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	<title><![CDATA[BOL: Related items]]></title>
	<link>https://bioinformaticsonline.com/related/31100?offset=1180</link>
	<atom:link href="https://bioinformaticsonline.com/related/31100?offset=1180" rel="self" type="application/rss+xml" />
	<description><![CDATA[]]></description>
	
	
<item>
  <guid isPermaLink='true'>https://bioinformaticsonline.com/researchlabs/view/7212/bioinformatics-group-at-boku-university</guid>
  <pubDate>Thu, 12 Dec 2013 17:53:10 -0600</pubDate>
  <link></link>
  <title><![CDATA[Bioinformatics group at Boku University]]></title>
  <description><![CDATA[
<p>The Bioinformatics group at Boku University has two main areas of interest, underpinning a common goal, the study of complex systems in living organisms. To overcome the engineered redundancies and combinatorial effects prevalent in higher eukaryotes, novel views augmenting the classical gene by gene approaches are required. We combine</p>

<p>1. Work to establish improved quantitative experimental assays (such as microarrays or differential in-gel electrophoresis) and<br />2. Development of modern computational methods (such as hierarchical probabilistic models or integration of heterogeneous data sources)</p>

<p>Lab page @ http://bioinf.boku.ac.at/</p>
]]></description>
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<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/43801/smudgeplot-inference-of-ploidy-and-heterozygosity-structure-using-whole-genome-sequencing-data</guid>
	<pubDate>Fri, 25 Feb 2022 04:42:09 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/43801/smudgeplot-inference-of-ploidy-and-heterozygosity-structure-using-whole-genome-sequencing-data</link>
	<title><![CDATA[Smudgeplot: Inference of ploidy and heterozygosity structure using whole genome sequencing data]]></title>
	<description><![CDATA[<p dir="auto">This tool extracts heterozygous kmer pairs from kmer count databases and performs gymnastics with them. We are able to disentangle genome structure by comparing the sum of kmer pair coverages (CovA + CovB) to their relative coverage (CovB / (CovA + CovB)). Such an approach also allows us to analyze obscure genomes with duplications, various ploidy levels, etc.</p>
<p dir="auto">Smudgeplots are computed from raw or even better from trimmed reads and show the haplotype structure using heterozygous kmer pairs. For example:</p>
<p dir="auto"><a href="https://user-images.githubusercontent.com/8181573/45959760-f1032d00-c01a-11e8-8576-ff0512c33da9.png" target="_blank"><img src="https://user-images.githubusercontent.com/8181573/45959760-f1032d00-c01a-11e8-8576-ff0512c33da9.png" alt="smudgeexample" style="border: 0px;"></a></p><p>Address of the bookmark: <a href="https://github.com/KamilSJaron/smudgeplot" rel="nofollow">https://github.com/KamilSJaron/smudgeplot</a></p>]]></description>
	<dc:creator>Neel</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/7216/free-math-books</guid>
	<pubDate>Thu, 12 Dec 2013 19:38:34 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/7216/free-math-books</link>
	<title><![CDATA[Free math books]]></title>
	<description><![CDATA[<p>Bioinformatics require some match skills, therefore I decided to provide this wonderful math eBooks links to the BOL community.</p>
<p>Please add ur links/bookmarks in comment section.</p><p>Address of the bookmark: <a href="http://physicsdatabase.com/free-math-books/" rel="nofollow">http://physicsdatabase.com/free-math-books/</a></p>]]></description>
	<dc:creator>Manisha Mishra</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/43923/monkeypox-virus-isolate-mpxv-usa-2022-ma001-complete-genome</guid>
	<pubDate>Tue, 26 Jul 2022 06:21:07 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/43923/monkeypox-virus-isolate-mpxv-usa-2022-ma001-complete-genome</link>
	<title><![CDATA[Monkeypox virus isolate MPXV_USA_2022_MA001, complete genome]]></title>
	<description><![CDATA[<pre>LOCUS       ON563414              197205 bp    DNA     linear   VRL 30-MAY-2022
DEFINITION  Monkeypox virus isolate MPXV_USA_2022_MA001, complete genome.
ACCESSION   ON563414
VERSION     ON563414.3
KEYWORDS    .
SOURCE      Monkeypox virus (monkeypox)
  ORGANISM  <a href="https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10244">Monkeypox virus</a>
            Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota;
            Pokkesviricetes; Chitovirales; Poxviridae; Chordopoxvirinae;
            Orthopoxvirus.</pre><p>Address of the bookmark: <a href="https://www.ncbi.nlm.nih.gov/nuccore/ON563414" rel="nofollow">https://www.ncbi.nlm.nih.gov/nuccore/ON563414</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/7387/bioinformatics-software-for-biologists-in-the-genomics-era</guid>
