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	<title><![CDATA[BOL: Related items]]></title>
	<link>https://bioinformaticsonline.com/related/31087?offset=1620</link>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/researchlabs/view/872/jayaram-lab</guid>
  <pubDate>Sun, 14 Jul 2013 14:04:37 -0500</pubDate>
  <link></link>
  <title><![CDATA[Jayaram Lab]]></title>
  <description><![CDATA[
<p>Responsible (a) for developing Chemgenome, Bhageerath &amp; Sanjeevini methods &amp; softwares for genome annotation, protein tertiary structure prediction &amp; computer aided drug design respectively, (b) for setting up a multi-teraflop supercomputing facility for Bioinformatics &amp; Computational Biology at IIT Delhi, and (c) for making the hardware and software freely accessible at (www.scfbio-iitd.res.in) to the global scientific user community.</p>

<p>Faculty facilitator/Founder Director for two start-up companies (Leadinvent incubated at IIT, Delhi from 2006-2009 &amp; Novoinformatics, under incubation at IIT Delhi since 2011).</p>

<p>Research Interest <br />Genome Analysis, Protein Structure Prediction and Drug Design.</p>

<p>Link @ http://www.scfbio-iitd.res.in/</p>
]]></description>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/blog/view/36483/popular-bioinformatics-educational-resources</guid>
	<pubDate>Fri, 04 May 2018 19:43:21 -0500</pubDate>
	<link>https://bioinformaticsonline.com/blog/view/36483/popular-bioinformatics-educational-resources</link>
	<title><![CDATA[Popular bioinformatics educational resources !]]></title>
	<description><![CDATA[<p>Followings are the list of popular bioinformatics educational resources</p><p><a href="http://Bii.a-star.edu.sg"><strong>Bii.a-star.edu.sg</strong></a></p><p>Bio research and development. Has course information and research information.</p><p><a href="http://Isb-sib.ch"><strong>Isb-sib.ch</strong></a></p><p>SIB operates the ExPASy proteomics server and the Swiss node of EMBnet. Teaching activities include a series of post-graduate courses given at the Universities of Geneva and Lausanne, as well as at the EPFL, and a Masters Degree in bioinformatics. Major research areas include the development of integrated databases and software resources in the field of proteomics.</p><p><a href="http://Bioinformatics.ca"><strong>Bioinformatics.ca</strong></a></p><p>Provides information about bioinformatics in Canada. Workshops, certification and resources.</p><p><a href="http://Chickscope.beckman.uiuc.edu"><strong>Chickscope.beckman.uiuc.edu</strong></a></p><p>Students raise chicken embryos in the classroom and obtain magnetic resonance images through the Internet.</p><p><a href="http://Bcb.iastate.edu"><strong>Bcb.iastate.edu</strong></a></p><p>Graduate program at Iowa State University offering Undergraduate Major (BCBio) and the PhD program (BCB).</p><p><a href="http://Bu.edu/bioinformatics/"><strong>Bu.edu/bioinformatics/</strong></a></p><p>Interdisciplinary PhD and Masters Programs that include an internship in the local industry companies. In conjunction with the NE masters program.</p><p><a href="http://Bioinformatics.ubc.ca"><strong>Bioinformatics.ubc.ca</strong></a></p><p>A computational biology research centre covering many areas of genomics, proteomics, computer science and statistics. Research, training, news and events, resources and support, director's message, faculty and personnel.</p><p><a href="http://Openhelix.com"><strong>Openhelix.com</strong></a></p><p>Provides onsite training on specific bioinformatics databases and tools. Also offers bioinformatic software testing and research consulting services.</p><p><a href="http://Igb.uci.edu"><strong>Igb.uci.edu</strong></a></p><p>Specializing in making publicly available software and database services for computational biology.</p><p><a href="http://Bioinformatics.pe.kr"><strong>Bioinformatics.pe.kr</strong></a></p><p>Maintained by Dr. Seyeon Weon, Korea providing information on courses, a database archive, software archive and online resources.</p><p><a href="http://Groups.yahoo.com/group/bimatics/"><strong>Groups.yahoo.com/group/bimatics/</strong></a></p><p>Bioinformatics group for students interested and/or working in the bioinformatics/computationalbiology fields. Offers opportunities to exchanging information and sharing ideas.</p><p><a href="http://Ncbi.nlm.nih.gov/books/NBK22183/"><strong>Ncbi.nlm.nih.gov/books/NBK22183/</strong></a></p><p>Information about several medically important genes and related diseases. Illustrates the use of bioinformatics in their study.</p><p><a href="http://Bioinfo.mbb.yale.edu/mbb452a/2003/"><strong>Bioinfo.mbb.yale.edu/mbb452a/2003/</strong></a></p><p>Bioinformatics course at Yale University. All course slides are available online.</p><p><a href="http://Cs.iastate.edu/~honavar/comp-bio-courses.html"><strong>Cs.iastate.edu/~honavar/comp-bio-courses.html</strong></a></p><p>Listing of computational molecular biology course pages that have extensive online course materials.</p><p><a href="http://Bioinf.manchester.ac.uk/dbbrowser/bioactivity/prefacefrm.html"><strong>Bioinf.manchester.ac.uk/dbbrowser/bioactivity/prefacefrm.html</strong></a></p><p>A web-based tutorial associated with "Introduction to bioinformatics" published by Addison Wesley Longman.</p><p><a href="http://Northeastern.edu/bioinformatics/"><strong>Northeastern.edu/bioinformatics/</strong></a></p><p>From the Biology department and in cooperation with Boston University. Emphasis on the ability to integrate knowledge from biological, computational, and mathematical disciplines.</p><p><a href="http://Biocomp.unibo.it/lsbioinfo/"><strong>Biocomp.unibo.it/lsbioinfo/</strong></a></p><p>A two year, international master's programme in bioinformatics at the Universita di Bologna, Italy.</p><p><a href="http://Cs.helsinki.fi/bioinformatiikka/mbi/programme.html"><strong>Cs.helsinki.fi/bioinformatiikka/mbi/programme.html</strong></a></p><p>A two year Masters Degree Programme in Bioinformatics (MBI) offered by the University of Helsinki and Helsinki University of Technology, Finland.</p><p><a href="http://Ornl.gov/sci/techresources/Human_Genome/education/education.shtml"><strong>Ornl.gov/sci/techresources/Human_Genome/education/education.shtml</strong></a></p><p>A resource for introductory information on the Human Genome Project.</p><p><a href="http://His.se/bioinformatics"><strong>His.se/bioinformatics</strong></a></p><p>A one-year, international master's programme in bioinformatics at the University of Skovde, Sweden.</p><p><a href="http://Members.tripod.com/C.elegans/"><strong>Members.tripod.com/C.elegans/</strong></a></p><p>Resources in biochemical, molecular, cellular, system, and organism biology, including over 25,000 indexed links, accumulated since 2000, from topic menus or from search interface.