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<channel>
	<title><![CDATA[BOL: Related items]]></title>
	<link>https://bioinformaticsonline.com/related/27333?offset=210</link>
	<atom:link href="https://bioinformaticsonline.com/related/27333?offset=210" rel="self" type="application/rss+xml" />
	<description><![CDATA[]]></description>
	
	<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/41459/jcvipython-utility-libraries-on-genome-assembly-annotation-and-comparative-genomics</guid>
	<pubDate>Tue, 17 Mar 2020 06:19:06 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/41459/jcvipython-utility-libraries-on-genome-assembly-annotation-and-comparative-genomics</link>
	<title><![CDATA[JCVI:Python utility libraries on genome assembly, annotation and comparative genomics]]></title>
	<description><![CDATA[<p>Collection of Python libraries to parse bioinformatics files, or perform computation related to assembly, annotation, and comparative genomics.</p>
<p>https://github.com/tanghaibao/jcvi</p>
<p>More at https://github.com/tanghaibao/jcvi/wiki</p><p>Address of the bookmark: <a href="https://github.com/tanghaibao/jcvi" rel="nofollow">https://github.com/tanghaibao/jcvi</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/14050/assistant-professor-in-bioinformatics-at-indian-institute-of-technology-delhi</guid>
  <pubDate>Fri, 15 Aug 2014 06:16:06 -0500</pubDate>
  <link></link>
  <title><![CDATA[Assistant Professor 	in Bioinformatics at Indian Institute of Technology Delhi]]></title>
  <description><![CDATA[
<p>Indian Institute of Technology Delhi Hauz Khas ,New Delhi – 110016</p>

<p>ROLLING ADVERTISEMENT NO. 01/2014(E-1)<br />ADVERTISEMENT FOR THE POSITIONS OF ASSISTANT PROFESSOR CANDIDATES CAN APPLY ANY TIME DURING THE YEAR.</p>

<p>IIT Delhi invites applications from qualified Indian Nationals, Persons of Indian Origin (PIOs) and Overseas Citizens of India (OCIs) for the following positions in the various Departments/Centres/Schools (in the fields<br />mentioned alongwith them):<br />Post Pay Band Assistant Professor and Assistant Professor (on Contract) Rs.15600-39100 (PB-3) (Minimum pay of Rs.30000/-)+ AGP Rs.8000/-</p>

<p>The following norms will be followed for fixing the basic pay + AGP for Assistant Professors appointed on<br />contract with Ph.D but experience of 3 years or less:-<br />Type Qualification &amp; Experience on the date of joining<br />Assistant Professor (Contract) PB3 (Rs. 15,600-39,100).</p>

<p>MINIMUM QUALIFICATIONS AND EXPERIENCE:<br />Ph.D. with First class at the preceding degree or equivalent in the appropriate branch with very good academic record throughout. A minimum of three years industrial/research/teaching experience, excluding however, the experience gained while Pursuing Ph. D. The candidates should preferably be below<br />35 years of age for male and 38 years for female ( to be relaxed by 5 years in case of persons with physical disability, SC/ST and 3 years in case of OBC-NCL).</p>

<p>Qualified persons include:<br />(a) Indian Nationals,<br />(b) Foreign Nationals who are “Persons of Indian Origin” (PIO) or Overseas<br />Citizens of India (OCI), in whose case, if selected, permission will be sought from Govt. of India<br />before he/she can join IIT Delhi, or<br />(c) Other Foreign Nationals, in whose case, if selected, appointment will be on a contract basis for up to 5 (five) years subject to permission from the Govt. of India before he/she can join IIT Delhi.<br />(d) Institute specifically encourages applicants from SC/ST/OBC category as well as persons<br />with disability to apply for these positions. </p>

<p>AMAR NATH &amp; SHASHI KHOSLA SCHOOL OF INFORMATION TECHNOLOGY:<br />Computational Neuroscience, Medical Applications of Information Technologies, Computational &amp; Systems Biology, Machine to Machine (M2M) Technologies, Embedded Systems &amp; Sensors, Computer Security.<br />KUSUMA SCHOOL OF BIOLOGICAL SCIENCES:<br />In-silico Biology Applications, Systems Biology, Infection Biology, Neurodegeneration. </p>

<p>More at http://www.iitd.ac.in/sites/default/files/jobs/faculty/spl-areas-rolling-advt.pdf</p>

