<?xml version='1.0'?><rss version="2.0" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:georss="http://www.georss.org/georss" xmlns:atom="http://www.w3.org/2005/Atom" >
<channel>
	<title><![CDATA[BOL: Related items]]></title>
	<link>https://bioinformaticsonline.com/related/33874?offset=30</link>
	<atom:link href="https://bioinformaticsonline.com/related/33874?offset=30" rel="self" type="application/rss+xml" />
	<description><![CDATA[]]></description>
	
	<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/36905/d-genies-a-tool-for-dotplot-large-genomes-in-an-interactive-efficient-and-simple-way</guid>
	<pubDate>Mon, 11 Jun 2018 09:41:22 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/36905/d-genies-a-tool-for-dotplot-large-genomes-in-an-interactive-efficient-and-simple-way</link>
	<title><![CDATA[D-GENIES: A tool for Dotplot large Genomes in an Interactive, Efficient and Simple way]]></title>
	<description><![CDATA[D-GENIES – for Dotplot large Genomes in an Interactive, Efficient and Simple way – is an online tool designed to compare two genomes. It supports large genome and you can interact with the dot plot to improve the visualisation.

We use minimap version 2 to align the two genomes. Then, the PAF file is parsed and plotted into an interactive plot written with d3.js library.

D-Genies also allows to display dot plots from other aligners by uploading their PAF or MAF alignment file.

http://dgenies.toulouse.inra.fr/<p>Address of the bookmark: <a href="http://dgenies.toulouse.inra.fr/" rel="nofollow">http://dgenies.toulouse.inra.fr/</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/39872/miropeats-discovers-regions-of-sequence-similarity-amongst-any-set-of-dna-sequences</guid>
	<pubDate>Mon, 26 Aug 2019 17:55:24 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/39872/miropeats-discovers-regions-of-sequence-similarity-amongst-any-set-of-dna-sequences</link>
	<title><![CDATA[Miropeats: discovers regions of sequence similarity amongst any set of DNA sequences]]></title>
	<description><![CDATA[<p><span>Miropeats discovers regions of sequence similarity amongst any set of DNA sequences and then presents this similarity information graphically. Sequence similarity searching is a very general tool that forms the basis of many different biological sequence analyses but it is limited by the verbosity of traditional alignment presentation styles. Miropeats enhances the utility of conventional DNA sequence comparisons when looking at long lengths of sequence similarity by summarizing extensive large scale sequence similarities on a single page of graphics. The latest version of Miropeats can be used as a general pairwise alignment program or in its traditional role sorting out a big mess of overlapping or similar regions.</span></p><p>Address of the bookmark: <a href="http://www.littlest.co.uk/software/bioinf/old_packages/miropeats/" rel="nofollow">http://www.littlest.co.uk/software/bioinf/old_packages/miropeats/</a></p>]]></description>
	<dc:creator>Poonam Mahapatra</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/40865/dminda2-an-integrated-web-server-for-dna-motif-identification-and-analyses</guid>
	<pubDate>Sun, 02 Feb 2020 14:26:01 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/40865/dminda2-an-integrated-web-server-for-dna-motif-identification-and-analyses</link>
	<title><![CDATA[DMINDA2: an integrated web server for DNA motif identification and analyses]]></title>
	<description><![CDATA[<p><span>DMINDA (</span><strong>D</strong><span>NA&nbsp;</span><strong>m</strong><span>otif&nbsp;</span><strong>i</strong><span>dentification a</span><strong>nd a</strong><span>nalyses) is an integrated web server for DNA motif identification and analyses</span></p>
<p><span>More at&nbsp;http://bmbl.sdstate.edu/DMINDA2/</span></p>
<p><span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086085/">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086085/</a></span></p><p>Address of the bookmark: <a href="http://bmbl.sdstate.edu/DMINDA2/" rel="nofollow">http://bmbl.sdstate.edu/DMINDA2/</a></p>]]></description>
	<dc:creator>BioStar</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/44495/exrec-exclusion-of-recombined-dna</guid>
	<pubDate>Wed, 27 Mar 2024 20:48:26 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/44495/exrec-exclusion-of-recombined-dna</link>
	<title><![CDATA[ExRec: Exclusion of Recombined DNA]]></title>
	<description><![CDATA[<p><span>ExRec (Exclusion of Recombined DNA) is a Python pipeline that implements the four-gamete test to filter out recombined DNA sites from up to thousands of DNA sequence loci. The pipeline consists of five standalone applications: the first two convert folders of NEXUS or PHYLIP files into the standard input file for the main program that conducts the four-gamete filtering procedures. The pipeline outputs recombination-filtered data in concatenated NEXUS and PHYLIP formats and a tab-delimited table containing descriptive statistics for all loci and the results. This software also allows the user to output the longest non-recombined sequence blocks from loci (current best practice) or randomly select non-recombined blocks from loci (a newer approach). Two other applications in the package convert the recombination-filtered data into single-locus NEXUS or PHYLIP files. The ExRec package can thus facilitate species delimitation, species tree, and historical demography studies by providing loci that better meet the no-recombination assumption in coalescent-based analyses.</span></p>
<p><span>Link to the article:&nbsp;</span><a href="https://academic.oup.com/bioinformaticsadvances/article/3/1/vbad174/7455250?searchresult=1" target="_blank">https://academic.oup.com/bioinformaticsadvances/article/3/1/vbad174/7455250?searchresult=1</a><br><br><span>Link to the software:</span><br><a href="https://github.com/Sammccarthypotter/ExRec" target="_blank">https://github.com/Sammccarthypotter/ExRec</a></p><p>Address of the bookmark: <a href="https://github.com/Sammccarthypotter/ExRec" rel="nofollow">https://github.com/Sammccarthypotter/ExRec</a></p>]]></description>
