Welcome to phylobabble.org, a discussion forum for phylogenetic theory and applications. The primary goal of this forum is to discuss best practice and new developments in phylogenetics. Although we do have a Troubleshooting category for getting feedback on analyses, this is not a help site for running phylogenetics programs.

A great place to chat about phylogenetics for researchers and the broader community of students and science-interested citizens. 

Address of the bookmark: http://phylobabble.org/

Like other indel callers, Scalpel works by performing de novo assembly of regions of interest, so that misalignment to the reference genome cannot obscure the presence of an insertion or deletion. Scalpel's innovation is to repeatedly check its assembly before comparing to the reference genome, to account for simple sequence repeats that are a regular source of error in indel calling. When Scalpel assembles an exon, it collects reads that map to that exon (including partial matches), splits them into k-mers, and creates a de Bruijn graph to span the exon; however, if it detects repeats in the map, it iteratively increases the size of the k-mers by one base until the repeats are eliminated. This ensures that the final assembly of the exon is highly accurate while minimizing compute time.

The Cold Spring Harbor team's validation of Scalpel, published over the weekend in Nature Methods, compares Scalpel's performance on a live whole exome against HaplotypeCaller and SOAPindel. The donor is an individual with serious neurological disorders, which may be linked to a high incidence of indels. One thousand indels from this individual's exome, called by one or more of the informatics pipelines, were selected for focused resequencing. This resequencing revealed a 77% true positive rate for Scalpel calls, dramatically better than the rates for either of the competing tools; Scalpel performed especially well with indels longer than five base pairs, a traditional weak point for indel callers.

Finally, the authors demonstrate Scalpel's use on a large set of genetic data from nearly 600 families who donated samples to the Simons Simplex Collection, a project of the Simons Foundation Autism Research Initiative. Scalpel found a very high enrichment for indels in children affected by autism, compared with their unaffected siblings, a pattern that persisted even after excluding common variants.

Algorithms scripts @ https://github.com/jschendel/bioinformatics-algorithms-coursera

Address of the bookmark: https://github.com/jorvis/biocode

The objective of this conference is two-fold:

Understanding different algorithms of MD and their relevant applications.
Hands-on practical exercises using NAMD.

More at http://ccbb.jnu.ac.in/advmdbio/

WALK IN INTERVIEW

A walk-in Interview for the following position tenable at the Bioinformatics Infrastructure Facility (BIF), Department of Biotechnology, Alagappa University will be held at the Department of Biotechnology, Alagappa University, Karaikudi 630 003 on 15.05.2014 (Thursday) at 01:00 PM. This national facility is funded by the Department of Biotechnology, Ministry of Science and Technology, Government of India, New Delhi. The main objectives of the Centre involve teaching and research activities in bioinformatics/biotechnology.

RA (One Post):

Salary : Rs. 11000 p.m. plus admissible HRA

Qualification: M.Sc., in Bioinformatics/Biotechnology/Biophysics/Biochemistry/ Life Sciences

Interested candidates are encouraged to send their Curriculum Vitae by email to “sk_pandian@rediffmail.com” in advance. On the day of interview, the candidates must produce original certificates in proof of their educational qualification and experience and a recommendation letter from the Head of the Department/Institution where last studied/worked. Candidates who have already passed the required Degree alone are eligible to appear for interview. No TA&DA will be given for attending the interview.

Advertisement: http://www.alagappabiotech.org/Walk%20in%20interview.pdf

Research Associate (one post): Emoluments as per DST/DBT norms & as sanctioned in the project

Qualification: Candidates having Ph.D. degree (awarded) in any discipline of Life Sciences with good publication record are eligible to apply. Candidates having prior experience in the area of Genetic and molecular analysis of plant/fungus for disease resistance/susceptibility of transcriptome and genome analysis will be preferred.

Junior Research Fellow (one post): Emoluments as per DST/DBT norms & as sanctioned in the project

Qualification: Candidates having M.Sc./M.Tech degree in any discipline of Life Sciences/Engineering (with minimum 55% marks) are eligible to apply. The Candidate having prior work experience in Molecular biology of plants/animal/fungus or Computational biology with experience in analysis of next-generation sequencing data, protein-protein interaction and system biology will be given preference.

The positions are purely temporary and are co-terminus with the project. The initial appointment will be for one year, which can be extended/curtailed on the basis of assessment of the candidate’s performance and discretion of the Competent Authority. The eligible candidates may further be shortlisted based on the qualification/experience depending on the total number of applications received. NIPGR reserves the right to select the candidate against the above post depending upon the qualification(s) and experience of the candidate. Reservation of post shall be as per Govt. of India norms.

Eligible candidates may apply by sending their complete application in the enclosed format.

The attested copies of the certificates and proof of research experience (if any) are to be attached with the hard copy of application. The applications should reach at the address given below within 15 days from the date of advertisement. The envelope must be superscribed by “Application for the Post of RA/JRF in the CPCFG Project” of Dr. Praveen Verma.

http://www.nipgr.res.in/files/careers/app_format_RA_JRF.docx

Contact Person address
Dr. Praveen Verma
Staff Scientist-VI & Principal Investigator ,
National Institute of Plant Genome Research ,(NIPGR)
Aruna Asaf Ali Marg, P.O. Box NO. 10531,
New Delhi - 110067

Pay scale: Pay Band of Rs. 37400-67000 with AGP of Rs. 9000.

i. Educational Qualification: Good academic record with a Ph.D. Degree in the concerned/allied/relevant disciplines.

ii. A Master's Degree with at least 55% marks (or an equivalent grade in a point scale wherever grading system is followed).

iii. A minimum of eight years of experience of teaching and/or research in an academic/research position equivalent to that of Assistant Professor in a University, College or Accredited Research Institution/industry excluding the period of Ph.D. research with evidence of published work and a minimum of 5 publications as books and/or research/policy papers.

iv. Contribution to educational innovation, design of new curricula and courses, and technology - mediated teaching learning process with evidence of having guided doctoral candidates and research students.

v. A minimum score as stipulated in the Academic Performance Indicator (API) based Performance Based Appraisal System (PBAS), set out in UGC Regulation.

