The aims of bio/medical research are also broad, including:
• Understanding mechanism of disease
• Understanding the impact of genetic and external factors on human health
• Designing and evaluating new therapeutic interventions
• Health genomics

List of Research Institutes in India (Biological Sciences)

BANGALORE
Ashoka Trust for Ecology and the Environment
Royal Enclave, Srirampura, Jakkur Post, Bangalore-560064
Email: info@atree.org
Web: www.atree.org/
Research: ATREE deals with issues relating to the environmental, social and economic dimensions, and implications of, biological resources and natural ecosystems

Indian Institute of Science
Indian Institute of Science, Bangalore 560 012, Karnataka
Email:regr@admin.iisc.ernet.in
Web: www.iisc.ernet.in/
Research Areas: Biochemistry, ecological sciences, microbiology & cell biology, molecular biophysics, molecular reproduction, development & genetics.

Jawaharlal Nehru Centre for Advanced Scientific Research
Jakkur, Bangalore 560 064, Karnataka
Email: academic@jncasr.ac.in
Web: www.jncasr.ac.in/
Research Areas: Evolutionary and organismal biology, molecular biology and genetics.

National Centre for Biological Science
GKVK, Bellary Road,
Email: dean@ncbs.res.in
Web: www.ncbs.res.in
Research Areas: The research interests of the faculty range from single molecules to systems biology.

National Institute of Mental Health and Neurosciences
Bangalore 560029, Karnataka
Email: info@nimhans.kar.nic.in
Web: nimhans.kar.nic.in/
Research Areas: Biophysics, biostatistics, clinical psychology, epidemiology, human genetics, mental health education, neuroanaesthesia, neurochemistry, neuro imaging and interventional radiology, neurology, neuromicrobiology, neuropathology, neurophysiology, neurosurgery, neurovirology.

Stem Cell Institute
NCBS, GKVK, Bellary Road,
Email: ramas@ncbs.res.in
Web: underconstruction

University of Agricultural Sciences
GKVK, Bangalore 5600065, Karnataka
Email: root@uas.kar.nic.in
Web: uasbng.kar.nic.in/Default.htm
BARODA

Maharaja Sayajirao University of Baroda
Fatehgunj, Vadodara 390 002, Gujarat
Web: msubaroda.ac.in/

BHOPAL
Indian Institute of Science Education and Research–Bhopal
Govindpura, Bhopal - 23
E-mail: director@iiserbhopal.ac.in
Web: www.iiserbhopal.ac.in/
Research Areas: All areas of basic sciences – Biology, chemistry, math and physics
BHUBANESHWAR
Institute of Life Sciences
Bhubaneswar 751 023, Orissa
Web: www.ils.res.in
Research Areas: Cancer, malaria, age diseases, stress biology, ecophysiology, plant molecular physiology, filariasis, tuberculosis, bio-perspecitve, agricultural biotechnology, bio-informatics.

National Institute of Science Education and Research – Bhubaneshwar
Institute of Physics Campus, Bhubaneswar, Orissa - 751 005,
e-mail : director@niser.ac.in
Web: www.niser.ac.in/
Research Areas: All areas of basic sciences – Biology, chemistry, math and physics.

Regional Research Laboratory
Bhubaneswar 751 013, Orissa
Email: root@csrrlbhu.ren.nic.in
Web: www.icast.org.in/csir/rrl_bhu.html
Research Areas: Survey & cultivation of aromatic, medicinal and other economic plants.

Utkal University
Vani Vihar, Bhubaneswar 751 004, Orissa
Web: www.utkaluniversity.org/
CHANDIGARH
Indian Institute of Science Education and Research –Mohali
Chandigarh
Email: webmaster@iisermohali.ac.in
Web: www.iisermohali.ac.in/
Research Areas: All areas of basic sciences – Biology,
chemistry, math and physics

Institute of Microbial Technology
Sector 39–A, Chandigarh 160 036
Email: raghava@imtech.res.in
Web: www.imtech.res.in/
Research Areas: Molecular biology and microbial genetics,
animal cell/tissue culture and protein engineering.

Panjab University
Chandigarh 160 014
Email: pulib@puchd.ren.nic.in
Web: www.puchd.ac.in/

Postgraduate institute of Medical Education and Research
Sector-12, Chandigarh, 160 012
Email: pgimer@chd.nic.in
Web: pgimer.nic.in/
Research Areas: Obstetrics and gynaecology, psychiatry,
biochemistry, haematology, clinical parasitology etc.
CHENNAI
Indian Institute of Technology Madras
Chennai 600 036, Tamil Nadu
Email: tppro@acer.iitm.ernet.in
Web: www.iitm.ac.in
Research Areas: Engineering: Biotechnology.

University of Madras
University Centenary Building, Chepauk, Chennai 600 005, Tamil Nadu
Email: webmaster@unom.ac.in
Web: www.unom.ac.in/
DARJEELING
University of North Bengal
Raja Rammohunpur, Darjeeling 734 430, West Bengal
Email:(Registrar): regnbu@dte.vsnl.net.in
Web: www.nbu.ac.in/
DELHI
All India Institute of Medical Sciences
New Delhi
Email: webmastr@aiims.ac.in
Web: www.aiims.ac.in/

Institute of Genomics and Integrative Biology
Delhi University Campus, Mall Road, Delhi 110 007
Email: info@igib.res.in
Web: www.igib.res.in/
Research Areas: Allergy and immunology, diagnostics, genetic engineering, bio-organics and high-tech reagents.

