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	<title><![CDATA[BOL: Related items]]></title>
	<link>https://bioinformaticsonline.com/related/31156?offset=1180</link>
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	<description><![CDATA[]]></description>
	
	<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/pages/view/34463/single-cell-rnaseq-data-analysis-tutorial</guid>
	<pubDate>Mon, 27 Nov 2017 16:24:29 -0600</pubDate>
	<link>https://bioinformaticsonline.com/pages/view/34463/single-cell-rnaseq-data-analysis-tutorial</link>
	<title><![CDATA[Single Cell RNAseq data analysis tutorial !!]]></title>
	<description><![CDATA[<ul>
<li>A major breakthrough (replaced microarrays) in the late 00&rsquo;s and has been widely used since</li>
<li>Measures the&nbsp;average expression level&nbsp;for each gene across a large population of input cells</li>
<li>Useful for comparative transcriptomics, e.g.&nbsp;samples of the same tissue from different species</li>
<li>Useful for quantifying expression signatures from ensembles, e.g.&nbsp;in disease studies</li>
<li>Insufficient&nbsp;for studying heterogeneous systems, e.g.&nbsp;early development studies, complex tissues (brain)</li>
<li>Does&nbsp;not&nbsp;provide insights into the stochastic nature of gene expression</li>
</ul><p>Following are the useful links:</p><p><a href="http://hemberg-lab.github.io/scRNA.seq.course/scRNA-seq-course.pdf" target="_blank">Single Cell RNAseq data analysis Tutorial</a></p><p><a href="https://f1000research.com/articles/5-2122/v2" target="_blank">A step-by-step workflow for low-level analysis of single-cell RNA-seq data</a></p><p><a href="https://www.bioconductor.org/help/workflows/simpleSingleCell/" target="_blank">A step-by-step workflow for low-level analysis of single-cell RNA-seq data with Bioconductor</a></p><p>SCell: single-cell RNA-seq analysis software</p><p><a href="https://github.com/diazlab/SCell">https://github.com/diazlab/SCell</a></p><p>Beta-Poisson model for single-cell RNA-seq data analyses</p><p><a href="https://github.com/nghiavtr/BPSC">https://github.com/nghiavtr/BPSC</a></p><p>Sincera: A Computational Pipeline for Single Cell RNA-Seq Profiling Analysis</p><p><a href="https://research.cchmc.org/pbge/sincera.html">https://research.cchmc.org/pbge/sincera.html</a></p><p>SC3 &ndash; consensus clustering of single-cell RNA-Seq data</p><p><a href="http://biorxiv.org/content/early/2016/09/02/036558">http://biorxiv.org/content/early/2016/09/02/036558</a></p><p>Citrus: A toolkit for single cell sequencing analysis</p><p><a href="http://biorxiv.org/content/early/2016/09/14/045070">http://biorxiv.org/content/early/2016/09/14/045070</a></p><p>Single-Cell Resolution of Temporal Gene Expression during Heart Development</p><p><a href="http://www.cell.com/developmental-cell/fulltext/S1534-5807%2816%2930682-7">http://www.cell.com/developmental-cell/fulltext/S1534-5807(16)30682-7</a></p><p>Scalable latent-factor models applied to single-cell RNA-seq data separate biological drivers from confounding effects</p><p><a href="http://biorxiv.org/content/early/2016/11/15/087775">http://biorxiv.org/content/early/2016/11/15/087775</a></p><p>Single cell transcriptomes identify human islet cell signatures and reveal cell-type-specific expression changes in type 2 diabetes</p><p><a href="http://genome.cshlp.org/content/early/2016/11/18/gr.212720.116.abstract">http://genome.cshlp.org/content/early/2016/11/18/gr.212720.116.abstract</a></p><p>SCODE: An efficient regulatory network inference algorithm from single-cell RNA-Seq during differentiation</p><p><a href="http://biorxiv.org/content/early/2016/11/21/088856">http://biorxiv.org/content/early/2016/11/21/088856</a></p><p>SCOUP is a probabilistic model to analyze single-cell expression data during differentiation</p><p><a href="https://github.com/hmatsu1226/SCOUP">https://github.com/hmatsu1226/SCOUP</a></p><p>scLVM is a modelling framework for single-cell RNA-seq data</p><p><a href="https://github.com/PMBio/scLVM">https://github.com/PMBio/scLVM</a></p><p>Selective Locally linear Inference of Cellular Expression Relationships (SLICER) algorithm for inferring cell trajectories</p><p><a href="https://github.com/jw156605/SLICER">https://github.com/jw156605/SLICER</a></p><p>SinQC: A Method and Tool to Control Single-cell RNA-seq Data Quality</p><p><a