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	<title><![CDATA[BOL: Related items]]></title>
	<link>https://bioinformaticsonline.com/related/27967?offset=680</link>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/44375/phyloherb-a-high%E2%80%90throughput-phylogenomic-pipeline-for-processing-genome-skimming-data</guid>
	<pubDate>Wed, 06 Sep 2023 00:14:28 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/44375/phyloherb-a-high%E2%80%90throughput-phylogenomic-pipeline-for-processing-genome-skimming-data</link>
	<title><![CDATA[PhyloHerb: A high‐throughput phylogenomic pipeline for processing genome skimming data]]></title>
	<description><![CDATA[<p dir="auto"><span>Phylo</span>genomic Analysis Pipeline for&nbsp;<span>Herb</span>arium Specimens</p>
<p dir="auto"><span>What is PhyloHerb</span>: PhyloHerb is a wrapper program to process&nbsp;<span>genome skimming</span>&nbsp;data collected from plant materials. The outcomes include the plastid genome (plastome) assemblies, mitochondrial genome assemblies, nuclear ribosomal DNAs (NTS+ETS+18S+ITS1+5.8S+ITS2+28S), alignments of gene and intergenic regions, and a species tree. It is designed to be a high throughput program dealing with lower quality data. Examples include&nbsp;<span>low-coverage (5x cpDNA) plastome phylogeny, recycling plastid genes from target enrichment data, retrieving low-copy nuclear genes from medium coverage (5x nucDNA) genome skimming</span>.</p>
<p dir="auto"><span>License</span>: GNU General Public License</p>
<p dir="auto"><span>Citation</span>:</p>
<ul dir="auto">
<li>Cai, Liming, Hongrui Zhang, and Charles C. Davis. 2022. PhyloHerb: A high‐throughput phylogenomic pipeline for processing genome‐skimming data. Applications in Plant Sciences 10(3): 1&ndash;9.&nbsp;<a href="https://doi.org/10.1002/aps3.11475">https://doi.org/10.1002/aps3.11475</a></li>
</ul><p>Address of the bookmark: <a href="https://github.com/lmcai/PhyloHerb/" rel="nofollow">https://github.com/lmcai/PhyloHerb/</a></p>]]></description>
	<dc:creator>Abhi</dc:creator>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/19597/assistant-professor-at-gauhati-university-guwahati</guid>
  <pubDate>Tue, 16 Dec 2014 01:15:30 -0600</pubDate>
  <link></link>
  <title><![CDATA[Assistant Professor at GAUHATI UNIVERSITY, GUWAHATI]]></title>
  <description><![CDATA[
<p>Advt. No.T/2014/4</p>

<p>Ref. No. GU/Estt/T/308(VI)/2014/6451-61</p>

<p>Applications are invited from the Indian citizens for five (5) teaching posts of Assistant Professor (Contractual) under various departments of Gauhati University. Details of the advertisement, other terms and conditions and the application forms are available in the University website www.gauhati.ac.in</p>

<p>Asstt. Professor (Contractual)</p>

<p>    2. M.Sc. Microbiology Course in Botany</p>

<p>    3 1.M.Sc. Microbiology/M.Sc. Botany (Specialization in Microbiology)/M.Sc. Biochemistry (1 post). (Preference will be given to candidates having experience in Biochemistry).</p>

<p>    2.M.Sc. Microbiology/M.Sc. Botany (Specialization in Microbiology)/M.Sc. Biotechnology(1 post). (Preference will be given to candidates having experience in Bioinformatics).</p>

<p>    3.M.Sc. Microbiology/M.Sc. Botany (Specialization in Microbiology)/M.Sc.  Biotechnology(1 post). (Preference will be given to candidates having experience in Microbial Genetics).</p>

<p>As per UGC norms</p>

<p>Pay Band &amp; Academic Grade Pay : (Consolidated pay) : Rs. 21,600/- per month</p>

<p>Application Form : Prescribe application form may download from the G.U. website www.gauhati.ac.in</p>

