<![CDATA[BOL: Related items]]> https://bioinformaticsonline.com/related/34394?offset=130 https://bioinformaticsonline.com/bookmarks/view/42280/urmap-an-ultra-fast-read-mapper Thu, 29 Oct 2020 23:03:54 -0500 https://bioinformaticsonline.com/bookmarks/view/42280/urmap-an-ultra-fast-read-mapper <![CDATA[URMAP, an ultra-fast read mapper]]> URMAP, a new read mapping algorithm. URMAP is an order of magnitude faster than BWA with comparable accuracy on several validation tests. On a Genome in a Bottle (GIAB) variant calling test with 30× coverage 2×150 reads, URMAP achieves high accuracy (precision 0.998, sensitivity 0.982 and F-measure 0.990) with the strelka2 caller. However, GIAB reference variants are shown to be biased against repetitive regions which are difficult to map and may therefore pose an unrealistically easy challenge to read mappers and variant callers.

More at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320720/

Address of the bookmark: https://github.com/rcedgar/urmap

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