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	<title><![CDATA[BOL: Related items]]></title>
	<link>https://bioinformaticsonline.com/related/36833?offset=90</link>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/40546/clincnv-detection-of-copy-number-changes-in-germlinetriosomatic-contexts-in-ngs-data</guid>
	<pubDate>Thu, 16 Jan 2020 23:16:02 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/40546/clincnv-detection-of-copy-number-changes-in-germlinetriosomatic-contexts-in-ngs-data</link>
	<title><![CDATA[ClinCNV: Detection of copy number changes in Germline/Trio/Somatic contexts in NGS data]]></title>
	<description><![CDATA[<p><span>ClinCNV detects CNVs in germline and somatic context in NGS data (targeted and whole-genome). We work in cohorts, so it makes sense to try&nbsp;</span><code>ClinCNV</code><span>&nbsp;if you have more than 10 samples (recommended amount - 40 since we estimate variances from the data). By "cohort" we mean samples sequenced with the same enrichment kit with approximately the same depth (ie 1x WGS and 30x WGS better be analysed in separate runs of ClinCNV). Of course it is better if your samples were sequenced within the same sequencing facility.</span></p><p>Address of the bookmark: <a href="https://github.com/imgag/ClinCNV" rel="nofollow">https://github.com/imgag/ClinCNV</a></p>]]></description>
	<dc:creator>Neel</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/40946/free-genomics-data</guid>
	<pubDate>Fri, 07 Feb 2020 14:08:31 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/40946/free-genomics-data</link>
	<title><![CDATA[Free Genomics data !]]></title>
	<description><![CDATA[<p><span>The specimens were collected by the Oxford Wytham Woods and Edinburgh Lohse lab teams. DNA extraction and sequencing was carried out by the Sanger Institute Scientific Operations teams. Assemblies were carried out by the Tree of Life team (Shane McCarthy) and colleagues in Pacific Biosciences (Jonas Korlach).</span></p>
<p><a href="https://www.darwintreeoflife.org/an-initial-set-of-raw-genome-assemblies-from-the-darwin-tree-of-life-project/">https://www.darwintreeoflife.org/an-initial-set-of-raw-genome-assemblies-from-the-darwin-tree-of-life-project/</a></p><p>Address of the bookmark: <a href="https://www.darwintreeoflife.org/an-initial-set-of-raw-genome-assemblies-from-the-darwin-tree-of-life-project/" rel="nofollow">https://www.darwintreeoflife.org/an-initial-set-of-raw-genome-assemblies-from-the-darwin-tree-of-life-project/</a></p>]]></description>
	<dc:creator>BioStar</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/41464/phytozome-v121-plant-science-community-hub-for-accessing-palnts-genomic-data</guid>
	<pubDate>Tue, 17 Mar 2020 07:30:17 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/41464/phytozome-v121-plant-science-community-hub-for-accessing-palnts-genomic-data</link>
	<title><![CDATA[Phytozome  v12.1: plant science community hub for accessing palnts genomic data]]></title>
	<description><![CDATA[<p>Phytozome, the Plant Comparative Genomics portal of the Department of Energy's Joint Genome Institute, provides JGI users and the broader plant science community a hub for accessing, visualizing and analyzing JGI-sequenced plant genomes, as well as selected genomes and datasets that have been sequenced elsewhere. As of release v12.1.6, Phytozome hosts 93 assembled and annotated genomes, from 82 Viridiplantae species. More than half of these genomes have been sequenced, assembled and/or annotated with JGI Plant Science program resources. By integrating this large collection of plant genomes into a single resource and performing comprehensive and uniform annotation and analyses, Phytozome facilitates accurate and insightful comparative genomics studies.</p><p>Address of the bookmark: <a href="https://phytozome.jgi.doe.gov/pz/portal.html" rel="nofollow">https://phytozome.jgi.doe.gov/pz/portal.html</a></p>]]></description>