<p>Last date of receipt of filled-in application is 08.01.2015.</p>

<p>Advertisement: www.gauhati.ac.in/openfile.php?file=Notice1258.pdf</p>
]]></description>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/blog/view/44773/genetic-basis-of-tail-loss-evolution</guid>
	<pubDate>Tue, 04 Mar 2025 12:12:36 -0600</pubDate>
	<link>https://bioinformaticsonline.com/blog/view/44773/genetic-basis-of-tail-loss-evolution</link>
	<title><![CDATA[Genetic basis of tail-loss evolution]]></title>
	<description><![CDATA[<p>The paper <em>"On the genetic basis of tail-loss evolution in humans and apes (https://www.nature.com/articles/s41586-024-07095-8)"</em>, published in <em>Nature</em>, investigates the genetic mechanisms that led to the loss of tails in humans and apes. The study suggests that a specific genetic mutation, involving the insertion of an <em>Alu</em> element (a type of transposable DNA sequence), played a critical role in the evolutionary transition from tailed primates to tailless hominoids.</p><h3><strong>Key Findings of the Study:</strong></h3><ol>
<li>
<p><strong>Alu Insertion and Tail Loss:</strong><br /> The researchers discovered an <em>Alu</em>-mediated genetic change in a common ancestor of modern apes and humans. This change disrupted the normal function of a gene involved in tail development, leading to the suppression of tail formation.</p>
</li>
<li>
<p><strong>Gene Disruption Mechanism:</strong><br /> The <em>Alu</em> insertion was found within a regulatory region of the <em>TBXT</em> gene (also known as <em>T</em> or <em>Brachyury</em>), which is crucial for tail development in vertebrates. This insertion likely altered the gene's expression patterns, leading to tail reduction over evolutionary time.</p>
</li>
<li>
<p><strong>Functional Evidence from Model Organisms:</strong><br /> To test their hypothesis, the researchers introduced similar genetic modifications in mice. The modified mice exhibited shortened or absent tails, supporting the idea that the identified mutation played a role in tail loss in hominoids.</p>
</li>
<li>
<p><strong>Evolutionary Implications:</strong><br /> The findings suggest that small, random genomic changes&mdash;such as transposable element insertions&mdash;can have profound effects on body morphology. This study provides evidence that mobile DNA elements (like <em>Alu</em>) can drive major evolutionary transitions.</p>
</li>
<li>
<p><strong>Relevance to Human Evolution:</strong><br /> Understanding the genetic basis of tail loss helps in reconstructing the evolutionary history of hominins (the lineage that includes humans and our extinct relatives). It also sheds light on how genetic variations contribute to anatomical diversity among primates.</p>
</li>
</ol><h3><strong>Significance of the Study:</strong></h3><p>This research highlights the role of transposable elements in shaping evolutionary traits and provides a concrete genetic explanation for a defining characteristic of humans and great apes. It also demonstrates how mutations in regulatory regions of developmental genes can lead to significant anatomical changes.</p>]]></description>
	<dc:creator>LEGE</dc:creator>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/19695/china-university-of-macau-phd-position-2015-in-bioinformatics-computer-science</guid>
  <pubDate>Mon, 22 Dec 2014 00:12:49 -0600</pubDate>
  <link></link>
  <title><![CDATA[China University of Macau PhD Position 2015 in Bioinformatics, Computer Science]]></title>
  <description><![CDATA[
<p>The Computational Biology and Bioinformatics Group at the University of Macau is inviting applications for PhD Position. Applicants will work on a research project focusing on the flexible receptor protein-ligand docking algorithms for computer-aided drug design.  The candidate will be working as part of a team in developing novel metaheuristic algorithms and scoring functions for large-scale, highly flexible protein-ligand docking problems. The duration of this PhD position is 2-3 years, starting in August 2015. Remuneration paid to candidate is MOP 11000-14000/month (~USD 1375-1750/month). The applications should be submitted before March 2015.</p>

<p>Study Subject(s): PhD position is award in the field of Bioinformatics/Computer Science.<br />Course Level: Position is available for pursuing PhD degree level at the University of Macau.<br />Scholarship Provider: University of Macau<br />Scholarship can be taken at: China</p>

<p>Eligibility: The ideal candidate would be a master degree holder in Bioinformatics or related disciplines with knowledge in Medical sciences or Life sciences (with GPA of at least 3.0 on a 4-point scale or equivalent) . Knowledge in programming (C and C++) and Linux scripting are necessary; experience in molecular docking, molecular dynamics simulations or molecular modeling is an advantage. The candidate should be fluent in spoken and written English; preference will be given to applicants with good publication records in relevant areas.</p>

<p>Scholarship Open for International Students: Researchers from China can apply for this PhD position.</p>

