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	<title><![CDATA[BOL: Related items]]></title>
	<link>https://bioinformaticsonline.com/related/27821?offset=920</link>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/videolist/watch/4959/evolution-and-cancer</guid>
	<pubDate>Fri, 27 Sep 2013 11:28:49 -0500</pubDate>
	<link>https://bioinformaticsonline.com/videolist/watch/4959/evolution-and-cancer</link>
	<title><![CDATA[Evolution and Cancer]]></title>
	<description><![CDATA[<iframe width="" height="" src="https://www.youtube-nocookie.com/embed/j3uKOcNwYBw" frameborder="0" allowfullscreen></iframe>Air date:  Wednesday, January 04, 2012, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local  
 
Category:  Wednesday Afternoon Lectures  
Description:  There is a broad consensus that cancer is the result of somatic cells having serially gained, by a series of mutations, the ability to grow independently, to recruit resources from the circulation and the stroma, to invade local tissues, and to found anatomically distant metastases, ultimately killing the host. From the point of view of the cancer-causing somatic cell population, this is evolution driven by mutation and selection. Genomics has resulted in a parallel consensus that the central functions of all eukaryotes are highly conserved, not only at the level of individual protein functions, but also complex biological pathways and systems. These ideas motivated a comparison between results of molecular genetic studies of experimental evolution in yeast and the molecular genetic phenomena associated with tumorigenesis and tumor progression. We find some very striking similarities, including recurring genomic rearrangements, alterations of the regulation of specific growth-promoting genes, population-genetic features that affect the fitness trajectories of growth rate variants in evolving populations, and physiological and metabolic similarities derived from the conservation of the basic plan of growth and cell multiplication among all eukaryotes. It is hoped that some of the insights from yeast will aid the interpretation of sequence changes found in tumors, especially in the urgent necessity to distinguish 'driver' from 'passenger' mutations." 

David Botstein's fundamental contributions to modern genetics include the development of genetic methods for understanding biological functions and the discovery of the functions of many yeast and bacterial genes. In 1980, Botstein and three colleagues proposed a method for mapping human genes that laid the groundwork for the Human Genome Project. The basic principle of the mapping scheme was to develop, by recombinant DNA techniques, random single-copy DNA probes capable of detecting DNA sequence polymorphisms when hybridized to restriction digests, or specific fragments, of an individual's DNA. The method was used in subsequent years to identify several human disease genes, such as Huntington's and BRCA1. Variations of this method enabled the sequencing phase of the Human Genome Project. 

In the 1990s Botstein, having moved to Stanford University School of Medicine, collaborated with Patrick O. Brown of Stanford in exploiting DNA microarrays to study genome-wide gene expression patterns in yeast and in human cancers. This required developing a new statistical method and graphical interface, widely used today to interpret genomic data. Botstein also has helped to create, with Michael Ashburner and Gerald Rubin, a bioinformatics initiative to unify the representation of gene and gene product attributes across all species, called Gene Ontology. He graduated from Harvard College and earned his doctorate from the University of Michigan. He worked at Massachusetts Institute of Technology from 1967 to 1988; served as vice president for science at Genentech from 1988 to 1990; chaired the Department of Genetics at the Stanford University School of Medicine from 1990 to 2003; and joined the Princeton University faculty in 2003. He has sat on numerous editorial boards and was the founding editor of Molecular Biology of the Cell. Among recent major awards, Bostein won the Peter Gruber Foundation Prize in Genetics in 2003, the Apple Science Innovator Award in 2008, and the Albany Medical Center Prize in 2010. 

The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide. 