<p>http://www.iitd.ac.in/content/faculty-positions</p>
]]></description>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/17504/postdoc-scientist-bioinformatics-at-ccmb</guid>
  <pubDate>Fri, 26 Sep 2014 19:58:41 -0500</pubDate>
  <link></link>
  <title><![CDATA[PostDoc Scientist Bioinformatics at CCMB]]></title>
  <description><![CDATA[
<p>1. Project Assistant/Junior Research Fellow/ Project Fellow [PA_JRF_PF]</p>

<p>a) M.Sc/or equivalent in biological sciences/related areas [Position Code: PA_JRF_PF_a]<br />b) B.E/B.Tech/ M.Sc in biotechnology/bioinformatics/computer science/Chemistry/Physics or MCA [Position Code: PA_JRF_PF_b]<br />c) M.Sc/or equivalent in wildlife sciences/ecology/environmental sciences or MBBS/BVSc/MVSc. [Position Code: PA_JRF_PF_c]</p>

<p>(Candidates with result awaited are NOT eligible to apply)</p>

<p>Upper Age limit 28years</p>

<p>Rs.12000 / Rs.16000 (as sanctioned by the funding agency)</p>

<p>2. Post Doctoral Fellow/Research Associate in multiple research areas [PDF_RA]</p>

<p>Ph.D. (submitted/awarded) in any branch of biological Sciences. Candidates with Ph.D. in other sciences are also encouraged to apply.</p>

<p>Experience in molecular biology, biochemistry, structural biology, cell biology, infectious disease, conservation genetics, veterinary science, reproductive biology, and molecular diagnostics is desired but not mandatory.</p>

<p>[Position Code: PDF_RA]</p>

<p>UpperAge limit 35years</p>

<p>Rs. 22000- 26000 (as sanctioned by the funding agency)</p>

<p>3. Post Doctoral Scientist Fellow [PDSF]</p>

<p>Ph.D in any of the following areas: bioinformatics, next generation sequencing, high throughput data analysis, proteomics, bio-statistics, computer science, information technology, computer hardware and networking/clustering, parallel processing.<br />[Position Code: PDSF]</p>

<p>Upper Age limit 40 years</p>

<p>Rs. 40000 consolidated (as sanctioned by the funding agency)</p>

<p>Download Application: Last date for apply online: 09th Oct 2014</p>

<p>Advertisement: www.ccmb.res.in//index.php?view=notifications&amp;mid=0&amp;id=71&amp;nid=38</p>

<p>Apply online http://www.ccmb.res.in/positions/temp_notif/online_form.html</p>

<p>More at http://www.ccmb.res.in//index.php?view=notifications&amp;mid=0&amp;id=71&amp;nid=38</p>
]]></description>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/38169/amstat-display-statistics-of-large-sequence-files-from-next-generation-sequencing-projects</guid>
	<pubDate>Fri, 09 Nov 2018 13:34:56 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/38169/amstat-display-statistics-of-large-sequence-files-from-next-generation-sequencing-projects</link>
	<title><![CDATA[AMStat: display statistics of large sequence files from next generation sequencing projects]]></title>
	<description><![CDATA[<p><span>SAMStat is an efficient C program to quickly display statistics of large sequence files from next generation sequencing projects. When applied to&nbsp;</span><a href="http://samstat.sourceforge.net/#about">SAM/BAM</a><span>&nbsp;files all statistics are reported for unmapped, poorly and accurately mapped reads separately. This allows for identification of a variety of problems, such as remaining linker and adaptor sequences, causing poor mapping. Apart from this SAMStat can be used to verify individual processing steps in large analysis pipelines.</span></p><p>Address of the bookmark: <a href="http://samstat.sourceforge.net/" rel="nofollow">http://samstat.sourceforge.net/</a></p>]]></description>
	<dc:creator>Neel</dc:creator>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/17873/postdoc-position-in-protein-annotation-and-machine-learning-paris-france</guid>
  <pubDate>Sat, 04 Oct 2014 08:10:45 -0500</pubDate>
  <link></link>
  <title><![CDATA[Postdoc position in protein annotation and machine learning - Paris, France]]></title>
  <description><![CDATA[
<p>We are interested in finding an excellent postdoc with interests in protein functional annotation, machine learning and computer grids. The position is open for 3.5 years at the Université Pierre et Marie Curie, in the heart of Paris.</p>

<p>Research topic: Protein function annotation, multiple probabilistic models, domain architecture, machine learning, combinatorial optimization, computer grid.</p>