</p><p><a href="http://Bioinformatics.org/faq/#contents"><strong>Bioinformatics.org/faq/#contents</strong></a></p><p>Summary of basics of bioinformatics for the intelligent newcomer.</p><p><a href="http://Jiscmail.ac.uk/archives/bioinformatics.html"><strong>Jiscmail.ac.uk/archives/bioinformatics.html</strong></a></p><p>Forum featuring various aspects, events and developments in the bioinformatics field.</p><p><a href="http://Biinoida.blogspot.com"><strong>Biinoida.blogspot.com</strong></a></p><p>Blog focusing on bioinformatics, biotechnology, pharma regulatory affairs, IPR and clinical trials.</p><p><a href="http://Colorbasepair.com/bioinformatics_courses_tutorials.html"><strong>Colorbasepair.com/bioinformatics_courses_tutorials.html</strong></a></p><p>A list of on-line course materials and tutorials for bioinformatics and computational biology.</p><p><a href="http://Geospiza.com/education/"><strong>Geospiza.com/education/</strong></a></p><p>Instructional materials for teaching bioinformatics. These include animated tutorials on topicssuch as BLAST, finding mutations in a protein, and graphing with MS-Excel.</p><p><a href="http://Bioinformatics.fi"><strong>Bioinformatics.fi</strong></a></p><p>An international, two-year Master's programme jointly managed by the University of Tampere and the University of Turku, Finland.</p><p><a href="http://Perlsource.net"><strong>Perlsource.net</strong></a></p><p>Provides online courses in Perl programming for bioinformatic tools.</p>]]></description>
	<dc:creator>Rahul Nayak</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/pages/view/920/bioinformatics-algorithms</guid>
	<pubDate>Tue, 16 Jul 2013 03:35:15 -0500</pubDate>
	<link>https://bioinformaticsonline.com/pages/view/920/bioinformatics-algorithms</link>
	<title><![CDATA[Bioinformatics Algorithms]]></title>
	<description><![CDATA[<p>An algorithm is a computable set of steps to achieve a desired result.</p><p>We use algorithms every day. For example, a recipe for baking a cake is an algorithm. Most programs, with the exception of some artificial intelligence applications, consist of algorithms. Inventing elegant algorithms -- algorithms that are simple and require the fewest steps possible -- is one of the principal challenges in programming. An algorithm is a description of a procedure which terminates with a result. In other words an algorithm is a set of instructions, sometimes called a procedure or a function, that is used to perform a certain task. This can be a simple process, such as adding two numbers together, or a complex function, such as adding effects to an image. For example, in order to sharpen a digital photo, the algorithm would need to process each pixel in the image and determine which ones to change and how much to change them in order to make the image look sharper.</p><p>In mathematics, computer science, and related subjects, an algorithm is an effective method for solving a problem using a finite sequence of instructions. Algorithms are used for calculation, data processing, and many other fields.<br />Each algorithm is a list of well-defined instructions for completing a task. Starting from an initial state, the instructions describe a computation that proceeds through a well-defined series of successive states, eventually terminating in a final ending state. The transition from one state to the next is not necessarily deterministic; some algorithms, known as randomized algorithms, incorporate randomness.</p><p><strong>History</strong></p><p>The origin of the term comes from the ancients. The concept becomes more precise with the use of variables in mathematics. Algorithm in the sense of what is now used by computers appeared as soon as first mechanical engines were invented.<br />The word algorithm comes from the name of the 9th century Persian Muslim mathematician Abu Abdullah Muhammad ibn Musa Al-Khwarizmi. The word algorism originally referred only to the rules of performing arithmetic using Hindu-Arabic numerals but evolved via European Latin translation of Al-Khwarizmi's name into algorithm by the 18th century. The use of the word evolved to include all definite procedures for solving problems or performing tasks.<br />The algorithm of Archimedes gives an approximation of the Pi number.<br />Eratosthenes has defined an algorithim for retrieving prime numbers.<br />Averro&egrave;s (1126-1198) was using algorithmic methods for calculations.<br />Adelard de Bath (12 th) introduces the algorismus term, from Al-Khwarizmi.<br />During the 1800's up to the mid-1900's:<br /><br />- George Boole (1847) has invented the binary algebra, the basis of computers. Actually he has unified logic and calculation in a common symbolism.<br /><br />- Gottlob Frege (1879) formula language's, that is a lingua characterica, a language written with special symbols, "for pure thought", that is free from rhetorical embellishments... constructed from specific symbols that are manipulated according to definite rules.<br /><br />- Giuseppe Peano (1888) It's The principles of arithmetic, presented by a new method was the first attempt at an axiomatization of mathematics in a symbolic language.<br /><br />- Alfred North Whitehead and Bertrand Russell in their Principia Mathematica (1910-1913) has further simplified and amplified the work of Frege.<br /><br />- Kurt Go&euml;del (1931) cites the paradox of the liar that completely reduces rules of recursion to numbers.<br /><br />The concept of algorithm was formalized in 1936 through Alan Turing's Turing machines and Alonzo Church's lambda calculus, which in turn formed the foundation of computer science.<br />Stephen C. Kleene (1943) defined his now-famous thesis known as the "Church-Turing Thesis". In this context:<br /><br />" Algorithmic theories... In setting up a complete algorithmic theory, what we do is to describe a procedure, performable for each set of values of the independent variables, which procedure necessarily terminates and in such manner that from the outcome we can read a definite answer, "yes" or "no," to the question, "is the predicate value true?"</p><p><strong>Classification</strong></p><p><strong>Classification by purpose</strong></p><p>Each algorithm has a goal, for example, the purpose of the Quick Sort algorithm is to sort data in ascending or descending order. But the number of goals is infinite, and we have to group them by kind of purposes:</p><p><strong>Classification by implementation</strong></p><p>An algorithm may be implemeted according to different basical principles.</p><ul>
<li>Recursive or iterative</li>
</ul><p>A recursive algorithm is one that calls itself repeatedly until a certain condition matches. It is a method common to functional programming.&nbsp;<br />Iterative algorithms use repetitive constructs like loops.<br />Some problems are better suited for one implementation or the other. For example, the towers of hanoi problem is well understood in recursive implementation. Every recursive version has an iterative equivalent iterative, and vice versa.</p><ul>