For more information, visit: The NIH Director's Wednesday Afternoon Lecture Series  
Author:  Dr. David Botstein, Princeton University  
Runtime:  00:59:58  

Permanent link:  http://videocast.nih.gov/launch.asp?17046]]></description>
	
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/44294/opportunity-at-mcdermott-center-bioinformatics-lab</guid>
  <pubDate>Sat, 01 Apr 2023 09:56:39 -0500</pubDate>
  <link></link>
  <title><![CDATA[Opportunity at McDermott Center Bioinformatics Lab]]></title>
  <description><![CDATA[
<p>Our team, composed of experts from diverse backgrounds including genetics, cancer biology, computer science, bioinformatics, and microbiology, stays current with evolving bioinformatics techniques. We offer consulting, customized service, and collaboration opportunities. We suggest visiting us to discuss your experiment design and results, as we can tailor our assistance to meet your specific research goals.</p>

<p>https://labs.utsouthwestern.edu/bioinformatics-lab/positions</p>
]]></description>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/5253/pre-or-postdoctoral-research-fellowship-in-structural-bioinformatics-in-padova</guid>
  <pubDate>Wed, 02 Oct 2013 15:12:22 -0500</pubDate>
  <link></link>
  <title><![CDATA[Pre- or postdoctoral research fellowship in Structural Bioinformatics in Padova]]></title>
  <description><![CDATA[
<p>University of Padova (URL: http://protein.bio.unipd.it/)</p>

<p>A research fellowship is available at the BioComputing Laboratory, University of Padova (URL: http://protein.bio.unipd.it/). A highly motivated and creative candidate is sought to work on structural bioinformatics. Specifically, the project entails the development of novel methods, tools and databases for the analysis of protein structures. The BioComputing Laboratory is a group of a dozen people working on several aspects of prediction of protein structure &amp; function employing techniques at the intersection between biology, medicine, chemistry, physics &amp; computer science. Our aim is to integrate the development of novel methods and their application to biologically relevant problems. We are looking for candidates with a solid Bioinformatics background, programming experience (Python, Perl, C++ and/or Java) and good knowledge of molecular biology (protein structure/function, signalling pathways). Candidates should have a degree with top marks, optionally hold a PhD, and be highly motivated to work on interdisciplinary research. Good knowledge of English, an open-minded spirit, being collaborative and creative are crucial. The fellowship, which should start in late 2013, is initially for one year. It will be commensurate to experience, can be extended depending on performance and may lead to a PhD degree. The successful candidate will be located at the BioComputing Laboratory, University of Padova. Travel support for conferences and/or research visits abroad may be provided. To apply, please send your CV, a brief description of your research background and the names of two (or more) references to Prof. Silvio Tosatto (Email: silvio.tosatto@unipd.it). </p>

<p>Contact Person (Referent): Silvio Tosatto<br />Ref. E-Mail: silvio.tosatto@unipd.it<br />Tel: +39 049 827 6269<br />Fax: +39 049 827 6260<br />Group Web Page: http://protein.bio.unipd.it/</p>
]]></description>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/44624/bioinformatics-workshops</guid>
	<pubDate>Wed, 31 Jul 2024 02:16:53 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/44624/bioinformatics-workshops</link>
	<title><![CDATA[Bioinformatics Workshops !]]></title>
	<description><![CDATA[<p>When delving into bioinformatics, having access to reliable resources is crucial for effective research and analysis. Key online resources include the National Center for Biotechnology Information (NCBI), which offers tools like BLAST for sequence alignment and comprehensive gene databases. For presentations and educational materials, exploring SlideShare for introductory and advanced bioinformatics topics can provide valuable insights and learning aids.</p>
<p>https://evomics.org/2024-workshop-on-genomics/</p><p>Address of the bookmark: <a href="https://evomics.org/2024-workshop-on-genomics/" rel="nofollow">https://evomics.org/2024-workshop-on-genomics/</a></p>]]></description>
	<dc:creator>Abhi</dc:creator>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/7217/contract-faculty-bioinformatics-at-maulana-azad-national-institute-of-technology</guid>
  <pubDate>Thu, 12 Dec 2013 20:46:52 -0600</pubDate>
  <link></link>
  <title><![CDATA[Contract Faculty-Bioinformatics at Maulana Azad National Institute of Technology]]></title>
  <description><![CDATA[
<p>Contract Faculty-Bioinformatics at Maulana Azad National Institute of Technology</p>