href="http://www.morgridge.net/SinQC.html">http://www.morgridge.net/SinQC.html</a></p><p>TSCAN: Pseudo-time reconstruction and evaluation in single-cell RNA-seq analysis</p><p><a href="https://github.com/zji90/TSCAN">https://github.com/zji90/TSCAN</a></p><p>Visualization and cellular hierarchy inference of single-cell data using SPADE</p><p><a href="http://www.nature.com/nprot/journal/v11/n7/full/nprot.2016.066.html">http://www.nature.com/nprot/journal/v11/n7/full/nprot.2016.066.html</a></p><p>OEFinder: Identify ordering effect genes in single cell RNA-seq data</p><p><a href="https://github.com/lengning/OEFinder">https://github.com/lengning/OEFinder</a></p>]]></description>
	<dc:creator>Robert M Willioms</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/29282/cosmic</guid>
	<pubDate>Sat, 01 Oct 2016 15:04:10 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/29282/cosmic</link>
	<title><![CDATA[COSMIC]]></title>
	<description><![CDATA[<p>The accurate description and annotation of structural variants can be complex. &nbsp;This is due to the different resolution that variants are reported from traditional&nbsp;cytogenetic coordinates down to the actual base pair positions. Furthermore, multiple&nbsp;rearrangements in a single area of the genome can make cataloguing and interpreting&nbsp;their effects challenging.&nbsp;</p>
<p>The Rearrangement Overview page describes the one or more breakpoints which make up a structural&nbsp;variant. A breakpoint is defined as a region or point where the sample sequence has altered&nbsp;from the reference sequence. Minimum interpretation is made of this data. One variant event&nbsp;can consist of one or multiple breakpoints. The Syntax (shown above the table) gives a detailed description of the variant and its location &nbsp;(e.g. chr11:g.36585230_76606619del, a deletion of&nbsp;roughly 40Mb on chromosome 11). Syntax is based on HGVS mutation nomenclature recommendations&nbsp;[http://www.hgvs.org/rec.html].&nbsp;</p>
<p>http://cancer.sanger.ac.uk/cosmic/help/rearrangement/overview</p><p>Address of the bookmark: <a href="http://cancer.sanger.ac.uk/cosmic/help/rearrangement/overview" rel="nofollow">http://cancer.sanger.ac.uk/cosmic/help/rearrangement/overview</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/29410/entrez-direct-e-utilities-on-the-unix-command-line</guid>
	<pubDate>Wed, 19 Oct 2016 08:06:24 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/29410/entrez-direct-e-utilities-on-the-unix-command-line</link>
	<title><![CDATA[Entrez Direct: E-utilities on the UNIX Command Line]]></title>
	<description><![CDATA[<p>Entrez Direct (EDirect) is an advanced method for accessing the NCBI's suite of interconnected databases (publication, sequence, structure, gene, variation, expression, etc.) from a UNIX terminal window. Functions take search terms from command-line arguments. Individual operations are combined to build multi-step queries. Record retrieval and formatting normally complete the process.</p>
<p>EDirect also provides an argument-driven function that simplifies the extraction of data from document summaries or other results that are returned in structured XML format. This can eliminate the need for writing custom software to answer ad hoc questions. Queries can move seamlessly between EDirect commands and UNIX utilities or scripts to perform actions that cannot be accomplished entirely within Entrez.</p><p>Address of the bookmark: <a href="https://www.ncbi.nlm.nih.gov/books/NBK179288/" rel="nofollow">https://www.ncbi.nlm.nih.gov/books/NBK179288/</a></p>]]></description>
	<dc:creator>Anjana</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/29576/impute2</guid>
	<pubDate>Thu, 27 Oct 2016 11:21:44 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/29576/impute2</link>
	<title><![CDATA[IMPUTE2]]></title>
	<description><![CDATA[<p><strong>IMPUTE2</strong>&nbsp;is a computer program for phasing observed genotypes and imputing missing genotypes. Most people use just a couple of the program's basic functions, but we have also built up a collection of specialized and powerful options. If you are new to&nbsp;<strong>IMPUTE2</strong>, or indeed to phasing and imputation in general, we suggest that you start by learning the basics.</p>