<li>Logical or procedural</li>
</ul><p>An algorithm may be viewed as controlled logical deduction.&nbsp;<br />A logic component expresses the axioms which may be used in the computation and a control component determines the way in which deduction is applied to the axioms.&nbsp;<br />This is the basis of the logic programming. In pure logic programming languages the control component is fixed and algorithms are specified by supplying only the logic component.</p><ul>
<li>Serial or parallel</li>
</ul><p>Algorithms are usually discussed with the assumption that computers execute one instruction of an algorithm at a time. This is a serial algorithm, as opposed to parallel algorithms, which take advantage of computer architectures to process several instructions at once. They divide the problem into sub-problems and pass them to several processors. Iterative algorithms are generally parallelizable. Sorting algorithms can be parallelized efficiently.</p><ul>
<li>Deterministic or non-deterministic</li>
</ul><p>Deterministic algorithms solve the problem with a predefined process whereas non-deterministic algorithm must perform guesses of best solution at each step through the use of heuristics.<br /><br /><strong>Classification by design paradigm</strong></p><p>A design paradigm is a domain in research or class of problems that requires a dedicated kind of algorithm:</p><ul>
<li>Divide and conquer</li>
</ul><p>A divide and conquer algorithm repeatedly reduces an instance of a problem to one or more smaller instances of the same problem (usually recursively), until the instances are small enough to solve easily. One such example of divide and conquer is merge sorting. Sorting can be done on each segment of data after dividing data into segments and sorting of entire data can be obtained in conquer phase by merging them.<br />The binary search algorithm is an example of a variant of divide and conquer called decrease and conquer algorithm, that solves an identical subproblem and uses the solution of this subproblem to solve the bigger problem.</p><ul>
<li>Dynamic programming</li>
</ul><p>The shortest path in a weighted graph can be found by using the shortest path to the goal from all adjacent vertices.&nbsp;<br />When the optimal solution to a problem can be constructed from optimal solutions to subproblems, using dynamic programming avoids recomputing solutions that have already been computed.&nbsp;<br />- The main difference with the "divide and conquer" approach is, subproblems are independent in divide and conquer, where as the overlap of subproblems occur in dynamic programming.&nbsp;<br />- Dynamic programming and memoization go together. The difference with straightforward recursion is in caching or memoization of recursive calls. Where subproblems are independent, this is useless. By using memoization or maintaining a table of subproblems already solved, dynamic programming reduces the exponential nature of many problems to polynomial complexity.</p><ul>
<li>The greedy method</li>
</ul><p>A greedy algorithm is similar to a dynamic programming algorithm, but the difference is that solutions to the subproblems do not have to be known at each stage. Instead a "greedy" choice can be made of what looks the best solution for the moment.&nbsp;<br />The most popular greedy algorithm is finding the minimal spanning tree as given by Kruskal.</p><ul>
<li>Linear programming</li>
</ul><p>The problem is expressed as a set of linear inequalities and then an attempt is made to maximize or minimize the inputs. This can solve many problems such as the maximum flow for directed graphs, notably by using the simplex algorithm.&nbsp;<br />A complex variant of linear programming is called integer programming, where the solution space is restricted to all integers.</p><ul>
<li>Reduction also called transform and conquer</li>
</ul><p>Solve a problem by transforming it into another problem. A simple example: finding the median in an unsorted list is first translating this problem into sorting problem and finding the middle element in sorted list. The main goal of reduction is finding the simplest transformation possible.</p><ul>
<li>Using graphs</li>
</ul><p>Many problems, such as playing chess, can be modeled as problems on graphs. A graph exploration algorithms are used.&nbsp;<br />This category also includes the search algorithms and backtracking.<br /><br /><strong>The probabilistic and heuristic paradigm</strong></p><ul>
<li>Probabilistic</li>
</ul><p>Those that make some choices randomly.</p><ul>
<li>Genetic</li>
</ul><p>Attempt to find solutions to problems by mimicking biological evolutionary processes, with a cycle of random mutations yielding successive generations of "solutions". Thus, they emulate reproduction and "survival of the fittest".</p><ul>
<li>Heuristic</li>
</ul><p>Whose general purpose is not to find an optimal solution, but an approximate solution where the time or resources to find a perfect solution are not practical.</p><p><strong>Classification by complexity</strong></p><p>Some algorithms complete in linear time, and some complete in exponential amount of time, and some never complete.</p><p><strong>Algorithms resources on net.</strong></p><p><a href="http://www.cs.uga.edu/~cai/courses/compbio/2008fall/bookchapters/Chapter08/Ch08_GraphsDNAseq.pdf">Graph Algorithms in Bioinformatics</a></p><p><a href="http://zikuladevs.com/notes/Part%20II%20Revision/Bio_Alg_Descriptions[1].pdf">Bioinformatics Algorithms Description</a></p><p><a href="http://users.aims.ac.za/~marshall/BioinformaticsCourse.html">Bioinformatics Algorithms Course Page</a></p><p><a href="http://www.cybertory.org/downloads/bae/BioinformaticsAlgorithmsExcelDoc.pdf">Bioinformatics Algorithm Demonstrations</a></p><p><a href="http://www.cse.sc.edu/~maxal/csce590b/Lect01-02.pdf">Introduction to Bioinformatics Algorithms Lectures 1-2 by Dr. Max Alekseyev USC, 2009</a></p><p><a href="http://lectures.molgen.mpg.de/online_lectures.html">Online Lectures on Bioinformatics</a></p><p><a href="http://www.ks.uiuc.edu/Training/Tutorials/science/bioinformatics-tutorial/bioinformatics.pdf.bak">Sequence Alignment Algorithms</a></p><p><a href="http://www.avatar.se/molbioinfo2001/seqali-dyn.html">Algorithm for sequence alignment: dynamic programming</a></p><p><a href="http://www.4tphi.net/~awalters/PI/pi.pdf">Network Protocol Analysis using Bioinformatics Algorithms</a></p><p><strong>Bioinformatics Algorithms Links</strong></p><p><strong>Dynamic Programming</strong></p><p>Particularly good sites...