<p>Job Description:F.No.11/10(1)/929 Qualifications: Candidates should have Ph.D. degree. If Ph.D. candidates are not available at least Post Graduate degree with GATE/NET qualification is a must. Walk-in-Interview on 19.12.2013 at 2.30 P.M. to 5.30 P.M .. at Maulana Azad National Institute of Technology: Bhopal For more details,please visit website:http://www.manit.ac.in/manitbhopal/Year2013/Recruitment/Contract_faculty/contract%20faculty%202013-2014.pdf</p>

<p>For more @ http://www.manit.ac.in/manitbhopal/Year2013/Recruitment/Contract_faculty/contract%20faculty%202013-2014.pdf</p>

<p>Web address @ :http://www.manit.ac.in</p>
]]></description>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/44669/bioinformatician-at-qub-uk</guid>
  <pubDate>Tue, 01 Oct 2024 21:43:23 -0500</pubDate>
  <link></link>
  <title><![CDATA[Bioinformatician at QUB, UK]]></title>
  <description><![CDATA[
<p>The post-holder will work under the direction of the Precision Medicine Centre of Excellence's (PMC) Bioinformatics lead and collaborate closely with the Scientific and Clinical leads. The primary responsibilities will be to develop, validate and maintain data analysis pipelines and algorithms that enable the comprehensive analysis of genomic information derived from cancer specimens, within the context of clinical studies. The PMC is an ISO 15189:2012 accredited medical laboratory (Ref 20634), providing an integrated cancer diagnostic and clinical research service that combines high throughput genomics and digital pathology (www.qub.ac.uk/research-centres/PMC).</p>

<p>About the person:</p>

<p>Essential criteria:</p>

<p>Hold or be about to obtain* a PhD in Computational biology, Bioinformatics, computing science or related subjects. (*must be obtained within 3 months of the closing date for the post) or MSc equivalent with at least 3 years' work experience in a relevant role.<br />Significant relevant research experience in genomics or work experience in a relevant technical/scientific role.<br />Significant experience in managing and analysing NGS data and other big data.<br />Experience in developing and maintaining analysis pipelines.<br />Experience working with Linux/UNIX environments.<br />Proficiency with python, bash, R and/or equivalent languages.<br />To be successful at shortlisting stage, please ensure you clearly evidence in your application how you meet the essential and, where applicable, desirable criteria listed in the Candidate Information document linked on our website.</p>

<p>More at https://hrwebapp.qub.ac.uk/tlive_webrecruitment/wrd/run/ETREC107GF.open</p>
]]></description>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/researchlabs/view/5623/yau-group</guid>
  <pubDate>Tue, 15 Oct 2013 13:05:15 -0500</pubDate>
  <link></link>
  <title><![CDATA[Yau Group]]></title>
  <description><![CDATA[
<p>Yau Group are a new research group based at the Wellcome Trust Centre for Human Genetics and the Department of Statistics at the University of Oxford.</p>

<p>Yau Group develops statistical and computational methods for the analysis of genomic datasets with a particular interest in cancer sequencing applications and the use of Bayesian Statistics.</p>

<p>Yau Group are currently have projects in somatic mutation analysis of heterogeneous cancers, data fusion or integration techniques and single cell genomics.</p>

<p>More @ http://www.well.ox.ac.uk/~cyau/index.html</p>
]]></description>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/44702/postdoc-in-comparative-single-cell-genomics-at-university-of-basel</guid>
  <pubDate>Fri, 06 Dec 2024 23:41:20 -0600</pubDate>
  <link></link>
  <title><![CDATA[Postdoc in Comparative Single Cell Genomics at University of Basel]]></title>
  <description><![CDATA[
<p>A fully funded 4-year Postdoc position is available in the lab of Patrick<br />Tschopp at the University of Basel, Switzerland, study the molecular and<br />tissue-scale dynamics during the embryonic formation of the vertebrate<br />skeleton and compare it across different vertebrate species with distinct<br />habitats.</p>

<p>We are looking for a highly motivated candidate with a PhD degree in<br />Bioinformatics or a related field. Candidates are expected to have a<br />strong background in evolutionary biology and/or comparative functional<br />genomics. Additional experiences in single cell functional genomics<br />analyses, statistics and computational data analyses are a plus, as is<br />an interest in comparative developmental (EvoDevo) questions.</p>