<p>Scholarship Description:</p>

<p>The Computational Biology and Bioinformatics Group at the University of Macau is looking for a motivated PhD student in Bioinformatics or Computer Science to work on a research project focusing on the flexible receptor protein-ligand docking algorithms for computer-aided drug design.  The candidate will be working as part of a team in developing novel metaheuristic algorithms and scoring functions for large-scale, highly flexible protein-ligand docking problems.</p>

<p>Number of award(s): There is only one PhD position available.</p>

<p>Duration of award(s): The duration of this PhD position is 2-3 years.</p>

<p>What does it cover? Remuneration paid to candidate is  MOP 11000-14000/month (~USD 1375-1750/month).</p>

<p>Selection Criteria: Not Known</p>

<p>Notification: Not Known</p>

<p>How to Apply: Send your current CV, your academic transcripts, a letter of motivation and research interests, two letters of recommendations from academic faculty to Dr. Shirley Siu at shirleysiu[at]umac.mo before March 2015.</p>

<p>Scholarship Application Deadline: The applications should be submitted before March 2015.</p>
]]></description>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/file/view/88/regular-expression-cheat-sheet</guid>
	<pubDate>Tue, 09 Jul 2013 17:38:42 -0500</pubDate>
	<link>https://bioinformaticsonline.com/file/view/88/regular-expression-cheat-sheet</link>
	<title><![CDATA[Regular Expression Cheat Sheet]]></title>
	<description><![CDATA[<p><span>The Regular Expression are the sole of Perl language, and for bioinformatician it is just a magical stick to resolve gingatic string data. We did not find any good and user friendly regular expression cheat sheet, hence write our own cheat sheet.&nbsp;</span><span>The Regular Expressions Cheat Sheet, a quick reference guide for regular expressions, including symbols, ranges, grouping, assertions and some sample patterns to get you started.</span></p>]]></description>
	<dc:creator>Jitendra Narayan</dc:creator>
	<enclosure url="https://bioinformaticsonline.com/file/download/88" length="14944" type="application/pdf" />
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/19811/jnu-neurosciencesystems-biologymathematical-modeling-jrf-vacancies</guid>
  <pubDate>Fri, 26 Dec 2014 11:22:20 -0600</pubDate>
  <link></link>
  <title><![CDATA[JNU Neuroscience/Systems Biology/Mathematical modeling JRF Vacancies]]></title>
  <description><![CDATA[
<p>School of Computational and Integrative Sciences<br />Jawaharlal Nehru University<br />New Delhi 110067</p>

<p>Recruitment for Project</p>

<p>Applications were invited from the citizens of India for filling up the following temporary position for the CSIR sponsored Fellowship in the School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi 110067. This position is temporary for a period of two and half years or tenable only for the duration of the project. The requisite qualifications &amp; experience are given below.</p>

<p>Project Title : "Understanding Complex dynamics and Information processing in Brain Networks"<br />Funding Agency : CSIR</p>

<p>Principal Investigator : Dr. R.K. Brojen Singh</p>

<p>Position : Junior Research Fellow(One post)</p>

<p>Salary : As per CSIR rules and guidelines for JRF.</p>

<p>Qualifications &amp; Experience : M.Sc. in Physics/Mathematics/Biology/B.Tech. In Eng. Physics/Comp. Sc. and desirable CSIR-UGC NET Qualified. Candidates should also have at least one years research experience after M. Sc./B.Tech. in works related to Neuroscience/Mathematical modeling.</p>

<p>Candidates possessing requisite qualifications may apply either on plain paper stating the project title along with CV and send to the following address or send as email attachment (pdf or word format) so as to reach on or before 8 January, 2014.</p>

<p>Dr. R.K. Brojen Singh<br />School of Computational and Integrative Sciences<br />Jawharlal Nehru University<br />New Delhi 110067<br />Email: brojen@jnu.ac.in, brojen@mail.jnu.ac.in</p>
]]></description>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/videolist/watch/3917/the-story-of-you-encode-and-the-human-genome</guid>
	<pubDate>Sat, 24 Aug 2013 18:49:03 -0500</pubDate>
	<link>https://bioinformaticsonline.com/videolist/watch/3917/the-story-of-you-encode-and-the-human-genome</link>
	<title><![CDATA[The Story of You: ENCODE and the human genome]]></title>
	<description><![CDATA[<iframe width="" height="" src="https://www.youtube-nocookie.com/embed/TwXXgEz9o4w" frameborder="0" allowfullscreen></iframe><p>Ever since a monk called Mendel started breeding pea plants we've been learning about our genomes. In 1953, Watson, Crick and Franklin described the structure of the molecule that makes up our genomes: the DNA double helix. Then, in 2001, scientists wrote down the entire 3-billion letter code contained in the average human genome. Now they're trying to interpret that code; to work out how it's used to make different types of cells and different people. The ENCODE project, as it's called, is the latest chapter in the story of you. To read the ENCODE research papers and more, visit http://www.nature.com/ENCODE</p>]]></description>
	