Download application form from website: http://www.allduniv.ac.in/

Send your application to the Registrar, University of Allahabad, Allahabad-211002 (U.P.) on or before 30th April 2014

For more details: http://www.allduniv.ac.in/images/adv/backlog/advt-details.pdf OR http://www.allduniv.ac.in/images/news/extension-notice.pdf

Last Apply Date: 30 May 2014

Stay at home if you have coronavirus symptoms

Stay at home if you have either:

• a high temperature – you feel hot to touch on your chest or back
• a new, continuous cough – this means you've started coughing repeatedly

DO NOT TAKE

Ibrufen

https://amp.theguardian.com/world/2020/mar/14/anti-inflammatory-drugs-may-aggravate-coronavirus-infection

How to avoid catching and spreading coronavirus (social distancing)

Everyone should do what they can to stop coronavirus spreading.

It is particularly important for people who:

• are 70 or over
• have a long-term condition
• are pregnant
• have a weakened immune system

Below are the 52 Coronavirus COVID-19 Testing sites/locations in India.

State: Andhra Pradesh       

1. Sri Venkateswara Institute of Medical Sciences, Tirupati
2. Andhra Medical College, Visakhapatnam, Andhra Pradesh
3. GMC, Anantapur, AP

State: Andaman & Nicobar islands

1. Regional Medical Research Centre, Port Blair, Andaman, and Nicobar

State: Assam

1. Gauhati Medical College, Guwahati
2.  Regional Medical Research Center, Dibrugarh

State: Bihar

1. Rajendra Memorial Research Institute of Medical Sciences, Patna

State: Chandigarh

1. Post Graduate Institute of Medical Education & Research, Chandigarh

State: Chhattisgarh

1. All India Institute Medical Sciences, Raipur

Union Territory: Delhi-NCT 

1. All India Institute Medical Sciences, Delhi
2. National Centre for Disease Control, Delhi

State: Gujarat

1. BJ Medical College, Ahmedabad
2. M.P.Shah Government Medical College, Jamnagar

State: Haryana

1. Pt. B.D. Sharma Post Graduate Inst. of Med. Sciences, Rohtak, Haryana
2. BPS Govt Medical College, Sonipat

State: Himachal Pradesh

1. Indira Gandhi Medical College, Shimla, Himachal Pradesh
2. Dr.Rajendra Prasad Govt. Med. College, Kangra, Tanda, HP

Union Territory: Jammu and Kashmir

1. Sher‐e‐ Kashmir Institute of Medical Sciences, Srinagar
2. Government Medical College, Jammu

State: Jharkhand

1. MGM Medical College, Jamshedpur

State: Karnataka

1. Bangalore Medical College & Research Institute, Bangalore
2. National Institute of Virology Field Unit Bangalore
3. Mysore Medical College & Research Institute, Mysore
4. Hassan Inst. of Med. Sciences, Hassan, Karnataka
5. Shimoga Inst. of Med. Sciences, Shivamogga, Karnataka

State: Kerala

1. National Institute of Virology Field Unit, Kerala
2. Govt. Medical College, Thiruvananthapuram, Kerala
3. Govt. Medical College, Kozhikode, Kerala

State: Madhya Pradesh

1. All India Institute Medical Sciences, Bhopal
2. National Institute of Research in Tribal Health (NIRTH), Jabalpur

State: Meghalaya

1. NEIGRI of Health and Medical Sciences, Shillong, Meghalaya

State: Maharashtra

1. Indira Gandhi Government Medical College, Nagpur
2. Kasturba Hospital for Infectious Diseases, Mumbai

State: Manipur

1. J N Inst. of Med. Sciences Hospital, Imphal‐East, Manipur

State: Odisha

1. Regional Medical Research Center, Bhubaneswar

Union Territory: Puducherry

1. Jawaharlal Institute of Postgraduate Medical Education & Research, Puducherry

State: Punjab

1. Government Medical College, Patiala, Punjab
2. Government Medical College, Amritsar

State: Rajasthan

1. Sawai Man Singh, Jaipur
2. Dr. S.N Medical College, Jodhpur
3. Jhalawar Medical College, Jhalawar, Rajasthan
4. SP Med. College, Bikaner, Rajasthan

State: Tamil Nadu

1. King’s Institute of Preventive Medicine & Research, Chennai
2. Government Medical College, Theni

State: Tripura

1. Government Medical College, Agartala

State: Telangana

1. Gandhi Medical College, Secunderabad

State: Uttar Pradesh

1. King’s George Medical University, Lucknow
2. Institute of Medical Sciences, Banaras, Hindu University, Varanasi
3. Jawaharlal Nehru Medical College, Aligarh

State: Uttarakhand

1. Government Medical College, Haldwani

State: West Bengal

1. National Institute of Cholera and Enteric Diseases, Kolkata
2. IPGMER, Kolkata