Indian Institute of Technology Delhi
Hauz Khas, New Delhi 110 016
Email: malhotra@admin.iitd.ernet.in
Web: www.iitd.ac.in
Research Areas: Engineering: Biochemical engineering & biotechnology.
International Centre for Genetic Engineering and Biotechnology

ICGEB Campus, Aruna Asaf Ali Marg,
New Delhi 110 067
Web: www.icgeb.trieste.it/
Research Areas: Mammalian biology:
Virology immunology, malaria,
recombinant gene products,
Plant molecular biology, plant transformation,
insect resistance, plant resistance.

Jawaharlal Nehru University
New Delhi
Email: webmaster@mail.jnu.ac.in
Web: www.jnu.ac.in

National Centre for Plant Genome Research
JNU Campus, New Delhi
Email: tapas_s3@yahoo.co.in
Web: ncpgr.nic.in/
Research Areas: Nutritional, structural, and functional genomics of various plant systems.

National Institute of Immunology
Aruna Asaf Ali Marg, New Delhi 110 067
Web: www.nii.res.in/
Research Areas: Gene regulation, immunity & infection, molecular design, reproduction & development.

TERI University
Vasant Kunj, New Delhi - 110 070 / India
E-mail: registrar@teri.res.in
Web: www.teriuniversity.ac.in
Research Areas: Environmental Studies, Natural Resources Management, Climate Science and Policy, Plant Biotechnology

University of Delhi
University Road, Delhi 110 007
Email: webmaster@du.ac.in
Web: www.du.ac.in/
GOA
National Centre for Antarctic and Ocean Research
Headland Sada, Vasco-da-Gama 403 804, Goa
Email: info@ncaor.org
Research Areas: Co–ordination and implementation of the Indian Antarctic Programme.


National Institute of Oceanography
Dona Paula 403 004, Goa
Email: webmaster@darya.nio.org
Web: www.nio.org/
Research Areas: International geosphere-bio-sphere programme, marine biotechnology.
GURGAON
National Brain Research Centre
Near NSG Campus, Nainwal Mode, Manesar, Gurgaon, Haryana
Email: info@nbrc.ac.in
Web: www.nbrc.ac.in/
Research Areas: Brain research.
GUWAHATI
Indian Institute of Technology Guwahati
North Guwahati, Guwahati 781 039, Assam
Email: mcb@iitg.ernet.in
Web: www.iitg.ernet.in
Research Areas: Engineering: Biotechnology.


Gauhati University
Gopinath Bordoloi Nagar, Guwahati 781 014, Assam
Web: http://www.gauhati.ac.in/.
HYDERABAD
Centre for Cellular & Molecular Biology
Uppal Road, Hyderabad 500 007, Andhra Pradesh
Email: (Director): lalji@ccmb.res.in
Web: www.ccmb.res.in/
Research Areas: Biophysics & biochemistry, molecular biology, genetics & evolution, biomedicines & biotechnology.


Centre for DNA Fingerprinting and Diagnostics
CDFD, Bldg. 7, Gruhakalpa, 5-4-399/B, Nampally, Hyderabad - 500 001.
Email: director@cdfd.org.in
Web: www.cdfd.org.in/
Research Areas: Automated genome analysis, bacterial genetics, cancer biology, cell biology & gene expression, computational biology, computational & functional genomics, immunology, mammalian genetics, molecular genetics, molecular oncology, molecular virology, structural biology, transcription, developmental neuroscience and drosophila genetics.


Indian Institute of Chemical Technology
Uppal Road, Hyderabad 500 007, Andhra Pradesh
Email: kvr@iict.ap.nic.in, sampath@iict.ap.nic.in
Web: www.iictindia.org/
Research Areas: Pesticides, drugs, organic intermediates and fine chemicals.


LV Prasad Eye Intstitute
Hyderabad, Andhra Pradesh, India
Email: communications@lvpei.org
Web: www.lvpei.org/
LVPEI is a World Health Organization Collaborating Center for Prevention of Blindness. Equipped with cutting-edge technology and distinguished professionals in the field of Eye care


University of Hyderabad
P.O. Central University, Gachibowli, Hyderabad 500 046, Andhra Pradesh
Email: trctcs@uohyd.ernet.in
Web: www.uohyd.ernet.in/
IMPHAL
Institute of Bioresources and Sustainable Development
Takyelpat, Imphal 795 001, Manipur
Email: ibsd_imp@sancharnet.in, ibsd-imphal@man.nic.in
Web: ibsd-imphal.nic.in/
Research Areas: Conservation of biodiversity and sustainable utilisation of biodiversity.
ITANAGAR
North Eastern Regional Institute of Science and Technology
Itanagar, Nirjuli, Papumpare 791 109, Arunachal Pradesh
Email: dir@nerist.ernet.in
Web: www.nerist.ac.in/
Research Areas: Agricultural engineering, forestry.
JAIPUR
University of Rajasthan
Jaipur 320 004, Rajasthan
Email: info@uniraj.org
Web: www.uniraj.org/
JAMMU and KASHMIR
Regional Research Laboratory
Canal Road, Jammu 130 001, Jammu & Kashmir
Email: (Director): qazi_gn@yahoo.com, root@csrrljm.ren.nic.in
Web: www.rrljammu.org/
Research Areas: Natural products & organic chemistry, improvement & cultivation of medicinal and aromatic plants, post harvest technology and applied microbiology & mutation genetics.