<p>You should begin by downloading the program from&nbsp;<a href="https://mathgen.stats.ox.ac.uk/impute/impute_v2.html#download">here</a>. You will need to choose the link that matches your computing platform and then follow the instructions for opening the download package.</p>
<p>Once you have done this, you will be ready to try some example analyses on the test data that are provided with the download. The section on&nbsp;<a href="https://mathgen.stats.ox.ac.uk/impute/impute_v2.html#examples">Examples</a>&nbsp;shows how to use the most common&nbsp;<strong>IMPUTE2</strong>&nbsp;functions. We suggest that you work through these examples and try to understand what the elements of each command are doing. If you don't understand something or would like to know if the program can perform a function that isn't listed, you can read our&nbsp;<a href="https://mathgen.stats.ox.ac.uk/impute/impute_v2.html#faq">FAQ</a>&nbsp;or submit a question to our&nbsp;<a href="https://mathgen.stats.ox.ac.uk/impute/impute_v2.html#mail_list">mail list</a>.</p>
<p>When you have learned the basic functionality of the program, you can use several features of this website to prepare your own analysis:</p>
<ul>
<li>Learn about&nbsp;<a href="https://mathgen.stats.ox.ac.uk/impute/impute_v2.html#best_practices">best practices</a>&nbsp;for imputation.</li>
<li>Download&nbsp;<a href="https://mathgen.stats.ox.ac.uk/impute/impute_v2.html#reference">reference data</a>&nbsp;that you can use to impute genotypes in your study.</li>
<li>Look through a complete list of&nbsp;<a href="https://mathgen.stats.ox.ac.uk/impute/impute_v2.html#options">program options</a>.</li>
</ul><p>Address of the bookmark: <a href="https://mathgen.stats.ox.ac.uk/impute/impute_v2.html" rel="nofollow">https://mathgen.stats.ox.ac.uk/impute/impute_v2.html</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/29603/statistical-for-biological-research</guid>
	<pubDate>Thu, 03 Nov 2016 04:59:48 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/29603/statistical-for-biological-research</link>
	<title><![CDATA[Statistical for biological research]]></title>
	<description><![CDATA[<p>There is no disputing the importance of statistical analysis in biological research, but too often it is considered only after an experiment is completed, when it may be too late.</p>
<p>This collection highlights important statistical issues that biologists should be aware of and provides practical advice to help them improve the rigor of their work.</p>
<p><em>Nature Methods</em>' <strong><a href="http://www.nature.com/collections/qghhqm/pointsofsignificance">Points of Significance</a></strong> column on statistics explains many key statistical and experimental design concepts. <strong><a href="http://www.nature.com/collections/qghhqm/resources">Other resources</a></strong> include an online plotting tool and links to statistics guides from other publishers.</p><p>Address of the bookmark: <a href="http://www.nature.com/collections/qghhqm" rel="nofollow">http://www.nature.com/collections/qghhqm</a></p>]]></description>
	<dc:creator>Neel</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/40611/deepvariant-an-analysis-pipeline-that-uses-a-deep-neural-network-to-call-genetic-variants-from-next-generation-dna-sequencing-data</guid>
	<pubDate>Sat, 25 Jan 2020 13:28:09 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/40611/deepvariant-an-analysis-pipeline-that-uses-a-deep-neural-network-to-call-genetic-variants-from-next-generation-dna-sequencing-data</link>
	<title><![CDATA[DeepVariant : an analysis pipeline that uses a deep neural network to call genetic variants from next-generation DNA sequencing data.]]></title>
	<description><![CDATA[<p><span>DeepVariant is an analysis pipeline that uses a deep neural network to call genetic variants from next-generation DNA sequencing data.</span></p>
<p><span><span>DeepVariant is an analysis pipeline that uses a deep neural network to call genetic variants from next-generation DNA sequencing data. DeepVariant relies on&nbsp;</span><a href="https://github.com/google/nucleus">Nucleus</a><span>, a library of Python and C++ code for reading and writing data in common genomics file formats (like SAM and VCF) designed for painless integration with the&nbsp;</span><a href="https://www.tensorflow.org/">TensorFlow</a><span>&nbsp;machine learning framework.</span></span></p>
