BOL: Related items

4273π: Bioinformatics education on low cost ARM hardware

Jitendra Narayan — Mon, 02 Sep 2013 07:02:43 -0500

Are you teaching bioinformatics at universities and found it complicated by typical computer classroom settings. As well as running software locally and online, students should gain experience of systems administration. Hmm don't worry there is one new OS for the rescue. 4273π, an operating system image for Raspberry Pi based on Raspbian Linux. It provides an attractive, general-purpose computing environment, within which the course 4273π Bioinformatics for Biologists is embedded.

Though far slower than current desktop and laptop computers, the Raspberry Pi is notably faster than the Cray 1 supercomputer, a marvel of computer speed in its day. The Raspberry Pi approach includes all the benefits of the laptop approach, above, but at lower cost. In addition, the Raspberry Pi is a new and exciting computer system, which in itself can add interest to the course.

As the Raspbian operating system, Raspberry Pi firmware and hardware and 4273π Bioinformatics for Biologists teaching material develop, further releases of 4273π will be made available. It is anticipated that there will be a minimum of two releases per year during the next four years.

4273π is a means to teach bioinformatics, including systems administration tasks, to undergraduates at low cost.

Descriptive paper @ http://www.biomedcentral.com/1471-2105/14/243

Image source: BMC Bioinformatics

Huber Lab

Mon, 09 Sep 2013 21:57:03 -0500

The Huber group develops computational and statistical methods to design and analyse novel experimental approaches in genetics and cell biology.

Future projects and goals

Large-scale systematic maps of gene-gene and gene-environment interactions by automated phenotyping, using image analysis, machine learning, sparse model building and causal inference.
DNA-, RNA- and ChIP-Seq and their applications to gene expression regulation: statistical and computational foundations.
Cancer genomics, genomes as biomarkers, cancer phylogeny.
Image analysis for systems biology: measuring the dynamics of cell cycle and of cell migration of individual cells under normal conditions and many different perturbations (RNAi, drugs).

More @ http://www.embl.de/research/units/genome_biology/huber/index.html

jobTree based python wrapper to run the genome simulation tool suite Evolver

Jit — Fri, 08 Dec 2017 16:26:32 -0600

evolverSimControl (eSC) can be used to simulate multi-chromosome genome evolution on an arbitrary phylogeny (Newick format). In addition to simply running evolver, eSC also automatically creates statistical summaries of the simulation as it runs including text and image files. Also included are convenience scripts to: check on a running simulation and see detailed status and logging information; extract fasta sequence files from the leaf nodes of a completed simulation; extract pairwise multiple alignment files (.maf) from leaf and branch nodes from a completed simulation and with the help of mafJoin, join them together into a single maf covering the entire simulation.

Address of the bookmark: https://github.com/dentearl/evolverSimControl

Asst. PROF IN BIOINFORMATICS at JAIPUR NATIONAL UNIVERSITY

Thu, 12 Sep 2013 07:18:02 -0500

JAIPUR NATIONAL UNIVERSITY, SCHOOL OF LIFE SCIENCES (SIILAS CAMPUS) URGENTLY REQUIRES

Asst. PROF IN BIOINFORMATICS.

QUALIFICATION: AS PER UGC

DESIRABLE: 1 YEAR EXPERIENCE IN ACADEMICS

CONTACT immediately

Prof D.S.Bhatia
Director
9351288070

Last date within 7 days of the publication.

Find more @ http://jnujaipur.ac.in/downloads/AdvtDec2012.jpg

Magic-BLAST: a tool for mapping large next-generation RNA or DNA sequencing runs against a whole genome or transcriptome.

Jit — Tue, 26 Dec 2017 22:23:39 -0600

Magic-BLAST is a tool for mapping large next-generation RNA or DNA sequencing runs against a whole genome or transcriptome. Each alignment optimizes a composite score, taking into account simultaneously the two reads of a pair, and in case of RNA-seq, locating the candidate introns and adding up the score of all exons. This is very different from other versions of BLAST, where each exon is scored as a separate hit and read-pairing is ignored.

Magic-BLAST incorporates within the NCBI BLAST code framework ideas developed in the NCBI Magic pipeline, in particular hit extensions by local walk and jump (http://www.ncbi.nlm.nih.gov/pubmed/26109056), and recursive clipping of mismatches near the edges of the reads, which avoids accumulating artefactual mismatches near splice sites and is needed to distinguish short indels from substitutions near the edges.