</p><p>&bull;<a href="http://www.cis.upenn.edu/~sahuguet/MSA/">http://www.cis.upenn.edu/~sahuguet/MSA/</a><br />&bull;<a href="http://www.blc.arizona.edu/courses/bioinformatics/align.html">http://www.blc.arizona.edu/courses/bioinformatics/align.html</a><br />&bull;<a href="http://www.cs.monash.edu.au/~lloyd/tildeStrings/Notes/DPA.html">http://www.cs.monash.edu.au/~lloyd/tildeStrings/Notes/DPA.html</a><br />&bull;<a href="http://www.cs.orst.edu/~schut/cs325/dynamic.htm">http://www.cs.orst.edu/~schut/cs325/dynamic.htm</a><br />&bull;<a href="http://www.catalase.com/dprog.htm">http://www.catalase.com/dprog.htm</a><br />&bull;<a href="http://bioweb.ncsa.uiuc.edu/~bioph490/BIOPH2.html#SEQUENCE_COMP">http://bioweb.ncsa.uiuc.edu/~bioph490/BIOPH2.html#SEQUENCE_COMP</a><br />&bull;<a href="http://www.qucis.queensu.ca/home/cisc365/javascript/dp1/index.html">http://www.qucis.queensu.ca/home/cisc365/javascript/dp1/index.html</a><br />Other sites...<br />&bull;<a href="http://bioweb.ncsa.uiuc.edu/~bioph490/dynamic_programming_demo.html">http://bioweb.ncsa.uiuc.edu/~bioph490/dynamic_programming_demo.html</a><br />&bull;<a href="http://www.qucis.queensu.ca/home/cisc365/365overheads.html">http://www.qucis.queensu.ca/home/cisc365/365overheads.html</a><br />&bull;<a href="http://www.qucis.queensu.ca/home/cisc365/dp/dp.p01.html">http://www.qucis.queensu.ca/home/cisc365/dp/dp.p01.html</a><br />&bull;<a href="http://www.dgp.toronto.edu/csc270/tut_dp.html">http://www.dgp.toronto.edu/csc270/tut_dp.html</a><br />&bull;<a href="http://queue.ieor.berkeley.edu/~jshu/knapsack/DP/dp.html">http://queue.ieor.berkeley.edu/~jshu/knapsack/DP/dp.html</a><br />&bull;<a href="http://mat.gsia.cmu.edu/classes/dynamic/dynamic.html">http://mat.gsia.cmu.edu/classes/dynamic/dynamic.html</a><br />&bull;<a href="http://www.cs.sandia.gov/~scistra/class_3">http://www.cs.sandia.gov/~scistra/class_3</a><br />&bull;<a href="http://levine.sscnet.ucla.edu/Econ101/dynamic.htm">http://levine.sscnet.ucla.edu/Econ101/dynamic.htm</a><br />&bull;<a href="http://mat.gsia.cmu.edu/classes/stoch_dynamic/stoch_dynamic.html">http://mat.gsia.cmu.edu/classes/stoch_dynamic/stoch_dynamic.html</a><br />&bull;<a href="http://mat.gsia.cmu.edu/classes/dynamic/node8.html">http://mat.gsia.cmu.edu/classes/dynamic/node8.html</a><br />&bull;<a href="http://www.maths.mu.oz.au/~moshe/dp/bibl/bibliography.html">http://www.maths.mu.oz.au/~moshe/dp/bibl/bibliography.html</a><br />&bull;<a href="http://cartan.gmd.de/PAPER/ismb95/ismb_html.html">http://cartan.gmd.de/PAPER/ismb95/ismb_html.html</a><br />&bull;<a href="http://screwdriver.bu.edu/bibliography/dynamic_programming.htm">http://screwdriver.bu.edu/bibliography/dynamic_programming.htm</a><br />&bull;<a href="http://www.norvig.com/design-patterns/">http://www.norvig.com/design-patterns/</a><br />&bull;<a href="http://tome.cbs.univ-montp1.fr/htmltxt/Doc/manual/node137.html">http://tome.cbs.univ-montp1.fr/htmltxt/Doc/manual/node137.html</a><br />&bull;<a href="http://poem.princeton.edu/~verdu/dynamic.html">http://poem.princeton.edu/~verdu/dynamic.html</a><br />&bull;<a href="http://www.orca1.com/opushelpweb/opusDynamic_Programming.html">http://www.orca1.com/opushelpweb/opusDynamic_Programming.html</a><br />&bull;<a href="http://screwdriver.bu.edu/cn760-lectures/l7/index.htm">http://screwdriver.bu.edu/cn760-lectures/l7/index.htm</a><br />&bull;<a href="http://www.ms.unimelb.edu.au/~moshe/dp/dp.html">http://www.ms.unimelb.edu.au/~moshe/dp/dp.html</a><br />&bull;<a href="http://mat.gsia.cmu.edu/ORCS/0255.html">http://mat.gsia.cmu.edu/ORCS/0255.html</a><br />&bull;<a href="http://aae.wisc.edu/e703/notes/a13dynpr.htm">http://aae.wisc.edu/e703/notes/a13dynpr.htm</a><br />&bull;<a href="http://bioweb.pasteur.fr/docs/modeller/node137.html">http://bioweb.pasteur.fr/docs/modeller/node137.html</a><br />&bull;<a href="http://www2.uwindsor.ca/~lama/my470/ddynamic.htm">http://www2.uwindsor.ca/~lama/my470/ddynamic.htm</a><br />&bull;<a href="http://students.ceid.upatras.gr/~papagel/project/ex5_6_1.htm">http://students.ceid.upatras.gr/~papagel/project/ex5_6_1.htm</a><br />&bull;<a href="http://www.cs.sunysb.edu/~algorith/lectures-good/node12.html">http://www.cs.sunysb.edu/~algorith/lectures-good/node12.html</a><br />&bull;<a href="http://www.cs.sunysb.edu/~algorith/lectures-good/node12.html">http://www.cs.sunysb.edu/~algorith/lectures-good/node12.html</a><br />&bull;<a href="http://www.utdallas.edu/~scniu/documents/7315.htm">http://www.utdallas.edu/~scniu/documents/7315.htm</a><br />&bull;<a href="http://www.ii.uib.no/~pinar/seminar/larry.html">http://www.ii.uib.no/~pinar/seminar/larry.html</a><br />&bull;<a href="http://www.deakin.edu.au/~gecole/books.html">http://www.deakin.edu.au/~gecole/books.html</a><br />&bull;<a href="http://www.cseg.engr.uark.edu/~wessels/algs/notes/dynamic.html">http://www.cseg.engr.uark.edu/~wessels/algs/notes/dynamic.html</a><br />&bull;<a href="http://www.csc.liv.ac.uk/~ped/teachadmin/algor/dyprog.html">http://www.csc.liv.ac.uk/~ped/teachadmin/algor/dyprog.html</a><br />&bull;<a href="http://www.eli.sdsu.edu/courses/fall96/cs660/notes/dynamicProg/dynamicProg.html">http://www.eli.sdsu.edu/courses/fall96/cs660/notes/dynamicProg/dynamicProg.html</a><br />&bull;<a href="http://www.cs.indiana.edu/l/www/ftp/techreports/TR514.html">http://www.cs.indiana.edu/l/www/ftp/techreports/TR514.html</a><br />&bull;<a href="http://www.cs.brandeis.edu/~mairson/poems/node3.html">http://www.cs.brandeis.edu/~mairson/poems/node3.html</a><br />&bull;<a href="http://www.cis.tu-graz.ac.at/igi/oaich/animations/Dynamic2.html">http://www.cis.tu-graz.ac.at/igi/oaich/animations/Dynamic2.html</a><br />&bull;<a href="http://bioweb.ncsa.uiuc.edu/~workshop/">http://bioweb.ncsa.uiuc.edu/~workshop/</a></p><p><br />Smith Waterman<br />&bull;<a href="http://genome-www.stanford.edu/Saccharomyces/help/sw_alignment.html">http://genome-www.stanford.edu/Saccharomyces/help/sw_alignment.html</a><br />&bull;<a href="http://genome-www.stanford.edu/Saccharomyces/help/sw_details.html">http://genome-www.stanford.edu/Saccharomyces/help/sw_details.html</a><br />&bull;<a href="http://www.stanford.edu/~sntaylor/bioc218/final.htm">http://www.stanford.edu/~sntaylor/bioc218/final.htm</a><br />&bull;<a href="http://www.maths.tcd.ie/~lily/pres2/sld009.htm">http://www.maths.tcd.ie/~lily/pres2/sld009.htm</a><br />&bull;<a href="http://bioweb.ncsa.uiuc.edu/~workshop/Lab_3/Smith-Waterman.htm">http://bioweb.ncsa.uiuc.edu/~workshop/Lab_3/Smith-Waterman.htm</a><br />&bull;<a href="http://www.tigem.it/LOCAL/SW/threshold.html">http://www.tigem.it/LOCAL/SW/threshold.html</a><br />&bull;<a href="http://sgbcd.weizmann.ac.il/genweb/help/smith-waterman.html">http://sgbcd.weizmann.ac.il/genweb/help/smith-waterman.html</a><br />&bull;<a href="http://cbrg.ethz.ch/ServerBooklet/section2_3_5.html">http://cbrg.ethz.ch/ServerBooklet/section2_3_5.html</a><br />Needleman &amp; Wunsch<br />&bull;<a href="http://www.maths.tcd.ie/~lily/pres2/sld003.htm">http://www.maths.tcd.ie/~lily/pres2/sld003.htm</a><br />&bull;<a href="http://acer.gen.tcd.ie/~amclysag/nwswat.html">http://acer.gen.tcd.ie/~amclysag/nwswat.html</a><br />&bull;<a href="http://www.nada.kth.se/~erikw/thesis/chapter2_3.html">http://www.nada.kth.se/~erikw/thesis/chapter2_3.html</a><br />&bull;<a href="http://www.irbm.it/irbm-course95/gb/docs/amps/subsection3_6_1.html">http://www.irbm.it/irbm-course95/gb/docs/amps/subsection3_6_1.html</a><br />&bull;<a href="http://www.ibc.wustl.edu/~zuker/Bio-5495/align-html/node3.html">http://www.ibc.wustl.edu/~zuker/Bio-5495/align-html/node3.html</a></p><p><strong>General (NW vs. SW vs. HMM, etc.)