	<pubDate>Sun, 22 Dec 2013 17:31:05 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/7387/bioinformatics-software-for-biologists-in-the-genomics-era</link>
	<title><![CDATA[Bioinformatics software for biologists in the genomics era]]></title>
	<description><![CDATA[<p>The genome sequencing revolution is approaching a landmark figure of 1000 completely sequenced genomes. Coupled with fast-declining, per-base sequencing costs, this influx of DNA sequence data has encouraged laboratory scientists to engage large datasets in comparative sequence analyses for making evolutionary, functional and translational inferences. However, the majority of the scientists at the forefront of experimental research are not bioinformaticians, so a gap exists between the user-friendly software needed and the scripting/programming infrastructure often employed for the analysis of large numbers of genes, long genomic segments and groups of sequences. We see an urgent need for the expansion of the fundamental paradigms under which biologist-friendly software tools are designed and developed to fulfill the needs of biologists to analyze large datasets by using sophisticated computational methods. We argue that the design principles need to be sensitive to the reality that comparatively small teams of biologists have historically developed some of the most popular biological software packages in molecular evolutionary analysis. Furthermore, biological intuitiveness and investigator empowerment need to take precedence over the current supposition that biologists should re-tool and become programmers when analyzing genome scale datasets.</p><p>Address of the bookmark: <a href="http://bioinformatics.oxfordjournals.org/content/23/14/1713.full" rel="nofollow">http://bioinformatics.oxfordjournals.org/content/23/14/1713.full</a></p>]]></description>
	<dc:creator>Poonam Mahapatra</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/44483/baclife-an-automated-genome-mining-tool-for-identification-of-lifestyle-associated-genes</guid>
	<pubDate>Fri, 15 Mar 2024 04:59:14 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/44483/baclife-an-automated-genome-mining-tool-for-identification-of-lifestyle-associated-genes</link>
	<title><![CDATA[bacLIFE: an automated genome mining tool for identification of lifestyle associated genes]]></title>
	<description><![CDATA[<p style="margin-top: 0px; margin-bottom: 16px; color: #1f2328; font-size: 16px; font-style: normal; font-weight: 400; text-align: start; background-color: #ffffff;" dir="auto">bacLIFE is a streamlined computational workflow that annotates bacterial genomes and performs large-scale comparative genomics to predict bacterial lifestyles and to pinpoint candidate genes, denominated<span>&nbsp;</span><strong style="font-weight: var(--base-text-weight-semibold, 600);">lifestyle-associated genes (LAGs)</strong>, and biosynthetic gene clusters associated with each lifestyle detected. This whole process is divided into different modules:</p>
<ul style="margin-top: 0px; margin-bottom: 16px; color: #1f2328; font-size: 16px; font-style: normal; font-weight: 400; text-align: start; background-color: #ffffff;" dir="auto">
<li><strong style="font-weight: var(--base-text-weight-semibold, 600);">Clustering module</strong><span>&nbsp;</span>Predicts, clusters and annotates the genes of every input genome</li>
<li style="margin-top: 0.25em;"><strong style="font-weight: var(--base-text-weight-semibold, 600);">Lifestyle prediction</strong><span>&nbsp;</span>Employs a machine learning model to forecast bacterial lifestyle or other specified metadata</li>
<li style="margin-top: 0.25em;"><strong style="font-weight: var(--base-text-weight-semibold, 600);">Analitical module (Shiny app)</strong><span>&nbsp;</span>Results from the previous modules are embedded in a user-friendly interface for comprehensive and interactive comparative genomics.</li>
</ul>
<p style="margin-top: 0px; margin-bottom: 16px; color: #1f2328; font-size: 16px; font-style: normal; font-weight: 400; text-align: start; background-color: #ffffff;" dir="auto">You can find the complete wiki here [<a href="https://github.com/Carrion-lab/bacLIFE/wiki/bacLIFE-wiki">https://github.com/Carrion-lab/bacLIFE/wiki/bacLIFE-wiki</a>]</p><p>Address of the bookmark: <a href="https://github.com/Carrion-lab/bacLIFE" rel="nofollow">https://github.com/Carrion-lab/bacLIFE</a></p>]]></description>
	<dc:creator>BioStar</dc:creator>
</item>

<item>
  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/7753/jrf-pondicherry-university</guid>
  <pubDate>Fri, 03 Jan 2014 16:48:56 -0600</pubDate>
  <link></link>
  <title><![CDATA[JRF @ PONDICHERRY UNIVERSITY]]></title>
  <description><![CDATA[
<p>PONDICHERRY UNIVERSITY</p>