<p>This project is run on the Laboratoire de Biologie Computationnelle et Quantitative UMR7238 CNRS-UPMC – Analytical Genomics team, headed by A.Carbone. It is co-advised with Pierre-Henri Wuillemin, Laboratoire d’Informatique de Paris 6 – Equipe DECISION.</p>

<p>The postdoc will be payed under a contract of Ingénieur de Recherche lasting 3.5 years and it is available from September 1st, 2014.</p>

<p>Group Web Page: http://www.lcqb.upmc.fr/AnalGenom/home.html</p>

<p>Ref. E-Mail: Alessandra Carbone alessandra.carbone@lip6.fr</p>
]]></description>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/18382/google-genomics</guid>
	<pubDate>Fri, 17 Oct 2014 02:14:14 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/18382/google-genomics</link>
	<title><![CDATA[Google Genomics]]></title>
	<description><![CDATA[<p>Google Genomics provides an API to store, process, explore, and share DNA sequence reads, reference-based alignments, and variant calls, using Google's cloud infrastructure.</p>
<ul>
<li><strong>Store</strong> alignments and variant calls for one genome or a million.</li>
<li><strong>Process</strong> genomic data in batch by running principal component analysis or Hardy-Weinberg equilibrium, in minutes or hours, by using parallel computing frameworks like MapReduce.</li>
<li><strong>Explore</strong> data by slicing alignments and variants by genomic range across one or multiple samples -- for your own algorithms or for visualization; or interactively process entire cohorts to find transition/transversion ratios, allelic frequency, genome-wide association and more using BigQuery.</li>
<li><strong>Share</strong> genomic data with your research group, collaborators, the broader community, or the public. You decide.</li>
</ul>
<p>Google Genomics is implementing the API defined by the <a href="http://genomicsandhealth.org/">Global Alliance for Genomics and Health</a> for visualization, analysis and more. Compliant software can access Google Genomics, local servers, or any other implementation.</p><p>Address of the bookmark: <a href="https://cloud.google.com/genomics/" rel="nofollow">https://cloud.google.com/genomics/</a></p>]]></description>
	<dc:creator>Reshma Khatun</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/41146/lofreq-a-sequence-quality-aware-ultra-sensitive-variant-caller-for-ngs-data</guid>
	<pubDate>Tue, 18 Feb 2020 03:24:22 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/41146/lofreq-a-sequence-quality-aware-ultra-sensitive-variant-caller-for-ngs-data</link>
	<title><![CDATA[LoFreq*: A sequence-quality aware, ultra-sensitive variant caller for NGS data]]></title>
	<description><![CDATA[<p>LoFreq* (i.e. LoFreq version 2) is a fast and sensitive variant-caller for inferring SNVs and indels from next-generation sequencing data. It makes full use of base-call qualities and other sources of errors inherent in sequencing (e.g. mapping or base/indel alignment uncertainty), which are usually ignored by other methods or only used for filtering.</p>
<p>https://github.com/CSB5/lofreq</p>
<p>http://csb5.github.io/lofreq/installation/</p>
<p>https://github.com/CSB5/lofreq/tree/master/dist</p><p>Address of the bookmark: <a href="http://csb5.github.io/lofreq/" rel="nofollow">http://csb5.github.io/lofreq/</a></p>]]></description>
	<dc:creator>BioStar</dc:creator>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/18578/research-scientist-%E2%80%93-national-institute-of-cholera-and-enteric-diseases</guid>
  <pubDate>Wed, 22 Oct 2014 10:26:46 -0500</pubDate>
  <link></link>
  <title><![CDATA[Research Scientist – National Institute of Cholera and Enteric Diseases]]></title>
  <description><![CDATA[
<p>The following post is to be filled up on purely temporary basis under the project entitled "Second phase of Task Force Biomedical Informatics Center of ICMR" under Dr. Santasabuj Das, Scientist 'D' of this Institute:-</p>

<p>01. Scientist II 01<br />Essential: Ph.D. degree in Life Sciences from a recognized university along with a minimum of 2 years of research experience in Bioinformatics as evidenced by publications in the peer reviewed journals.</p>

<p>OR<br />Ph.D. degree in Bioinformatics from a recognized university.</p>

<p>OR<br />M.Sc. in Bioinformatics from a recognized university along with a minimum of 3 years of research experience in Bioinformatics as evidenced by publications in the peer reviewed journals.</p>

<p>Desirable:<br />Thorough Knowledge about In silico genome analysis and comparative genomics.<br />Experience with in silico identification of novel virulence factors of pathogens, host-pathogen interactions and Systems Biology.<br />Additional Postdoctoral research experience in relevant subjects from a recognized institutions.</p>