Address of the bookmark: https://ncbi.github.io/magicblast/

Research Associate@ School of Computational and Integrative Sciences under Jawaharlal Nehru University

Fri, 22 Nov 2013 19:06:44 -0600

School of Computational and Integrative Sciences under Jawaharlal Nehru University, New Delhi invited applications for filling up 4 posts of Research Associates (RA) and Junior Research Fellow (JRF) (2 posts each) purely on temporary basis, liable to be terminated at any time without prior notice or ceased/withdrawn by the funding agency. The vacancies are for a Department of Biotechnology, Government of India funded project entitled "Computational Core for Plant Metabolomics" (Project ID: 632) being administered by Prof Indira Ghosh. Interested candidates should send their applications till 13 December 2013.
Important Dates
Last Date for receipt of applications: 13 December 2013
Vacancy Details
Total Vacancies: 4 posts
Type of recruitment: Temporary
Sl. No.: 01
Name of the Post: Research Associate
No of Posts: 1 post
Remuneration: Rs. 23000 + 30%
Qualifications: PhD in Bioinformatics / computational biology / Biophysics / Physical Chemistry / Computer Science. Computational experience, proven by paper published, is a necessary qualification.
Sl. No.: 02
Name of the Post: Research Associate
No of Posts: 1 post
Remuneration: Rs. 23000 + 30%
Qualifications: PhD in Computational Biology / Bioinformatics & related subjects. Computational experience, proven by paper published, is a necessary qualification.
Sl. No.: 03
Name of the Post: Junior Research Fellow
No of Posts: 1 post
Remuneration: Rs. 12000 + 30%
Qualifications: M. Sc. / B. Tech. preferably in Computational Biology /Bioinformatics and related fields with experience in Website designing & maintenance of Database.
Sl. No.: 04
Name of the Post: Junior Research Fellow
No of Posts: 1 post
Remuneration: Rs. 12000 + 30%
Qualifications: M. Sc. / MCA / B. Tech. preferably in Computational Biology / Computer science with experience in Programming in Java / Python, C++ etc & designing of Database.
Selection Procedure: Selection will be done on the basis of candidates’ performance in the Interview.
Candidates short-listed / selected for Interview will be informed through email only.
How to Apply: Interested eligible candidates should send their applications, in the prescribed format, along with their current CV by post to “Prof Indira Ghosh, Project Investigator, Hall#6, School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi-110 067” so as to reach the concerned authority by 13 December 2013.
Name of the post applied for’ must be superscripted on the envelope containing the application.
NOTE: For the post of Research Associates, only those candidates who have submitted thesis are eligible to apply. However, salary will be provided as per DBT / DST guidelines (i.e. candidates who have qualified NET /BET / BINC will have higher pay scale).
Candidates interested to register for PhD may not apply for JRF.
More @ http://www.jnu.ac.in/Career/currentjobs.htm

Carefully opt for human reference genome

biogeek — Tue, 18 Feb 2020 07:43:32 -0600

Heng Li posted several issues with the human reference genomes given in these resources and suggests the following compressed FASTA file to be used as hg38/GRCh38 human reference genome.

if you map reads to GRCh38 or hg38, use the following:

ftp://ftp.ncbi.nlm.nih.gov/genomes/all/GCA/000/001/405/GCA_000001405.15_GRCh38/seqs_for_alignment_pipelines.ucsc_ids/GCA_000001405.15_GRCh38_no_alt_analysis_set.fna.gz

There are several other versions of GRCh37/GRCh38. What’s wrong with them? Here are a collection of potential issues:

More at http://lh3.github.io/2017/11/13/which-human-reference-genome-to-use

Address of the bookmark: http://lh3.github.io/2017/11/13/which-human-reference-genome-to-use

Human Genome Meeting 2014, Geneva, Switzerland

Fri, 20 Sep 2013 12:36:44 -0500

The spectacular advances of the last few years resulted in the rapid analysis of the genome sequence of each individual. The biomedical world is now faced with the enormous challenges of assigning pathogenicity to each genomic variant, the functional analysis of the genome of each individual, and the accurate and detailed phenotypic characterization. Advances in these challenges are likely to fundamentally change the medical practice in a global scale.

This 2014 HUGO Meeting in Geneva will be a Forum for discussions on innovative approaches, and proposals to tackle the anticipated challenges.

Time : 27 April 2014 - 30 April 2014

For enquiries, please email hugo2014@mci-group.com or visit www.hugo-international.org

More at http://www.hgm2014-geneva.org/

Circlator: automated circularization of genome assemblies using long sequencing reads

Poonam Mahapatra — Tue, 15 May 2018 09:42:32 -0500

A tool to circularize genome assemblies. The algorithm and benchmarks are described in the Genome Biology manuscript. Citation: "Circlator: automated circularization of genome assemblies using long sequencing reads", Hunt et al, Genome Biology 2015 Dec 29;16(1):294. doi: 10.1186/s13059-015-0849-0. PMID: 26714481.

Address of the bookmark: http://sanger-pathogens.github.io/circlator/

Molecular and Computational Biology Research School

Fri, 20 Sep 2013 09:01:18 -0500

The ambition of the Molecular and Computational Biology Research School (MCB) is to create an attractive and stimulating training environment for PhD students in molecular and computational biology, both to better serve the needs for relevant training in the field, and to stimulate crossdiscipline developments in the research of the parties.

http://www.uib.no/rs/mcb