	<dc:creator>LEGE</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/blog/view/38238/list-of-motif-discovery-tools</guid>
	<pubDate>Tue, 20 Nov 2018 03:54:26 -0600</pubDate>
	<link>https://bioinformaticsonline.com/blog/view/38238/list-of-motif-discovery-tools</link>
	<title><![CDATA[List of motif discovery tools !]]></title>
	<description><![CDATA[<div><div>In genetics, a sequence motif is a nucleotide or amino-acid sequence pattern that is widespread and has, or is conjectured to have, a biological significance. For proteins, a sequence motif is distinguished from a structural motif, a motif formed by the three-dimensional arrangement of amino acids which may not be adjacent.</div><div>&nbsp;</div><div>Following are the list of tools for motif discovery:</div><div>&nbsp;</div><div><a href="http://genius.embnet.dkfz-heidelberg.de/menu/biounit/open-husar/">2Dsweep -- protein annotation by secondary structure elements</a></div><p>Perform secondary structure predictions on protein sequences.</p></div><div><div><a href="http://floresta.eead.csic.es/3dfootprint/">3D-footprint -- database of DNA-binding protein structures</a></div><p>Find binding specificity information about DNA-protein complexes.</p></div><div><div><a href="http://floresta.eead.csic.es/3dfootprint/">3D-footprint: DNA-binding protein database</a></div><p>Find information about the binding specificity of DNA-binding proteins.</p></div><div><div><a href="http://3d-partner.life.nctu.edu.tw/">3D-partner -- a web server to infer interacting partners and binding models</a></div><p>Predict interacting partners and binding models.</p></div><div><div><a href="http://motif.stanford.edu/distributions/3motif/">3MOTIF -- a protein structure visualization system for conserved sequence motifs</a></div><p>Use this web-based sequence motif visualization system to display sequence motif information in its appropriate three-dimensional (3D) context.</p></div><div><div><a href="http://bioinfo.mpiz-koeln.mpg.de/afawe/">AFAWE -- Automatic functional annotation in a distributed Web Services Environment</a></div><p>Protein function prediction and annotation in an integrated environment powered by web service.</p></div><div><div><a href="http://anchor.enzim.hu/">ANCHOR -- Prediction of Protein Binding Regions in Disordered Proteins</a></div><p>Find information about protein binding.</p></div><div><div><a href="http://annie.bii.a-star.edu.sg/annie/home.do">ANNIE -- ANNotation and Interpretation Environment for Protein Sequences</a></div><p>Use to predict function from de novo protein sequences.</p></div><div><div><a href="http://bioinformatica.isa.cnr.it/ASC/">Active Sequences Collection (ASC) database -- A new tool to assign functions to protein sequences</a></div><p>Search for short active protein sequences with demonstrated biological activities.</p></div><div><div><a href="http://blocks.fhcrc.org/">Blocks -- Ungapped segments in conserved protein sequences</a></div><p>Search for ungapped segments corresponding to the most highly conserved regions of proteins.</p></div><div><div><a href="http://cast.engr.uic.edu/">CASTp -- computed atlas of surface topography of proteins with structural and topographical mapping of functionally annotated residues</a></div><p>Identify and measure surface accessible pockets as well as interior inaccessible cavities, for proteins and other molecules.</p></div><div><div><a href="http://www.ebi.ac.uk/thornton-srv/databases/CSA">CSA -- The Catalytic Site Atlas</a></div><p>To search for catalytic residue annotation for enzymes in the Protein Data Bank.</p></div><div><div><a href="http://www.sbg.bio.ic.ac.uk/~confunc/">ConFunc -- Conserved residue Protein Function Prediction Server</a></div><p>Predict protein function using Gene Ontology.</p></div><div><div><a href="http://consurf.tau.ac.il/">ConSurf-DB -- evolutionary conservation profiles of protein structures database</a></div><p>Automatically calculate evolutionary conservation scores of key amino acid residues and map them on protein structures.</p></div><div><div><a href="http://salilab.org/DBAli/">DBAli -- A Database of Structure Alignments</a></div><p>Mine the protein structure space.</p></div><div><div><a href="http://dilimot.embl.de/">DILIMOT -- discovery of linear motifs in proteins</a></div><p>Predict short linear motifs (3-8 residues) in a set of protein sequences.</p></div><div><div><a href="http://www.ebi.ac.uk/dasty/">Dasty2 -- an Ajax protein DAS client</a></div><p>A web client for visualizing protein sequence feature information using DAS.</p></div><div><div><a href="http://genius.embnet.dkfz-heidelberg.de/menu/biounit/open-husar/">DomainSweep -- protein annotation by domain analysis</a></div><p>Identify the domain architecture within a protein sequence.</p></div><div><div><a href="http://e1ds.csbb.ntu.edu.tw/">E1DS -- catalytic site prediction based on 1D signatures of concurrent conservation</a></div><p>Predict enzyme catalytic site.</p></div><div><div><a href="http://elm.eu.org/">ELM -- Eukarotic Linear Motif Resource</a></div><p>Predict functional sites in eukaryotic proteins.</p></div><div><div><a href="http://us.expasy.org/tools/#proteome">EXPASY Proteome Tools Collection</a></div><p>Use a collection of tools for protein analyses.</p></div><div><div><a href="http://us.expasy.org/tools/findmod/">EXPASY-Findmod</a></div><p>Predict potential protein post-translational modifications and find potential single amino acid substitutions in peptides.</p></div><div><div><a href="http://mbs.cbrc.jp/EzCatDB/">EzCatDB -- the Enzyme Catalytic-mechanism Database</a></div><p>Search for information related to the catalytic mechanisms of enzymes.</p></div><div><div><a href="http://bioinf.cs.ucl.ac.uk/ffpred/">FFPred -- feature-based function prediction</a></div><p>An integrated feature-based function prediction server for vertebrate proteomes.</p></div><div><div><a href="http://www.ebi.ac.uk/printsscan/">FingerPRINT Scan</a></div><p>Identify the closest matching PRINTS sequence motif fingerprints in a protein sequence.</p></div><div><div><a href="http://firedb.bioinfo.cnio.es/">FireDB -- a database of functionally important residues from proteins of known structure</a></div><p>Search for functional annotation of important sites in proteins with known structures.