BOL: Related items

Lawley Lab

Mon, 09 May 2016 03:29:51 -0500

Lawley Lab are covered with a complex microbial community, known as our microbiota, which plays important roles in our physiology, immunity, metabolism and sustenance. Within the human gastrointestinal tract alone there are over 1,000 bacterial species, which amounts to approximately 10 times more cells than we harbor in our entire body and 200 times more genes than are found within our genome. Lawley Lab are really a 'supraorganism' consisting of our 'human' and 'microbial' selves.

More at http://www.sanger.ac.uk/science/groups/lawley-lab

Release Notes for Genome Workbench 2.10.5

Jit — Thu, 12 May 2016 13:49:41 -0500

New Features in latest release

New ProSplign tool integrated with Genome Workbench (Tutorial, Video)
New export function for BAM/cSRA coverage graphs (Tutorial)
New export function for alignments GFF3 format ((Tutorial))
Tree View: implemented new export mode based on selections (tutorial coming)
Tree View: added support for distance based circular trees
Tree View: new rooting mode (Midpoint Root) results in more balanced trees (Tutorial)
Tree View: added possibility to right-click on an edge between two nodes and "Place Root at Middle of Branch" – to re-root at mid-branch (Tutorial)

cutadapt

Radha Agarkar — Fri, 13 May 2016 04:54:50 -0500

Cutadapt finds and removes adapter sequences, primers, poly-A tails and other types of unwanted sequence from your high-throughput sequencing reads.

Cleaning your data in this way is often required: Reads from small-RNA sequencing contain the 3’ sequencing adapter because the read is longer than the molecule that is sequenced. Amplicon reads start with a primer sequence. Poly-A tails are useful for pulling out RNA from your sample, but often you don’t want them to be in your reads.

Cutadapt helps with these trimming tasks by finding the adapter or primer sequences in an error-tolerant way. It can also modify and filter reads in various ways. Adapter sequences can contain IUPAC wildcard characters. Also, paired-end reads and even colorspace data is supported. If you want, you can also just demultiplex your input data, without removing adapter sequences at all.

Cutadapt comes with an extensive suite of automated tests and is available under the terms of the MIT license.

If you use cutadapt, please cite DOI:10.14806/ej.17.1.200 .

Address of the bookmark: https://cutadapt.readthedocs.io/en/stable/installation.html#quickstart

Navin Lab

Wed, 18 May 2016 16:40:14 -0500

NAvin laboratory has pioneered the development of single cell sequencing technologies. They apply these tools to study complex biological processes that occur in human cancers including tumor initation, clonal evolution, invasion, metastasis and chemoresistance. These processes have previously been difficult to study with genomic technologies using bulk tissues

More at http://www.navinlab.com/navinlab/home.html

MOSAIK: A Hash-Based Algorithm for Accurate Next-Generation Sequencing Short-Read Mapping

Neel — Fri, 20 May 2016 18:53:49 -0500

MOSAIK is a stable, sensitive and open-source program for mapping second and third-generation sequencing reads to a reference genome. Uniquely among current mapping tools, MOSAIK can align reads generated by all the major sequencing technologies, including Illumina, Applied Biosystems SOLiD, Roche 454, Ion Torrent and Pacific BioSciences SMRT. Indeed, MOSAIK was the only aligner to provide consistent mappings for all the generated data (sequencing technologies, low-coverage and exome) in the 1000 Genomes Project. To provide highly accurate alignments, MOSAIK employs a hash clustering strategy coupled with the Smith-Waterman algorithm. This method is well-suited to capture mismatches as well as short insertions and deletions. To support the growing interest in larger structural variant (SV) discovery, MOSAIK provides explicit support for handling known-sequence SVs, e.g. mobile element insertions (MEIs) as well as generating outputs tailored to aid in SV discovery.