</strong></p><p>&bull;<a href="http://www.maths.tcd.ie/~lily/pres2/">http://www.maths.tcd.ie/~lily/pres2/</a><br />&bull;<a href="http://acer.gen.tcd.ie/~amclysag/nwswat.html">http://acer.gen.tcd.ie/~amclysag/nwswat.html</a><br />&bull;<a href="http://laguerre.psc.edu/biomed/TUTORIALS/SEQUENCE/MULTIPLE/tutorial.html">http://laguerre.psc.edu/biomed/TUTORIALS/SEQUENCE/MULTIPLE/tutorial.html</a><br />&bull;<a href="http://www.cse.ucsc.edu/research/compbio/">http://www.cse.ucsc.edu/research/compbio/</a></p><p><strong>Hmms</strong></p><p>&bull;<a href="http://www.medmicro.mds.qmw.ac.uk/HMMER/main.html">http://www.medmicro.mds.qmw.ac.uk/HMMER/main.html</a><br />&bull;<a href="http://alfredo.wustl.edu/ismb96/abs/p02.html">http://alfredo.wustl.edu/ismb96/abs/p02.html</a><br />&bull;<a href="http://www.cse.ucsc.edu/research/compbio/html_format_papers/hughkrogh96/cabios.html">http://www.cse.ucsc.edu/research/compbio/html_format_papers/hughkrogh96/cabios.html</a><br />&bull;<a href="http://wwwsyseng.anu.edu.au/~jason/hmmlinks.html">http://wwwsyseng.anu.edu.au/~jason/hmmlinks.html</a><br />&bull;<a href="http://www.breadfan.com/markov.html">http://www.breadfan.com/markov.html</a><br />&bull;<a href="http://cslu.cse.ogi.edu/HLTsurvey/ch1node34.html">http://cslu.cse.ogi.edu/HLTsurvey/ch1node34.html</a><br />&bull;<a href="http://www.ibc.wustl.edu/service/hmmalign/glocal.html">http://www.ibc.wustl.edu/service/hmmalign/glocal.html</a><br />&bull;<a href="http://www.cse.ucsc.edu/research/compbio/html_format_papers/ismb94/node5.html">http://www.cse.ucsc.edu/research/compbio/html_format_papers/ismb94/node5.html</a><br />&bull;<a href="http://www.iscs.nus.edu.sg/~luakt/ic3222/lecture/nlp18new/index.htm">http://www.iscs.nus.edu.sg/~luakt/ic3222/lecture/nlp18new/index.htm</a><br />&bull;<a href="http://www.cse.ucsc.edu/research/compbio/sam.html">http://www.cse.ucsc.edu/research/compbio/sam.html</a>&nbsp;SAM Software for HMMs</p><p><strong>Genetic Algorithms</strong><br /><br />&bull;<a href="http://www.staff.uiuc.edu/~carroll/ga.html">http://www.staff.uiuc.edu/~carroll/ga.html</a><br />&bull;<a href="http://kal-el.ugr.es/gags.html">http://kal-el.ugr.es/gags.html</a><br />&bull;<a href="http://kal-el.ugr.es/~jmerelo/GAJS.html">http://kal-el.ugr.es/~jmerelo/GAJS.html</a><br />&bull;<a href="http://www.genetic-programming.org/">http://www.genetic-programming.org/</a><br />&bull;<a href="http://www.iitk.ac.in/kangal/deb_tut.shtml">http://www.iitk.ac.in/kangal/deb_tut.shtml</a></p>]]></description>
	<dc:creator>Jitendra Narayan</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/38472/gpsrdocker-docker-based-container-that-contain-all-softwareweb-servers-developed-in-the-field-of-bioinformatics</guid>
	<pubDate>Sun, 16 Dec 2018 13:04:46 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/38472/gpsrdocker-docker-based-container-that-contain-all-softwareweb-servers-developed-in-the-field-of-bioinformatics</link>
	<title><![CDATA[gpsrdocker: docker-based container that contain all software/web servers developed in the field of bioinformatics.]]></title>
	<description><![CDATA[<p><span>GPSRdocker (</span><a href="http://webs.iiitd.edu.in/gpsrdocker/">http://webs.iiitd.edu.in/gpsrdocker/</a><span>) is&nbsp; Presently it contain software developed at G. P. S. Raghava's group (</span><a href="http://webs.iiitd.edu.in/raghava/">http://webs.iiitd.edu.in/raghava/</a><span>&nbsp;). </span></p>
<p><span>The programs and the package are free software for academic users. Permission to use, copy, and modify any part of this software for educational, research and non-profit purposes is hereby granted. In this package or Docker image, number of other supported software has been integrated which may be under other licenses, along with any direct or indirect dependencies of the primary software being contained. As for any pre-built image usage, it is the image user's responsibility to ensure that any use of this image complies with any relevant licenses for all software contained within. </span></p>
<p><span>All software packages are distributed in the hope that they will be useful but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. If you have any query, please contact at raghava@iiitd.ac.in.</span></p><p>Address of the bookmark: <a href="https://hub.docker.com/r/raghavagps/gpsrdocker/" rel="nofollow">https://hub.docker.com/r/raghavagps/gpsrdocker/</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
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<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/pages/view/1161/genomics-for-bioinformatician</guid>
	<pubDate>Sat, 20 Jul 2013 07:03:00 -0500</pubDate>
	<link>https://bioinformaticsonline.com/pages/view/1161/genomics-for-bioinformatician</link>
	<title><![CDATA[Genomics for Bioinformatician]]></title>
	<description><![CDATA[<p>Genomics is the study of the genomes of organisms. The field includes intensive efforts to determine the entire DNA sequence of organisms and fine-scale genetic mapping efforts. The field also includes studies of intragenomic phenomena such as heterosis, epistasis, pleiotropy and other interactions between loci and alleles within the genome. In contrast, the investigation of the roles and functions of single genes is a primary focus of molecular biology or genetics and is a common topic of modern medical and biological research. Research of single genes does not fall into the definition of genomics unless the aim of this genetic, pathway, and functional information analysis is to elucidate its effect on, place in, and response to the entire genome's networks.