</p></div><div><div><a href="http://bioserv.rpbs.univ-paris-diderot.fr/cgi-bin/Frog2">Frog2 -- a FRee Online druG 3D conformation generator</a></div><p>Produce 3D conformations of small drug compounds.</p></div><div><div><a href="http://www.hgpd.jp/">HGPD -- Human Gene and Protein Database</a></div><p>A database presenting experiment-based results in human proteomics.</p></div><div><div><a href="http://hhsenser.tuebingen.mpg.de/">HHsenser -- exhaustive transitive profile search using HMMx96HMM comparison</a></div><p>Conduct exhaustive intermediate profile searches of a set of homologous protein sequences.</p></div><div><div><a href="http://loschmidt.chemi.muni.cz/hotspotwizard/">HotSpot Wizard -- Substrate Specificity Hot Spot Identification web server</a></div><p>Design protein mutations in site-directed mutagenesis.</p></div><div><div><a href="http://phylogenomics.berkeley.edu/intrepid/">INTREPID -- INformation-theoretic TREe traversal for Protein functional site IDentification</a></div><p>Use for protein functional site identification.</p></div><div><div><a href="http://www.cbs.dtu.dk/">Integrating protein annotation resources through the Distributed Annotation System</a></div><p>Annotate protein using this integrated annotation resource.</p></div><div><div><a href="http://www.ebi.ac.uk/InterProScan/">InterProScan -- protein domains identifier</a></div><p>Identify protein family (and DNA) domains, patterns, motifs, protein families, and functional sites.</p></div><div><div><a href="http://kfc.mitchell-lab.org/">KFC -- Knowledge-based FADE and Contacts</a></div><p>Interactive forecasting of protein interaction hot spots.</p></div><div><div><a href="http://biominer.bime.ntu.edu.tw/magiicpro/">MAGIIC-PRO -- detecting functional signatures by efficient discovery of long patterns in protein sequences</a></div><p>Discover long patterns in protein sequences.</p></div><div><div><a href="http://prodata.swmed.edu/malisam">MALISAM -- Manual ALIgnments for Structurally Analogous Motifs</a></div><p>Database containing pairs of structural analogs and their alignments.</p></div><div><div><a href="http://meme.nbcr.net/">MEME -- discovering and analyzing DNA and protein sequence motifs</a></div><p>Find sequence patterns in DNA and protein sequences.</p></div><div><div><a href="http://www.nii.res.in/modpropep.html">MODPROPEP -- a program for knowledge-based modeling of protein-peptide complexes</a></div><p>A web server for knowledge-based modeling of protein-peptide complexes, specifically peptides in complex with major histocompatibility complex (MHC) proteins and kinases.</p></div><div><div><a href="http://www.bioinfo.tsinghua.edu.cn/~tigerchen/memo.html">MeMo -- a web tool for prediction of protein methylation modifications</a></div><p>Predict protein methylation sites.</p></div><div><div><a href="http://caps.ncbs.res.in/MegaMotifbase/index.html">MegaMotifBase -- a database of structural motifs in protein families and superfamilies</a></div><p>Find structural segments or motifs for protein structures.</p></div><div><div><a href="http://mnm.engr.uconn.edu/MNM/SMSSearchServlet">Minimotif Miner -- a tool for investigating protein function</a></div><p>Find motifs in a protein sequence.</p></div><div><div><a href="http://umber.sbs.man.ac.uk/dbbrowser/motif3d/motif3d.html">Motif3D -- Relating protein sequence motifs to 3D structure</a></div><p>Visualize protein sequence motifs on the 3D protein structures.</p></div><div><div><a href="http://myhits.isb-sib.ch/cgi-bin/motif_scan">MotifScan</a></div><p>Find presence of any known protein motif (Prosite and Pfam) in a protein sequence.</p></div><div><div><a href="http://bioinfo3d.cs.tau.ac.il/MultiBind">MultiBind -- Multiple Alignment of Protein Binding Sites</a></div><p>Recognize spatial chemical binding patterns common to a set of protein structures.</p></div><div><div><a href="http://mendel.imp.univie.ac.at/myristate/SUPLpredictor.htm">NMT -- The MYR Predictor</a></div><p>Analyze proteins for the presence of N-terminal N-myristoylation site.</p></div><div><div><a href="http://www.cbs.dtu.dk/services/NetNGlyc/">NetNGlyc -- N-Glycosylation sites prediction tool</a></div><p>Find the presence of N-Glycosylation sites in human proteins.</p></div><div><div><a href="http://www.cbs.dtu.dk/services/NetOGlyc/">NetOGly 3.1 -- O-glycosylation sites prediction tool</a></div><p>Find the presence of O-GalNAc (mucin type) glycosylation sites in mammalian proteins.</p></div><div><div><a href="http://www.cbs.dtu.dk/services/NetPhos/">NetPhos 2.0 -- Phosphorylation sites predictions</a></div><p>Analyze eukaryotic proteins for the presence of serine, threonine and tyrosine phosphorylation sites.</p></div><div><div><a href="http://www.cbs.dtu.dk/services/NetPhosK/">NetPhosK 1.0 Server -- kinase specific eukaryotic protein phosphorylation sites prediction tool</a></div><p>Find possible kinase specific phosphorylation sites in eukaryotic proteins.</p></div><div><div><a href="http://networkin.info/search.php">NetworKIN -- a resource for exploring cellular phosphorylation networks</a></div><div>&nbsp;</div></div><div><div><a href="http://neuroproteomics.scs.uiuc.edu/neuropred.html">NeuroPred -- a tool to predict cleavage sites in neuropeptide precursors and provide the masses of the resulting peptides</a></div><p>Predict cleavage sites at basic amino acid locations in neuropeptide precursor sequences.</p></div><div><div><a href="http://www.ebi.ac.uk/patentdata/nr/">Non-Redundant Patent Sequences - Patented Sequence Database</a></div><p>Find information about patented nucleotide and protein sequences.</p></div><div><div><a href="http://www.cbs.dtu.dk/databases/OGLYCBASE/">O-GLYCBASE</a></div><p>Search for information about glycoproteins with O-linked and C-linked glycosylation sites.</p></div><div><div><a href="http://www.pandora.cs.huji.ac.il/">PANDORA -- Protein ANnotation Diagram ORiented Analysis</a></div><p>Find information about protein sequence annotations.</p></div><div><div><a href="http://sunserver.cdfd.org.in:8080/protease/PAR_3D/index.html">PAR-3D -- Protein Active site Residue - 3D structural motif</a></div><p>A server to predict protein active site residues.