<p>We offer a dynamic and interactive research environment with state-of-the<br />art research facilities, good research funding and internationally<br />competitive salaries.</p>

<p>The Tschopp lab (www.evolution.unibas.ch/tschopp/research/)<br />studies the gene regulatory mechanisms of cell type<br />specification and evolution in vertebrates. See also our<br />preprints at https://doi.org/10.1101/2024.03.26.586769 and<br />https://doi.org/10.1101/2024.11.28.625862 Applications should include<br />a motivation letter, a CV, a list of publications, a statement about<br />research interests, as well as the names and contact details of at<br />least two referees. Applications (in the form of a single .pdf file)<br />should be sent to Patrick Tschopp (patrick.tschopp@unibas.ch); review<br />of applications will begin on January 1st 2025, and will continue until<br />the position is filled.</p>

<p>Patrick Tschopp</p>
]]></description>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/7218/associate-professor-centre-for-bioinformatics-at-maharshi-dayanand-university-rohtak</guid>
  <pubDate>Thu, 12 Dec 2013 20:49:59 -0600</pubDate>
  <link></link>
  <title><![CDATA[Associate Professor - Centre for Bioinformatics at Maharshi Dayanand University, Rohtak]]></title>
  <description><![CDATA[
<p>ADVERTISEMENT No. PR-54/2013</p>

<p>No. of Posts and Specialization: 1(UR)</p>

<p>Educational Qualification:</p>

<p>(i) Good academic record with a Ph.D. Degree in the concerned /allied /relevant disciplines.</p>

<p>(ii) The Ph.D. Degree shall be a mandatory qualification for all candidates to be appointed as Associate Professor through direct recruitment.</p>

<p>(iii) A Master‟s Degree with at least 55% marks (or an equivalent grade in a point scale wherever grading system is followed).</p>

<p>(iv) A minimum of eight years of experience of teaching and /or research in an academic /research position equivalent to that of Assistant Professor in a University, College or Accredited Research Institution/Industry excluding the period of Ph.D research with evidence of published work and a minimum of 5 publications as books and /or research papers in refereed journals only/policy papers.</p>

<p>(v) Contribution to educations innovation, design of new curricula and courses and technology-mediated teaching learning process with evidence of having guided doctoral candidates and research students.</p>

<p>(vi) A minimum score as stipulated in the Academic Performance Indicator (API) based performance Based Appraisal System (PBAS), set out in this notification in as mentioned in the advertisement.</p>

<p>Send your application to the A.R (Estt.Teaching), M.D.University, Rohtak on or before December 23, 2013.</p>

<p>For more details: http://www.mdurohtak.ac.in/pdf/Notices_Pdf/new_notice/Teaching%20Vacancy%20%28ADVT.%20No.%20PR-54%20of%202013%29.pdf</p>