	<dc:creator>Surabhi Chaudhary</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/42040/proactiv-estimation-of-promoter-activity-from-rna-seq-data</guid>
	<pubDate>Thu, 13 Aug 2020 10:21:44 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/42040/proactiv-estimation-of-promoter-activity-from-rna-seq-data</link>
	<title><![CDATA[proActiv: Estimation of Promoter Activity from RNA-Seq data]]></title>
	<description><![CDATA[<p>proActiv is an R package that estimates promoter activity from RNA-Seq data. proActiv uses aligned reads and genome annotations as input, and provides absolute and relative promoter activity as output. The package can be used to identify active promoters and alternative promoters, the details of the method are described in&nbsp;<a href="https://github.com/GoekeLab/proActiv#reference">Demircioglu et al</a>.</p>
<p>Additional data on differential promoters in tissues and cancers from TCGA, ICGC, GTEx, and PCAWG can be downloaded here:&nbsp;<a href="https://jglab.org/data-and-software/">https://jglab.org/data-and-software/</a></p><p>Address of the bookmark: <a href="https://github.com/GoekeLab/proActiv" rel="nofollow">https://github.com/GoekeLab/proActiv</a></p>]]></description>
	<dc:creator>BioStar</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/42661/3d-genome-browser-explore-chromatin-interaction-data-such-as-hi-c-chia-pet-capture-hi-c-plac-seq-and-more</guid>
	<pubDate>Fri, 22 Jan 2021 20:19:32 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/42661/3d-genome-browser-explore-chromatin-interaction-data-such-as-hi-c-chia-pet-capture-hi-c-plac-seq-and-more</link>
	<title><![CDATA[3D Genome Browser: explore chromatin interaction data, such as Hi-C, ChIA-PET, Capture Hi-C, PLAC-Seq, and more]]></title>
	<description><![CDATA[<p><span>Beside visualizing chromatin interaction data, you can also seamlessly browse other omics data such as ChIP-Seq or RNA-Seq for the same genomic region, and gain a complete view of both regulatory landscape and 3D genome structure for any given gene. You can also check the expression of any queried gene across hundreds of tissue/cell types measured by the ENCODE consortium. Finally, please check out the virtual 4C page, where we provide multiple methods to link distal cis-regulatory elements with their potential target genes, including virtual 4C, ChIA-PET and cross-cell-type correlation of proximal and distal DHSs.</span></p><p>Address of the bookmark: <a href="http://3dgenome.fsm.northwestern.edu/index.html" rel="nofollow">http://3dgenome.fsm.northwestern.edu/index.html</a></p>]]></description>
	<dc:creator>BioStar</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/43641/refseq-viraal-genome-sequences</guid>
	<pubDate>Sat, 11 Dec 2021 08:35:18 -0600</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/43641/refseq-viraal-genome-sequences</link>
	<title><![CDATA[Refseq viraal genome sequences !]]></title>
	<description><![CDATA[<p>List of all viruses on NCBI&nbsp;</p>
<p>https://ftp.ncbi.nlm.nih.gov/refseq/release/viral/</p><p>Address of the bookmark: <a href="https://ftp.ncbi.nlm.nih.gov/refseq/release/viral/" rel="nofollow">https://ftp.ncbi.nlm.nih.gov/refseq/release/viral/</a></p>]]></description>
	<dc:creator>Jit</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/44529/contigextender-a-new-approach-to-improving-de-novo-sequence-assembly-for-viral-metagenomics-data</guid>
	<pubDate>Wed, 08 May 2024 07:32:45 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/44529/contigextender-a-new-approach-to-improving-de-novo-sequence-assembly-for-viral-metagenomics-data</link>
	<title><![CDATA[ContigExtender: a new approach to improving de novo sequence assembly for viral metagenomics data]]></title>