University of Jammu
Jammu 180 006, Jammu & Kashmir
Web: www.jammuuniversity.org/

University of Kashmir
Hazratbal,Srinagar-190006,Jammu and Kashmir
Email: info@kashmiruniversity.net
Web: http://www.kashmiruniversity.net/

Sher-i-Kashmir Institute of Medical Science (SKIMS)
Srinagar, Jammu and Kashmir
Email: skimsweb@gmail.com
Web: http://www.skims.ac.in/

Sher-e-Kashmir University of Agricultural Sciences and Technology (SKUAST)
Shalimar Campus, Srinagar - 191121 Jammu and Kashmir
Email: skuastkashmir@gmail.com
Web: http://www.skuastkashmir.ac.in/
Research Areas: Agricultural Sciences, fisheries and veterinary sciences.
JORHAT
Regional Research Laboratory
Jorhat 785 006, Assam
Email: drrljt@csir.res.in, inform@csir.res.in
Web: jorhat.nic.in/rrl.htm
Research Areas: Agrochemicals, drugs and drug intermediates, organic chemistry, biochemistry.
KANPUR
Indian Institute of Technology Kanpur
GT Road, Kalyanpur, Kanpur 208 016, Uttar Pradesh
Email: infocell@iitk.ac.in
Web: www.iitk.ac.in/
Research Areas: Engineering: Biological sciences & bioengineering.
KHARAGPUR
Indian Institute of Technology Kharagpur
Kharagpur 721 302, West Bengal
Email: (PRO): ashok@hijli.iitkgp.ernet.in
Web: www.iitkgp.ernet.in/
Research Areas: Engineering: Biotechnology.
KOCHI
Cochin University of Science and Technology
South Kalamessery, Kochi 682 022, Kerala
Email: webmaster@cusat.ac.in
Web: www.cusat.ac.in/.
KOLKATA
Bose Institute
93/1, Acharya Prafulla Chandra Road, Kolkata 700 009, West Bengal
Email: sidroy@bic.boseinst.ernet.in
Web: www.boseinstitute.org/
Research Areas: Bioinformatics & computational biology, structure and functional dynamics of biomolecules, drug modeling, molecular genetics of microbes, transgenic plants etc.


Indian Institute of Chemical Biology
4, Raja S.C. Mullick Road, Jadavpur, Kolkata 700 032, West Bengal
Email: (Director): director@iicb.res.in
Web: www.iicb.res.in/
Research Areas: Natural products of medicinal, biological and industrial value, immunoassay techniques, tissue-targeted drug-delivery system.


Indian Institute of Science Education and Research –Kolkata
Mohanpur, Nadia, West Bengal
Web: www.iiserkol.ac.in/
Research Areas: All areas of basic sciences – Biology, chemistry, math and physics


Indian Statistical Institute, Kolkata
203 Barrackpore Trunk Road, Kolkata 700 108, West Bengal
Email: postmaster@isical.ac.in
Web: www.isical.ac.in/
Research Areas: Agricultural and ecological research, biological anthropology, human genetics.


Jadavpur University
188 Raja S.C. Mallik Road, Kolkata 700 032, West Bengal
Email: registrar@jdvu.ac.in
Web: www.jadavpur.edu/


University of Calcutta
Kolkata 700 009, West Bengal
Web: www.kolkata.org/cu/
KURUKSHETRA
Kurukshetra University
Kurukshetra 136 119, Haryana
Email: jskadian@rediffmail.com
Web: kuk.ernet.in/
LUCKNOW
Birbal Sahni Institute of Palaeobotany
53 University Road, Lucknow, Uttar Pradesh
Email: director@bsip.res.in
Web: www.bsip-india.org/index.htm
Research Areas: Botanical palaeobotany: Morphotaxonomy, palaeoecology, palaeogeography, phylogeny and evolution.


Central Drug Research Institute
Chattar Manzil Palace, Post Box No. 173, Lucknow 226 001, Uttar Pradesh
Email: info@cdriindia.org
Web: www.cdriindia.org/
Research Areas: Development of contraceptives, new drugs for tropical diseases (malaria, filariasis, leishmaniasis), cardio-vascular and central nervous system disorders.


Indian Institute of Science Education and Research –Kolkata
Mohanpur, Nadia, West Bengal
Web: www.iiserkol.ac.in/
Research Areas: All areas of basic sciences – Biology, chemistry, math and physics


Indian Statistical Institute, Kolkata
203 Barrackpore Trunk Road, Kolkata 700 108, West Bengal
Email: postmaster@isical.ac.in
Web: www.isical.ac.in/
Research Areas: Agricultural and ecological research, biological anthropology, human genetics.


Central Institute of Medicinal and Aromatic Plants
Lucknow 226 015, Uttar Pradesh
Email: director@cimap.res.in
Web: www.cimap.res.in/
Research Areas: Agrotechnologies for medicinal and aromatic plants, phytochemistry, plant physiology and biochemistry, pathology, genetics, entomology and pharmacognosy.


Industrial Toxicology Research Centre
Mahatma Gandhi Marg, P.O. Box No. 80, Lucknow 226 001, Uttar Pradesh
Email: info@itrcindia.org
Web: www.itrcindia.org/
Research Areas: Neurotoxicology, environmental health, immunotoxicology and environmental biotechnology.


National Botanical Research Institute
Rana Pratap Marg, Lucknow 226 001, Uttar Pradesh
Email: p.pushpangadan@nbri.res.in
Web: www.nbri-lko.org/
Research Areas: Plant biotechnology, environmental sciences, taxonomy and ethnobotany, plant molecular biology.
MUMBAI
Advanced Centre for Treatment, Research and Education in Cancer (ACTREC)
Tata Memorial Centre, Navi Mumbai - 410 210
Web: www.actrec.gov.in/
Research Areas: Research investigations currently focus on molecular mechanisms of cancer, drug development and emerging therapies for treatment and prevention of cancer.