</p></div><div><div><a href="http://wwwmgs.bionet.nsc.ru/mgs/gnw/pdbsite/">PDBSite -- a database of the 3D structure of protein functional sites</a></div><p>Search for structural and functional information on the protein functional sites.</p></div><div><div><a href="http://wwwmgs.bionet.nsc.ru/mgs/systems/fastprot/pdbsitescan.html">PDBSiteScan -- A program for searching for active, binding and posttranslational modification sites in the 3D structures of proteins</a></div><p>Search 3D protein fragments similar in structure to known active, binding and posttranslational modification sites.</p></div><div><div><a href="http://pedant.gsf.de/">PEDANT -- Protein Extraction, Description and ANalysis Tool</a></div><p>Conduct genome wide functional and structural analysis.</p></div><div><div><a href="http://phosida.org/">PHOSIDA -- Phosphorylation site database</a></div><p>Search for phosphorylation data of any protein of interest.</p></div><div><div><a href="http://www.phosphorylation.biochem.vt.edu/">PHOSPHORYLATION SITE DATABASE</a></div><p>Search for information on prokaryotic proteins that undergo serine, threonine, or tyrosine phosphorylation.</p></div><div><div><a href="http://www.jcvi.org/pn-utility/web/smarty_wrapper/about.php">PNU -- Protein Naming Utility</a></div><p>Determine correct names for proteins.</p></div><div><div><a href="http://mbs.cbrc.jp/poodle/poodle-s.html">POODLE-S -- Predicition Of Order and Disorder by machine LEarning</a></div><p>Web application for predicting protein disorder by using physicochemical features and reduced amino acid set of a position-specific scoring matrix.</p></div><div><div><a href="http://gemdock.life.nctu.edu.tw/ppisearch/">PPISearch -- Protein-Protein Interaction Search</a></div><p>Find homologous protein-protein interactions across multiple species.</p></div><div><div><a href="http://www.ebi.ac.uk/ppsearch/">PPSearch</a></div><p>Search your query sequence against PROSITE pattern database for protein motifs.</p></div><div><div><a href="http://pridb.gdcb.iastate.edu/">PRIDB -- Protein-RNA Interface DataBase</a></div><p>Find information about protein-RNA complexes from the Protein Data Bank (PDB).</p></div><div><div><a href="http://umber.sbs.man.ac.uk/dbbrowser/PRINTS/">PRINTS and its automatic supplement, prePRINTS -- A compendium of protein fingerprints</a></div><p>Search for protein fingerprints.</p></div><div><div><a href="http://www.expasy.org/prosite/">PROSITE</a></div><p>Identify protein families and domains for a given protein sequence.</p></div><div><div><a href="http://www.imtech.res.in/raghava/prrdb/">PRRDB -- Pattern Recognition Receptor Database</a></div><p>A comprehensive database of pattern-recognition receptors and their ligands.</p></div><div><div><a href="http://www.arabidopsis.org/cgi-bin/patmatch/nph-patmatch.pl">PatMatch -- a program for finding patterns in peptide and nucleotide sequences</a></div><p>Search for short nucleotide or peptide sequences such as cis-elements in nucleotide sequences or small domains and motifs in protein sequences.</p></div><div><div><a href="http://pepcyber.umn.edu/PPEP/">PepCyber:P~PEP -- a database of human protein protein interactions mediated by phosphoprotein-binding domains</a></div><p>Database specialized in documenting human PPBD-containing proteins and PPBD-mediated interactions.</p></div><div><div><a href="http://us.expasy.org/tools/peptidecutter/">PeptideCutter -- protein cleavage sites prediction tool</a></div><p>Predicts potential protease cleavage sites and sites cleaved by chemicals in a given protein sequence.</p></div><div><div><a href="http://phobius.binf.ku.dk/">Phobius -- A combined transmembrane topology and signal peptide predictor</a></div><p>Predict combined transmembrane topology and signal peptides.</p></div><div><div><a href="http://phospho.elm.eu.org/">Phospho.ELM -- a database of phosphorylation sites</a></div><p>Search for eukaryotic phosphorylation sites.</p></div><div><div><a href="http://www.phospho3d.org/">Phospho3D -- a database of three-dimensional structures of protein phosphorylation sites</a></div><p>Search for 3D structure and functional annotation of phosphorylation sites in proteins.</p></div><div><div><a href="http://www.phosphosite.org/">PhosphoSite -- A bioinformatics resource dedicated to physiological protein phosphorylation.</a></div><p>Search the database of in vivo phosphorylation sites of human and mouse proteins</p></div><div><div><a href="http://pxgrid.med.monash.edu.au/polyq/">PolyQ -- Polyglutamine Database</a></div><p>Find information about polyglutamine (polyQ) repeats.</p></div><div><div><a href="http://www.ebi.ac.uk/pratt/">Pratt Protein motif and pattern discovery</a></div><p>Find the presence of protein motifs and patterns in an amino acid sequence.</p></div><div><div><a href="http://www.predisi.de/">PrediSi -- Prediction of Signal Peptides and their Cleavage Positions</a></div><p>Predict signal peptide sequences and their cleavage positions in bacterial and eukaryotic amino acid sequences.</p></div><div><div><a href="http://www.ebi.ac.uk/thornton-srv/databases/ProFunc/">ProFunc -- a server for predicting protein function from 3D structure</a></div><p>Predict protein functions based on known structures.</p></div><div><div><a href="http://bioinfo41.weizmann.ac.il/promate/promateus.html">ProMateus--an open research approach to protein-binding sites analysis</a></div><p>Predict the location of potential protein-protein binding sites for unbound proteins.</p></div><div><div><a href="http://www.proteus.cs.huji.ac.il/">ProTeus -- identifying signatures in protein termini</a></div><p>Identify short linear signatures in protein termini.</p></div><div><div><a href="http://genius.embnet.dkfz-heidelberg.de/menu/cgi-bin/w2h-open/w2h.open/w2h.startthis?SIMGO=w2h%2ewelcome">ProtSweep -- protein annotation by homology</a></div><p>Analyze and identify newly obtained protein sequences.</p></div><div><div><a href="http://protemot.csbb.ntu.edu.tw/">Protemot -- prediction of protein binding sites with automatically extracted geometrical templates</a></div><p>Predict protein binding sites in a protein sequence based on geometrical analysis of protein tertiary substructures.