	<description><![CDATA[<p dir="auto">ContigExtender, was developed to extend contigs, complementing de novo assembly. ContigExtender employs a novel recursive Overlap Layout Candidates (r-OLC) strategy that explores multiple extending paths to achieve longer and highly accurate contigs. ContigExtender is effective for extending contigs significantly in in silico synthesized and real metagenomics datasets.</p>
<p dir="auto">More at&nbsp;https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953547/</p>
<p dir="auto"><a href="https://camo.githubusercontent.com/72dc78177cd84dd0c667a2922a9fd984fb548b5ec94b11f9a547211a4adba3b1/68747470733a2f2f692e696d6775722e636f6d2f7734516944496a2e706e67" target="_blank"><img src="https://camo.githubusercontent.com/72dc78177cd84dd0c667a2922a9fd984fb548b5ec94b11f9a547211a4adba3b1/68747470733a2f2f692e696d6775722e636f6d2f7734516944496a2e706e67" alt="extension process" title="extension process" style="border: 0px;"></a></p><p>Address of the bookmark: <a href="https://github.com/dengzac/contig-extender" rel="nofollow">https://github.com/dengzac/contig-extender</a></p>]]></description>
	<dc:creator>LEGE</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/44541/powerful-books-for-learning-data-analysis-with-r</guid>
	<pubDate>Tue, 28 May 2024 07:42:56 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/44541/powerful-books-for-learning-data-analysis-with-r</link>
	<title><![CDATA[Powerful books for learning data analysis with R]]></title>
	<description><![CDATA[<p><span>R is powerful tool for data analysis, visualization, and machine learning. And it costs $0 to use! Here are six FREE books you can use to learn R today:</span></p>
<p><span>https://csgillespie.github.io/efficientR/</span></p>
<p><span>https://r-graphics.org/</span></p>
<p><span>https://rstudio-education.github.io/hopr/</span></p>
<p><span>https://r-pkgs.org/</span></p>
<p><span>https://r4ds.had.co.nz/</span></p>
<p>&nbsp;</p><p>Address of the bookmark: <a href="https://r-graphics.org/" rel="nofollow">https://r-graphics.org/</a></p>]]></description>
	<dc:creator>LEGE</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/bookmarks/view/10741/managing-and-analyzing-next-generation-sequence-data</guid>
	<pubDate>Sat, 10 May 2014 06:28:06 -0500</pubDate>
	<link>https://bioinformaticsonline.com/bookmarks/view/10741/managing-and-analyzing-next-generation-sequence-data</link>
	<title><![CDATA[Managing and Analyzing Next-Generation Sequence Data]]></title>
	<description><![CDATA[<p>Centralized Bioinformatics Core Facilities provide shared resources for the computational and IT requirements of the investigators in their department or institution. As such, they must be able to effectively react to new types of experimental technology. Recently faced with an unprecedented flood of data generated by the next generation of DNA sequencers, these groups found it necessary to respond quickly and efficiently to the informatics and infrastructure demands. Centralized Facilities newly facing this challenge need to anticipate time and design considerations of necessary components, including infrastructure upgrades, staffing, and tools for data analyses and management ...</p>
<p>More at http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1000369</p><p>Address of the bookmark: <a href="http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1000369" rel="nofollow">http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1000369</a></p>]]></description>
	<dc:creator>Rahul Agarwal</dc:creator>
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	<guid isPermaLink="true">https://bioinformaticsonline.com/pages/view/33869/import-r-data</guid>
	<pubDate>Wed, 12 Jul 2017 08:30:46 -0500</pubDate>
	<link>https://bioinformaticsonline.com/pages/view/33869/import-r-data</link>
	<title><![CDATA[Import R Data]]></title>