Bhabha Atomic Research Centre
Trombay, Mumbai 400 085, Maharashtra
Email: webmaster@magnum.barc.ernet.in
Web: www.barc.ernet.in/
Research Areas: Chemical and life sciences, nuclear agriculture.


Bombay Natural History Society
Hornbill House, Shaheed Bhagat Singh Road, Mumbai 400 023, Maharashtra
Email: bnhs@bom4.vsnl.net.in
Web: www.bnhs.org/


Indian Institute of Technology Bombay
Powai, Mumbai 400 076, Maharashtra
Email: registrar@iitb.ac.in
Web: www.iitb.ac.in/
Research Areas: Earth sciences; Science: Biology, chemistry, mathematics, physics.


Tata Institute of Fundamental Research
Homi Bhabha Road, Navy Nagar, Colaba, Mumbai 400 005.
Web: www.tifr.res.in/
Department of Biological Sciences: www.tifr.res.in/~dbs
Research Areas: TIFR is a multidisciplinary research organisation working in the area of Natural Sciences (Biology, Chemistry, and Physics), Mathematics and Computer Science.


University of Mumbai
Vidyanagari, Kalina, Santa Cruz (W), Mumbai 400 098, Maharashtra
Web: www.mu.ac.in/


National Botanical Research Institute
Rana Pratap Marg, Lucknow 226 001, Uttar Pradesh
Email: p.pushpangadan@nbri.res.in
Web: www.nbri-lko.org/
Research Areas: Plant biotechnology, environmental sciences, taxonomy and ethnobotany, plant molecular biology.
NAGPUR
National Environmental Engineering Research Institute
Nehru Marg, Nagpur 440 020, Maharashtra
Email: dirneeri@nagpur.dot.net.in
Web: www.neeri.nic.in/
Research Areas: Environmental biotechnology.
PUNE
Agharkar Research Institute
G.G. Agarkar Road, Pune 411 004, Maharashtra
Web: www.aripune.org/
Research Areas: Animal sciences, microbial sciences, plant sciences.


Indian Institute of Science Education and Research–Pune
Email: director@iiserpune.ac.in
Web: www.iiserpune.ac.in/
Research Areas: All areas of basic sciences – Biology, chemistry, math and physics.


National Chemical Laboratory
Dr. Homi Bhabha Road, Pune 411 008, Maharashtra
Email: director@ems.ncl.res.in
Web: www.ncl-india.org/
Research Areas: biotechnology, biochemistry.>


National Centre for Cell Sciences
NCCS Complex, Ganeshkhind, Pune 411 007, Maharashtra
Email: infonccs@giaspn01.vsnl.net.in
Web: www.nccs.res.in/
Research Areas: Cell biology, molecular biology, immunology, parasitology, hybridoma technology, tissue banking & tissue engineering, regenerative biology, virology (HIV), cancer biology, diabetes, cryobiology transplantation, gene therapy.


University of Pune
Ganeshkhind Road, Pune 411 007, Maharashtra Telephone: 020-5601305
Email: Registrar): regis@unipune.ernet.in
Web: www.unipune.ernet.in/
PALAMPUR
Institute of Himalayan Bioresource Technology
Post Box No. 6, Palampur 176 061, Himachal Pradesh
Email: root@csihbt.ren.nic.in, director@ihbt.csir.res.in
Web: www.icast.org.in/csir/ihbt.html
Research Areas: Floriculture, tea sciences, biotechnology and natural plant products.
PATIALA
Punjabi University
Patiala 147 002, Punjab
Email: ucc@pbi.ac.in
Web: www.universitypunjabi.org/
PILANI
Birla Institute of Technology and Science
Vidhya Vihar Campus, Pilani, 333 031, Rajasthan
Email: mmsanand@bits-pilani.ac.in
Web: www.bits-pilani.ac.in/
ROORKEE
Indian Institute of Technology Roorkee
Roorkee 247 667, Uttaranchal
Email: (Registrar): regis@iitr.ernet.in
Web: www.iitr.ernet.in/
Research Areas: Engineering: Biotechnology.
SHANTINIKETAN
Visva-Bharati University
Santiniketan, Birbhum 731 235, West Bengal
Email: Root@vbharat.ernet.in
Web: www.visva-bharati.ac.in/
SHILLONG
North-Eastern Hill University
Umshing, Shillong 793 022, Meghalaya
Email: admin@nehu.ac.in
Web: www.nehu.ac.in/
SILCHAR
Assam University
P.O. Box 63, Silchar 788 011, Assam
Email: auliba@sancharnet.in, asokesen@sancharnet.in
Web: assamuniversity.nic.in/
TRIVANDUM
Indian Institute of Science Education and Research–Trivandum
Trivandrum, Kerala,India.
Web: www.iisertvm.ac.in/
Research Areas: All areas of basic sciences – Biology, chemistry, math and physics


Rajiv Gandhi Centre for Biotechnology
Thycaud P.O., Thiruvananthapuram 695 , Kerala
Email: info@rgcb.res.in
Web: rgcb.res.in/
Research Areas: Disease biology and molecular medicine, Plant biotechnology


Regional Research Laboratory
Industrial Estate P.O., Pappanamcode, Thiruvananthapuram 695 019, Kerala
Email: root@csrrltrd.ren.nic.in
Web: w3rrlt.csir.res.in/
Research Areas: Chemistry of natural products, agroprocessing, photochemical systems including solar energy conversion, analysis of pollutants and waste-water technology.