<br /><br />Genomics was established by Fred Sanger when he first sequenced the complete genomes of a virus and a mitochondrion. His group established techniques of sequencing, genome mapping, data storage, and bioinformatic analyses in the 1970-1980s. A major branch of genomics is still concerned with sequencing the genomes of various organisms, but the knowledge of full genomes has created the possibility for the field of functional genomics, mainly concerned with patterns of gene expression during various conditions. The most important tools here are microarrays and bioinformatics. Study of the full set of proteins in a cell type or tissue, and the changes during various conditions, is called proteomics. A related concept is materiomics, which is defined as the study of the material properties of biological materials (e.g. hierarchical protein structures and materials, mineralized biological tissues, etc.) and their effect on the macroscopic function and failure in their biological context, linking processes, structure and properties at multiple scales through a materials science approach. The actual term 'genomics' is thought to have been coined by Dr. Tom Roderick, a geneticist at the Jackson Laboratory (Bar Harbor, ME) over beer at a meeting held in Maryland on the mapping of the human genome in 1986.<br /><br />The outcome of almost two years of intense discussions with literally hundreds of scientists and members of the public, has three major areas of focus: Genomics to Biology, Genomics to Health, and Genomics to Society.<br /><br /><strong><em>Genomics to Biology:</em></strong>&nbsp;<br />The human genome sequence provides foundational information that now will allow development of a comprehensive catalog of all of the genome's components, determination of the function of all human genes, and deciphering of how genes and proteins work together in pathways and networks.<br /><br /><strong><em>Genomics to Health:<br /></em></strong>Completion of the human genome sequence offers a unique opportunity to understand the role of genetic factors in health and disease, and to apply that understanding rapidly to prevention, diagnosis, and treatment. This opportunity will be realized through such genomics-based approaches as identification of genes and pathways and determining how they interact with environmental factors in health and disease, more precise prediction of disease susceptibility and drug response, early detection of illness, and development of entirely new therapeutic approaches.<br /><br /><strong><em>Genomics to Society:</em>&nbsp;<br /></strong>Just as the HGP has spawned new areas of research in basic biology and in health, it has created new opportunities in exploring the ethical, legal, and social implications (ELSI) of such work. These include defining policy options regarding the use of genomic information in both medical and non-medical settings and analysis of the impact of genomics on such concepts as race, ethnicity, kinship, individual and group identity, health, disease, and "normality" for traits and behaviors.<br /><br />This vision for the future of genomics is not just about the NHGRI. It encompasses the whole field of genomics, including the work of all the other Institutes and Centers at the NIH and of a number of other federal agencies. All of the NIH Institutes are already taking full advantage of the sequence and will apply its data to the better understanding of both rare and common diseases, almost all of which have a genetic component. A recent example of the way that the HGP and the knowledge and new technologies it has spawned are already facilitating science is the extremely rapid sequencing by groups in Canada and at the Centers for Disease Control and Prevention (CDC) in Atlanta of the genome of the virus that causes Severe Acute Respiratory Syndrome (SARS). The sequencing of the SARS virus genome provides insight into this new and deadly disease at a speed never before possible in science. In turn, this should lead to the rapid development of diagnostic tests and, in time, vaccines and effective treatments.<br /><br /><strong>Links for the addition material available on Net</strong></p><p><a href="http://pevsnerlab.kennedykrieger.org/bioinformatics/bioinf10_genomes.htm">Genomes and genomics:</a></p><p><a href="http://www.123genomics.com/learning.html">Bioinformatics and Genomics:</a></p><p><a href="http://www.ebi.ac.uk/pdbe/docs/roadshow_tutorial/strgenomics/tutorial.html">Structural genomics tutorial:</a></p><p><a href="http://www.hgu.mrc.ac.uk/Users/Philippe.Gautier/tutorial/index.html">Comparative Genomics Tutorial:</a></p><p><a href="http://www.scfbio-iitd.res.in/tutorial/genomics.html">GENOME TUTORIAL:</a></p><p><a href="http://genomebiology.com/content/pdf/gb-2001-3-1-reviews2001.pdf">Tools and resources for identifying protein families, domains and motifs</a></p><p><a href="http://www.ornl.gov/sci/techresources/Human_Genome/posters/chromosome/tools.shtml">Bioinformatics Tools</a><a href="http://www.ornl.gov/sci/techresources/Human_Genome/posters/chromosome/tools.shtml">&nbsp;<br />Tips, Tutorials, and Terminology for Using Selected Resources in Genome Database Guide:</a></p><p><a href="http://www.doe-mbi.ucla.edu/Reprints/R31%20Strong%20A%20Web-based%20Comparative%20Genomics%20tutorial%20Microbiology%20Eduction%202004.pdf">A Web-Based Comparative Genomics Tutorial for Investigating Microbial Genomes:</a></p><p><a href="http://www.genome.gov/27530225">Free Online Tutorials Teach Anyone How to Use Genome Databases:</a></p><p><a href="http://mkweb.bcgsc.ca/circos/?tutorials">Circos to create concise, explanatory, unique and print-ready visualizations of your data:</a></p><p><a href="http://www.igd.cornell.edu/Comparative%20Genomics/Comparative%20Genomics%20Proj.html">Genomics and Comparative Genomics</a><a href="http://www.igd.cornell.edu/Comparative%20Genomics/Comparative%20Genomics%20Proj.html">&nbsp;Learning Module:</a></p><p><a href="http://psb.stanford.edu/psb10/conference-materials/tutorials/compgen-notes.pdf">Computational Challenges in Comparative Genomics</a></p><p><a href="http://psb.stanford.edu/psb10/conference-materials/tutorials/compgen-notes.pdf">A Tutorial:</a></p><p><a href="http://gramene.agrinome.org/tutorials/modules_tutorial.pdf">A Comparative Genomics Resource for Grains</a>:</p><p><a href="http://www.plantcell.org/cgi/content/full/21/12/3718">PLAZA: A Comparative Genomics Resource to Study Gene and Genome Evolution in Plants:</a></p><p><a href="http://en.wikipedia.org/wiki/VISTA_(comparative_genomics)">VISTA</a><a href="http://en.wikipedia.org/wiki/VISTA_(comparative_genomics)">:</a></p><p>Software for Genomics</p><ol>
<li><strong>Artemis</strong>&nbsp;Artemis is a free genome viewer and annotation tool that allows visualization of sequence features and the results of analyses within the context of the sequence, and its six-frame translation.</li>
<li><strong>Chromas&nbsp;</strong>It will display and prints chromatogram files from ABI automated DNA sequencers, and Staden SCF files which the analysis programs for ALF, Li-Cor and Visible Genetics OpenGene sequencers can create.</li>
<li><strong>Glimmer</strong>&nbsp;A system for finding genes in microbial DNA, especially the genomes of bacteria and archaea.Glimmer (Gene Locator and Interpolated Markov Modeler) uses interpolated Markov models (IMMs) to identify the coding regions and distinguish them from noncoding DN</li>
