BOL: Related items

Precision Medicine

Rahul Agarwal — Sat, 24 Aug 2013 15:47:03 -0500

Coupling established clinical–pathological indexes with state-of-the-art molecular profiling to create diagnostic, prognostic, and therapeutic strategies precisely tailored to each patient's requirements — hence the term “Precision medicine”

Source:http://www.nejm.org/doi/full/10.1056/NEJMp1114866

Another video on precision medicine:

http://www.youtube.com/watch?v=Pi8W0yOXnzE

Precision Medicine basically intergrates bioinformatics, genomics , genetics, molecular biology and nanotechnology to deliver precise cure/diagnotics to a specific patient.

Examples:

The drug imatinib (Gleevec) designed to inhibit an altered enzyme produced by a fused version of two genes found in chronic myelogenous leukemia.
The breast cancer drug trastuzumab (Herceptin) works only for women whose tumors have a particular genetic profile called HER-2 positive.

E.g. source :

http://www.bionews-tx.com/news/2013/08/15/how-the-impact-of-cancer-genomics-on-precision-medicine-is-revolutionizing-cancer-treatment/

Address of the bookmark: http://www.cbsnews.com/video/watch/?id=50149783n

Bioinformatics market in India

Rahul Agarwal — Fri, 23 Aug 2013 07:08:49 -0500

Key Topics Covered in the Report:

The market size of the Indian Bioinformatics Industry , FY’2007-FY’2013
Market segmentation of India bioinformatics industry by application by sectors, FY’2007-FY’2013
Market Segmentation of India bioinformatics industry by products and services,FY’2007-FY’2013
Market Segmentation of India bioinformatics industry by applications of bioinformatics ,FY’2007-FY’2013
India bioinformatics industry trends and developments
Government regulations and initiatives of India bioinformatics industry
Major bioinformatics research institutes in India
Market Share of leading players in bioinformatics industry in India,FY’2013
Company profiles of major players in India bioinformatics industry
Future outlook and projections on the basis of revenue in India bioinformatics market, FY’2014-FY’2018

(Source: Ken Research)

Address of the bookmark: http://www.kenresearch.com/healthcare/biotechnology/india-bioinformatics-industry-research-report/392-91.html

Zombies like bacteria!!!

Rahul Agarwal — Tue, 03 Sep 2013 08:44:15 -0500

Do you believe in Zombies stories … Hmm confused? Don’t worry there is a news for you. Scientists from the Integrated Ocean Drilling Program have announced the findings of the long-lived bacteria, reproducing only once every 10,000 years, which have been found in rocks 2.5km (1.5 miles) below the ocean floor that are as much as 100 million years old.

" the microbes exist in very low concentrations, of around 1,000 microbes in every tea spoon full of rock, compared with billions or trillions of bacteria that would typically be found in the same amount of soil at Earth's surface."

Reference:

http://www.bbc.co.uk/news/science-environment-23855436

Introduction of Epigenomics

Rahul Agarwal — Sun, 06 Oct 2013 04:59:30 -0500

Address of the bookmark: http://www.genome.gov/27532724

A-allele of SLC24A5 gene is found to be responsible for variation in skin color of South-East Asians and Europeans

Rahul Agarwal — Tue, 12 Nov 2013 21:02:27 -0600

Key finding:

rs1426654 SNP of SLC24A5 gene is decider of skin pigmentation variation in South Asia
rs1426654-A allele is widely spread throughout the Indian subcontinent
Skin pigmentation is also account by the combination of processes like selection and demographic history of populations affected by their language and origin
Sign of positive selection in Europeans, Middle East, Pakistan, Central Asia and North India but not in South India
In European , A-allele is almost reached to fixation

Paper:

http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1003912