VARANASI
Banaras Hindu University
Varanasi 221 005, Uttar Pradesh
Email: webmaster@bhu.ac.in
Web: www.bhu.ac.in/index.html

Rajiv Gandhi Centre for Biotechnology
Thycaud P.O., Thiruvananthapuram 695 , Kerala
Email: info@rgcb.res.in
Web: rgcb.res.in/
Research Areas: Disease biology and molecular medicine, Plant biotechnology


Indian Council for Agricultural Research
Main Web site: www.icar.org.in/
Research Institutes under ICAR: www.icar.org.in/icar15.html


CSIR Laboratories
Main CSIR website–www.csir.res.in/

-------------------------------

Department of Atomic Energy
Main CSIR website–www.barc.ernet.in/


Department of Biotechnology
Main CSIR website–dbtindia.nic.in/index.asp

Dept. of Science & Technology
Main Website: Main Website: www.dst.gov.in/


Indian Council for Medical Research
Main Web site: icmr.nic.in/
Research Institutes under ICMR: icmr.nic.in/institute.htm#Permanent%20Institutes/Centres

Ministry of Environment and Forest
Main Web site: envfor.nic.in/
Research Institutes under ICAR: cyberjournalist.org.in/linksr.html

This course is organized with support from the IAP “Belgian Medical Genomics Initiative”, SymBioSys and the Genomics Core.

For inquiries, please email Ms Narcisse Opdekamp ( narcisse.opdekamp@uzleuven.be ).

More at >> http://gc.uzleuven.be/

Next generation quantitative genetics in plants. Jiménez-Gómez, Frontiers in Plant Science 2:77, 2011 Full Text [equally relevant to animal and microbial systems]

Sense from sequence reads: methods for alignment and assembly. Flicek & Birney, Nat Methods 6(11 Suppl):S6-S12, 2009. Full Text

Library construction and experimental design

Statistical design and analysis of RNA sequencing data. Auer & Doerge, Genetics 185(2):405-16, 2010. PubMedCentral

Biases in Illumina transcriptome sequencing caused by random hexamer priming. Hansen et al., Nucleic Acids Res. 38(12): e131, 2010. PubMedCentral

Analyzing and minimizing PCR amplification bias in Illumina sequencing libraries. Aird et al, Genome Biology 12:R18, 2011 Full Text

Amplification-free Illumina sequencing-library preparation facilitates improved mapping and assembly of GC-biased genomes. Kozarewa et al, Nature Methods 6(4):291-5, 2009 PubMedCentral

Cost-effective, high-throughput DNA sequencing libraries for multiplexed target capture. Rohland & Reich, Genome Research 22(5): 939–946. PubMedCentral

Data formats, data management, and alignment software tools

The Sequence Alignment/Map format and SAMtools. Li et al, Bioinformatics 25(16):2078-9, 2009 PubMedCentral

SAM format specification file

Efficient storage of high throughput sequencing data using reference-based compression. Fritz et al, Genome Res 21(5):734-40, 2011. Full Text

Compression of DNA sequence reads in FASTQ format. Deorowicz & Grabowski, Bioinformatics 27(6):860-2, 2011. PubMed

Fast and accurate short read alignment with Burrows-Wheeler transform. Li & Durbin, Bioinformatics 25(14):1754-60, 2009. PubMedCentral

Improving SNP discovery by base alignment quality. Li H, Bioinformatics 27(8):1157-8, 2011. PubMed

BEDTools: a flexible suite of utilities for comparing genomic features. Quinlan and Hall, Bioinformatics 26:841-842, 2010. Publisher Website

Data quality assessment, filtering, and correction

SolexaQA: At-a-glance quality assessment of Illumina second-generation sequencing data. Cox et al, BMC Bioinformatics 11:485, 2010. PubMedCentral

TileQC: a system for tile-based quality control of Solexa data. Dolan & Denver, BMC Bioinformatics 9:250, 2008 PubMedCentral [requires a reference sequence]

Quake: quality-aware detection and correction of sequencing errors. Kelley et al, Genome Biol 11(11):R116, 2010. PubMed

FastQC: a quality control tool for high-throughput sequence data. Home Page

FASTX-toolkit: FASTQ/A short-reads pre-processing tools Home Page

Reference-free validation of short read data. Schröder et al, PLoS One 5(9):e12681, 2010. PubMedCentral

Correction of sequencing errors in a mixed set of reads. Salmela, Bioinformatics 26(10):1284, 2010. Full Text [includes error correction of SOLiD reads in colorspace]

Repeat-aware modeling and correction of short read errors. Yang et al, BMC Bioinformatics 12(Supp1):S52, 2011 PubMedCentral [requires a reference sequence]

HiTEC: accurate error correction in high-throughput sequencing data. Ilie et al, Bioinformatics 27(3):295, 2011 Full Text

Error correction of high-throughput sequencing datasets with non-uniform coverage. Medvedev et al., Bioinformatics 27(13):i137-41, 2011. PubMedCentral

De novo assembly

Velvet: algorithms for de novo short read assembly using de Bruijn graphs. Zerbino & Birney, Genome Res 18(5):821-9, 2008. u>PubMedCentral

Assembly of large genomes using second-generation sequencing. Schatz et al, Genome Res 20(9):1165-73, 2010. PubMedCentral

High-quality draft assemblies of mammalian genomes from massively parallel sequence data. Gnerre et al, PNAS 108(4): 1513-18, 2011 PubMedCentral

Genome assembly has a major impact on gene content: a comparison of annotation in two Bos taurus assemblies. Florea  et al., PLoS One 6(6):e21400, 2011. PubMedCentral