<p>Rs. 44,000/- p.m. (consolidated) plus 30% HRA</p>

<p>Below 40 years</p>

<p>Applications along with Bio-Data containing detail work experience and full list of publications may be sent via email tosantasabujdas@yahoo.com latest by October 27, 2014.</p>

<p>Short-listed candidates will be called via email for an interview to be held at the institute in the second week of November, 2014.</p>

<p>Advertisement: www.niced.org.in/placements.htm</p>
]]></description>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/19636/google-genomics</guid>
	<pubDate>Thu, 18 Dec 2014 11:05:42 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/19636/google-genomics</link>
	<title><![CDATA[Google Genomics]]></title>
	<description><![CDATA[<ul>
<li>
<p><strong>Explore genetic variation interactively.</strong> Compare entire cohorts in seconds with SQL-like queries. Compute transition/transversion ratios, genome-wide association, allelic frequency and more.</p>
</li>
<li>
<p><strong>Process big genomic data easily.</strong> Run batch analyses like principal component analysis and Hardy-Weinberg equilibrium on as many samples as you like, in minutes or hours, with just a little code.</p>
</li>
<li>
<p><strong>Use Google's infrastructure and big data expertise.</strong> Store one genome or a million using Google Genomics and take advantage of the same infrastructure that powers Search, Maps, YouTube, Gmail and Drive.</p>
</li>
<li>
<p><strong>Support emerging global standards.</strong> Google Genomics is implementing the API defined by the Global Alliance for Genomics and Health for visualization, analysis and more. Compliant software can access Google Genomics, local servers, or any other implementation.</p>
</li>
</ul><p>Address of the bookmark: <a href="https://cloud.google.com/genomics/" rel="nofollow">https://cloud.google.com/genomics/</a></p>]]></description>
	<dc:creator>Tenzin Paul</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/blog/view/33306/ancestral-sequence-reconstruction-asr-or-ancestral-genesequence-reconstructionresurrection-tools-to-study-molecular-evolution</guid>
	<pubDate>Tue, 30 May 2017 04:20:05 -0500</pubDate>
	<link>https://bioinformaticsonline.com/blog/view/33306/ancestral-sequence-reconstruction-asr-or-ancestral-genesequence-reconstructionresurrection-tools-to-study-molecular-evolution</link>
	<title><![CDATA[Ancestral sequence reconstruction (ASR) or ancestral gene/sequence reconstruction/resurrection tools to study molecular evolution]]></title>
	<description><![CDATA[<p><span><strong>Ancestral sequence reconstruction</strong><span>&nbsp;(</span><strong>ASR</strong><span>) &ndash; also known as&nbsp;</span><strong>ancestral gene</strong><span>/</span><strong>sequence reconstruction</strong><span>/</span><strong>resurrection</strong><span>&nbsp;&ndash; is a technique used in the study of&nbsp;</span>molecular evolution<span>. The method consists of the synthesis of an ancestral&nbsp;</span>gene<span>&nbsp;and expression of the corresponding ancestral&nbsp;</span>protein<span>.&nbsp;</span><sup id="cite_ref-thornton_1-0"><a href="https://en.wikipedia.org/wiki/Ancestral_sequence_reconstruction#cite_note-thornton-1"></a></sup><span>The idea of protein 'resurrection' was suggested in 1963 by Pauling and Zuckerkandl.</span><sup id="cite_ref-2"><a href="https://en.wikipedia.org/wiki/Ancestral_sequence_reconstruction#cite_note-2"></a></sup><span>&nbsp;Some early efforts were made in the eighties-nineties, led by the laboratory of&nbsp;</span>Steven A. Benner<span>, showing the potential of this technique &ndash; one that only started to be fulfilled in the post-genomic era.</span><sup id="cite_ref-3"><a href="https://en.wikipedia.org/wiki/Ancestral_sequence_reconstruction#cite_note-3"></a></sup><span>&nbsp;Thanks to the improvement of algorithms and of better sequencing and synthesis techniques, the method was developed further in the early 2000s to allow the resurrection of a greater variety of and much more ancient genes.</span><sup id="cite_ref-4"><a href="https://en.wikipedia.org/wiki/Ancestral_sequence_reconstruction#cite_note-4"></a></sup><span>&nbsp;Over the last decade, ancestral protein resurrection has developed as a strategy to reveal the mechanisms and dynamics of protein evolution.