<p>Last Apply Date: 23 Dec 2013</p>
]]></description>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/blog/view/44716/exploring-rna-sequence-analysis-tools-for-every-bioinformatician</guid>
	<pubDate>Fri, 13 Dec 2024 04:03:04 -0600</pubDate>
	<link>https://bioinformaticsonline.com/blog/view/44716/exploring-rna-sequence-analysis-tools-for-every-bioinformatician</link>
	<title><![CDATA[Exploring RNA Sequence Analysis: Tools for Every Bioinformatician]]></title>
	<description><![CDATA[<p>RNA sequence analysis has become an essential part of modern biological research. From RNA-seq pipelines to specialized tools for specific RNA types, here's a comprehensive guide to tools you can use to make sense of RNA data.</p><h4><strong>1. RNA-Seq Analysis Pipelines</strong></h4><p>RNA-seq is one of the most popular techniques for studying RNA. These tools streamline processing raw sequence data:</p><ul>
<li><strong>FASTQC</strong>: For quality control of raw RNA-seq reads.</li>
<li><strong>Trimmomatic</strong>: For trimming and filtering RNA-seq reads.</li>
<li><strong>HISAT2/STAR</strong>: High-performance aligners for RNA-seq reads.</li>
<li><strong>FeatureCounts</strong>: For quantifying gene expression.</li>
<li><strong>DESeq2/EdgeR</strong>: For differential expression analysis.</li>
</ul><h4><strong>2. Transcriptome Assembly and Annotation</strong></h4><p>For analyzing transcriptomes from non-model organisms or assembling novel transcripts:</p><ul>
<li><strong>Trinity</strong>: For de novo transcriptome assembly.</li>
<li><strong>StringTie</strong>: For transcript assembly and quantification from RNA-seq alignments.</li>
<li><strong>TransDecoder</strong>: To predict coding regions within assembled transcripts.</li>
<li><strong>TAU</strong>: Tools for annotating non-coding and coding RNAs.</li>
</ul><h4><strong>3. Exploring Non-Coding RNA (ncRNA)</strong></h4><p>Non-coding RNAs play critical regulatory roles. Dedicated tools for studying them include:</p><ul>
<li><strong>Infernal</strong>: For identifying ncRNA sequences based on covariance models.</li>
<li><strong>Rfam</strong>: Database and tools for ncRNA families.</li>
<li><strong>miRDeep</strong>: For identifying microRNAs in RNA-seq datasets.</li>
</ul><h4><strong>4. RNA Structure and Motif Analysis</strong></h4><p>Structural biology of RNA helps in understanding its function:</p><ul>
<li><strong>RNAfold (ViennaRNA)</strong>: Predicts secondary structures from RNA sequences.</li>
<li><strong>RNAstructure</strong>: Tools for RNA secondary structure prediction and analysis.</li>
<li><strong>MEME Suite</strong>: For identifying motifs in RNA sequences.</li>
<li><strong>IntaRNA</strong>: For RNA-RNA interaction prediction.</li>
</ul><h4><strong>5. RNA Editing and Modifications</strong></h4><p>Epitranscriptomics is a growing field focusing on RNA modifications:</p><ul>
<li><strong>REDItools</strong>: For RNA editing analysis.</li>
<li><strong>m6Aboost</strong>: For identifying m6A modifications in RNA.</li>
</ul><h4><strong>6. Long-Read RNA Sequencing Analysis</strong></h4><p>Long-read technologies like Nanopore and PacBio are transforming RNA research:</p><ul>
<li><strong>FLAIR</strong>: For isoform-level analysis of long-read RNA-seq data.</li>
<li><strong>NanoMod</strong>: For detecting modifications in RNA from Nanopore sequencing.</li>
</ul><h4><strong>7. RNA-Protein Interactions</strong></h4><p>To study RNA-protein interactions and complexes:</p><ul>
<li><strong>RBPmap</strong>: For identifying RNA-binding protein motifs.</li>
<li><strong>PARalyzer</strong>: For analyzing PAR-CLIP data.</li>
</ul><h4><strong>8. Functional Enrichment Analysis</strong></h4><p>Understanding biological functions and pathways from RNA-seq data:</p><ul>
<li><strong>getENRICH</strong>: A tool designed for pathway enrichment analysis of non-model organisms (hypergeometric P-value calculation with FDR correction).</li>
<li><strong>ClusterProfiler</strong>: For GO and KEGG pathway enrichment analysis.</li>
</ul><h4><strong>9. Visualization and Data Sharing</strong></h4><p>Presenting and sharing RNA sequence analysis results effectively:</p><ul>
<li><strong>IGV</strong>: Genome browser for visualizing RNA-seq alignments.</li>
<li><strong>Circos</strong>: Circular visualization of RNA-seq data.</li>
<li><strong>DashBio</strong>: A Python library for creating bioinformatics visualizations.</li>
</ul><h4><strong>Conclusion</strong></h4><p>The bioinformatics landscape for RNA sequence analysis is vast, with tools catering to specific needs. Whether you&rsquo;re studying coding RNAs, non-coding RNAs, or exploring RNA-protein interactions, the right tools can transform your data into biological insights.</p>]]></description>
	<dc:creator>Neel</dc:creator>
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