Artemis: an integrated platform for visualization and analysis of high-throughput sequence-based experimental data. Carver et al, Bioinformatics 28(4):464 - 469, 2012 PubMedCentral

Efficient de novo assembly of large genomes using compressed data structures. Simpson & Durbin, Genome Research 22:549-556, 2012 Full Text [Describes the String Graph Assembler (SGA), which assembled a human genome in less than 6 days using 54 Gb of RAM and a 123-processor compute cluster for calculation of an FM-index of the 1.2 billion reads]

Readjoiner: a fast and memory efficient string graph-based sequence assembler. Gonnella & Kurtz, BMC Bioinformatics 13: 82, 2012 PubMedCentral

Assemblathon 1: A competitive assessment of de novo short read assembly methods. Earl et al, Genome Research 21:2224-2241, 2011 Full Text

Chromatin immunoprecipation analysis: ChIP-seq

ChIP-seq: advantages and challenges of a maturing technology. Park, Nat Rev Genet. 10:669-80, 2009 PubMed

ChIP-seq and Beyond: new and improved methodologies to detect and characterize protein-DNA interactions. Furey, Nat Rev Genet 13: 840–852, 2012 Publisher Web Site

MuMoD: a Bayesian approach to detect multiple modes of protein–DNA binding from genome-wide ChIP data. Narlikar, Nucleic Acids Res 41:21–32, 2013 PubMed

Transcriptome analysis

Assembly and comparison to genome

Full-length transcriptome assembly from RNA-Seq data without a reference genome. Grabherr et al, Nature Biotechnology 29:644 - 652, 2011. PubMed [The software is called Trinity, and is available on Sourceforge.]

Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome. Peng et al, Nature Biotechnology 30:253 - 260, 2012. PubMed [Several comments on this paper question whether the reported differences are in fact evidence of editing or are simply sequencing errors - the authors stand by their conclusions, but the controversy demonstrates the importance of robust data analysis methods.]

Optimization of de novo transcriptome assembly from next-generation sequencing data. Surget-Groba & Montoya-Burgos, Genome Res 20(10):1432-40, 2010. Full Text

Rnnotator: an automated de novo transcriptome assembly pipeline from stranded RNA-Seq reads. Martin et al, BMC Genomics 11:663, 2010 Full Text

De novo assembly and analysis of RNA-seq data. Robertson et al, Nature Methods 7:909-912, 2010 Full Text [describes Trans-ABySS, a pipeline to use the ABySS parallel assembler for de novo transcriptome analysis]

Differential expression analysis

R-SAP: a multi-threading computational pipeline for the characterization of high-throughput RNA-sequencing data. Mittal & McDonald, Nucleic Acids Res, 2012 Full Text

Targeted RNA sequencing reveals the deep complexity of the human transcriptome. Mercer et al, Nature Biotechnology 30:99 - 104, 2012 Publisher Website

Differential gene and transcript expression analysis of RNA-Seq experiments with TopHat and Cufflinks. Trapnell et al, Nature Protocols 7:562 - 578, 2012 Publisher Website

Characterization and improvement of RNA-Seq precision in quantitative transcript expression profiling. Łabaj et al, Bioinformatics 27:i383 - i391, 2011 Full Text

Improving RNA-Seq expression estimates by correcting for fragment bias. Roberts et al, Genome Biol 12:R22, 2011 PubMed Central

Cloud-scale RNA-sequencing differential expression analysis with Myrna. Langmead et al, Genome Biol 11:R83, 2010 Full Text

From RNA-seq reads to differential expression results. Oshlack et al, Genome Biol 11(12):220, 2010 Full Text

DEGseq: an R package for identifying differentially expressed genes from RNA-seq data. Wang et al., Bioinformatics. 26(1):136-8. 2010 PubMed

DEseq: Differential expression analysis for sequence count data. Anders and Huber, Genome Biology 11:R106, 2010 Full Text

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Robinson et al., Bioinformatics 26(1):139-40 2010 PubMedCentral

Two-stage Poisson model for testing RNA-seq data. Auer and Doerge, SAGMB 10(1), article 26 Full Text

Experimental design, preprocessing, normalization and differential expression analysis of small RNA sequencing experiments. McCormick et al., Silence2(1):2, 2011 PubMedCentral

RNA-Seq gene expression estimation with read mapping uncertainty. Li et al, Bioinformatics 26:493-500, 2010 PubMedCentral [describes the RSEM software package]

Comparing genomes and assemblies; variant detection

Versatile and open software for comparing large genomes. Kurtz et al, Genome Biol (5(2):R12, 2004. PubMedCentral [describes the MUMmer software for full-genome alignment & comparisons]

Searching for SNPs with cloud computing. Langmead et al, Genome Biol 10(11):R134, 2009 Full Text

Calling SNPs without a reference sequence. Ratan et al, BMC Bioinformatics 11:130, 2010 PubMedCentral

Microindel detection in short-read sequence data. Krawitz et al, Bioinformatics 26(6):722-9, 2010. Full Text

vipR: variant identification in pooled DNA using R. Altmann et al., Bioinformatics 27: i77-i84, 2011. PubMedCentral

Geoseq: a tool for dissecting deep-sequencing datasets. Gurtowski et al, BMC Bioinformatics 11:506, 2010. PubMedCentral [Geoseq is a web service that allows searching deep sequencing datasets with a reference sequence of a gene of interest]

Detecting and annotating genetic variations using the HugeSeq pipeline. Lam et al, Nature Biotechnology 30:226 - 229, 2012 Publisher Website, Home Page

Genome-wide LORE1 retrotransposon mutagenesis and high-throughput insertion detection in Lotus japonicus. Urbański et al, Plant J 64:731-741, 2012. Publisher Website [This paper describes a 2-dimensional pooling strategy with barcoding to allow use of Illumina sequencing to screen for retrotransposon insertion mutations, and includes a software package called FSTpoolit for analysis of the resulting sequence reads.]