<p><span><a href="https://ai.googleblog.com/2017/12/deepvariant-highly-accurate-genomes.html">https://ai.googleblog.com/2017/12/deepvariant-highly-accurate-genomes.html</a></span></p>
<p><span><a href="https://www.biorxiv.org/content/10.1101/092890v6">https://www.biorxiv.org/content/10.1101/092890v6</a></span></p>
<p><span><img src="https://4.bp.blogspot.com/-2KlXZO60sWE/WiGc8qlZfxI/AAAAAAAACOs/s1pNiKI8jsAvJLr1E_po5udDO8eObm_awCLcBGAs/s640/image3.png" width="640" height="427" alt="image" style="border: 0px;"></span></p><p>Address of the bookmark: <a href="https://github.com/google/deepvariant" rel="nofollow">https://github.com/google/deepvariant</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/29679/comparative-genomics-educational-material-and-papers-bookmarks</guid>
	<pubDate>Wed, 09 Nov 2016 16:23:30 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/29679/comparative-genomics-educational-material-and-papers-bookmarks</link>
	<title><![CDATA[Comparative genomics educational material and papers bookmarks]]></title>
	<description><![CDATA[<p><span>Alignment of the porcine genome against seven other mammalian genomes (</span><a href="http://www.nature.com/nature/journal/v491/n7424/full/nature11622.html#supplementary-information">Supplementary Information</a><span>) identified homologous synteny blocks (HSBs). Using porcine HSBs and stringent filtering criteria, 192 pig-specific evolutionary breakpoint regions (EBRs) were located. The number of porcine EBRs </span><span>is comparable to the number of bovine-lineage-specific EBRs (100) reported earlier using a slightly lower resolution (500</span><span><span>&thinsp;</span></span><span>kilobases (kb)), indicating that both lineages evolved with an average rate of ~2.1 large-scale rearrangements per million years after the divergence from a common cetartiodactyl ancestor ~60</span><span><span>&thinsp;</span></span><span>Myr ago</span><sup><a href="http://www.nature.com/nature/journal/v491/n7424/full/nature11622.html#ref2" title="Meredith, R. W. et al. Impacts of the Cretaceous Terrestrial Revolution and KPg extinction on mammal diversification. Science 334, 521-524 (2011)">2</a></sup><span>. This rate compares to ~1.9 rearrangements per million years within the primate lineage (</span><a href="http://www.nature.com/nature/journal/v491/n7424/full/nature11622.html#supplementary-information">Supplementary Table 11</a><span>). A total of 20 and 18 cetartiodactyl EBRs (shared by pigs and cattle) were detected using the pig and human genomes as a reference, respectively.</span></p><p>Address of the bookmark: <a href="http://www.nature.com/nature/journal/v491/n7424/abs/nature11622.html" rel="nofollow">http://www.nature.com/nature/journal/v491/n7424/abs/nature11622.html</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/41209/juicebox-visualization-and-analysis-software-for-hi-c-data</guid>
	<pubDate>Fri, 21 Feb 2020 00:33:38 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/41209/juicebox-visualization-and-analysis-software-for-hi-c-data</link>
	<title><![CDATA[Juicebox: Visualization and analysis software for Hi-C data]]></title>
	<description><![CDATA[<p>Juicebox is visualization software for Hi-C data. This distribution includes the source code for Juicebox,&nbsp;<a href="https://github.com/theaidenlab/juicer/wiki/Download">Juicer Tools</a>, and&nbsp;<a href="https://aidenlab.org/assembly/">Assembly Tools</a>.&nbsp;<a href="https://github.com/theaidenlab/juicebox/wiki/Download">Download Juicebox here</a>, or use&nbsp;<a href="https://aidenlab.org/juicebox">Juicebox on the web</a>. Detailed documentation is available&nbsp;<a href="https://github.com/theaidenlab/juicebox/wiki">on the wiki</a>. Instructions below pertain primarily to usage of command line tools and the Juicebox jar files.</p>
<p>Juicebox can now be used to visualize and interactively (re)assemble genomes. Check out the Juicebox Assembly Tools Module website&nbsp;<a href="https://aidenlab.org/assembly">https://aidenlab.org/assembly</a>&nbsp;for more details on how to use Juicebox for assembly.</p>
<p>GUI at&nbsp;<a href="https://aidenlab.org/juicebox/">https://aidenlab.org/juicebox/</a></p><p>Address of the bookmark: <a href="https://github.com/aidenlab/Juicebox" rel="nofollow">https://github.com/aidenlab/Juicebox</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>