&nbsp;</span></span></p><p><img src="https://upload.wikimedia.org/wikipedia/commons/thumb/e/e4/ASR_phylogeny.png/510px-ASR_phylogeny.png" alt="image" width="610" height="435" style="border: 0px; border: 0px;"></p><p><span>Following are the list of&nbsp;</span><strong style="font-size: 12.8px;">Ancestral /sequence/ reconstruction</strong><span>&nbsp;(</span><strong style="font-size: 12.8px;">ASR</strong><span>) tools:&nbsp;</span></p><p><a href="http://www.bx.psu.edu/miller_lab/car/" target="_blank" title="To inferCars official website"><span>inferCars</span></a></p><p><span><span><span><span><span>Reconstructs contiguous regions of an ancestral genome. Given information about adjacencies between conserved segments in each modern species, our goal is to infer segment order in the ancestral genome. To get a clean and precise statement of the problem, we formalize it using graph theory. We develop an algorithm that identifies a most parsimonious scenario for the history of each individual adjacency, although the whole-genome prediction is not guaranteed to optimize traditional measures like the number of breakpoints. We introduce weights to the graph edges to model the reliability of each adjacency.</span></span></span></span></span></p><p><span><span><a href="http://paleogenomics.irmacs.sfu.ca/ANGES/" target="_blank" title="To ANGES official website">ANGES</a>:</span><a href="http://paleogenomics.irmacs.sfu.ca/ANGES/" target="_blank" title="To ANGES official website">reconstructing ANcestral GEnomeS maps</a></span></p><p><span><span><span><span><span><span>A suite of Python programs that allows reconstructing ancestral genome maps from the comparison of the organization of extant-related genomes. ANGES can reconstruct ancestral genome maps for multichromosomal linear genomes and unichromosomal circular genomes. It implements methods inspired from techniques developed to compute physical maps of extant genomes.</span></span></span></span></span></span></p><p><a href="http://virulence.molgen.mpg.de/cocos/" target="_blank" title="To Cocos official website"><span>Cocos</span></a></p><p><span><span><span><span><span><span><span>Constructs phylogenies of multi-domain proteins. With a given species tree and domain phylogenies, the procedure infers the composition of ancestral multi-domain proteins. Cocos implements and extend a suggested algorithmic approach by Behzadi and Vingron in an easy-to-use program. Such method could be applied to reconstruction of partial homologous units such as bacterial operons or protein complexes.</span></span></span></span></span></span></span></p><p><a href="https://github.com/msrosenberg/MySSP" target="_blank" title="To MySSP official website"><span>MySSP</span></a></p><p><span><span><span><span><span><span><span><span>Constructs an initial DNA sequence at the root of the tree and simulates evolution across the tree using a variety of common models of DNA evolution. MySSP is a program for the simulation of DNA sequence evolution across a phylogenetic tree. It is designed for large-scale studies, including simulation of multiple replicates and outputs sequences into NEXUS, MEGA, or FASTA formats. MySSP has a fairly simple graphical user interface (GUI) for basic use, but also has a specialized batch script interpreter to allow for more complicated or large-scale simulations.</span></span></span></span></span></span></span></span></p><p><span><span><a href="http://www.cs.cmu.edu/~ckingsf/software/parana/" target="_blank" title="To PARANA official website">PARANA</a>:&nbsp;</span><a href="http://www.cs.cmu.edu/~ckingsf/software/parana/" target="_blank" title="To PARANA official website">Parsimonious Ancestral Reconstruction And Network Analysis</a></span></p><p><span><span><span><span><span><span><span><span><span>Performs parsimony based inference of ancestral biological networks. Given multiple extant networks and phylogenetic information relating extant nodes, PARANA finds a parsimonious set of ancestral interaction events (edge gains and losses) which explain the extant networks. The framework adopted by PARANA is able to represent network evolution under models that support gene duplication and loss and independent interaction gain and loss. The method works on both directed and undirected networks and can incorporate asymmetric interaction gain and loss costs. In contrast to previous approaches, PARANA does not require knowing the relative ordering of unrelated duplication events and thus, works on phylogenetic trees even where branch lengths are not provided.</span></span></span></span></span></span></span></span></span></p><p><span><span><a href="http://www-labs.iro.umontreal.ca/~mabrouk/" target="_blank" title="To GapAdj official website">GapAdj</a>:&nbsp;</span><a href="http://www-labs.iro.umontreal.ca/~mabrouk/" target="_blank" title="To GapAdj official website">Gapped Adjacencies</a></span></p><p><span><span><span><span><span><span><span><span><span><span>A synteny-based method that is flexible enough to handle a model of evolution involving whole genome duplication events, in addition to rearrangements, gene insertions, and losses. Ancestral relationships between markers are defined in term of Gapped Adjacencies, i.e. pairs of markers separated by up to a given number of markers. It improves on a previous restricted to direct adjacencies, which revealed a high accuracy for adjacency prediction, but with the drawback of being overly conservative, i.e. of generating a large number of contiguous ancestral regions (CARs).