Functioning of efflux systems in Gram-negative bacteria
Determinants of the compound-efflux system interactions
Action of inhibitors on efflux systems
Structural and dynamical features of the efflux systems

TatA
Assembly of the TatA system
Study of the dynamical features of the charge zipper

Methods
Setup of a kinetic Monte Carlo (KMC) scheme to study the flux of antibiotics through porins and efflux systems
Setup of protocol to integrate MD results in a ligand-based approach

Viral inhibitors
Interactions of selected compounds with RNA-dependent RNA polymerases (RdRps) of HCV and BVDV
Assessment of the role of mutations in RdRps
Antimicrobial peptides

Interactions of antimicrobial peptides with membranes: structure and dynamics
Interactions between antimicrobial peptides in the presence of different membranes
Protein-protein interactions
Effects of mutations

Lab Page
http://www.dsf.unica.it/~paolo/Site/Home.html

Identify pairs of contigs that are syntenic and move one of them to the haplotig 'pool'. The pipeline uses mapped read coverage and Minimap2 alignments to determine which contigs to keep for the haploid assembly. Dotplots are optionally produced for all flagged contig matches, juxtaposed with read-coverage, to help the user determine the proper assignment of any remaining ambiguous contigs. The pipeline will run on either a haploid assembly (i.e. Canu, FALCON or FALCON-Unzip primary contigs) or on a phased-diploid assembly (i.e. FALCON-Unzip primary contigs + haplotigs). Here are two examples of how Purge Haplotigs can improve a haploid and diploid assembly.

Address of the bookmark: https://bitbucket.org/mroachawri/purge_haplotigs

Genome Annotation and Functional Genomics

Bergman Lab is actively engaged in the development and application of computational methods to improve the annotation of functional biological features in genome sequences. Bergman Lab work focuses on improving annotation of non-protein-coding regions of the genome including conserved noncoding sequences (CNSs), cis-regulatory modules (CRMs), transcription factor binding sites (TFBSs), transposable elements (TEs) and noncoding RNA (ncRNA) genes. Current projects include improving the (i) annotation of TEs in the fly and yeast genomes, (ii) annotation of CRMs and TFBSs in the fly genome, and (iii) analysis of transposon knockout collections in flies. Research in this area is supported by the EC FP7 programme.

Genome and Molecular Evolution
Text and Data Mining

More @ http://bergmanlab.smith.man.ac.uk/

The Program first constructs all exact match pairs by a suffix-array based algorithm and extends them to long highly similar pairs. Then Smith-Waterman algorithm is used to adjust the ends of LTR pair candidates to get alignment boundaries. These boundaries are subject to re-adjustment using supporting information of TG..CA box and TSRs and reliable LTRs are selected. Next, LTR_FINDER tries to identify PBS, PPT and RT inside LTR pairs by build-in aligning and counting modules. RT identification includes a dynamic programming to process frame shift. For other protein domains, LTR_FINDER calls ps_scan (from PROSITE, http://www.expasy.org/prosite/) to locate cores of important enzymes if they occur.

Address of the bookmark: https://github.com/xzhub/LTR_Finder

Nature Biotechnology spoke with Altschul and several other originators of computational biology software programs widely used today (Table 1). The conversations explored what makes certain software tools successful, the unique challenges of developing them for biological research and how the field of computational biology, as a whole, can move research agendas forward. What follows is an edited compilation of interviews.

Detail @ http://www.nature.com/nbt/journal/v31/n10/full/nbt.2721.html

News Source @ Nature

Address of the bookmark: http://genomearchitect.github.io/

No. of Posts and Specialization: 1(UR)

Educational Qualification:

(i) Good academic record with a Ph.D. Degree in the concerned /allied /relevant disciplines.

(ii) The Ph.D. Degree shall be a mandatory qualification for all candidates to be appointed as Associate Professor through direct recruitment.

(iii) A Master‟s Degree with at least 55% marks (or an equivalent grade in a point scale wherever grading system is followed).

(iv) A minimum of eight years of experience of teaching and /or research in an academic /research position equivalent to that of Assistant Professor in a University, College or Accredited Research Institution/Industry excluding the period of Ph.D research with evidence of published work and a minimum of 5 publications as books and /or research papers in refereed journals only/policy papers.

(v) Contribution to educations innovation, design of new curricula and courses and technology-mediated teaching learning process with evidence of having guided doctoral candidates and research students.

(vi) A minimum score as stipulated in the Academic Performance Indicator (API) based performance Based Appraisal System (PBAS), set out in this notification in as mentioned in the advertisement.

Send your application to the A.R (Estt.Teaching), M.D.University, Rohtak on or before December 23, 2013.

For more details: http://www.mdurohtak.ac.in/pdf/Notices_Pdf/new_notice/Teaching%20Vacancy%20%28ADVT.%20No.%20PR-54%20of%202013%29.pdf

Last Apply Date: 23 Dec 2013

Scientists have reconstructed the genome of an ancient human who lived nearly 5,700 years ago in Southern Denmark from the birch pitch- an ancient tar-like substance.

By sequencing the sample, researchers not only discovered the ancient human DNA but also microbial DNA reflecting the oral microbiome of the person who chewed the pitch, along with plant and animal DNA that could be the recent meal she might have consumed.

The DNA sample is comparable in quality to well-preserved teeth and skull bones. The DNA suggests that the chewer was a female, most likely with dark skin, dark brown hair and blue eyes.

NOTIFICATION FOR FACULTY RECRUITMENT – 2013

(Faculty openings in Technology, Science, Architecture and Management at NIT Calicut, Kerala)

National Institute of Technology Calicut, Kerala, established under Act XXIX/ 2007of the Parliament is one of the leading technological institutions in the Country with nearly 6000 students enrolled for various UG, PG and Ph.D. programmes in Technology, Science, Architecture and Management. The Institute invites applications from Indian nationals, possessing consistent excellent academic record, commitment to quality teaching and potential for carrying out outstanding research, for the post of Assistant Professors in various departments against the backlog reserved vacancies for Scheduled Caste (SC), Scheduled Tribe (ST), Other Backward Communities (OBC) and Persons with Disabilities (PWDs) and also under open merit quota as detailed below. Candidates belonging to SC, ST and OBC desirous of considering for selection under UR category also shall specifically indicate so in column 4.

Reservation quota for PWDs will be counted against the respective community. Young, meritorious, dynamic and student friendly academicians are welcome to join hands with the existing team in their effort to transform this Institute to a world class educational institution.

Candidates possessing Ph.D. degree will be considered for appointment on contract basis initially.

They will be considered for movement to AGP `7000 after one year of satisfactory performance.

Meritorious candidates possessing M.Tech./M.Phil. (*) with remarkably good potential to carry out outstanding research and already pursuing Ph.D. or aspiring to pursue Ph.D. will also be considered for appointment on contract, initially for a period of 3 years, extendable for a further period of 2 years on a year to year basis or till the candidate acquires Ph.D. degree whichever is earlier. Renewal of contract
will be done on an annual basis, subject to satisfactory progress of Ph.D. work, good conduct and good performance in teaching. Faculty appointed on contract basis will not be treated as regular staff till they are regularized, subject to the conditions stated earlier. The Institute has adopted 4-tier flexible faculty structure recommended by MHRD.

More Info : http://www.nitc.ac.in/index.php/?url=content/submenu/2345/5

Check out the detail at https://www.ncbi.nlm.nih.gov/nuccore/MN908947