	<description><![CDATA[<p>It is often necessary to import sample textbook data into R before you start working on your homework.</p><div id="node-69"><div><p><strong>Excel File</strong></p><p>Quite frequently, the sample data is in&nbsp;<span>Excel&nbsp;</span>format, and needs to be imported into R prior to use. For this, we can use the function&nbsp;<span>read.xls&nbsp;</span>from the&nbsp;<span>gdata&nbsp;</span>package. It reads from an Excel spreadsheet and returns a&nbsp;<a href="http://www.r-tutor.com/r-introduction/data-frame">data frame</a>. The following shows how to load an Excel spreadsheet named&nbsp;<span>"mydata.xls"</span>. This method requires Perl runtime to be present in the system.</p><blockquote><div id="listing-68"><span><a></a></span>&gt;&nbsp;library(gdata)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;#&nbsp;load&nbsp;gdata&nbsp;package&nbsp;<br /><span><a></a></span>&gt;&nbsp;help(read.xls)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;#&nbsp;documentation&nbsp;<br /><span><a></a></span>&gt;&nbsp;mydata&nbsp;=&nbsp;read.xls("mydata.xls")&nbsp;&nbsp;#&nbsp;read&nbsp;from&nbsp;first&nbsp;sheet</div></blockquote><p>Alternatively, we can use the function&nbsp;<span>loadWorkbook&nbsp;</span>from the&nbsp;<span>XLConnect&nbsp;</span>package to read the entire workbook, and then load the worksheets with&nbsp;<span>readWorksheet</span>. The&nbsp;<span>XLConnect&nbsp;</span>package requires Java to be pre-installed.</p><blockquote><div id="listing-69"><span><a></a></span>&gt;&nbsp;library(XLConnect)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;#&nbsp;load&nbsp;XLConnect&nbsp;package&nbsp;<br /><span><a></a></span>&gt;&nbsp;wk&nbsp;=&nbsp;loadWorkbook("mydata.xls")&nbsp;<br /><span><a></a></span>&gt;&nbsp;df&nbsp;=&nbsp;readWorksheet(wk,&nbsp;sheet="Sheet1")</div></blockquote><p>&nbsp;</p><h4><a></a>Minitab File</h4><p>If the data file is in&nbsp;<span>Minitab Portable Worksheet&nbsp;</span>format, it can be opened with the function&nbsp;<span>read.mtp&nbsp;</span>from the&nbsp;<span>foreign&nbsp;</span>package. It returns a&nbsp;<a href="http://www.r-tutor.com/r-introduction/list">list</a>&nbsp;of components in the Minitab worksheet.</p><blockquote><div id="listing-70"><span><a></a></span>&gt;&nbsp;library(foreign)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;#&nbsp;load&nbsp;the&nbsp;foreign&nbsp;package&nbsp;<br /><span><a></a></span>&gt;&nbsp;help(read.mtp)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;#&nbsp;documentation&nbsp;<br /><span><a></a></span>&gt;&nbsp;mydata&nbsp;=&nbsp;read.mtp("mydata.mtp")&nbsp;&nbsp;#&nbsp;read&nbsp;from&nbsp;.mtp&nbsp;file</div></blockquote><p>&nbsp;</p><h4><a></a>SPSS File</h4><p>For the data files in&nbsp;<span>SPSS&nbsp;</span>format, it can be opened with the function&nbsp;<span>read.spss&nbsp;</span>also from the&nbsp;<span>foreign&nbsp;</span>package. There is a&nbsp;<span>"to.data.frame"&nbsp;</span>option for choosing whether a data frame is to be returned. By default, it returns a list of components instead.</p><blockquote><div id="listing-71"><span><a></a></span>&gt;&nbsp;library(foreign)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;#&nbsp;load&nbsp;the&nbsp;foreign&nbsp;package&nbsp;<br /><span><a></a></span>&gt;&nbsp;help(read.spss)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;#&nbsp;documentation&nbsp;<br /><span><a></a></span>&gt;&nbsp;mydata&nbsp;=&nbsp;read.spss("myfile",&nbsp;to.data.frame=TRUE)</div></blockquote><p>&nbsp;</p><h4><a></a>Table File</h4><p>A data table can resides in a text file. The cells inside the table are separated by blank characters. Here is an example of a table with 4 rows and 3 columns.</p><blockquote><div id="listing-72"><span><a></a></span>100&nbsp;&nbsp;&nbsp;a1&nbsp;&nbsp;&nbsp;b1&nbsp;<br /><span><a></a></span>200&nbsp;&nbsp;&nbsp;a2&nbsp;&nbsp;&nbsp;b2&nbsp;<br /><span><a></a></span>300&nbsp;&nbsp;&nbsp;a3&nbsp;&nbsp;&nbsp;b3&nbsp;<br /><span><a></a></span>400&nbsp;&nbsp;&nbsp;a4&nbsp;&nbsp;&nbsp;b4</div></blockquote><p>Now copy and paste the table above in a file named&nbsp;<span>"mydata.txt"&nbsp;</span>with a text editor. Then load the data into the workspace with the function&nbsp;<span>read.table</span>.