BOL: Related items

Five key traits to seek out in potential bioinformatics candidates !!!

Jit — Mon, 10 Aug 2015 12:53:50 -0500

Genomics and proteomics data are being collected in bulk, but mostly, traditional biologist don’t know what to do with it. Perhaps this is the reason why (not only this!!! ) computational biologist/bioinformatics scientists are hot commodities in the research world.

In fact, there are huge demands for expert biological data analyst. It’s a fairly new (not exactly) hot area, these bioinformatician are invaluable because they know and understand the significance of biological data for your research and how you can use it for better understanding of biological problems.

The bioinformatics can discover biological patterns and stories in genomic and proteomics data. They can develop the pipeline needed to properly collect, store and analyse it.

Once your research group is ready to make a larger investment and hire a bioinformatician to gain a competitive edge, there are several key traits to seek out in potential candidates. The best bioinformatician are:

1. Highly Skilled - programming skills, experience with the biological software and tools.

The biological data won’t illuminate much if the scientist analysing it doesn’t possess practical programming skills, experience with the biological software and tools and a thorough understanding of basic biological stuff. A solid background in mathematics and statistics is also an indispensable trait.

2. Insight - Real vision, robust understanding and deep insight.

In order to hire the best bioinformatics and computational biologist scientist for your needs, it is always recommended and mostly practiced by the recruiters, to ask each contender to write and develop a sample script/presentation based on a specific set of data you provide. Then, explore the approaches used to deal with data provided and pick up those candidates who convey real vision, robust understanding and deep insight.

3. Energetic – Curiosity to explore

Mostly natural curiosity and enthusiasm for solving big biological problems coupled with an ability to transform data into a scientific stories may place one candidate above the rest. In addition to achieve that, the bioinformatician should be agile enough to quickly modify their methods to suit changes within a particular research.

4. Researcher – Publications

Look for someone who has a keen sense and understanding of concern biological problems. You can judge it by looking at previously published papers and data. It is always recommended to have a look at GitHub and other repository for codes written by her/him.

5. Impressive communicator - Insight that can’t be expressed is worthless.

Good bioinformatics scientists are able to uncover biological patterns and are willing to explain those patterns in clear and helpful ways through thoughtful and open communication. In other words, they should must have good scientific writing skills. A computational biologis/bioinformatician should know how to present the data and tell a scientific story through numbers/images.

ngs-bits - Short-read sequencing tools

Neel — Thu, 16 Jan 2020 23:14:00 -0600

Binaries of ngs-bits are available via Bioconda. Alternatively, ngs-bits can be built from sources:

Binaries for Linux/macOS
From sources for Linux/macOS
From sources for Windows

Address of the bookmark: https://github.com/imgag/ngs-bits

JRF in Bioinformatics @ Central University of Rajasthan

Thu, 20 Aug 2015 05:28:21 -0500

Central University of Rajasthan
Department of Biotechnology
School of Life Sciences
Bandarsindri, Distt. Ajmer

Applications are invited for one JRF position supported by DST sponsored project in Bioinformatics with Dr. Tarun Kumar Bhatt.

Title of the project: Molecular Modeling of malaria parasite ‘secretome’: A potential drug target

Fellowship: Rs. 14000 consolidated

Duration of project: 36 months.

Essential Qualification: Master’s degree in Biotechnology/Bioinformatics with minimum 55% marks. Age limit as per government rule.

Candidates with good experience of molecular modeling, In-silico screening, MD simulation and database formation will be preferred. Good knowledge of Linux operating system is desirable.

How to apply: Interested candidate can send soft copy of application in format given below to tarun@curaj.ac.in on or before 29/08/2015.

1. Name
2. Fathers name
3. Date of Birth
5. Age
6. Sex
7. Address
8. Telephone / mobile no.
9. Email:
10. Academic qualifications starting from 10th class.
11. Summary of experience in molecular modeling, In-silico screening and database formation.

General Conditions:

1.Selected candidate would be informed for date and time of the interview via email .
2. No TA/DA will be paid for attending the interview.