<li><strong>Glimmer</strong>&nbsp;HMM&nbsp;A fast and accurate gene finder based on a GHMM architecture, developed specifically for eukaryotes. It incorporates splice site models adapted from the GeneSplicer program and uses interpolated Markov models for evaluating the coding regions.</li>
<li><strong>Glimmer</strong>&nbsp;M&nbsp;A gene finder derived from Glimmer, but developed specifically for eukaryotes. It is based on a dynamic programming algorithm that considers all combinations of possible exons for inclusion in a gene model and chooses the best of these combinations. The d</li>
<li><strong>MUMmer</strong>&nbsp;MUMmer is a system for rapidly aligning entire genomes, whether in complete or draft form.</li>
<li><strong>pDRAW</strong>&nbsp;pDRAW32 is being developed as a free time hobby project. It is far from finished, but as it has reached a point where it could be helpful for many labs, it is now available to the scientific community.</li>
<li><strong>Sequin</strong>&nbsp;Sequin is a stand-alone software tool developed by the NCBI for submitting and updating entries to the GenBank, EMBL, or DDBJ sequence databases. It is capable of handling simple submissions that contain a single short mRNA sequence, and complex submissio</li>
<li><strong>Staden&nbsp;</strong>The Staden Package consists of a series of tools for DNA sequence preparation (pregap4), assembly (gap4), editing (gap4) and DNA/protein sequence analysis (spin).</li>
</ol><p>For more software @&nbsp;<a href="http://bioinformaticsonline.com/bookmarks/view/926/list-of-popular-bioinformatics-softwaretools">http://bioinformaticsonline.com/bookmarks/view/926/list-of-popular-bioinformatics-softwaretools</a></p>]]></description>
	<dc:creator>Jitendra Narayan</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/news/view/39472/louisiana-biomedical-research-network-summer-bioinformatics-training-program</guid>
	<pubDate>Wed, 05 Jun 2019 15:30:01 -0500</pubDate>
	<link>https://bioinformaticsonline.com/news/view/39472/louisiana-biomedical-research-network-summer-bioinformatics-training-program</link>
	<title><![CDATA[Louisiana Biomedical Research Network: Summer Bioinformatics Training Program]]></title>
	<description><![CDATA[<p><img src="https://edu.t-bio.info/wp-content/uploads/2019/06/LBRN-Summer-Program1-CCT.jpg" alt="2019 summer bioinformatics training program" width="600" height="337.5" style="border: 0px;"></p><p>Louisiana Biomedical Research Network (LBRN) announces registration for it's Summer 2019 Bioinformatics Training Program. The program will be focused on processing, analysis and interpretation of next generation sequecning data for biologists. Learn more:</p><p>https://edu.t-bio.info/louisiana-biomedical-research-network-summer-2019-lbrn-bioinformatics-training-program/</p>]]></description>
	<dc:creator>eliabrodsky</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/news/view/1219/research-with-help-of-bioinformatics-helpful</guid>
	<pubDate>Fri, 02 Aug 2013 11:20:24 -0500</pubDate>
	<link>https://bioinformaticsonline.com/news/view/1219/research-with-help-of-bioinformatics-helpful</link>
	<title><![CDATA[Research with help of bioinformatics helpful]]></title>
	<description><![CDATA[<p>Endocrinologist G.R. Sridhar says</p><blockquote><p>Research with the help of bioinformatics with a trans-disciplinary approach is yielding good results.</p><p>http://www.thehindu.com/features/education/research/research-with-help-of-bioinformatics-helpful/article2295629.ece</p></blockquote>]]></description>
	<dc:creator>Jit</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/news/view/40115/naegleria-fowleri-brain-eating-amoebae</guid>
	<pubDate>Thu, 10 Oct 2019 22:12:03 -0500</pubDate>
	<link>https://bioinformaticsonline.com/news/view/40115/naegleria-fowleri-brain-eating-amoebae</link>
	<title><![CDATA[Naegleria fowleri: brain eating amoebae]]></title>
	<description><![CDATA[<div><em>Naegleria fowleri</em>&nbsp;is a free living, universally distributed amoeba, which is mostly found in natural, stagnant, warm water bodies such as ponds, lakes, etc. It is also reported to be present even in indoor water bodies, such as swimming pools within a temperature range of 40&ndash;45&deg;C.&nbsp;</div><div>&nbsp;</div><div><img src="https://d.newsweek.com/en/full/351971/naegleria-fowleri.jpg" alt="image" width="720" height="634" style="border: 0px; border: 0px;">&nbsp;</div><div><em style="font-size: 12.8px;">N. fowleri</em>&nbsp;infects the central nervous system of human body by entering through the nose during swimming and outdoor baths in natural stagnant water bodies, leading to meningoencephalitis. It is a condition of inflammation of cerebral tissues and membranes of the brain and is mostly fatal in nature. Casualties due to N. fowleri infections are reported all across the globe including a few in India but only seven survivors in the entire world have been reported till 2015.</div><div>&nbsp;</div><div>You can find two genome assembly at&nbsp;</div><div><a href="https://www.ncbi.nlm.nih.gov/assembly/?term=naegleria%20fowleri">https://www.ncbi.nlm.nih.gov/assembly/?term=naegleria%20fowleri</a></div><div>&nbsp;</div><div>More at&nbsp;<a href="https://www.ncbi.nlm.nih.gov/search/all/?term=naegleria+fowleri">https://www.ncbi.nlm.nih.gov/search/all/?term=naegleria+fowleri</a></div>]]></description>
	<dc:creator>Neel</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/blog/view/1295/five-points-for-bioinformatics-softwaretools</guid>
	<pubDate>Mon, 05 Aug 2013 04:12:32 -0500</pubDate>
	<link>https://bioinformaticsonline.com/blog/view/1295/five-points-for-bioinformatics-softwaretools</link>
	<title><![CDATA[Five points for bioinformatics software/tools]]></title>
	<description><![CDATA[<p><span>In the bioinformatics sector we mostly spend time on computational analysis of huge amounts of data and try to make sense of it, biologically. But, most of the newbie bioinformaticians are faced with dilemma when they receive biological sequence data for the first time. They mostly found confusing over open source, user friendly GUI, and commercial bioinformatics software. Don&rsquo;t be surprise this is true and also not an easy task to decide, because analytical step is the most crucial part and believe to be the biggest bottleneck in publishing paper in high impact journals. Through this blog I would like to address the pros and cons of both kind of software/tools and try to assist (Hmmm not really, It looks convince) you to make decision on your software selections.</span></p><p><span><img src="http://bioinformaticsonline.com/mod/photo/five.jpg" alt="image" style="border: 0px;"></span></p><p><span>The most common newbie questions are:</span><span></span></p><p><span>Should I try to use these free open source programs? &nbsp;Why are we not trying GUI software for computational analysis? Should I use commercial bioinformatics programs/software?