</p><blockquote><div id="listing-73"><span><a></a></span>&gt;&nbsp;mydata&nbsp;=&nbsp;read.table("mydata.txt")&nbsp;&nbsp;#&nbsp;read&nbsp;text&nbsp;file&nbsp;<br /><span><a></a></span>&gt;&nbsp;mydata&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;#&nbsp;print&nbsp;data&nbsp;frame&nbsp;<br /><span><a></a></span>&nbsp;&nbsp;&nbsp;V1&nbsp;V2&nbsp;V3&nbsp;<br /><span><a></a></span>1&nbsp;100&nbsp;a1&nbsp;b1&nbsp;<br /><span><a></a></span>2&nbsp;200&nbsp;a2&nbsp;b2&nbsp;<br /><span><a></a></span>3&nbsp;300&nbsp;a3&nbsp;b3&nbsp;<br /><span><a></a></span>4&nbsp;400&nbsp;a4&nbsp;b4</div></blockquote><p>For further detail of the function&nbsp;<span>read.table</span>, please consult the R documentation.</p><blockquote><div id="listing-74"><span><a></a></span>&gt;&nbsp;help(read.table)</div></blockquote><p>&nbsp;</p><h4><a></a>CSV File</h4><p>The sample data can also be in&nbsp;<span>comma separated values&nbsp;</span>(CSV) format. Each cell inside such data file is separated by a special character, which usually is a comma, although other characters can be used as well.</p><p>The first row of the data file should contain the column names instead of the actual data. Here is a sample of the expected format.</p><blockquote><div id="listing-75"><span><a></a></span>Col1,Col2,Col3&nbsp;<br /><span><a></a></span>100,a1,b1&nbsp;<br /><span><a></a></span>200,a2,b2&nbsp;<br /><span><a></a></span>300,a3,b3</div></blockquote><p>After we copy and paste the data above in a file named&nbsp;<span>"mydata.csv"&nbsp;</span>with a text editor, we can read the data with the function&nbsp;<span>read.csv</span>.</p><blockquote><div id="listing-76"><span><a></a></span>&gt;&nbsp;mydata&nbsp;=&nbsp;read.csv("mydata.csv")&nbsp;&nbsp;#&nbsp;read&nbsp;csv&nbsp;file&nbsp;<br /><span><a></a></span>&gt;&nbsp;mydata&nbsp;<br /><span><a></a></span>&nbsp;&nbsp;Col1&nbsp;Col2&nbsp;Col3&nbsp;<br /><span><a></a></span>1&nbsp;&nbsp;100&nbsp;&nbsp;&nbsp;a1&nbsp;&nbsp;&nbsp;b1&nbsp;<br /><span><a></a></span>2&nbsp;&nbsp;200&nbsp;&nbsp;&nbsp;a2&nbsp;&nbsp;&nbsp;b2&nbsp;<br /><span><a></a></span>3&nbsp;&nbsp;300&nbsp;&nbsp;&nbsp;a3&nbsp;&nbsp;&nbsp;b3</div></blockquote><p>In various European locales, as the comma character serves as the decimal point, the function&nbsp;<span>read.csv2&nbsp;</span>should be used instead. For further detail of the&nbsp;<span>read.csv&nbsp;</span>and&nbsp;<span>read.csv2&nbsp;</span>functions, please consult the R documentation.</p><blockquote><div id="listing-77"><span><a></a></span>&gt;&nbsp;help(read.csv)</div></blockquote><p>&nbsp;</p><h4><a></a>Working Directory</h4><p>Finally, the code samples above assume the data files are located in the R&nbsp;<span>working</span>&nbsp;<span>directory</span>, which can be found with the function&nbsp;<span>getwd</span>.</p><blockquote><div id="listing-78"><span><a></a></span>&gt;&nbsp;getwd()&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;#&nbsp;get&nbsp;current&nbsp;working&nbsp;directory</div></blockquote><p>You can select a different working directory with the function&nbsp;<span>setwd()</span>, and thus avoid entering the full path of the data files.</p><blockquote><div id="listing-79"><span><a></a></span>&gt;&nbsp;setwd("")&nbsp;&nbsp;&nbsp;#&nbsp;set&nbsp;working&nbsp;directory</div></blockquote><p>Note that the forward slash should be used as the path separator even on Windows platform.</p><blockquote><div id="listing-80"><span><a></a></span>&gt;&nbsp;setwd("C:/MyDoc")</div></blockquote></div></div>]]></description>
	<dc:creator>Abhimanyu Singh</dc:creator>
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