<p>CENTRE FOR BIOINFORMATICS</p>

<p>PUDUCHERRY</p>

<p>Applications are invited for one Project Assistant to work in the UGC sponsored Research Award "Molecular Docking and Dynamics studies to understand the interacting mechanism of oncogenic 101 protein with its cellular proteins".</p>

<p>The duration for the fellowship is 12months only with consolidated pay ofRs. 5,000 per month.</p>

<p>Application on plain paper with following details: Name, Address, Data of Birth, Father's Name, Nationality, Educational Qualification (SSLC onwards-enclose attested copies of certificate) and Researcb Experience may be addressed to Dr. R. Krishna, Principle Investigator (PI), UGC Research Award, Centre for Bioinformatics, Pondicherry University, Pondicherry - 605 014.</p>

<p>Application should reach in January 261h , 2013.</p>

<p>Essential Qualification: M.Sc. in Bioinformatics/Biophysics with good academic record.</p>

<p>Qualification for Project Fellow:</p>

<p>M.Sc in Bioinformatics/Biophysics.</p>

<p>The person to be considered for appointment as Project Fellow must have second class master degree with a minimum of 55% marks in the subject concerned or a related subject.</p>

<p>The candidate to be appointed as Project Fellows should be below thc age of40 years at the time of appointment.</p>

<p>Desirable Qualification for this Project: Research Experience in Small/Macromolecule Crystallography and Structural Bioinformatics.</p>

<p>For more details, refer the web site: www.pondiuni.edu.in/sites/default/files/BIC-311213.pdf</p>
]]></description>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/blog/view/45376/can-ai-decide-which-genomic-model-to-trust</guid>
	<pubDate>Sat, 24 Oct 2026 03:10:06 -0500</pubDate>
	<link>https://bioinformaticsonline.com/blog/view/45376/can-ai-decide-which-genomic-model-to-trust</link>
	<title><![CDATA[Can AI Decide Which Genomic Model to Trust?]]></title>
	<description><![CDATA[<p>Imagine you're sitting with a genomic dataset of some sort (thousands of SNPs), a set of plant phenotypes and the one very simple question: can we predict what these plants will become? The first thing you'd probably do is reach for machine learning. That's where the real problem lies. Which model do we use? GBLUP? Bayesian ridge? LASSO? Random Forest? A neural net? How do we know that the model that looks so good on a single cross-validation split will still be good tomorrow? In genomic prediction we're often just left to pick these things manually. The problem is that a single cross-validation split can make a model look incredibly good when in reality it's not. This is the problem that Nagendra Pratap Singh and Venugopal Mendu have set out to solve with GenoBridge (https://github.com/nps-genomics/GenoBridge), a sample size adaptive machine learning pipeline designed to reduce the amount of human guesswork involved. The paper (Plant Methods, September 2026) describes a pipeline that instead of asking the user to pick a model and parameters in advance, adapts the analysis based on the size of the sample. It tests multiple models and evaluates them via cross-validation. The premise is simple but powerful: don't just ask if a model can predict, ask if the model can predict when the data it's being tested on are genuinely unseen. GenoBridge therefore places a strong emphasis on cross-validated R2 as well as correlation, using the reproducibility of the predictive signal as a gate before moving into GWAS. In other words prediction is the first checkpoint: if the genomic signal can't generalise then we shouldn't be trusting the downstream association results. Once a trait has passed that checkpoint it proceeds into kinship based mixed model GWAS to provide a bridge between prediction and biological interpretation.</p><p>The authors tested the pipeline across 5 datasets from 4 species, spanning an almost 80-fold difference in sample size (from 136 to over 10,700 individuals) and found that the predictive accuracy was within 0.02-0.05 of the standard GBLUP and Bayesian ridge regression approaches, again without the user having to manually select a model. More importantly the pipeline was able to recover known biological signals (FLC, FT and DOG1 in Arabidopsis, Waxy and GW5 in rice and Glu-D1 in wheat) and produced well calibrated association statistics. The most interesting observation though is that prediction accuracy and biological association are not necessarily the same thing. Two traits with identical predictive performance could have association significance that varied by over 60 orders of magnitude. So knowing how well we can predict a trait doesn't necessarily tell us anything about the distribution of the genetic architecture of that trait across the genome. That's where GenoBridge is actually of value. It's not just another machine learning pipeline. It's an example of an adaptive analytical workflow that doesn't just throw algorithms at the data but asks whether the data actually justify the next analytical step. As the amount of genomic data we generate continues to grow and the number of computational methods available to us increases, the bottleneck may not be in finding the right algorithm at all. The bottleneck may be in deciding which algorithm we can actually trust.</p><p>GenoBridge offers a potential solution: let the data tell you which model is appropriate, validate the prediction rigorously and only then move from prediction to biological discovery. That may be where computational genomics is heading. Rather than a future in which there is one single 'best' model, we may be heading towards a future of intelligent systems that know when a model is appropriate, when a result is reliable and when the biology is actually telling us something that we should be listening to.</p><p>More at&nbsp;https://link.springer.com/article/10.1186/s13007-026-01596-5</p>]]></description>
	<dc:creator>BioStar</dc:creator>
</item>