</p></div><div><div><a href="http://quasimotifinder.tau.ac.il/">QuasiMotiFinder -- protein annotation by searching for evolutionarily conserved motif-like patterns</a></div><p>Search for evolutionarily conserved motif-like patterns in protein sequences.</p></div><div><div><a href="http://bindr.gdcb.iastate.edu/RNABindR">RNABindR -- software for prediction of RNA binding residues in proteins</a></div><p>Web-based server for analyzing and predicting RNA binding sites in proteins.</p></div><div><div><a href="http://caps.ncbs.res.in/scanmot/scanmot.html">SCANMOT -- searching for similar sequences using a simultaneous scan of multiple sequence motifs</a></div><p>Search for similarities between proteins by simultaneous matching of multiple motifs.</p></div><div><div><a href="http://bioinf.fbb.msu.ru/SDPpred/">SDPpred -- A Tool for Prediction of Amino Acid Residues that Determine Differences in Functional Specificity of Homologous Proteins</a></div><p>Predict residues in protein sequences that determine the proteins' functional specificity.</p></div><div><div><a href="http://tamm.mit.edu/SDR/">SDR -- Specificity Determining Residues Database</a></div><p>Predict specificity-determining residues in protein families.</p></div><div><div><a href="http://bioware.ucd.ie/~slimdisc/">SLiMDisc -- Short, Linear Motif Discovery</a></div><p>Find shared motifs in proteins with a common attribute.</p></div><div><div><a href="http://sumosp.biocuckoo.org/">SUMOsp -- a web server for sumoylation site prediction</a></div><p>Conduct in silico sumoylation sites prediction.</p></div><div><div><a href="http://oxytricha.princeton.edu/SWAKK/">SWAKK -- a web server for detecting positive selection in proteins using a sliding window substitution rate analysis</a></div><p>Detect protein sequence section under positive evolution selection.</p></div><div><div><a href="http://www.expasy.org/tools/scanprosite/">ScanProsite</a></div><p>Search for motifs and patterns within protein sequences.</p></div><div><div><a href="http://www.expasy.org/tools/scanprosite/">ScanProsite -- detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteins</a></div><p>Detect patterns, profiles and motifs in a protein sequence.</p></div><div><div><a href="http://scansite.mit.edu/">ScanSite 2.0 -- Proteome-wide prediction of cell signaling interactions using short sequence motifs</a></div><p>Search for motifs within proteins that are likely to be phosphorylated by specific protein kinases or bind to domains such as SH2 domains, 14-3-3 domains or PDZ domains.</p></div><div><div><a href="http://sepresa.bio-x.cn/">SePreSA -- SErver for the PREdiction of populations susceptible to Serious Adverse drug reaction</a></div><p>Find information about populations carrying polymorphisms within protein binding pockets that make them susceptible to serious adverse drug reaction (SADR).</p></div><div><div><a href="http://motif.genome.jp/">Sequence Motif Search</a></div><p>Search the presence of a motif in either amino acid sequence or nucleotide sequence.</p></div><div><div><a href="http://www.csbio.sjtu.edu.cn/bioinf/Signal-3L/">Signal-3L -- A 3-layer approach for predicting signal peptides</a></div><p>Predict signal peptides.</p></div><div><div><a href="http://www.cbs.dtu.dk/services/SignalP/">SignalP -- Machine learning approaches to the prediction of signal peptides, their cleavage sites, and other protein sorting signals</a></div><p>Predict signal peptides and their cleavage sites.</p></div><div><div><a href="http://us.expasy.org/tools/sulfinator/">Sulfinator -- tyrosine sulfation sites prediction tool</a></div><p>Predict the presence of tyrosine sulfation sites in protein sequences</p></div><div><div><a href="http://bioinf-services.charite.de/supersite/">SuperSite -- Ligand Binding Site Database</a></div><p>Look at protein structure from a ligand and binding site perspective.</p></div><div><div><a href="http://www.ch.embnet.org/">Swiss EMBnet node web server</a></div><p>Use a collection of bioinformatics tools at this portal site.</p></div><div><div><a href="http://bioinfo.montp.cnrs.fr/?r=t-reks">T-REKS -- identification of Tandem REpeats in sequences with a K-meanS based algorithm</a></div><p>Find information about tandem repeats in proteins that carry fundamental biological functions and are related to a number of human diseases.</p></div><div><div><a href="http://tmbeta-genome.cbrc.jp/TMFunction/">TMFunction -- The Functional Database of Membrane Proteins</a></div><p>Find information about functional residues in alpha-helical and beta-barrel membrane proteins.</p></div><div><div><a href="http://topdom.enzim.hu/">TOPDOM -- Conservatively Located Domains and Motifs in Transmembrane Proteins</a></div><p>Database of domains and motifs with conservative location in transmembrane proteins.</p></div><div><div><a href="http://motif.stanford.edu/distributions/emotif/">The EMOTIF database</a></div><p>Search for highly conserved and specific protein sequence motifs.</p></div><div><div><a href="http://treedetv2.bioinfo.cnio.es/treedet/index.html">TreeDet -- Predicting Functional Residues in Protein Sequence Alignments</a></div><p>Predict functional sites in protein sequence alignments use different methodologies.</p></div><div><div><a href="http://motif.bmi.ohio-state.edu/ChIPMotifs/">W-ChIPMotifs -- ChIP-based protein Motif discovery web server</a></div><p>Find de novo protein motifs from chromatin immunoprecipitation data.</p></div><div><div><a href="http://feature.stanford.edu/webfeature/">WebFEATURE -- an interactive web tool for identifying and visualizing functional sites on macromolecular structures</a></div><p>Scan query structures for functional sites in both proteins and nucleic acids.</p></div><div><div><a href="http://wwwmgs.bionet.nsc.ru/mgs/programs/panalyst/">WebProAnalyst -- an interactive tool for analysis of quantitative structurex96activity relationships in protein families</a></div><p>Analyze quantitative structure-activity relationship of related protein families.