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	<title><![CDATA[BOL: Related items]]></title>
	<link>https://bioinformaticsonline.com/related/31300?offset=1230</link>
	<atom:link href="https://bioinformaticsonline.com/related/31300?offset=1230" rel="self" type="application/rss+xml" />
	<description><![CDATA[]]></description>
	
	
<item>
  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/42172/sr-scientist-bioinformatics-vacancies-at-indian-institute-of-toxicology-research-india</guid>
  <pubDate>Tue, 01 Sep 2020 07:21:04 -0500</pubDate>
  <link></link>
  <title><![CDATA[Sr. Scientist Bioinformatics Vacancies at Indian Institute of Toxicology Research, India]]></title>
  <description><![CDATA[
<p>Start date of online Registration: Wednesday August 19, 2020 11:00 Hrs IST<br />Last date for Registration: Monday September 21, 2020 17:30 Hrs IST<br />Last date for submission of online application: Monday September 21, 2020 17:30 Hrs IST<br />Last date of Receipt of physical copy of application at CSIR-IITR: Tuesday October 05, 2020 17:30 Hrs IST</p>

<p>Pay Matrix Level-12<br />No. of Post-01<br />(UR)<br />Post – Sr. Scientist<br />Area Bioinformatics<br />Age limit : 37 years<br />PhD in Computational Biology/Bioinformatics with 2 years experience in desired area<br />Or<br />ME/M.Tech in Bioinformatics or Genome Informatics or Genetic Engineering with 3 years experience in desired area<br />Experience of understanding fundamental science behind Artificial Intelligence, machine learning, novel Artificial Intelligence algorithms and architectures, software engineering principles for Artificial Intelligence, natural language processing with proficiency in programming as evident by publications in SCI journals with high impact factor. To be part a group of scientists working in the area of genomics, running the central<br />bioinformatics facility, developing independent projects and providing bioinformatics support to the user scientists of the Institute.</p>

<p>More at </p>

<p>http://14.139.62.50/CSIR-IITR%20Scientist%20Recruitment%20Adv%202020.pdf</p>
]]></description>
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<item>
  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/42264/bioinformatics-jobs-at-acrannolife</guid>
  <pubDate>Sun, 25 Oct 2020 22:51:35 -0500</pubDate>
  <link></link>
  <title><![CDATA[Bioinformatics jobs at Acrannolife]]></title>
  <description><![CDATA[
<p>Acrannolife are looking for skilled Bioinformatics Scientists with a minimum of 2yrs Experience in NGS data analysis including Nanopore Sequencing.</p>

<p>This is an opportunity to work on projects that would fundamentally alter the way certain chronic conditions are treated and monitored.</p>

<p>About acrannolife:</p>

<p>We are a team of Post Docs, PhDs, Engineers, Clinicians, and MBAs working towards a future where biology intersects with software(Computational Biology).</p>

<p>We are incubated in Atal Incubation Centre - CCMB and have been backed by some of the leading thought leaders ranging from business to clinical practices.</p>

<p>Interested candidates can fill this form. https://lnkd.in/gtq47hy</p>

<p>and send their CV to hr@acrannolife.com</p>
]]></description>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/pages/view/2518/genome-browsers</guid>
	<pubDate>Fri, 16 Aug 2013 19:04:47 -0500</pubDate>
	<link>https://bioinformaticsonline.com/pages/view/2518/genome-browsers</link>
	<title><![CDATA[Genome Browsers]]></title>
	<description><![CDATA[<p>Genome Browser is the platform/database used for searching and retreiving sequences and annotation of genomes belong to various eukaryotes, prokaryotes, etc.</p><p>Following are the weblink for different available browsers:</p><p><a href="http://www.ensembl.org/index.html">http://www.ensembl.org/index.html</a></p><p><a href="http://ensemblgenomes.org/">http://ensemblgenomes.org/</a></p><p><a href="http://genome.ucsc.edu/">http://genome.ucsc.edu/</a></p><p><a href="http://www.ncbi.nlm.nih.gov/genome">http://www.ncbi.nlm.nih.gov/genome</a></p><p><a href="http://www.ebi.ac.uk/genomes/">http://www.ebi.ac.uk/genomes/</a></p><p><a href="http://flybase.org/">http://flybase.org/</a></p><p><a href="http://cmr.jcvi.org/tigr-scripts/CMR/CmrHomePage.cgi">http://cmr.jcvi.org/tigr-scripts/CMR/CmrHomePage.cgi</a></p><p><a href="http://www.sanger.ac.uk/resources/databases/">http://www.sanger.ac.uk/resources/databases/</a></p>]]></description>
	<dc:creator>Rahul Agarwal</dc:creator>
</item>