<item>
  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/7998/faculty-positions-at-iiit-allahabad</guid>
  <pubDate>Thu, 23 Jan 2014 06:19:34 -0600</pubDate>
  <link></link>
  <title><![CDATA[FACULTY POSITIONS AT IIIT-ALLAHABAD]]></title>
  <description><![CDATA[
<p>OPENINGS OF FACULTY POSITIONS AT IIIT-ALLAHABAD</p>

<p>(Under Tenure-Track Model)</p>

<p>Open Advt. No IIITA/DIC/16012014</p>

<p>IIIT-Allahabad has several Openings for the Faculty positions at the Assistant Professor level.</p>

<p>It is a regular tenure-track faculty positions for 3-5 years in teaching and research. A regular faculty is expected to engage heavily in research and teaching. The eligibility criteria for regular faculty positions are similar as in IITs. For an Assistant Professor position, a candidate must have a PhD (in IT/Computer Science &amp;/or Engineering/Electrical, Electronics &amp;/or Communication Engineering/etc; for interdisciplinary areas the PhD may be in an appropriate field), plus three years experience. However, for PhDs from a well known University/Institute (e.g. IITs/IISc/TIFR/ISI in India or well known research universities across the world), and a good research/academic record, the 3 years experience requirement may be waived.</p>

<p>The pay scale for faculty is same as in IITs. Other benefits include initiation research grant, travel support, book grant, professional society membership, etc., and personal benefits such as medical/LTC, on campus subsidized family housing with excellent modern infrastructural facilities.</p>

<p>Areas of Interest</p>

<p>IIIT-Allahabad aims to build strong research groups in important and emerging areas in CS/IT/ECE as well as in emerging interdisciplinary areas, and applications are invited in all these areas. Some of the areas of special interest, besides strengthening the existing research areas, are : Software Engineering, Theoretical Computer Science, Cyber Physical Systems, Robotics, Network science, Digital Media, Computational neuroscience, Machine learning, Healthcare informatics, Computational Biology, Communications networks (both at hardware and protocol levels), Circuits (including VLSI, analog, low power, etc), Energy systems and technologies, Biomedical electronics and systems, Computer Architecture, signal/image processing, Embedded and control systems.</p>

<p>Application Process</p>

<p>Interested candidates can apply by sending their detailed CV with list of publications clearly mentioning Journal names and citation index with three references through email entitled “Faculty positions at IIIT Allahabad” to faculty.applications@iiita.ac.in. Do not send your applications in any other email addresses. Applications will be considered regularly, hence there is no deadline for applying.</p>

<p>Important Clarifications on Eligibility</p>

<p>A PhD in CS/IT (or other disciplines, as announced) is the minimum expected requirement for an Assistant Professor.</p>

<p>Advertisement: http://iiita.ac.in/pub/Faculty-Position-IIITA1.pdf</p>
]]></description>
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<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/news/view/4183/320000-viruses-in-mammals-yet-to-sequenced-in-future</guid>
	<pubDate>Tue, 03 Sep 2013 08:35:30 -0500</pubDate>
	<link>https://bioinformaticsonline.com/news/view/4183/320000-viruses-in-mammals-yet-to-sequenced-in-future</link>
	<title><![CDATA[320000 viruses in mammals yet to sequenced in future!!!]]></title>
	<description><![CDATA[<p>With current biological technique improvements, finally it is now possible to look at millions of unknown viruses at genomic level and understand the mechanism. According to available data, close to 70 per cent of emerging viral diseases such as HIV/AIDS, West Nile, Ebola, SARS, and influenza, are zoonoses - infections of animals that cross into humans.</p><p>To address the challenges of describing and estimating virodiversity, a team of investigators from Center for Infection and Immunity (CII) and EcoHealth Alliance began in jungles of Bangladesh - home to the flying fox.</p><p>Reference:</p><p><a href="http://economictimes.indiatimes.com/news/news-by-industry/et-cetera/mammals-harbour-at-least-320000-new-viruses/articleshow/22253268.cms">http://economictimes.indiatimes.com/news/news-by-industry/et-cetera/mammals-harbour-at-least-320000-new-viruses/articleshow/22253268.cms</a></p><p><a href="http://www.bbc.co.uk/news/science-environment-23932400">http://www.bbc.co.uk/news/science-environment-23932400</a></p>]]></description>
	<dc:creator>Rahul Agarwal</dc:creator>
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