</p></div><div><div><a href="http://motif.stanford.edu/distributions/eblocks/">eBLOCKs -- enumerating conserved protein blocks to achieve maximal sensitivity and specificity</a></div><p>Search for ungapped alignments of highly conserved regions among a protein family or superfamily.</p></div><div><div><a href="http://ef-site.hgc.jp/eF-seek/">eF-seek -- prediction of the functional sites of proteins by searching for similar electrostatic potential and molecular surface shape</a></div><p>Predict the functional sites of proteins.</p></div><div><div><a href="http://firedb.bioinfo.cnio.es/Php/FireStar.php">firestar -- prediction of functionally important residues using structural templates and alignment reliability</a></div><p>An expert system for predicting ligand-binding residues in protein structures.</p></div><div><div><a href="http://caps.ncbs.res.in/imotdb/">iMOTdb -- a comprehensive collection of spatially interacting motifs in proteins</a></div><p>Automatically identify spatially interacting motifs among distantly related proteins sharing similar folds and possessing common ancestral lineage.</p></div>]]></description>
	<dc:creator>Neel</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/blog/view/41455/coronavirus-covid-%E2%80%9019-testing-sites-in-india</guid>
	<pubDate>Mon, 16 Mar 2020 16:13:41 -0500</pubDate>
	<link>https://bioinformaticsonline.com/blog/view/41455/coronavirus-covid-%E2%80%9019-testing-sites-in-india</link>
	<title><![CDATA[Coronavirus COVID ‐19 Testing Sites In India]]></title>
	<description><![CDATA[<p>COVID-19 is a new illness that can affect your lungs and airways. It's caused by a virus called coronavirus.</p><h2>Stay at home if you have coronavirus symptoms</h2><p>Stay at home if you have either:</p><ul>
<li>a high temperature &ndash; you feel hot to touch on your chest or back</li>
<li>a new, continuous cough &ndash; this means you've started coughing repeatedly</li>
</ul><h2>DO NOT TAKE</h2><p><em>Ibrufen</em></p><p><em>https://amp.theguardian.com/world/2020/mar/14/anti-inflammatory-drugs-may-aggravate-coronavirus-infection</em></p><h2>How to avoid catching and spreading coronavirus (social distancing)</h2><p>Everyone should do what they can to stop coronavirus spreading.</p><p>It is particularly important for people who:</p><ul>
<li>are 70 or over</li>
<li>have a long-term condition</li>
<li>are pregnant</li>
<li>have a weakened immune system</li>
</ul><p><img src="https://www.hindustantimes.com/rf/image_size_960x540/HT/p2/2020/03/16/Pictures/_c0c377e0-6789-11ea-8a5c-cb364e4c5304.png" alt="image" width="960" height="543" style="border: 0px; border: 0px;"></p><p><strong>Below are the 52 Coronavirus COVID-19 Testing sites/locations in India.</strong></p><p>State:&nbsp;Andhra Pradesh&nbsp; &nbsp; &nbsp; &nbsp;</p><ol>
<li>Sri Venkateswara Institute of Medical Sciences, Tirupati</li>
<li>Andhra Medical College, Visakhapatnam, Andhra Pradesh</li>
<li>GMC, Anantapur, AP</li>
</ol><p>State:&nbsp;Andaman &amp; Nicobar islands</p><ol>
<li>Regional Medical Research Centre, Port Blair, Andaman, and Nicobar</li>
</ol><p>State:&nbsp;Assam</p><ol>
<li>Gauhati Medical College, Guwahati</li>
<li>&nbsp;Regional Medical Research Center, Dibrugarh</li>
</ol><p>State:&nbsp;Bihar</p><ol>
<li>Rajendra Memorial Research Institute of Medical Sciences, Patna</li>
</ol><p>State: Chandigarh</p><ol>
<li>Post Graduate Institute of Medical Education &amp; Research, Chandigarh</li>
</ol><p>State: Chhattisgarh</p><ol>
<li>All India Institute Medical Sciences, Raipur</li>
</ol><p>Union Territory: Delhi-NCT&nbsp;</p><ol>
<li>All India Institute Medical Sciences, Delhi</li>
<li>National Centre for Disease Control, Delhi</li>
</ol><p>State: Gujarat</p><ol>
<li>BJ Medical College, Ahmedabad</li>
<li>M.P.Shah Government Medical College, Jamnagar</li>
</ol><p>State: Haryana</p><ol>
<li>Pt. B.D. Sharma Post Graduate Inst. of Med. Sciences, Rohtak, Haryana</li>
<li>BPS Govt Medical College, Sonipat</li>
</ol><p>State: Himachal Pradesh</p><ol>
<li>Indira Gandhi Medical College, Shimla, Himachal Pradesh</li>
<li>Dr.Rajendra Prasad Govt. Med. College, Kangra, Tanda, HP</li>
</ol><p>Union Territory: Jammu and Kashmir</p><ol>
<li>Sher‐e‐ Kashmir Institute of Medical Sciences, Srinagar</li>
<li>Government Medical College, Jammu</li>
</ol><p>State: Jharkhand</p><ol>
<li>MGM Medical College, Jamshedpur</li>
</ol><p>State: Karnataka</p><ol>
<li>Bangalore Medical College &amp; Research Institute, Bangalore</li>
<li>National Institute of Virology Field Unit Bangalore</li>
<li>Mysore Medical College &amp; Research Institute, Mysore</li>
<li>Hassan Inst. of Med. Sciences, Hassan, Karnataka</li>
<li>Shimoga Inst. of Med. Sciences, Shivamogga, Karnataka</li>
</ol><p>State: Kerala</p><ol>
<li>National Institute of Virology Field Unit, Kerala</li>
<li>Govt. Medical College, Thiruvananthapuram, Kerala</li>
<li>Govt. Medical College, Kozhikode, Kerala</li>
</ol><p>State: Madhya Pradesh</p><ol>
<li>All India Institute Medical Sciences, Bhopal</li>
<li>National Institute of Research in Tribal Health (NIRTH), Jabalpur</li>
</ol><p>State: Meghalaya</p><ol>
<li>NEIGRI of Health and Medical Sciences, Shillong, Meghalaya</li>
</ol><p>State: Maharashtra</p><ol>
<li>Indira Gandhi Government Medical College, Nagpur</li>
<li>Kasturba Hospital for Infectious Diseases, Mumbai</li>
</ol><p>State: Manipur</p><ol>
<li>J N Inst. of Med. Sciences Hospital, Imphal‐East, Manipur</li>
</ol><p>State: Odisha</p><ol>
<li>Regional Medical Research Center, Bhubaneswar</li>
</ol><p>Union Territory: Puducherry</p><ol>
<li>Jawaharlal Institute of Postgraduate Medical Education &amp; Research, Puducherry</li>
</ol><p>State: Punjab</p><ol>
<li>Government Medical College, Patiala, Punjab</li>
<li>Government Medical College, Amritsar</li>
</ol><p>State: Rajasthan</p><ol>
<li>Sawai Man Singh, Jaipur</li>
<li>Dr. S.N Medical College, Jodhpur</li>
<li>Jhalawar Medical College, Jhalawar, Rajasthan</li>
<li>SP Med. College, Bikaner, Rajasthan</li>
</ol><p>State: Tamil Nadu</p><ol>
<li>King&rsquo;s Institute of Preventive Medicine &amp; Research, Chennai</li>
<li>Government Medical College, Theni</li>
</ol><p>State: Tripura</p><ol>
<li>Government Medical College, Agartala</li>