</span></span></span></span></span></span></span></span></span></span></p><p><a href="http://ancestors.bioinfo.uqam.ca/"><span><span><span><span><span><span><span><span><span><span>ANCESTOR</span></span></span></span></span></span></span></span></span></span></a></p><p><span><span><span><span><span><span><span><span><span><span><span>A web server allowing one to easily and quickly perform the last three steps of the ancestral genome reconstruction procedure. Ancestors implements several alignment algorithms, an indel maximum likelihood solver and a context-dependent maximum likelihood substitution inference algorithm. The results presented by the server include the posterior probabilities for the last two steps of the ancestral genome reconstruction and the expected error rate of each ancestral base prediction.</span></span></span></span></span></span></span></span></span></span></span></p><p><a href="http://bioinfo.lifl.fr/procars/" target="_blank" title="To ProCARs official website"><span>ProCARs</span></a></p><p>Reconstructs ancestral gene orders as contiguous ancestral regions (CARs) with a progressive homology-based method. ProCARs runs from a phylogeny tree (without branch lengths needed) with a marked ancestor and a block file. This homology-based method is based on iteratively detecting and assembling ancestral adjacencies, while allowing some micro-rearrangements of synteny blocks at the extremities of the progressively assembled CARs. The method starts with a set of blocks as the initial set of CARs, and detects iteratively the potential ancestral adjacencies between extremities of CARs, while building up the CARs progressively by adding, at each step, new non-conflicting adjacencies that induce the less homoplasy phenomenon. The species tree is used, in some additional internal steps, to compute a score for the remaining conflicting adjacencies, and to detect other reliable adjacencies, in order to reach completely assembled ancestral genomes.</p><p><a href="http://fastml.tau.ac.il/" target="_blank" title="To FastML official website"><span>FastML</span></a></p><p>A user-friendly tool for the reconstruction of ancestral sequences. FastML implements various novel features that differentiate it from existing tools: (i) FastML uses an indel-coding method, in which each gap, possibly spanning multiples sites, is coded as binary data. FastML then reconstructs ancestral indel states assuming a continuous time Markov process. FastML provides the most likely ancestral sequences, integrating both indels and characters; (ii) FastML accounts for uncertainty in ancestral states: it provides not only the posterior probabilities for each character and indel at each sequence position, but also a sample of ancestral sequences from this posterior distribution, and a list of the k-most likely ancestral sequences; (iii) FastML implements a large array of evolutionary models, which makes it generic and applicable for nucleotide, protein and codon sequences; and (iv) a graphical representation of the results is provided, including, for example, a graphical logo of the inferred ancestral sequences.</p><p><a href="http://rth.dk/resources/maxAlike/" target="_blank" title="To maxAlike official website"><span>maxAlike</span></a></p><p>Reconstructs a genomic sequence for a specific taxon based on sequence homologs in other species. The input is a multiple sequence alignment and a phylogenetic tree that also contains the target species. For this target species, the algorithm computes nucleotide probabilities at each sequence position. Consensus sequences are then reconstructed based on a certain confidence level.</p><p><span><span><a href="http://www.geneorder.org/server.php" target="_blank" title="To MLGO official website">MLGO</a>:&nbsp;</span><a href="http://www.geneorder.org/server.php" target="_blank" title="To MLGO official website">Maximum Likelihood for Gene Order Analysis</a></span></p><p>A web tool for the reconstruction of phylogeny and/or ancestral genomes from gene-order data. MLGO was designed for analysis of large-scale genomic changes including not only rearrangements but also gene insertions, deletions and duplications. MLGO can be used to infer a phylogeny from genome rearrangement and gene order data, and can also obtain an estimation of ancestral genomes, given an input tree. MLGO takes the advantage of binary encoding on gene-order data, supports a fairly general model of genomic evolution (rearrangements plus duplications, insertions, and losses of genomic regions), and successfully accommodates itself into the framework of maximized likelihood.</p><p>Image Reference : Wiki</p>]]></description>
	<dc:creator>Jit</dc:creator>
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