<item>
  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/42374/postdoc-in-comparative-genomics</guid>
  <pubDate>Tue, 08 Dec 2020 09:26:40 -0600</pubDate>
  <link></link>
  <title><![CDATA[Postdoc in comparative genomics]]></title>
  <description><![CDATA[
<p>We are looking for a highly motivated researcher for an 18 month postdoctoral position collaborating in an exciting project on comparative genomics of marine fish and shellfish species. In the project, we use genome resequencing data from a range of species to reconstruct the demographic history and characterize genomic signals associated with population divergence and local adaptation in high gene flow scenarios. The work will improve our understanding of interacting evolutionary processes and provide valuable data for securing sustainable management and conservation of exploited resources. Applicants are encouraged to develop their own research ideas within this framework.</p>

<p>The fellowship is part of a larger Nordic collaborative project, MarGen_II, financed by the EU Interreg Öresund-Kattegat-Skagerrak Programme, the Danish Rod and Net License Funds and the National Institute of Aquatic Resources (DTU Aqua). The project will primarily be carried out in the population genetics group, Section for Marine Living Resources, situated in Silkeborg, Denmark. DTU Aqua is an institute at the Technical University of Denmark. In addition, the position offers many opportunities for collaborating with Nordic and other European colleagues in the field.</p>

<p>Application:<br />Apply online at<br />https://www.dtu.dk/english/About/JOB-and-CAREER/vacant-positions/job?id=d198fd80-4856-4a56-943d-485106026504.<br />The deadline is 4 January 2021. For further information, please contact<br />Senior Researcher Jakob Hemmer-Hansen, jhh@aqua.dtu.dk.</p>

<p>You can read more about DTU Aqua at www.aqua.dtu.dk<br />and the population genetics group at<br />https://www.aqua.dtu.dk/english/research/population_genetics.</p>

<p>All interested candidates irrespective of age, gender, race, disability,<br />religion or ethnic background are encouraged to apply.</p>

<p>Jakob Hemmer Hansen</p>
]]></description>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/42670/icgeb-bioinformatics-job</guid>
  <pubDate>Sat, 23 Jan 2021 21:01:55 -0600</pubDate>
  <link></link>
  <title><![CDATA[ICGEB Bioinformatics Job]]></title>
  <description><![CDATA[
<p>The following vacancies are available in the various ongoing bioinformatics projects at.<br />Translational Bioinformatics Group (https://www.icgeb.org/dinesh-gupta/), ICGEB, New Delhi, India. Shortlisted candidates will be welcomed for an on-line interview at ICGEB. Only the chosen applicants will be informed individually. Preference will be given to the applicants with experience related to Bioinformatics as well as Computational area.</p>

<p>Interested applicants must submit their complete, updated Curriculum Vitae, mentioning details of two references as well as various other details at – http://14.139.62.220/survey/index.php/2021/01/21/icgeb-dbt-project-vacancy/</p>