</ol><p>State: Telangana</p><ol>
<li>Gandhi Medical College, Secunderabad</li>
</ol><p>State: Uttar Pradesh</p><ol>
<li>King&rsquo;s George Medical University, Lucknow</li>
<li>Institute of Medical Sciences, Banaras, Hindu University, Varanasi</li>
<li>Jawaharlal Nehru Medical College, Aligarh</li>
</ol><p>State: Uttarakhand</p><ol>
<li>Government Medical College, Haldwani</li>
</ol><p>State: West Bengal</p><ol>
<li>National Institute of Cholera and Enteric Diseases, Kolkata</li>
<li>IPGMER, Kolkata</li>
</ol>]]></description>
	<dc:creator>Neel</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/blog/view/42329/10-ngs-services-companies-around-the-globe</guid>
	<pubDate>Sun, 22 Nov 2020 23:56:17 -0600</pubDate>
	<link>https://bioinformaticsonline.com/blog/view/42329/10-ngs-services-companies-around-the-globe</link>
	<title><![CDATA[10 NGS services companies around the globe !]]></title>
	<description><![CDATA[<p><strong>The global&nbsp;NGS services market&nbsp;is expected to reach USD 13.1 billion by 2025.&nbsp;</strong>Here are the&nbsp;<strong style="font-size: 12.8px;">top 10 NGS services companies to look for &ndash;</strong></p><p><strong>1.&nbsp;<a href="https://www.illumina.com/">Illumina, Inc. (U.S.)</a></strong></p><p>Illumina, Inc. was founded in 1998 and is headquartered at San Diego, U.S. Illumina, Inc. is one of the leading players in DNA sequencing and array-based technologies, serving customers in the research, clinical, and applied markets. The company offers products for applications in the life sciences, oncology, reproductive health, agriculture, and other emerging segments. The company serves government laboratories, genomic research centers, academics institutions as well as pharmaceutical, biotechnology, agrigenomics, commercial molecular diagnostics laboratories and consumer genomics companies. Illumina, Inc. has its geographic presence in North America, Europe, Latin America, Asia-pacific, and others.</p><p><strong>2.&nbsp;<a href="https://www.qiagen.com/us/">QIAGEN N.V. (Netherlands)</a></strong></p><p>QIAGEN N.V. was incorporated in 1986 and is headquartered at Venlo, The Netherlands. The Company is engaged in providing Sample to Insight solutions that transform biological samples into molecular insights. QIAGEN provides its workflow to customers in molecular diagnostics, assay technologies, bioservices and automation systems.&nbsp; The company&rsquo;s genome services are suitable for custom/tailored projects that allow access to genomic sequence information.&nbsp; The Company market its products in more than 100 countries across the Americas, Europe, Asia, Australia, and the Middle-East &amp;Africa through its subsidiaries and channel partners.</p><p><strong>3.&nbsp;<a href="https://www.perkinelmer.com/">PerkinElmer, Inc. (U.S.)</a></strong></p><p>PerkinElmer, Inc. was founded in 1947 and is headquartered in Waltham, Massachusetts, the U.S. PerkinElmer, Inc. offers its products &amp; services and solutions for the diagnostics, food, environmental, industrial, life sciences research and laboratory services markets. The company offer comprehensive genetic testing solutions that help to provide insight into the complex nature of rare and inherited diseases. Some of the subsidiaries of the company are Caliper Life Sciences, Improvision, Viacell Inc., ViaCord LLC, among many others. The company has its facilities located in Europe (France, Germany, and Belgium), U.S. and Asia (China, India, and Japan).</p><p><strong>4.&nbsp;<a href="https://www.eurofins.com/">Eurofins Scientific SE (Luxembourg)</a></strong></p><p>Eurofins Scientific SE was founded in 1987 and is headquartered in Luxembourg, Europe. The company offers a portfolio of over 130,000 analytical methods and more than 150 million assays performed each year to establish the safety, identity, composition, authenticity, origin, traceability, and purity of biological substances and products, as well as carry out human diagnostic services. The company has its geographic presence across 39 countries in Europe, North and South America, and Asia-Pacific.</p><p><strong>5.&nbsp;<a href="https://www.gatc-biotech.com/en/index.html">GATC Biotech AG (Germany)</a></strong></p><p>GATC Biotech AG was founded in 1990 and is headquartered in Constance, Germany. The company provides DNA and RNA sequencing and bioservices solutions to academics and industrial areas. It also provides next generation sequencing services including genomes, targeted (re)-sequencing, human sample sequencing, transcriptomes, metagenomes, regulomes, pre-sequencing, NGS barcode labels, and next generation sequencing technologies; and bioservices services, including bioservices tools, pipelines and workflows, compute resources, data analysis reports, and case studies. GATC Biotech AG operates as a subsidiary of Eurofins Scientific SE. It offers its products through distributors in Italy, Japan, Portugal, Spain, and the Czech Republic.</p><p><strong>6.<a href="https://www.macrogen.com/">&nbsp;Macrogen, Inc. (South Korea)</a></strong></p><p>Macrogen, Inc. was founded in 1997 and is headquartered in Seoul, South Korea. Macrogen, Inc. provides next generation sequencing services such as whole genome, de novo, exome, targeted, transcriptomics, metagenome, and epigenome sequencing.&nbsp; The company also provides a variety of services such as oligo synthesis, database construction, genome research, and bioservices analysis system consulting services. Macrogen, Inc. provides genome research services in Korea and internationally.</p><p><strong>7.&nbsp;<a href="https://www.genotypic.co.in/">Genotypic Technology Pvt. Ltd. (India)</a></strong></p><p>Genotypic Technology Pvt. Ltd. was incorporated in 1998 and is headquartered in Bangalore, India. Genotypic Technology is the first Genomics service provider in India providing Microarray, Next Generation Sequencing (NGS), Bioservices and solutions to domestic/ international pharma, biotech companies and academia. The company provides its services for protocol optimization, probe designing, array layouts, project designing, and nucleic acid analysis to in-depth analysis. Genotypic Technology has its geographic presence in North America, Europe, Asia Pacific, Middle East &amp; Africa, and Latin America.