More at http://www.navinlab.com/navinlab/home.html

http://gkno.me/how-to/install.html

http://gkno.me/software.html

Address of the bookmark: http://gkno.me/

In the mid 1960's scientists discovered that many genomes contain stretches of highly repetitive DNA sequences ( see Reassociation Kinetics Experiments, and C-Value Paradox ). These sequences were later characterized and placed into five categories:

Simple Repeats - Duplications of simple sets of DNA bases (typically 1-5bp) such as A, CA, CGG etc.
Tandem Repeats - Typically found at the centromeres and telomeres of chromosomes these are duplications of more complex 100-200 base sequences.
Segmental Duplications - Large blocks of 10-300 kilobases which are that have been copied to another region of the genome.
Interspersed Repeats
Processed Pseudogenes, Retrotranscripts, SINES - Non-functional copies of RNA genes which have been reintegrated into the genome with the assitance of a reverse transcriptase.
DNA Transposons
Retrovirus Retrotransposons
Non-Retrovirus Retrotransposons ( LINES )

Currently up to 50% of the human genome is repetitive in nature and as improvements are made in detection methods this number is expected to increase.

On the other hand; In genetics, the term palindrome refers to a sequence of nucleotides along a DNA (deoxyribonucleic acid) or RNA (ribonucleic acid) strand that contains the same series of nitrogenous bases regardless from which direction the strand is analyzed. Akin to a language palindrome—wherein a word or phrase is spelled the same left-to-right as right-to-left (e.g., the word RADAR or the phrase "able was I ere I saw elba")—with genetic palindromes it does not matter whether the nucleic acid strand is read starting from the 3' (three prime) end or the 5' (five prime) end of the strand.

Recent research on palindromes centers on understanding palindrome formation during gene amplification. Other studies have attempted to relate palindrome formation to molecular mechanisms involved in double stranded breaks and in the formation of inverted repeats. Assisted by high speed computers, other groups of scientists link palindrome formation to the conservation of genetic information.

Related to the direction of transcription by RNA polymerase, DNA strands have upstream and downstream terminus defined by differing chemical groups at each end. The ends of each strand of DNA or RNA are termed the 5' (phosphate bound to the 5' position carbon) and 3' (phosphate bound to the 3' carbon) ends to indicate a polarity within the molecule. Using the letters A, T, C, G, to represent the nitrogenous bases adenine, thymine, cytosine, and guanine found in DNA, and the letters A, U, C, G to represent the nitrogenous bases adenine, uracil, cytosine, guanine found in RNA (Note that uracil in RNA replaces the thymine found in DNA), geneticists usually represent DNA by a series of base codes (e.g., 5' AATCGGATTGCA 3'). The base codes are usually arranged from the 5' end to the 3' end.

Because of specific base pairing in DNA (i.e., adenine (A) always bonds with (thymine (T) and cytosine (C) always bonds with guanine (G)) the complimentary stand to the sequence 5' AATCGGATTGCA 3' would be 3' TTAGCCTAACGT 5'.

With palindromes the sequences on the complimentary strands read the same in either direction. For example, a sequence of 5' GAATTC3' on one strand would be complimented by a 3' CTTAAG 5' strand. In either case, when either strand is read from the 5' prime end the sequence is GAATTC. Another example of a palindrome would be the sequence 5' CGAAGC 3' that, when reversed, still reads CGAAGC.

Palindromes are important sequences within nucleic acids. Often they are the site of binding for specific enzymes (e.g., restriction endobucleases) designed to cut the DNA strands at specific locations (i.e., at palindromes).

Palindromes may arise from brakeage and chromosomal inversions that form inverted repeats that compliment each other. When a palindrome results from an inversion, it is often referred to as an inverted repeat. For example, the sequence 5' CGAAGC 3', if inverted (reversed 180°), still reads CGAAGC.

The European Molecular Biology Open Software Suite (EMBOSS) includes some basic tools for finding tandem repeats and inverted repeats (see B.6.22. Applications in group Nucleic:repeats). There are many on-line services providing the EMBOSS tools, for example:

• Wageningen Bioinformatics Webportal EMBOSS explorer
• Mobyle@Pasteur
• Soaplab2 Web Services at Vital-IT

For more sophisticated repeat finding you will want to look at tools using Repbase for example:

• CENSOR
  • CENSOR@GIRI
  • CENSOR@EMBL-EBI
• RepeatMasker
• MUMmer (scan_for_match)
• Emboss Palindrome

Other nucleotide repeat finding methods found by a couple of web searches:

• Tandem Repeats Finder
• RECON
• RepeatRunner
• REPuter
• Imperfect Microsatellite Extractor (IMEx)
• Spectral Repeat Finder (SRF)
• REPFIND
• CRISPRfinder
• GrailEXP
• CONREPP
• find_palindromes
• Palindrome
• EMBOSS Palindrome
• Palindrome Search

Address of the bookmark: http://www.cytoscape.org/

School of Life Sciences

Department of Animal Biology

Applications are invited on a plane paper (along with copies of educational qualifications and experience) from eligible candidates for the selection of following position to work under a collaborative research project entitled “Development and application of high resolution genome conformation capture technology to investigate genome architecture in space and time” between University of Hyderabad and CR Rao advanced Institute of Mathematics, Statistics and Computer Sciences, sponsored by Department of Biotechnology, Government of India, New Delhi

