credit and
Qualification Framework level 12 (PhD) in animal biology, genomics and
health or related discipline with an extensive and established reputation
in research and significant teaching experience within the subject area.

This post is full time and open ended.

Visit our website for further information on The University of
Glasgow's, School of Biodiversity, One Health & Veterinary Medicine,
https://www.gla.ac.uk/schools/bohvm/

Informal Enquiries should be directed to Professor Roman Biek,
Roman.Biek@glasgow.ac.uk

Apply online at:
https://my.corehr.com/pls/uogrecruit/erq_jobspec_version_4.jobspec?p_id=153610

	This module runs in Semester 2.
	It is taught by Dr Ed Keedwell (Module Coordinator)
	Module Descriptor: ECM3413
	Lecture Times: Tuesday 5pm, 171\| Thursday, 171
	Workshop Times: Wednesday 11am Blue Room (Weeks 29,33 &40)
	Assessment: 2 CAs each worth 15% \| 1 Examination worth 70%

	PPT\|PDF\| Lecture 1 - Introduction to Bioinformatics (& Biology)
	PPT\|PDF\| Lecture 2 - Genome Sequences: from fragments to sequences
	PPT\|PDF\| Lecture 3 - Sequence Alignment 1
	PPT\|PDF\| Lecture 4 - Global Pairwise Sequence Alignment
	PPT\|PDF\| Lecture 5 - Local Pairwise Sequence Alignment (Smith-Waterman & BLAST)
	DOC\| Workshop 1 - Using BLAST and other Bioinformatics Databases
	PPT\|PDF\| Lecture 6 - Multiple Sequence Alignment
	PPT\|PDF\| Lecture 7 - BLAST (in more detail) & FASTA
	PPT\|PDF\| Lecture 8 - Sequence Alignment Conclusion & Other Sequence Analyses
	PPT\|PDF\| Lecture 9 - Markov Chains and Intro to Hidden Markov Models
	PPT\|PDF\| Lecture 10 - Hidden Markov Models
	PPT\|PDF\| Lecture 11 - Classification in Bioinformatics
	DOC\|Workshop 2 - Using See5
	Workshop Data - Part 1 - adult.names \| adult.data \| adult.test, Part 3 - wdbc.names\| wdbc.data
	PPT\|PDF\| Lecture 12 - Gene Expression Data
	PPT\|PDF\| Lecture 13 - Decision Trees and Gene Expression Classification
	PPT\|PDF\| Lecture 14 - Other Methods for Gene Expression Classification
	PPT\|PDF\| Lecture 15 - Gene Regulation
	PPT\|PDF\| Lecture 16 - Neural Networks in Gene Expression Analysis
	PPT\|PDF\| Lecture 17 - Genome Analysis
	PPT\|PDF\| Lecture 18 - Conclusion/Revision Lecture

	PDF\| CA1 - Manual Sequence Alignment
	PDF\|Promoter.names\|Promoter.data\|ML.names\|ML.data\| CA2 - Data Mining in Bioinformatics

	Lesk, A.M., (2002) Introduction to Bioinformatics, Oxford University Press
	Higgs, P.G., (2005) Bioinformatics and Molecular Evolution, Blackwell Publishing

	Baldi, P., Brunak, S., (2001) Bioinformatics: The Machine Learning Approach, MIT Press
	Keedwell, E., Narayanan, A., (2005) Intelligent Bioinformatics: The Application of Artificial Intelligence Techniques to Bioinformatics Problems, Wiley