Address of the bookmark: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090581

Senior Project Fellow Bioinformatics at NBRI

Sat, 21 May 2016 21:01:05 -0500

Walk In Interview No. 03/Project/2016
Senior Project Fellow Bioinformatics Job vacancies in CSIR- National Botanical Research Institute (NBRI), Lucknow
Area III: Molecular Biology & Biotechnology
Qualification : 1st Class M.Sc. in Bioinformatics/Biotechnology/ Life Science /Biochemistry/Botany with 2 years research experience and at least one publication in SCI Journal or 1st class M.Tech in Bioinformatics
Age : 32 years
Salary : Rs.18000
How to apply
Date & Venue of Interview For Area III: 27-05-2016 at 11.00 A.M. at Conference Room, T.N. Khushoo Block, NBRI, Lucknow.

http://www.nbri.res.in/temp.php

Cytoscape

Anjana — Mon, 23 May 2016 02:32:00 -0500

Cytoscape is an open source software platform for visualizing complex networks and integrating these with any type of attribute data. A lot of Apps are available for various kinds of problem domains, including bioinformatics, social network analysis, and semantic web.

Address of the bookmark: http://www.cytoscape.org/

RA at UNIVERSITY OF HYDERABAD

Sun, 29 May 2016 11:50:37 -0500

UNIVERSITY OF HYDERABAD

School of Life Sciences

Department of Animal Biology

Applications are invited on a plane paper (along with copies of educational qualifications and experience) from eligible candidates for the selection of following position to work under a collaborative research project entitled “Development and application of high resolution genome conformation capture technology to investigate genome architecture in space and time” between University of Hyderabad and CR Rao advanced Institute of Mathematics, Statistics and Computer Sciences, sponsored by Department of Biotechnology, Government of India, New Delhi

Name and No. of positions JRF‐ONE

Emoluments for the position Rs. 25,000/p.m. + Eligible HRA

Qualifications MSc or M.Tech in any branch of biology/bioinformatics/computational biology/computer sciences/Mathematics/Physics

Duration Appointments are made initially for ONE year and can be extended further TWO years or until the duration of project

Our laboratory is interested in understanding signalling and spatiotemporal dynamics of 3‐Dimensional genome architecture and gene expression during embryonic stem cell differentiation by utilizing a combination of cellular, molecular genetics, Biochemical and computational tools in combination with next generation sequencing based chromatin structure analysing methods. Successful candidates shall pursue project related to either experimental or computational analysis of genome and Epigenomics data derived from human and mouse cells. Experience in Computational biology, bioinformatics, statistics, machine learning and algorithmic development is required. Knowledge of programming languages (e.g. C, C++, Perl, Python, Ruby etc.) and statistical framework (e.g. R, matlab, etc.) is preferable. Basic understanding of molecular biology will be an added advantage.

Interested candidates with the above mentioned qualification can send their curriculum vitae to Dr. K. Sreenivasulu, Department of Animal Biology, School of Life Sciences, South campus, University of Hyderabad or via email at positionssklab@gmail.com or svksl@uohyd.ernet.in.

Candidates with CSIR/UGC/ICMR/DBT/BINC qualifications if interested in above mentioned area of research are welcomed to approch principal investigator for a position leading to PhD. Last date for submission of applications is 17/06/2016. Eligible candidates will be called for an interview and they should carry all original certificates of the qualifying exam. No TA/ DA will be paid for attending the interview or at the time of joining the post.

Advertisement: http://www.uohyd.ac.in/images/recruitment/jrf_260516.pdf

HistoneDB 2.0 – with variants

Anjana — Fri, 03 Jun 2016 05:06:20 -0500

This histone database can be used to explore the diversity of histone proteins and their sequence variants in many organisms. The resource was established to better understand how sequence variation may affect functional and structural features of nucleosomes. To get started, select a histone type to explore its variants.

More at http://www.ncbi.nlm.nih.gov/projects/HistoneDB2.0/index.fcgi/browse/

Address of the bookmark: http://www.ncbi.nlm.nih.gov/projects/HistoneDB2.0/index.fcgi/browse/

MutaBind

Jit — Mon, 06 Jun 2016 13:34:09 -0500

MutaBind is a new computational method and server created through NCBI research efforts that maps mutations on a protein structural complex, calculates changes in binding affinity, identifies deleterious mutations and produces a downloadable mutant structural model. http://www.ncbi.nlm.nih.gov/projects/mutabind/index.fcgi/

MutaBind guides you through this process, step by step, starting with selecting a protein complex and inputting PDB code or uploading PDB files. You can also retrieve results with a job ID number, view help documents, and review the MutaBind method and references.

More at http://www.ncbi.nlm.nih.gov/projects/mutabind/index.fcgi/