<p>The last date of submission of applications is January 31st, 2021.</p>

<p>Research Associate : PhD. Degree in Computational Biology/Bioinformatics.</p>

<p>Consolidated Salary: 58280/- pm (including HRA).</p>

<p>More at https://www.icgeb.org/project-positions-translational-bioinformatics-group/ and https://www.icgeb.org/category/vacancies/</p>
]]></description>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/38452/silix-implements-an-ultra-efficient-algorithm-for-the-clustering-of-homologous-sequences</guid>
	<pubDate>Wed, 12 Dec 2018 09:22:41 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/38452/silix-implements-an-ultra-efficient-algorithm-for-the-clustering-of-homologous-sequences</link>
	<title><![CDATA[SiLiX: implements an ultra-efficient algorithm for the clustering of homologous sequences]]></title>
	<description><![CDATA[<p>The software package SiLiX implements<strong>&nbsp;an ultra-efficient algorithm for the clustering of homologous sequences</strong>, based on single transitive links (<em>single linkage</em>) with alignment coverage constraints.</p>
<p>SiLiX adopts a graph-theoretical framework to interpret similarity pairs as edges of a network. A very efficient algorithm, based on the&nbsp;<em>Disjoint Sets Data Structure</em>, allows the computation of sequence families with&nbsp;<strong>low time and space requirements</strong>.</p>
<p><strong>A parallel version</strong>&nbsp;of SiLiX, based on MPI, is also available in this package and has been proved to be scalable, so that its allows the study of&nbsp;<strong>very large datasets</strong>.</p>
<p>SiLiX is already included in the analysis pipeline for&nbsp;<a href="http://pbil.univ-lyon1.fr/databases/hogenom/acceuil.php">HOGENOM</a>.</p><p>Address of the bookmark: <a href="http://lbbe.univ-lyon1.fr/SiLiX?lang=fr" rel="nofollow">http://lbbe.univ-lyon1.fr/SiLiX?lang=fr</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/pages/view/42810/bioinformatics-in-africa-part3-mali</guid>
	<pubDate>Sat, 06 Feb 2021 13:28:44 -0600</pubDate>
	<link>https://bioinformaticsonline.com/pages/view/42810/bioinformatics-in-africa-part3-mali</link>
	<title><![CDATA[Bioinformatics in Africa: Part3 - Mali]]></title>
	<description><![CDATA[<p>International&nbsp;Center&nbsp;for&nbsp;Excellence&nbsp;in&nbsp;Research&nbsp;(ICER):</p><p>The&nbsp;ICER&nbsp;is&nbsp;a&nbsp;research&nbsp;center&nbsp;composed&nbsp;of&nbsp;the&nbsp;following&nbsp;three&nbsp;programs: 1. The&nbsp;Malaria&nbsp;Research&nbsp;and&nbsp;Training&nbsp;Center&nbsp;&shy;&nbsp;Parasitology&nbsp;Group,&nbsp; 2. The&nbsp;Malaria&nbsp;Research&nbsp;and&nbsp;Training&nbsp;Center&nbsp;&shy;&nbsp;Entomology&nbsp;Group&nbsp; 3. The&nbsp;SEREFO&nbsp;Group.</p><p>The&nbsp;first&nbsp;two&nbsp;programs&nbsp;develop&nbsp;biomedical&nbsp;researches&nbsp;in&nbsp;malaria,&nbsp;Filariasis&nbsp;and&nbsp;Leishmaniasis.&nbsp;The&nbsp; third&nbsp;program&nbsp;develops&nbsp;biomedical&nbsp;researches&nbsp;in&nbsp;tuberculosis&nbsp;and&nbsp;HIV.</p><p>Bioinformatics&nbsp;was&nbsp;introduced&nbsp;recently&nbsp;to&nbsp;the&nbsp;ICER&nbsp;and&nbsp;is&nbsp;constantly&nbsp;growing.&nbsp;The&nbsp;ICER&nbsp;has&nbsp;one&nbsp; team,&nbsp;headed&nbsp;by&nbsp;Sidy&nbsp;SOUMARE,&nbsp;which&nbsp;supports&nbsp;the&nbsp;three&nbsp;programmes&nbsp;in&nbsp;all&nbsp;their&nbsp;needs&nbsp;in&nbsp; informatics&nbsp;and&nbsp;bioinformatics.&nbsp;This&nbsp;team&nbsp;can&nbsp;beneficiate&nbsp;from&nbsp;some&nbsp;computational&nbsp;facilities&nbsp;(4&nbsp; blast&nbsp;servers,&nbsp;15&nbsp;other&nbsp;servers&nbsp;and&nbsp;around&nbsp;200&nbsp;terminals),&nbsp;but&nbsp;the&nbsp;ICER&nbsp;staff&nbsp;needs&nbsp;some&nbsp;training&nbsp;in&nbsp; order&nbsp;to&nbsp;be&nbsp;able&nbsp;to&nbsp;administrate&nbsp;these&nbsp;facilities.</p><p>Research&nbsp;Interest&nbsp;and&nbsp;Activities: The&nbsp;following&nbsp;are&nbsp;the&nbsp;present&nbsp;areas&nbsp;of&nbsp;research&nbsp;interest: 1. Functional&nbsp;genomics 2. Analysis&nbsp;of&nbsp;microarray&nbsp;data 3. Interaction&nbsp;between&nbsp;the&nbsp;vector&nbsp;and&nbsp;the&nbsp;parasite.</p>]]></description>
	<dc:creator>BioStar</dc:creator>
</item>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/blog/view/44848/trust-but-verify-sequencing-your-cell-lines-might-reveal-an-uninvited-guest</guid>
