The work will focus on the functional studies of small RNAs by using next-generation sequencing approaches.

Candidates should hold a Ph.D. degree and have strong background in bioinformatics.
The University of Nice Sophia-Antipolis provides a wide range of facilities and training essential for biomedical research.

Interested applicants should send a PDF with a cover letter stating research interests and qualifications, an updated CV, a summary of previous research experience and contact information for two references to Michele Trabucchi ( mtrabucchi@unice.fr )

Homepage: http://www.unice.fr/c3m/EN/Equipe10.html

Research Associate (one post): Emoluments as per DST/DBT norms & as sanctioned in the project

Qualification: Candidates having Ph.D. degree (awarded) in any discipline of Life Sciences with good publication record are eligible to apply. Candidates having prior experience in the area of Genetic and molecular analysis of plant/fungus for disease resistance/susceptibility of transcriptome and genome analysis will be preferred.

Junior Research Fellow (one post): Emoluments as per DST/DBT norms & as sanctioned in the project

Qualification: Candidates having M.Sc./M.Tech degree in any discipline of Life Sciences/Engineering (with minimum 55% marks) are eligible to apply. The Candidate having prior work experience in Molecular biology of plants/animal/fungus or Computational biology with experience in analysis of next-generation sequencing data, protein-protein interaction and system biology will be given preference.

The positions are purely temporary and are co-terminus with the project. The initial appointment will be for one year, which can be extended/curtailed on the basis of assessment of the candidate’s performance and discretion of the Competent Authority. The eligible candidates may further be shortlisted based on the qualification/experience depending on the total number of applications received. NIPGR reserves the right to select the candidate against the above post depending upon the qualification(s) and experience of the candidate. Reservation of post shall be as per Govt. of India norms.

Eligible candidates may apply by sending their complete application in the enclosed format.

The attested copies of the certificates and proof of research experience (if any) are to be attached with the hard copy of application. The applications should reach at the address given below within 15 days from the date of advertisement. The envelope must be superscribed by “Application for the Post of RA/JRF in the CPCFG Project” of Dr. Praveen Verma.

http://www.nipgr.res.in/files/careers/app_format_RA_JRF.docx

Contact Person address
Dr. Praveen Verma
Staff Scientist-VI & Principal Investigator ,
National Institute of Plant Genome Research ,(NIPGR)
Aruna Asaf Ali Marg, P.O. Box NO. 10531,
New Delhi - 110067

Address of the bookmark: http://www.gigasciencejournal.com/content/2/1/15?utm_content=buffer25ee0&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer

The Indian Institute of Science (IISc) has been recognised as an Institution of Eminence (IoE) by the Government of India. As a part of the IoE initiative, IISc has created the Raman Post-Doc Program, a highly selective Post-Doc program with 50 positions. The Institute invites applications for intensely motivated individuals with an established record of high quality research, for the positions of Raman Post-Docs. Overseas Citizens of India (OCI), Persons of Indian Origin (PIO), and foreign nationals are also eligible to apply.

The information below specifically pertains to applicants intending to work with Faculty in the Biological Sciences Division.

This is a rolling advertisement and candidates can apply any time during the year. The applications will be reviewed every four months around the following dates: April 30, August 31, December 31.

Further details about the various departments and interdisciplinary centres, faculty profiles, academic programs, and areas of research are available at the departmental websites

and also at www.iisc.ac.in

Note: Candidates should preferably be less than 32 years of age at the time of applying.

De Bruijn Graphs for NGS Assembly
Algorithms for PacBio Reads
Software and Hardware Concepts for Bioinformatics
Finding us in Homolog.us (Search Algorithms)
NGS Genome and RNAseq Assembly - a Hands on Primer
Introduction to PERL, Python, R and C/C++ for Bioinformatics

Address of the bookmark: http://www.homolog.us/Tutorials/

Research Interests
• Bioinformatics / computational biology
• Algorithms for genome sequencing
• Applied graph / combinatorial / discrete algorithms
• Algorithms design and analysis
• High performance computing

More at https://at-cg.github.io/

Reference

Cuccuru G1, Orsini M, Pinna A, Sbardellati A, Soranzo N, Travaglione A, Uva P, Zanetti G, Fotia G. (2014) Orione, a web-based framework for NGS analysis in microbiology. Bioinformatics [Epub ahead of print]. [article]

Address of the bookmark: http://orione.crs4.it/

Most people who have a balanced translocation have the right amount of chromosome material but it has been rearranged in some way. This may happen if two chromosomes swap pieces (a reciprocal translocation). In other cases two whole chromosomes may become stuck together (a Robertsonian translocation). This page describes what happens when someone has a reciprocal translocation.

Reciprocal chromosomal translocations occur following double-strand breaks (DSBs) in DNA when a section of one chromosome is exchanged with that of another, non-homologous chromosome. These exchanges may produce a dysfunctional fusion gene that disrupts cell growth and survival pathways, such as the translocations seen in leukemia and childhood sarcomas.

Chromosomal translocations have been well studied in cancer cell lines which are associated with two types of cancer, acute myeloid leukemia and Ewing's sarcoma, but determining how they contribute to cancer development is complicated by additional mutations and altered gene expression profiles in these cultured cells. Now, Juan Carlos Ramirez, head of the Viral Vector Facility at the Fundacion Centro Nacional de Investigaciones Cardiovasculares (CNIC) and his colleagues Raul Torres at CNIC and Sandra Rodriguez-Peralez at the Spanish National Cancer Center (CNIO) in Madrid, Spain have used a new genome editing tool, CRISPR-Cas9, to induce chromosomal translocations for the first time in a human cell line and in primary cells. The study's authors conclude by stating that the use of this technology will allow for the clarification of how and why chromosomal translocation occurs, which without doubt will allow new anti-cancer therapeutic strategies to be tackled.

Using RNA-Guided Endonuclease (RGEN) technology or CRISPR/Cas9 genome engineering technology, CNIO and CNIC researchers have shown that it is possible to obtain such chromosomal translocations. The CRISPR-Cas9 system is extremely simple to introduce a cut at the desired locus, easier to design, and cheaper than many other systems. Using the CRISPR-Cas9 system, Ramirez and his colleagues reproduced the translocations observed in Ewing’s Sarcoma (ES) and Acute Myeloid Leukemia (AML) patient cell lines in HEK293 cells and also generated the ES translocation in human mesenchymal stem cells and the AML translocation in umbilical cord blood cells.

By focusing on chromosomal translocation without the confounding characteristics of established cell lines, these new cells lines should help answer the fundamental question of what causes a cell to become cancerous. Ramirez and his team now look forward to modeling other chromosome translocations in a variety of cell types.

Reference:

http://en.wikipedia.org/wiki/Chromosomal_translocation

http://www.nature.com/ncomms/2014/140603/ncomms4964/abs/ncomms4964.html