Genotyping by sequencing

Genome-wide genetic marker discovery and genotyping using next-generation sequencing. Davey et al., Nat Rev Genet 12(7):499-510, 2011 PubMed [A review of methods available at the time]

A robust, simple genotyping-by-sequencing (GBS) approach for high diversity species. Elshire et al., PLoS One 6(5):e19379, 2011. Full Text

Development of high-density genetic maps for barley and wheat using a novel two-enzyme genotyping-by-sequencing approach. Poland et al., PLoS One 7(2): e32253, 2012. Full Text

Double digest RADseq: an inexpensive method for de novo SNP discovery and genotyping in model and non-model species. Peterson et al, PLoS One 7(5):e37135, . 2012. Full Text

Imputation of unordered markers and the impact on genomic selection accuracy. Rutkowski et al, G3 3(3):427-39, 2013. Full Text

Diversity Arrays Technology (DArT) and next-generation sequencing combined: genome-wide, high-throughput, highly informative genotyping for molecular breeding of Eucalyptus. Sansaloni et al., BMC Proceedings 5(Suppl 7):P54, 2011 Full Text

High-throughput genotyping by whole-genome resequencing. Huang et al., Genome Res 19(6):1068-76, 2009. Full Text

Multiplexed shotgun genotyping for rapid and efficient genetic mapping. Andolfatto et al. Genome Res 21(4):610-7, 2011. Full Text

Restriction-site Associated DNA (RAD) markers

Rapid SNP discovery and genetic mapping using sequenced RAD markers. Baird et al, PLoS One 3(10):e3376, 2008 Full Text

Linkage mapping and comparative genomics using next-generation RAD sequencing of a non-model organism. Baxter et al., PLoS One 6(4):e19315, 2011. Full Text

Genome evolution and meiotic maps by massively parallel DNA sequencing: spotted gar, an outgroup for the teleost genome duplication. Amores et al, Genetics 188(4):799-808, 2011. PubMed

Construction and application for QTL analysis of a Restriction-site Associated DNA (RAD) linkage map in barley. Chutimanitsakun et al, BMC Genomics 4; 12:4, 2011. Full Text

RAD tag sequencing as a source of SNP markers in Cynara cardunculus L. Scaglione et al., BMC Genomics 13:3, 2012. Full Text

Paired-end RAD-seq for de novo assembly and marker design without available reference. Willing et al., Bioinformatics 27(16):2187-93, 2011. Publisher Website

Local de novo assembly of RAD paired-end contigs using short sequencing reads. Etter et al., PLOS ONE 6(4): e18561, 2011. Full Text

Stacks: building and genotyping loci de novo from short-read sequences. Catchen et al., G3: Genes, Genomes, Genetics, 1:171-182, 2011. Full Text, Home Page

Rainbow: an integrated tool for efficient clustering and assembling RAD-seq reads. Chong et al, Bioinformatics 28(21):2732-7, 2012. Publisher Website

UK RAD Sequencing Wiki page, with bibliography and RADTools software download Home Page

Workspace environments

Papers

Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences. Goecks et al, Genome Biol 11(8):R86, 2010 PubMedCentral

Galaxy Cloudman: Delivering compute clusters. BMC Bioinformatics 11(Suppl. 12):S4, 2010 Full Text

The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. McKenna et al, Genome Res 20(9):1297-303, 2010. PubMedCentral

A framework for variation discovery and genotyping using next-generation DNA sequencing data. DePristo et al., Nat Genet 43(5):491-8, 2011. PubMed

Online resources

The R statistical computing environment includes Bioconductor, a specialized set of tools for analysis of microarray and high-throughput sequencing data. Introductory materials from on-line or short workshops are widely available online; examples are Evomics2012 Bioconductor-tutorial.pdf, and Intro to Bioconductor. Materials from an advanced course on high-throughput genetic data analysis are at Seattle 2012 materials. Thomas Girke of UC-Riverside has written a very complete set of manuals describing the use of R and Bioconductor for analysis of genomic datasets, available at R and Bioconductor Manuals.
Manuals and contributed documentation for R are available at the R-project.org website, and video tutorials are also available on Youtube; those posted by Tutorlol are brief, clear, and to the point.
Materials from a series of mini-courses in R taught in 2010 at UCLA are available:

• Intro to programming and graphics
• Data manipulation and functions
• Graphics for exploratory data analysis
• Introductory statistics
• Linear regression

A Little Book of R for Bioinformatics is an on-line resource with information and exercises to provide practice in bioinformatics analysis of DNA sequences and other biological data in R.
Many books on specific topics in R programming are also available through Amazon or other vendors.

Cloud computing resources

The case for cloud computing in genome informatics. Lincoln Stein, Genome Biol. 11(5):207, 2010 Pubmed

Galaxy Cloudman: delivering cloud compute clusters. Afgan et al, BMC Bioinformatics 11(Suppl 12):S4, 2010 Full Text

CloudBioLinux is an open-source project that provides a bioinformatics Linux system for cloud computing, pre-configured with a variety of software tools installed and ready to use.