	<pubDate>Wed, 04 Jun 2025 00:07:57 -0500</pubDate>
	<link>https://bioinformaticsonline.com/blog/view/44848/trust-but-verify-sequencing-your-cell-lines-might-reveal-an-uninvited-guest</link>
	<title><![CDATA[Trust But Verify: Sequencing Your Cell Lines Might Reveal an Uninvited Guest]]></title>
	<description><![CDATA[<p>High-throughput sequencing has become indispensable in cell biology, enabling detailed insights into chromatin structure, gene expression, and regulatory dynamics. Yet, when faced with unexpectedly low mapping rates to the human genome, researchers often rush to troubleshoot technical parameters&mdash;sequencer quality, adapter trimming, or aligner settings.</p><p>Before you go down that path, consider this critical biological question:<br /> <strong>Are you sequencing human cells&mdash;or bacterial contamination?</strong></p><h2>The Silent Saboteur: Mycoplasma in Cell Cultures</h2><p><em>Mycoplasma</em> contamination remains one of the most widespread and underdiagnosed issues in tissue culture work. Studies suggest that <strong>15&ndash;35% of cell lines in use may be contaminated</strong>, often without visible signs. Unlike other microbial infections, <em>Mycoplasma</em> does not produce cloudiness, odor, or a change in pH. Many researchers won&rsquo;t detect it unless they specifically test for it.</p><p>The consequences, however, are profound. <em>Mycoplasma</em> can significantly alter:</p><ul>
<li>
<p>Host gene expression patterns</p>
</li>
<li>
<p>Cell proliferation rates</p>
</li>
<li>
<p>Epigenetic profiles and chromatin accessibility</p>
</li>
<li>
<p>Cytokine signaling and immune responses</p>
</li>
</ul><p>In short, it can skew your results, compromise your biological conclusions, and invalidate weeks or months of research.</p><h2>A Simple Diagnostic Step: Map Against <em>Mycoplasma</em> Genomes</h2><p>If you encounter poor alignment rates to the human genome, consider mapping your reads to a <em>Mycoplasma</em> reference genome&mdash;or better yet, use a <strong>combined human + <em>Mycoplasma</em></strong> reference. There have been cases where over half of all reads, initially assumed to be from human cells, were in fact bacterial in origin. This check is fast, easy, and could save your project.</p><h2>How Contamination Happens&mdash;and Persists</h2><p><em>Mycoplasma</em> is small (0.1&ndash;0.3 &mu;m), lacks a cell wall, and can pass through standard filters undetected. Common sources include:</p><ul>
<li>
<p>Contaminated reagents (e.g., FBS)</p>
</li>
<li>
<p>Infected cell lines obtained from other labs</p>
</li>
<li>
<p>Poor aseptic technique or shared equipment</p>
</li>
</ul><p>Once present, it spreads quickly between cultures and can persist for months, silently affecting results.</p><h2>Why Treatment Is Difficult</h2><p>While antibiotics such as Plasmocin or BM-Cyclin are sometimes used, they often offer only partial resolution and may themselves alter cell behavior. In many cases, the best course of action is to <strong>discard the contaminated culture</strong> and start with a fresh, verified stock.</p><h2>Practical Recommendations for Researchers</h2><ul>
<li>
<p><strong>Routinely test for <em>Mycoplasma</em></strong> using PCR, qPCR, or fluorescence-based assays</p>
</li>
<li>
<p><strong>Incorporate contamination screens into your sequencing QC pipeline</strong></p>
</li>
<li>
<p><strong>Use combined reference genomes</strong> when mapping ambiguous reads</p>
</li>
<li>
<p><strong>Practice strict aseptic technique</strong> and monitor all incoming cell lines</p>
</li>
<li>
<p><strong>Don&rsquo;t ignore unexplained data anomalies</strong>&mdash;they might point to contamination</p>
</li>
</ul><h2>Closing Thought: Contamination Is a Biological Variable</h2><p>It&rsquo;s easy to view poor mapping as a technical issue, but sometimes the problem lies deeper&mdash;in the biology itself. <em>Mycoplasma</em> contamination doesn&rsquo;t just interfere with sequencing; it interferes with science. As a research community, we must treat contamination not as an afterthought, but as a key variable to control.</p><p>So next time your reads won&rsquo;t align, don&rsquo;t just tune the aligner. Ask if your cells are telling the truth&mdash;or if they're hiding something.</p>]]></description>
	<dc:creator>LEGE</dc:creator>
</item>