More at http://www.curaj.ac.in/2015/Rec/aug/Advertisement%20for%20post%20of%20JRF%20under%20DST%20project%28BioTech%29.pdf

Automatic Filtering, Trimming, Error Removing and Quality Control for fastq data

Rahul Nayak — Mon, 13 Nov 2017 05:10:23 -0600

Automatic Filtering, Trimming, Error Removing and Quality Control for fastq data
AfterQC can simply go through all fastq files in a folder and then output three folders: good, bad and QC folders, which contains good reads, bad reads and the QC results of each fastq file/pair.
Currently it supports processing data from HiSeq 2000/2500/3000/4000, Nextseq 500/550, MiniSeq...and other Illumina 1.8 or newer formats

Address of the bookmark: https://github.com/OpenGene/AfterQC

Bioinformatics Training Fellowship !!

Fri, 28 Aug 2015 16:02:25 -0500

Applications are invited from suitable candidates for six months ‘Training Fellowship’ in Bioinformatics under the BTISNET program of DBT in the Distributed Information Sub center (DISC) facility at NIPGR, New Delhi, under the supervision of Dr. Gitanjali Yadav, Scientist, NIPGR.

Project Title No. of post(s) Designation Stipend in Tenure Start End
Establishment of Distributed Information Sub-Centre (DISC) 02 Trainee Fellow / Student Fellow 5,000/- p.m Six months 01/01/2016 30/06/2016

Essential Qualification:

Traineeship: Candidate having B.Tech or Master Degree or equivalent in Bioinformatics/ Biotechnology with strong interest in Computational Biology and First class/ division throughout academic career may apply.

Studentship: Students currently pursuing the final year of B.Tech or Masters Degree or equivalent in Bioinformatics/ Biotechnology, requiring a thesis as a necessary pre-requisite for completion of respective degree and First class/ division throughout academic career may apply.

Desirable Qualification: Proficiency in Coding Algorithms and Bioinformatics Applications, evidenced by short trainings or computing courses.

The positions are purely temporary and co-terminus with the tenure of the training period as mentioned above. NIPGR reserves the right to select the candidate against the above fellowship depending upon the qualification and experience of the candidate. Reservations shall be as per Govt. of India norms. The applicants will have no claim implicit or explicit for consideration against any regular position of DISC/NIPGR.

Eligible candidates may apply online application form available

at http://www.nipgr.res.in/discform.html within 15 days from the date of

advertisement.Applications received through any other mode will be disqualified outright.

More at http://www.nipgr.res.in/discform.html

IONiseR: tools for the quality assessment of data produced by Oxford Nanopore’s MinION sequencer

Jit — Thu, 23 Nov 2017 10:24:19 -0600

This package is intended to provide tools for the quality assessment of data produced by Oxford Nanopore’s MinION sequencer. It includes a functions to generate a number plots for examining the statistics that we think will be useful for this task.

However, nanopore sequencing is an emerging and rapidly developing technology. It is not clear what will be most informative. We hope that IONiseR will provide a framework for visualisation of metrics that we haven’t thought of, and welcome feedback at mike.smith@embl.de.

If you’re not interested in the quality assement of the raw or event level data, and want to jump straight to the getting FASTQ format files from fast5 files you can go straight to the final section of this document.

Address of the bookmark: https://www.bioconductor.org/packages/devel/bioc/vignettes/IONiseR/inst/doc/IONiseR.html

RA Bioinformatics at University of Delhi

Thu, 10 Sep 2015 16:02:37 -0500

BIOINFORMATICS INFRASTRUCTURE FACILITY

GARGI COLLEGE (University of Delhi)

SiriFort Road, New Delhi-110049

Walk- in- interview Bioinformatics Infrastructure Facility (BIF), Gargi College, University of Delhi invites to appear for interview on 29th September, 2015 at 9.30 AM for filling up the following purely temporary position sponsored by DBT, New Delhi.

1. Traineeship – 01 (one post) purely temporary for a period of six months.

Salary: Rs.8000/- p.m. fixed.

Essential Qualification: Post Graduate degree in Bioinformatics or any other branch of Life Sciences preferably with dissertation in Bioinformatics.

Desirable Qualification: Prior knowledge of programming languages such as C, VB, SQL etc. and software/database development.

2. Research Associate-01(one post) purely temporary for a period of nine months.

Salary: Rs 36000/-+HRA p.m fixed.

Essential Qualification: PhD in Bioinformatics/Biological Sciences/Computer Science or allied sciences with proven experience in bioinformatics.

3. Studentship- 01 (one post) purely temporary for a period of six months.

Salary: Rs.8000/- p.m. fixed.