Name and No. of positions JRF‐ONE

Emoluments for the position Rs. 25,000/p.m. + Eligible HRA

Qualifications MSc or M.Tech in any branch of biology/bioinformatics/computational biology/computer sciences/Mathematics/Physics

Duration Appointments are made initially for ONE year and can be extended further TWO years or until the duration of project

Our laboratory is interested in understanding signalling and spatiotemporal dynamics of 3‐Dimensional genome architecture and gene expression during embryonic stem cell differentiation by utilizing a combination of cellular, molecular genetics, Biochemical and computational tools in combination with next generation sequencing based chromatin structure analysing methods. Successful candidates shall pursue project related to either experimental or computational analysis of genome and Epigenomics data derived from human and mouse cells. Experience in Computational biology, bioinformatics, statistics, machine learning and algorithmic development is required. Knowledge of programming languages (e.g. C, C++, Perl, Python, Ruby etc.) and statistical framework (e.g. R, matlab, etc.) is preferable. Basic understanding of molecular biology will be an added advantage.

Interested candidates with the above mentioned qualification can send their curriculum vitae to Dr. K. Sreenivasulu, Department of Animal Biology, School of Life Sciences, South campus, University of Hyderabad or via email at positionssklab@gmail.com or svksl@uohyd.ernet.in.

Candidates with CSIR/UGC/ICMR/DBT/BINC qualifications if interested in above mentioned area of research are welcomed to approch principal investigator for a position leading to PhD. Last date for submission of applications is 17/06/2016. Eligible candidates will be called for an interview and they should carry all original certificates of the qualifying exam. No TA/ DA will be paid for attending the interview or at the time of joining the post.

Advertisement: http://www.uohyd.ac.in/images/recruitment/jrf_260516.pdf

More at http://www.ncbi.nlm.nih.gov/projects/HistoneDB2.0/index.fcgi/browse/

Address of the bookmark: http://www.ncbi.nlm.nih.gov/projects/HistoneDB2.0/index.fcgi/browse/

Publication:

• L. Salmela, R. Walve, E. Rivals, and E. Ukkonen: Accurate selfcorrection of errors in long reads using de Bruijn graphs. Accepted to RECOMB-Seq 2016.

Download:

• LoRMA 0.3 source files
• README

Address of the bookmark: https://www.cs.helsinki.fi/u/lmsalmel/LoRMA/

Karnal -132001 (Haryana)

A walk-in-Interview is proposed to be held at National Bureau of Animal Genetic Resources, Karnal (Haryana)-132001 at 10:30 AM on 05.09.2016 for the selection of Three Research Associate & One Young Professional - II as per details given below:

Name of the Scheme / Project: Center for Agricultural Bioinformatics. The post duration is Upto 31.032017 or earlier & Co-terminus with the project.

Research Associate (Three posts)

Date & Time of Interview: 10.30 A.M. on 05.09.2016

Essential Qualifications: PhD degree in any one of discipline/Subject Biotechnology/ Animal Genetics and Breeding/ Biochemistry/ Bioinformatics/Molecular Genetics OR Master’s degree in any one of above mentioned discipline/Subject with 4 years/5 years of Bachelor’s degree having 1st division or 60% marks or equivalent overall grade point average, with at least two years of research experience as evidenced from Fellowship/Associateship

Desirable Qualifications: Experience in Database/Next Generation Sequencing Data analysis for 02 RA posts or working experience in molecular biology, gene expression data analysis, SNP genotyping and sequence data analysis, functional gene characterization for 01 RA post.

Young Professionals II One position

Date & Time of Interview: 10.30 A.M. on 05.09.2016

Essential: B. Tech or M.Tech. in Bioinformatics / Computer Science / Computer Application.

Desirable: Experience in Linux, MySQL, Java, C++/ PHP/ PERL R based data analysis and application development in Bioinformatics.

More Info : http://14.139.252.116/ADvertisementforCabinScheme.pdf

Title of Project : 1. “Analysis Of The Structures Of Known Antimicrobial Peptides Using Machine Learning Algoitms And Molecular Dynamics Simulations”

Senior Research Fellow /1 Post

Qualification: First class M.Sc. in Bioinformatics/ Biological Sciences from recognized university with 2 years research experience and CSIR/UGC/ICMR net qualified OR First class M.Sc. in Bioinformatics/ Biological Sciences from recognized university with 2 years research experience Research experience in bioinformatics and wetlab methods.

Age: Not exceeding 35 Years

Pay Scale : Rs.18,000/- + 30% HRA Rs.14,000/- + 30% HRA

Project Assistant (Level-II) /1 Post

Qualification: First class M.Sc. in Bioinformatics/ Biological Sciences/Computer Sciences Training experience in bioinformatics and wetlab methods .

Age: Not exceeding 28 Years

Pay Scale : Rs.8,000
How to apply
Candidates must bring along with them all the relevant documents in original and one set of attested photocopies of the same and one passport size recent colour photograph.

Walk-in-Interview on 28.06.2016 between 09:00 hrs. to 12:00 hrs.

More at http://www.nirrh.res.in/links/job_oppotunities.htm

Source: http://www.nipgr.res.in/careers/vacancies_latest.php#
Form at http://www.nipgr.res.in/files/careers/format_RA_JRF_LA.doc