<![CDATA[BOL: Related items]]> https://bioinformaticsonline.com/related/33461?offset=170 https://bioinformaticsonline.com/bookmarks/view/36026/mmseqs20-ultra-fast-and-sensitive-protein-search-and-clustering-suite Thu, 22 Mar 2018 10:40:51 -0500 https://bioinformaticsonline.com/bookmarks/view/36026/mmseqs20-ultra-fast-and-sensitive-protein-search-and-clustering-suite <![CDATA[MMseqs2.0: ultra fast and sensitive protein search and clustering suite]]> MMseqs2 (Many-against-Many sequence searching) is a software suite to search and cluster huge protein sequence sets. MMseqs2 is open source GPL-licensed software implemented in C++ for Linux, MacOS, and (as beta version, via cygwin) Windows. The software is designed to run on multiple cores and servers and exhibits very good scalability. MMseqs2 can run 10000 times faster than BLAST. At 100 times its speed it achieves almost the same sensitivity. It can perform profile searches with the same sensitivity as PSI-BLAST at over 400 times its speed.

The MMseqs2 user guide is available as Github Wiki or as PDF file (Thanks to pandoc!)

Please cite: Steinegger M and Soeding J. MMseqs2 enables sensitive protein sequence searching for the analysis of massive data sets. Nature Biotechnology, doi: 10.1038/nbt.3988 (2017).

Address of the bookmark: https://github.com/soedinglab/MMseqs2

]]> Jit https://bioinformaticsonline.com/bookmarks/view/44329/metabuli-%EB%B6%84%EB%A6%AC-improves-metagenomic-read-classification Sat, 03 Jun 2023 20:15:04 -0500 https://bioinformaticsonline.com/bookmarks/view/44329/metabuli-%EB%B6%84%EB%A6%AC-improves-metagenomic-read-classification <![CDATA[Metabuli 분리 improves metagenomic read classification]]> Metabuli 분리 improves metagenomic read classification through metamers, DNA-AA k-mers, to be sensitive and specific, recovering 99% and 98% of DNA or AA classifiers.

 

Metabuli is metagenomic classifier that jointly analyze both DNA and amino acid (AA) sequences. DNA-based classifiers can make specific classifications, exploiting point mutations to distinguish close taxa. AA-based classifiers have higher sensitivity in detecting homology between query and reference sequences, leverageing higher conservation of AA sequences. Metabuli combines the information of both sequence types using a novel k-mer structure, metamer, to enable both specific and sensitive characterization of metagenomic samples. In addition, it can classify reads against a database of any size as long as it fits in the hard disk.

Address of the bookmark: https://github.com/steineggerlab/Metabuli

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