</p><p><strong>8.&nbsp;<a href="https://www.genewiz.com/">GENEWIZ, Inc. (U.S.)</a></strong></p><p>GENEWIZ, Inc. was founded in 1999 and is headquartered in South Plainfield, New Jersey, the U.S.; The company is a leading provider of research service in the field of Next Generation Sequencing, Sanger DNA sequencing, sequencing of bacteria and phage, gene synthesis, DNA cloning, genomics including mutation analysis, single nucleotide polymorphism, and bioservices. GENEWIZ, Inc. has its geographic presence in U.S., China, Germany, France, Japan, and the U.K.</p><p><strong>9.&nbsp;<a href="https://www.genomics.cn/">Beijing Genomics Institute (China)</a></strong></p><p>Beijing Genomics Institute (BGI) is the world&rsquo;s largest genomics organization and non-profit research institution that was founded in 1999 and is headquartered in Shenzhen, China. The Company provides a wide range of commercial next generation sequencing services and genetic tests for medical institutions, agricultural and environmental applications. The Company operates all across the globe through its subsidiaries, namely, BGI China (Mainland), BGI Asia Pacific, BGI Americas (North and South America) and BGI Europe (Europe and Africa).</p><p><strong>10.&nbsp;<a href="https://www.scigenom.com/">SciGenom Labs Pvt. Ltd (India)</a></strong></p><p>SciGenom Labs Pvt. Ltd was founded in 2010 and is headquartered in Cochin, India with offices in Chennai &amp; Hyderabad in India, and San Francisco in the U.S. It is a Genomics R&amp;D services company that provides genomic sequencing and NGS services to life sciences and healthcare businesses globally as well as academic and government institutions in India.</p><p>Popular mentions &ndash; MedGenome (India), DNA Link, Inc. (South Korea), Otogenetics Corporation (U.S.), Novogene Corporation (China), LGC Limited (U.K.), CD Genomics (U.S.), SeqLL, LLC (U.S.)</p>]]></description>
	<dc:creator>BioStar</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/view/1926</guid>
	<pubDate>Sun, 11 Aug 2013 11:42:32 -0500</pubDate>
	<link>https://bioinformaticsonline.com/view/1926</link>
	<title><![CDATA[Want to Know which genome assembler rule the world ?]]></title>
	<description><![CDATA[<p><span><strong>Assemblathon 2</strong>: evaluating de novo methods of genome assembly&nbsp;</span></p><p><span><a href="http://www.gigasciencejournal.com/content/2/1/10/abstract">http://www.gigasciencejournal.com/content/2/1/10/abstract</a></span></p><p><span><a href="http://blogs.nature.com/news/2013/07/genome-assembly-contest-prompts-soul-searching.html">http://blogs.nature.com/news/2013/07/genome-assembly-contest-prompts-soul-searching.html</a></span></p><p><a href="http://assemblathon.org/post/44431915644/feedback-and-analysis-of-the-assemblathon-2-p">http://assemblathon.org/post/44431915644/feedback-and-analysis-of-the-assemblathon-2-p</a></p><p>&nbsp;</p>]]></description>
	<dc:creator>Rahul Agarwal</dc:creator>
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/videolist/watch/3917/the-story-of-you-encode-and-the-human-genome</guid>
	<pubDate>Sat, 24 Aug 2013 18:49:03 -0500</pubDate>
	<link>https://bioinformaticsonline.com/videolist/watch/3917/the-story-of-you-encode-and-the-human-genome</link>
	<title><![CDATA[The Story of You: ENCODE and the human genome]]></title>
	<description><![CDATA[<iframe width="" height="" src="https://www.youtube-nocookie.com/embed/TwXXgEz9o4w" frameborder="0" allowfullscreen></iframe><p>Ever since a monk called Mendel started breeding pea plants we've been learning about our genomes. In 1953, Watson, Crick and Franklin described the structure of the molecule that makes up our genomes: the DNA double helix. Then, in 2001, scientists wrote down the entire 3-billion letter code contained in the average human genome. Now they're trying to interpret that code; to work out how it's used to make different types of cells and different people. The ENCODE project, as it's called, is the latest chapter in the story of you. To read the ENCODE research papers and more, visit http://www.nature.com/ENCODE</p>]]></description>
	
</item>
<item>
	<guid isPermaLink="true">https://bioinformaticsonline.com/videolist/watch/4761/dna-is-packaged-in-a-chromosome-experiment</guid>
	<pubDate>Mon, 23 Sep 2013 18:01:12 -0500</pubDate>
	<link>https://bioinformaticsonline.com/videolist/watch/4761/dna-is-packaged-in-a-chromosome-experiment</link>
	<title><![CDATA[DNA is packaged in a chromosome experiment]]></title>
	<description><![CDATA[<iframe width="" height="" src="https://www.youtube-nocookie.com/embed/fecfROFrp_c" frameborder="0" allowfullscreen></iframe>For more information, log on to-
http://shomusbiology.weebly.com/
Download the study materials here-
http://shomusbiology.weebly.com/bio-materials.html
A nucleosome is the basic unit of DNA packaging in eukaryotes, consisting of a segment of DNA wound in sequence around four histone protein cores.[1] This structure is often compared to thread wrapped around a spool.[2]

Nucleosomes form the fundamental repeating units of eukaryotic chromatin,[3] which is used to pack the large eukaryotic genomes into the nucleus while still ensuring appropriate access to it (in mammalian cells approximately 2 m of linear DNA have to be packed into a nucleus of roughly 10 µm diameter). Nucleosomes are folded through a series of successively higher order structures to eventually form a chromosome; this both compacts DNA and creates an added layer of regulatory control, which ensures correct gene expression. Nucleosomes are thought to carry epigenetically inherited information in the form of covalent modifications of their core histones. Nucleosomes were observed as particles in the electron microscope by Don and Ada Olins [4] and their existence and structure (as histone octamers surrounded by approximately 200 base pairs of DNA) were proposed by Roger Kornberg.[5][6] The role of the nucleosome as a general gene repressor was demonstrated by Lorch et al. in vitro [7] and by Han and Grunstein in vivo.]]></description>
	
</item>

</channel>
</rss>