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	<guid isPermaLink="true">https://bioinformaticsonline.com/videolist/watch/4960/genome-epigenome-new-understanding-of-the-pathogens-in-your-food</guid>
	<pubDate>Fri, 27 Sep 2013 11:30:45 -0500</pubDate>
	<link>https://bioinformaticsonline.com/videolist/watch/4960/genome-epigenome-new-understanding-of-the-pathogens-in-your-food</link>
	<title><![CDATA[Genome + Epigenome = New Understanding of the Pathogens in Your Food]]></title>
	<description><![CDATA[<iframe width="" height="" src="https://www.youtube-nocookie.com/embed/hGtHs_C1BFA" frameborder="0" allowfullscreen></iframe>UC Davis's Bart Weimer describes foodborne pathogens and their proclivity for rapid genome rearrangement. The 100K Pathogen Genome Project he leads is using PacBio long-read sequencing to close genomes and analyze methylation; Weimer reports that his team has already discovered new epigenetic modifications in Salmonella and Listeria with the technology. www.pacb.com/microbe]]></description>
	
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	<guid isPermaLink="true">https://bioinformaticsonline.com/news/view/20015/illumina-smartphone-chip</guid>
	<pubDate>Tue, 30 Dec 2014 23:19:54 -0600</pubDate>
	<link>https://bioinformaticsonline.com/news/view/20015/illumina-smartphone-chip</link>
	<title><![CDATA[Illumina Smartphone Chip !!!]]></title>
	<description><![CDATA[<p>Illumina, the company that claims it brought human genome sequencing down to $1000 prices, has now turned its attention to a consumer product - a chip that you can plug into your smartphone and have it read your genetic information.<br /><br />The biggest challenge ahead of Illumina is simplifying the process of genetic sequencing. Currently, Illumina&rsquo;s DNA sequencers are gigantic machines that use techinques like colorimetry to work, but while the core technology is computational, it takes some 30 steps to extract genetic data and run it through. This process will likely have to be hugely simplified on mobile devices, given the fact that some studies require extracting 10 mililiters of blood. Illumina researchers are also working on finding the optimal technology for this on-chip DNA sequencing - be it electrical, optical, or other.<br /><br />Illumina is one of the most prominent names in genetics, often said to be the Intel of genetic sequencing, as just like Intel it provides the algorithms, the processing brain that runs a DNA reading task.<br /><br />In other recent smartphone-related biotech news, drug company Pfizer launched its REMOTE project, a new type of clinical trial that does not require going to a hospital for checks - targeted at patients with overactive bladder problems, the FDA-approved REMOTE project allowed to gather data from patients from over 10 states remotely, via mobile devices.<br /><br /></p><p>This is indeed the Illumina answer to Apple's Health app, HealthBook, Google HealthFit.</p>]]></description>
	<dc:creator>Robert M Willioms</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/file/view/18653/genetic-code-amino-acid</guid>
	<pubDate>Sun, 26 Oct 2014 07:45:58 -0500</pubDate>
	<link>https://bioinformaticsonline.com/file/view/18653/genetic-code-amino-acid</link>
	<title><![CDATA[Genetic code - Amino Acid]]></title>
	<description><![CDATA[<p>The genetic code consists of 64 triplets of nucleotides. These triplets are called codons.With three exceptions, each codon encodes for one of the 20 amino acids used in the synthesis of proteins. That produces some redundancy in the code: most of the amino acids being encoded by more than one codon.</p><p>The image summarise all in one.</p><p>More at http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Codons.html</p>]]></description>
	<dc:creator>Poonam Mahapatra</dc:creator>
	<enclosure url="https://bioinformaticsonline.com/file/download/18653" length="226605" type="image/jpeg" />
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