<item>
  <guid isPermaLink='true'>https://bioinformaticsonline.com/opportunity/view/42907/lecturer-in-evolutionary-biology-bioinformatics-at-department-of-zoology-te-tari-matai-kararehe-division-of-sciences-te-rohe-a-ahikaroa</guid>
  <pubDate>Tue, 23 Feb 2021 02:05:15 -0600</pubDate>
  <link></link>
  <title><![CDATA[Lecturer in Evolutionary Biology (Bioinformatics) at DEPARTMENT of ZOOLOGY | TE TARI MĀTAI KARAREHE DIVISION of SCIENCES | TE ROHE A AHIKAROA]]></title>
  <description><![CDATA[
<p>DEPARTMENT of ZOOLOGY | TE TARI MĀTAI KARAREHE<br />DIVISION of SCIENCES | TE ROHE A AHIKAROA</p>

<p>Applications are invited for the position of Lecturer in Evolutionary Biology (Bioinformatics).</p>

<p>We are seeking a person with a relevant doctorate, and demonstrated potential to develop as an outstanding researcher and teacher in evolutionary bioinformatics in the Department of Zoology. The position affords an exciting opportunity for an emerging scholar to research and teach in a vibrant and diverse Department. The successful candidate will develop a transformative and collaborative research program, supporting the university's commitment to excellence in research.</p>

<p>Your skills and experience</p>

<p>A PhD with a background in analysis of high-throughput sequencing data and evolutionary biology.<br />Knowledge of and familiarity with a range of bioinformatics skills, concepts, and practices as they relate to the biology of animals, including genomic, transcriptomic and metabarcoding data analyses.<br />A strong interest, and experience, in research and teaching of bioinformatics and evolutionary genomics.<br />An ability to contribute to teaching and learning environments that support engagement of students and staff with bioinformatics and genomics.<br />Be committed to and or have established connections or track record of working with national and local bioinformaticians. <br />Be committed to being a productive collaborator with a track record of working collegially.<br />Further details</p>

<p>This is a confirmation-path (tenure track) position at the level of Lecturer. The successful candidate is expected to take up duties by 1 July 2021.</p>

<p>To see a full job description and to apply online go to: https://otago.taleo.net/careersection/2/jobdetail.ftl?job=2100342</p>
]]></description>
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  <guid isPermaLink='true'>https://bioinformaticsonline.com/researchlabs/view/38551/gupta-lab</guid>
  <pubDate>Sat, 29 Dec 2018 13:18:31 -0600</pubDate>
  <link></link>
  <title><![CDATA[Gupta Lab]]></title>
  <description><![CDATA[
<p>Work include (i) understanding the evolutionary relationships among different prokaryotic and eukaryotic organisms; (ii) Understanding the cellular functions of these lineage-specific signature proteins as well as lineage-specific conserved inserts and deletions in important housekeeping proteins by genetic and biochemical studies; (iii) Development of novel diagnostic methods (PCR based and immunological) for identification of different groups of organisms based upon these signature proteins and conserved indels; (iv) The use of these lineage-specific probes with predicitive ability to identify/explore the presence of different groups of organisms in metagenomic sequences from various environments.</p>

<p>https://fhs.mcmaster.ca/gupta-lab/index.html</p>
]]></description>
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