A tutorial on getting started with CloudBioLinux on the Amazon Web Services Elastic Compute Cloud (EC2)

“Deploying Galaxy on the Cloud” – slides from a presentation by Enis Afgan (Emory University) at the
 Bioinformatics Open Source Conference in Boston, July 2010

A screencast that provides a step-by-step guide to starting a Galaxy cluster in the EC2 environment

A webpage that has the same information in text form, and is the basis for the screencast

The iPlant Collaborative, an NSF-funded project to create computational resources for plant biology research, provides access to cloud computing resources through Atmosphere

SeqWare Query Engine: storing and searching sequence data in the cloud. O’Connor et al, BMC Bioinformatics 11(Suppl 12):S2, 2010 Full Text

An overview of the Hadoop/MapReduce/HBase framework and its current applications in bioinformatics. Taylor, BMC Bioinformatics 11(Suppl 12):S1, 2010 Full Text

Links to Linux command-line tutorials and resources

Tutorials for AWK, a powerful tool for handling data tables

• A set of awk notes from Boston University
• Bruce Barnett's awk tutorial
• Greg Goebel's awk tutorial
• Executing an awk command from R to simplify data exploratory analysis, from Lex Nederbragt

Tutorials for bash shell scripting

• A tutorial at linuxconfig.org
• A Getting Started With Bash tutorial at hypexr.org
• Mendel Cooper's Advanced Bash Shell-Scripting Guide

Tutorials for sed, the command-line stream editor

• A tutorial at Rutgers
• Peteris Krumins claims to have the World's Best Introduction to Sed; take a look and judge for yourself.
• Bruce Barnett's sed tutorial.

Links to other useful sites

The SEQanswers online community has forums on several topics related to sequencing; the bioinformatics forum is the most active.

The SEQanswers Software Wiki is a list of software for analysis of sequencing data

Biostar is another online community for questions and answers on bioinformatics and computational genomics.

Information on file formats used by the University of California - Santa Cruz Genome Browser is on the FAQ list

A manual for the Integrated Genome Browser visualization tool is here

Course materials for a short course entitled Introduction to R and Bioconductor, held in Seattle in Dec 2010

Genomic Regions Enrichment of Annotations Tool - A web service to test for over-representation of specific ontology categories among genes near ChIP-seq peaks

Next-gen-seq software - a list of software packages, both commercial and open-source, related to analysis of deep sequencing datasets

Software from the Center for Bioinformatics and Computational Biology, University of Maryland - many useful programs, all open-source

PLAZA: a comparative genomics resource to study gene and genome evolution in plants; described by Proost et al, Plant Cell 21:3718, 2010 Full Text

The European Bioinformatics Institute provides tools ArrayExpressHTS and R-Cloud for analysis of transcriptome data

Lab Page http://gabi.cidbio.org/index/

More at http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1000369

Address of the bookmark: http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1000369

a) M.Sc/or equivalent in biological sciences/related areas [Position Code: PA_JRF_PF_a]
b) B.E/B.Tech/ M.Sc in biotechnology/bioinformatics/computer science/Chemistry/Physics or MCA [Position Code: PA_JRF_PF_b]
c) M.Sc/or equivalent in wildlife sciences/ecology/environmental sciences or MBBS/BVSc/MVSc. [Position Code: PA_JRF_PF_c]

(Candidates with result awaited are NOT eligible to apply)

Upper Age limit 28years

Rs.12000 / Rs.16000 (as sanctioned by the funding agency)

2. Post Doctoral Fellow/Research Associate in multiple research areas [PDF_RA]

Ph.D. (submitted/awarded) in any branch of biological Sciences. Candidates with Ph.D. in other sciences are also encouraged to apply.

Experience in molecular biology, biochemistry, structural biology, cell biology, infectious disease, conservation genetics, veterinary science, reproductive biology, and molecular diagnostics is desired but not mandatory.

[Position Code: PDF_RA]

UpperAge limit 35years

Rs. 22000- 26000 (as sanctioned by the funding agency)

3. Post Doctoral Scientist Fellow [PDSF]

Ph.D in any of the following areas: bioinformatics, next generation sequencing, high throughput data analysis, proteomics, bio-statistics, computer science, information technology, computer hardware and networking/clustering, parallel processing.
[Position Code: PDSF]

Upper Age limit 40 years

Rs. 40000 consolidated (as sanctioned by the funding agency)

Download Application: Last date for apply online: 09th Oct 2014

Advertisement: www.ccmb.res.in//index.php?view=notifications&mid=0&id=71&nid=38

Apply online http://www.ccmb.res.in/positions/temp_notif/online_form.html

More at http://www.ccmb.res.in//index.php?view=notifications&mid=0&id=71&nid=38

Responsibilities

Lead teams of scientists in structuring, prototyping, and executing large-scale bioinformatic and other analysis.
Develop novel bioinformatics, statistical, data processing, pathway, data mining and other algorithms to identify biological signals and their clinical correlates in broad kinds of individual and population data.
Develop novel platform-level analytical tools for sequence-based assays (assembly, annotation, variant calling and interpretation, phasing, genome structure, etc.), expression assays (RNAseq and microarray), proteomics, and metabolomics.
Develop statistical models that robustly correlate complex laboratory-derived information with phenotypic and clinical information.
Create scientifically rigorous visualizations, communications, and presentations of results.

Reference @ https://www.google.com/about/careers/search#!t=jo&jid=62095001

More at http://bioinfo.vanderbilt.edu/zhanglab/

Current research interests include next-generation DNA sequencing, structural variation, genome rearrangements in cancer and evolution, and network analysis of somatic mutations in cancer. Earlier research included topics in comparative genomics, multiple sequence alignment, and motif finding.

More athttp://compbio.cs.brown.edu/