&rdquo;</span><span><br /></span><span><br />1. Let&rsquo;s be open</span><span></span></p><p><span>We generally think free and cheap are useless. But this concept is not applicable when we discuss open source software. Mostly, the bioinformatics software is developed by highly competitive biological programmers who believe in open sharing of knowledge. They come under Open Bioinformatics Foundation or O|B|F which is a non-profit, volunteer run organization focused on supporting open source programming in bioinformatics. The best part about open source tools/software is that they&rsquo;re free to download the source code and read exactly what the program does. If you are so inclined, you can view all of the parts of the program and see the logical flow of the pipeline. In addition, open source makes an excellent learning tool for any beginning bioinformatician. Moreover, you can modify existing open source programs to deal with cutting-edge problems or to customize your pipeline.</span><span>&nbsp;</span><span>Apart from your computational and analysis work, most of the reviewer also prefers the open source based results so that they can validate the results if validation required.</span></p><p><span>2. Code headache</span><span></span></p><p><span>As a bioinformatician you are supposed to know the basics of programming languages, and if you are not good at it, then please learn it as soon as possible because you are not a bio-analyst but biological programmers. The<span>&nbsp;</span>open source programs usually lack dedicated service and support teams (often because they were the product of an overworked doc/postdoc!) so you are responsible for troubleshooting your own errors most of the time.<span>&nbsp;</span>We commonly receive the HELP email to support and assist to setup the pipeline; you can also find this kind of request on any QA forum. I personally believe this coding horror brings the biggest downside of open-source programs; where you need some programming skills in order to implement the program in your pipeline. But, if you are not able to fix the pipeline and modify the open source code according to your requirements them you should re-think on your bioinformatician name tag!!!</span><span></span></p><p><span>3. Dive into the codes</span><span></span></p><p><span>Some of the biologist turn bioinformatician says &ldquo;if you can do the same thing with commercial software then why to get migraine with weird codes&rdquo;, well this statement looks to me that guys are keen to learn swimming but still don&rsquo;t like to get wet. If you are still using paid software and doing your work by customer support and clicking some of the well-designed GUI button then perhaps you are not interested in learning and trying new and challenging bioinformatics works. You are missing the basic flavour of bioinformatics. Let&rsquo;s dive into the coding world, I am sure your will enjoy it. I recommend your to swim freely in code&rsquo;s sea, and enjoy the journey; do not merely watch it from the outside. &nbsp;</span></p><p><span>4. Paid does not mean better</span><span></span></p><p><span>The bioinformatics company which are specializes in bioinformatics solutions develop well designed/packed, user friendly software by using a large number of specialised scientist, programmers and support staff. They also provide good services to accomplice your biological analysis work. This means that if you hit a &lsquo;snag&rsquo; with your data, help is likely only a phone call away! These companies price their products competitively against the cost of a dedicated bioinformatician. You may be able to afford the program, but not the additional staff! Additionally, most of the functionality that you need in your analysis is already coded into the program. Need to plot a graph? Just click this button right here. It is that easy.</span><span>&nbsp;</span><span>But, as a bioinformatician this is not generally well encouraged approach in biological analysis work, because the software is not available to everyone and your data can&rsquo;t be validated. Moreover, there is very less chances that anyone will repeat your work or love to do similar kind of research (because not all the labs in the world are rich like yours).</span></p><p><span>5. Take a caution<br /><br />In biological analysis work, in which you deal GB/TB of data are having maximum chances of getting errors, so please be careful and always cross check your data before coming to any conclusion. Even an error in two line code can alter your entire analysis and display weird results. Some of the scientist blindly believes on commercial software, which is entirely wrong. Using proprietary tools does not absolve you of the need to actually read and research the type of analysis that you are doing. This is particularly true in the case of genome assembly and annotation.</span></p><p><span><br />At the end, I would like to tell only one think that open source solutions allows you to do more cutting edge analysis than the commercial tools. So let&rsquo;s go for it.</span></p><p>Disclaimer:</p><p>This is my personal view. I have nothing to do with any company or open source community.&nbsp;The views expressed on these pages are mine alone and not those of my current/past employers. I do reserve the right to remove comments left by spammers or off-topic comments.</p>]]></description>
	<dc:creator>Jitendra Narayan</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/40959/bioinformatics-related-group</guid>
	<pubDate>Sun, 09 Feb 2020 03:17:16 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/40959/bioinformatics-related-group</link>
	<title><![CDATA[Bioinformatics related group]]></title>
	<description><![CDATA[<p>FaBI emerged from the respective groups of the four founding societies GI (German Informatics Society), DECHEMA (Society for Chemical Engineering and Biotechnology), GBM (Society for Biochemistry and Molecular Biology) and GDCh (German Chemical Society). In fall 2015, the GMDS (German Society for Medical Informatics, Biometry, and Epidemiology) joined FaBI. FaBI represents more than 750 members today and considers itself as a joint representation of interests of bioinformatics research in Germany and as an interlocutor for politics, economy, and society aiming at a strong informatics-based life science research.</p><p>Address of the bookmark: <a href="https://bioinformatik.de/en/bioinformatics-in-germany/research/research-groups.html" rel="nofollow">https://bioinformatik.de/en/bioinformatics-in-germany/research/research-groups.html</a></p>]]></description>
	<dc:creator>Rahul Agarwal</dc:creator>
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