<item>
  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/29886/research-officer-at-national-tea-research-foundation</guid>
  <pubDate>Fri, 18 Nov 2016 04:19:24 -0600</pubDate>
  <link></link>
  <title><![CDATA[Research Officer at National Tea Research Foundation]]></title>
  <description><![CDATA[
<p>National Tea Research Foundation (NTRF) a registered body, requires qualified and experienced agricultural research scientist for contractual appointment as per details below :</p>

<p>Post Research Officer, NTRF, Kolkata</p>

<p>Essential Post Graduate degree in Life Science having special paper in Bioinformatics. Post Graduate degree in Bioinformatics.</p>

<p>Desirable Ph. D. in the area of computational biology or bioinformatics.</p>

<p>Job Experience Work experience on database development, capable to work independently and efficient in bioinformatics related project.</p>

<p>Job Responsibility</p>

<p>To develop database on various aspects of tea research.</p>

<p>Screening of the In-house projects of NTRF at the preliminary level.</p>

<p>Review and evaluation of In-house projects of NTRF. Technical monitoring of the In-house projects of NTRF.</p>

<p>Reviewing the final technical report of the In-house projects of NTRF.</p>

<p>Putting-up of same proposals for taking approval and sanction of the competent authority.</p>

<p>Physical and technical verification of the In-house projects of NTRF.</p>

<p>To assist in organizing seminars / workshops / meetings etc.</p>

<p>Interested candidate may appear for walk-in Interview on 17 th November, 2016</p>

<p>More Info :</p>

<p>http://www.teaboard.gov.in/pdf/Recruitment_for_the_post_of_Research_Officer_pdf7538.pdf</p>
]]></description>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/41996/wgd%E2%80%94simple-command-line-tools-for-the-analysis-of-ancient-whole-genome-duplications</guid>
	<pubDate>Thu, 23 Jul 2020 05:49:45 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/41996/wgd%E2%80%94simple-command-line-tools-for-the-analysis-of-ancient-whole-genome-duplications</link>
	<title><![CDATA[wgd—simple command line tools for the analysis of ancient whole-genome duplications]]></title>
	<description><![CDATA[<p><span>wgd is a easy to use command-line tool for<span>&nbsp;</span></span><em>K</em><sub>S</sub><span><span>&nbsp;</span>distribution construction named wgd. The wgd suite provides commonly used<span>&nbsp;</span></span><em>K</em><sub>S</sub><span><span>&nbsp;</span>and colinearity analysis workflows together with tools for modeling and visualization, rendering these analyses accessible to genomics researchers in a convenient manner.</span></p>
<p><a href="https://academic.oup.com/bioinformatics/article/35/12/2153/5162749">https://academic.oup.com/bioinformatics/article/35/12/2153/5162749</a></p><p>Address of the bookmark: <a href="https://github.com/arzwa/wgd" rel="nofollow">https://github.com/arzwa/wgd</a></p>]]></description>
	<dc:creator>LEGE</dc:creator>
</item>

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