Essential Qualifications: Final year Post Graduate students pursuing a degree in Bioinformatics or any branch of Life Science with knowledge of bioinformatics.

Interested candidates are required to appear for the walk in interview on 29th September, 2015 at 9.30 AM in Principal’s Office, Gargi College, Sirifort Road, N. Delhi-110049, with their CVs, original documents and a set of Photostat copies of all original documents. Conditions: The original documents must be produced at the time of interview, otherwise will not be allowed to attend the same. No TA & DA will be paid for appearing in the interview. The institute reserves the right to fill or not to fill the positions depending upon qualifications/credentials of the candidates etc. The appointment does not confer any right over the job and will not be considered as institute’s service. Dr Aparajita Mohanty Dr Shashi Tyagi (Co-coordinator,BIF) (Coordinator, BIF)

http://gargi.du.ac.in/uploads/ngrey/News/Gargi_Advt_BIF_2015.pdf

GraphMap - A highly sensitive and accurate mapper for long, error-prone reads

Jit — Wed, 07 Jun 2017 04:18:16 -0500

GraphMap - A highly sensitive and accurate mapper for long, error-prone reads http://www.nature.com/ncomms/2016/160415/ncomms11307/full/ncomms11307.html

Features

    Mapping position agnostic to alignment parameters.
    Consistently very high sensitivity and precision across different error profiles, rates and sequencing technologies even with default parameters.
    Circular genome handling to resolve coverage drops near ends of the genome.
    E-value.
    Meaningful mapping quality.
    Various alignment strategies (semiglobal bit-vector and Gotoh, anchored).
    Overlapping of reads for de novo assembly.
    Transcriptome mapping through internal construction of a transcriptome from a given genomic reference and a GTF file.
    ...and much more.

GraphMap is also used as an overlapper in a new de novo genome assembly project called Ra (https://github.com/mariokostelac/ra-integrate).
Ra attempts to create de novo assemblies from raw nanopore and PacBio reads without requiring error correction, for which a highly sensitive overlapper is required.

Currently, development of a new spliced-alignment mode for mapping RNA-seq reads is under way.
Description of the current effort as well as how to reach the experimental implementation can be found here: doc/rnaseq.md.

Address of the bookmark: https://github.com/isovic/graphmap

National Research Centre on Plant Biotechnology for RA/JRF positions

Sat, 26 Sep 2015 20:32:49 -0500

National Research Centre on Plant Biotechnology - New Delhi, Delhi
National Research Centre on Plant Biotechnology recruitments job vacancies for RA/JRF positions

Name of post: Research Associate
Salary: Rs.36000/-+ 30% HRA*
Educational Qualification: Candidates should have PhD in Biotechnology / Bioinformatics Life Sciences (or) M.Sc Biotechnology / Bioinformatics with three years research experience in relevant field

Name of post: Junior Research Fellow
Salary: Rs.25000/-+ 30% HRA*
Educational Qualification: Candidates should have M.Sc in Biotechnology /Bioinformatics / Life Sciences with 1st Division or 60% marks or equivalent overall grade point from any recognized professional University

Age Limit: 35 years max. (5 years relaxation for SC/ST/OBC)

How to attend walk in interview?
Interested candidates may attend Walk- in-interview on 1st October, 2015 at 10 am at NRCPB, LBS Building, Pusa Campus, and New Delhi-110012 at the above address along with updated Bio-data (CV), ID Proof & attested copies of Certificates and Original to prove qualification & Experience.

Recruitment reference: http://www.nrcpb.org/jobslist

Reference-free prediction of rearrangement breakpoint reads

Neel — Thu, 08 Mar 2018 05:05:25 -0600

lideSort-BPR ( b reak p oint r eads) is based on a fast algorithm for all-against-all comparisons of short reads and theoretical analyses of the number of neighboring reads. When applied to a dataset with a sequencing depth of 100×, it finds ∼88% of the breakpoints correctly with no false-positive reads. Moreover, evaluation on a real prostate cancer dataset shows that the proposed method predicts more fusion transcripts correctly than previous approaches, and yet produces fewer false-positive reads. To our knowledge, this is the first method to detect breakpoint reads without using a reference genome.

https://github.com/ewijaya/slidesort-bpr

Address of the bookmark: https://code.google.com/archive/p/slidesort-bpr/